CN-121987514-A - Composition containing ergothioneine and preparation method and application thereof

Abstract

The application provides a composition containing ergothioneine, and a preparation method and application thereof. A first aspect of the application provides a composition comprising ergothioneine, anthocyanin, and bergamot. Anthocyanin can effectively prevent melanin excessive generation and improve existing melanin pigmentation to a certain extent, and bergamot can also inhibit melanin generation through various signal paths to improve melanin pigmentation. On the basis, the application tries to compound and match the two with ergothioneine with certain anti-inflammatory and antioxidant effects, and can realize better effect of improving melanin pigmentation than the single use or the multiplexing of the two.

Inventors

• LI XINYU
• ZHANG LIXIANG
• ZHI QIN
• ZHANG JIANSONG
• ZHOU BOHANG

Assignees

• 深圳市健翔生物制药有限公司

Dates

Publication Date

20260508

Application Date

20251231

Claims (10)

1. 1. A composition comprising ergothioneine, anthocyanin, and bergamot.
2. 2. The composition of claim 1, wherein the aglycone of anthocyanin comprises any one of cyanidin, delphinidin, malvidin, petuniin, pelargonidin, and paeoniflorin.
3. 3. The composition according to claim 1, wherein the mass ratio of ergothioneine, anthocyanin and bergamot is 1:5-10:1-10.
4. 4. The composition of claim 1, wherein the composition comprises, the composition further comprises epigallocatechin gallate.
5. 5. The composition according to claim 4, wherein the mass ratio of ergothioneine, anthocyanin, bergamot, and epigallocatechin gallate is 1 (5-10): 5-10.
6. 6. A process for the preparation of a composition according to any one of claims 1 to 5, comprising the step of mixing ergothioneine, anthocyanin and bergamot at a temperature below 40 ℃.
7. 7. Cosmetic product, characterized in that it comprises a composition according to any one of claims 1 to 5.
8. 8. The cosmetic according to claim 7, wherein the composition is added to the cosmetic in an amount of 0.01 to 5 wt%.
9. 9. The cosmetic according to claim 7, wherein the cosmetic is in the form of any one of cream emulsion, liquid, gel, powder, block, mud, wax, spray, aerosol, film base, and freeze-dried agent.
10. 10. Use of a composition according to any one of claims 1 to 5 or a cosmetic according to any one of claims 7 to 9 for the preparation of a product for inhibiting melanin pigmentation.

