CN-121987510-A - Ternary supermolecule eutectic composition containing mandelic acid, preparation method and application

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a ternary supermolecule eutectic composition containing mandelic acid, a preparation method and application thereof. The ternary supermolecular eutectic composition containing the mandelic acid comprises the mandelic acid, the succinic acid and the dimethyl sulfone in a mass ratio of 1-4:1:1. The preparation method comprises the steps of respectively taking mandelic acid, succinic acid and dimethyl sulfone, vacuum drying to remove water impurities, obtaining pretreated raw materials, adding the pretreated raw materials into a ball mill, adding absolute ethyl alcohol with the total mass of 10-20% of the raw materials as a grinding assisting solvent, grinding to obtain a mixture, and finally drying to remove the ethyl alcohol solvent to obtain the ternary supermolecule eutectic composition containing the mandelic acid. The ternary supermolecular eutectic prepared by adopting the specific raw material proportion and the specific process forms a stable crystal structure through a hydrogen bond network, can remarkably improve the stability, the exfoliating effect and the acne removing effect of the ternary supermolecular eutectic in cosmetic application, and has lower irritation to inflammatory skin.

Inventors

• PENG GUANJIE
• CHEN XIAOWEN
• Zhu Kaile
• LI QIAO
• CHEN XIAOHUI
• CHEN JINPING

Assignees

• 凡可生物技术(广州)有限公司

Dates

Publication Date

20260508

Application Date

20260411

Claims (10)

1. 1. A ternary supermolecular eutectic composition containing mandelic acid is characterized by comprising mandelic acid, succinic acid and dimethyl sulfone in a mass ratio of 1-4:1:1.
2. 2. The ternary supermolecular eutectic composition containing mandelic acid according to claim 1, wherein the ternary supermolecular eutectic composition consists of mandelic acid, succinic acid and dimethyl sulfone in a mass ratio of 2-3:1:1.
3. 3. A method for preparing a ternary supermolecular eutectic composition containing mandelic acid according to claim 1 or 2, characterized in that it comprises the following steps: (1) Raw material pretreatment, namely respectively taking mandelic acid, succinic acid and dimethyl sulfone according to mass ratio, and placing the mixture in a vacuum drying oven for vacuum drying to remove moisture impurities to obtain pretreated raw materials; (2) Mixing and grinding, namely adding the pretreated raw materials in the step (1) into a planetary ball mill, and adding absolute ethyl alcohol accounting for 10-20% of the total mass of the raw materials as a grinding assisting solvent for grinding to obtain a mixture; (3) Solvent removal, namely drying the mixture obtained in the step (2) to remove the ethanol solvent, so as to obtain the ternary supermolecule eutectic composition containing mandelic acid.
4. 4. The preparation method of the ternary supermolecular eutectic composition containing mandelic acid according to claim 3, wherein in the step (1), the vacuum drying is performed at 55-65 ℃ and-0.08-0.1 MPa for 12-36 h, and in the step (2), the grinding is performed at room temperature and 200-300 r/min for 1-2 h.
5. 5. The method of claim 3, wherein the drying step of removing the ethanol solvent in the step (3) is as follows: and (3) placing the mixture obtained after grinding in the step (2) in a fume hood, naturally volatilizing ethanol to constant weight at room temperature to obtain loose solid, then placing in a vacuum drying oven, and vacuum drying for 6-24 h at 45-55 ℃ and-0.08-0.1 MPa, and removing residual ethanol solvent to obtain high-purity ternary supermolecule eutectic composition powder.
6. 6. Use of a ternary supramolecular eutectic composition comprising mandelic acid according to claim 1 or 2 in cosmetics.
7. 7. The application of claim 6, wherein the cosmetic is essence, the addition amount of the ternary supermolecular eutectic composition containing mandelic acid in the essence is 6-12wt%, and the pH of the essence is controlled to be 3.0-5.0.
8. 8. The application of claim 7, wherein the essence formula comprises the following components in percentage by mass: 6-12% of ternary supermolecular eutectic, 4-6% Of 1, 3-propylene glycol, 0.1 To 0.3% of sodium hyaluronate, 0.5-2% Of panthenol, 0.05-0.15% Of dipotassium glycyrrhizinate, 0.1 To 0.6% of preservative, 0.1 To 0.3% of pH regulator, And the balance of deionized water.
9. 9. The application of claim 6, wherein the cosmetic is a toning lotion, the addition amount of the ternary supermolecule eutectic composition containing mandelic acid in the toning lotion is 1-5wt%, and the pH of the toning lotion is controlled to be 3.0-6.0.
10. 10. The use according to claim 9, wherein the cosmetic water formulation comprises the following components in percentage by mass: 1-5% of ternary supermolecular eutectic, 3-6% Of glycerol, Polyethylene glycol 1-3%, 0.1-1% Of plant extract, 0.01-0.1% Of EDTA disodium, 0.1 To 0.6% of preservative, 0.1 To 0.3% of pH regulator, And the balance of deionized water.