Description

Composition containing ergothioneine and preparation method and application thereof Technical Field The application relates to the technical field of cosmetics, in particular to a composition containing ergothioneine, and a preparation method and application thereof. Background Skin tone formation depends on the co-action of a variety of endogenous and exogenous pigments, one of which is melanin content. Melanin is synthesized in melanosomes by melanocytes (Melanocyte, MC), and is related to tyrosinase gene family, dopa tautomerase gene, pre-melanosome protein gene, etc., and can be mainly classified into true melanin (Eumelanin) and brown melanin (Pheomelanin), the former being a brownish black insoluble compound, and the latter being a reddish yellow soluble compound. Common cosmetics generally realize whitening and brightening by inhibiting the generation and deposition of melanin, inhibiting the proliferation of melanocytes, inhibiting the activity of tyrosinase, dopa tautomerase and the like in the process of melanin formation. With the continuous development of technology, natural active ingredients are favored in the cosmetic field because of their good efficacy, small side effects and high safety. Anthocyanin (anthocyanidin), also known as anthocyanidin, is a natural water-soluble pigment widely existing in plants, and has various biological activities such as antioxidation, anti-aging, free radical removal, anti-inflammatory, bacteriostasis, etc. Anthocyanins in the free form have poor structural stability and thus are more commonly formed by glycosidic bond substitution with saccharides, hundreds of which have been found. Researches show that anthocyanin can accelerate melanin metabolism and reduce skin pigmentation by regulating tyrosinase activity, but the effect still has a great improvement space compared with powerful products such as hydroquinone and the like. Disclosure of Invention The embodiment of the invention mainly aims at providing a composition containing ergothioneine, and a preparation method and application thereof. To achieve the above object, a first aspect of the present application provides a composition comprising ergothioneine, anthocyanin, and bergamot. The term "ergothioneine" is also known as 2-mercaptohistidine trimethylbetaine, CAS number 497-30-3, having the structural formula (I) below. Ergothioneine is a high-efficiency antioxidant, has potential neuroprotection and cardioprotection effects, and can alleviate disease pathology such as diabetes, cancer, etc. (I)。 The term "anthocyanin" is a natural water-soluble pigment that is widely found in plants and includes labile aglycone structures, common aglycone structures including 25, of which relatively common procyanidins, delphinidins, mallow, petuniins, pelargonidins, paeonins, and the like. In some embodiments, the anthocyanin forms a relatively stable anthocyanin from the aglycone structure and the glycosyl. In some embodiments, the glycosyl group comprises at least one of glucose, lactose, galactose, rhamnose, xylose, arabinose, and the like. In some embodiments, the glycosyl or aglycone in the anthocyanin is esterified with an aromatic or fatty acid (e.g., coumaric acid, ferulic acid, caffeic acid, parahydroxybenzoic acid, etc.). In some embodiments, the anthocyanin comprises at least one of cyanidin-3-glucoside, cyanidin-3-galactoside, pelargonidin-3-glucoside, delphinidin-3-glucoside, paeoniflorin-3-glucoside, malvidin-3-glucoside, petuniin-3-glucoside, and the like. The term "bergamotin" is also known as (E) -4- ((3, 7-dimethyloct-2, 6-dien-1-yl) oxy) -7H-furo [3,2-g ] chromen-7-one, CAS number 7380-40-7, formula (II) below. (II)。 In some embodiments, the mass ratio of ergothioneine to anthocyanin is 1:5-10, for example, 1:5, 6, 7, 8, 9, 10, specifically 1:5, 1:6, 1:7, 1:8, 1:9, 1:10. In some embodiments, the mass ratio of ergothioneine to bergamot is 1:1-10, for example, 1:1, 2, 3, 4, 5,6,7, 8, 9, 10, specifically 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10. In some embodiments, the mass ratio of anthocyanin to bergamot is 5-10:1-10, for example, 5, 6, 7, 8, 9, 10:1, 2,3, 4, 5, 6, 7, 8, 9, 10, specifically, 5, 6, 7, 8, 9, 10 5：1、5：2、5：3、5：4、5：5、5：6、5：7、5：8、5：9、5：10、6：1、6：2、6：3、6：4、6：5、6：6、6：7、6：8、6：9、6：10、7：1、7：2、7：3、7：4、7：5、7：6、7：7、7：8、7：9、7：10、8：1、8：2、8：3、8：4、8：5、8：6、8：7、8：8、8：9、8：10、9：1、9：2、9：3、9：4、9：5、9：6、9：7、9：8、9：9、9：10、10：1、10：2、10：3、10：4、10：5、10：6、10：7、10：8、10：9、10：10. In some embodiments, the mass ratio of ergothioneine, anthocyanin and bergamot is 1:5-10:1-10, for example, 1:5, 6, 7, 8, 9, 10:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, specifically, may be 1：5：1、1：6：1、1：7：1、1：8：1、1：9：1、1：10：1、1：5：2、1：6：2、1：7：2、1：8：2、1：9：2、1：10：2、1：5：3、1：6：3、1：7：3、1：8：3、1：9：3、1：10：3、1：5：4、1：6：4、1：7：4、1：8：4、1：9：4、1：10：4、1：5：5、1：6：5、1：7：5、1：8：5、1：9：5、1：10：5、1：5：6、1：6：6、1：7：6、1：8：6、1：9：6、1：10：6、1：5：7、1：6：7、1：7：7、1：8：7、1：9：7、1：10：7、1：5：8、1：6：8、1：7：8、1：8：8、1：9：8、1：10：8、1：5：9、1：6：9、1：7：9、1：8：9、1：9：9、1：10：9、1：5：3、1：6：10、1：7：10、1：8