Description

Ternary supermolecule eutectic composition containing mandelic acid, preparation method and application Technical Field The invention belongs to the technical field of cosmetics, and particularly relates to a ternary supermolecule eutectic composition containing mandelic acid, a preparation method and application thereof. Background Mandelic acid is also called mandelic acid and mandelic acid, has fat-soluble characteristic as alpha-hydroxy acid, can permeate deep skin cutin layer, mildly metabolize old and waste cutin, improve pores and lighten skin color, has inhibiting effect on inflammatory acnes, and is widely applied to skin-refreshing cosmetics. The existing commercial mandelic acid products are added in a free form, and have the technical defects that firstly, the water solubility is poor, a formula system is unstable and is often easy to crystallize and separate out, and secondly, the irritation is strong, the free mandelic acid directly contacts with the skin to reduce the pH value of the surface of the skin, and discomfort such as erythema, stinging and the like is caused to sensitive muscles. The supermolecular eutectic technology is to assemble active component and supplementary material molecule via intermolecular non-covalent bond, such as hydrogen bond and Van der Waals force, to form stable crystal structure, and this can improve the stability, solubility and bioavailability of active component obviously and reduce irritation. In the prior art, a binary supermolecular acid system has appeared, for example, the invention patent with publication number CN 116217379A describes that the tranexamic acid and the mandelic acid are reacted and combined into supermolecular salt, and the supermolecular tranexamic acid mandelic acid ion salt can better maintain the mandelic acid efficacy, such as oxidation resistance, melanin cell activity inhibition, tyrosinase activity inhibition and the like, and simultaneously can effectively improve the skin permeability of mandelic acid, improve the bioavailability of mandelic acid, and has lower skin irritation and enhanced application effect. However, the research on ternary supermolecular eutectic of mandelic acid is less at present, and the action mechanism and the technological condition for forming ternary supermolecular eutectic of mandelic acid lack corresponding theoretical and technical support. Disclosure of Invention In view of the above drawbacks and deficiencies of the prior art, a primary object of the present invention is to provide a ternary supermolecular eutectic composition containing mandelic acid. It is another object of the present invention to provide a method for preparing the ternary supramolecular eutectic composition containing mandelic acid. It is a further object of the present invention to provide the use of the ternary supramolecular eutectic composition containing mandelic acid as defined above in cosmetics. The invention aims at realizing the following technical scheme: A ternary supermolecular eutectic composition containing mandelic acid comprises mandelic acid, succinic acid and dimethyl sulfone in a mass ratio of 1-4:1:1. The above compositional conditions are necessary to form a particular ternary supramolecular eutectic composition. Preferably, the ternary supermolecule eutectic composition consists of mandelic acid, succinic acid and dimethyl sulfone in a mass ratio of 2-3:1:1. The ternary supermolecule eutectic composition obtained under the preferable proportioning condition has better application formula stability and application effect. The mandelic acid (CAS: 90-64-2) has conventional physicochemical properties of 152.15 molecular weight, 119-121 melting point, 150g/L water solubility (20 ℃) and 3.85 pKa (25 ℃) and is white crystal or crystalline powder, and has skin refreshing and acne removing effects. The eutectic composition is used as a core functional component, and has the following action mechanism that a carboxyl (-COOH) and hydroxyl (-OH) double-hydrogen bond donor is contained, a carboxylic acid dimer (-COOH. Cndot. HOOC-) is formed by the carboxyl and succinic acid at a specific ratio, and meanwhile, a-OH. Cndot. O=S hydrogen bond is formed by the hydroxyl and sulfonyl oxygen (O=S=O) of dimethyl sulfone. Succinic acid (CAS: 110-15-6) has conventional physicochemical properties of molecular weight 118.09, melting point 185-187 ℃, water solubility 56.2g/L (20 ℃) and pKa 4.21/5.64. The active mechanism of the invention is that the active component contains dicarboxyl, which is used as a molecular bridge and can be combined with mandelic acid molecule at the same time, thus solving the problem of dispersibility of mandelic acid and strengthening the stability of eutectic structure. Succinic acid is used as a dicarboxylic acid in the present application to enhance the exfoliating efficacy of mandelic acid. Dimethyl sulfone (CAS: 67-71-0) has conventional physicochemical properties of 78.13 molecular weight, 10