CN-121987523-A - Heat-resistant liquid crystal emulsion system based on sodium hyaluronate and preparation method and application thereof

Abstract

The invention relates to the technical field of cosmetics and preparations thereof, and discloses a heat-resistant liquid crystal emulsion system based on acetylated sodium hyaluronate, a preparation method and application thereof, wherein the heat-resistant liquid crystal emulsion system comprises, by weight, 1-6 parts of liquid crystal emulsifier, 0.01-0.2 part of acetylated sodium hyaluronate, 5-60 parts of grease, 0.1-1 part of thickener, 0.1-1 part of preservative and 100 parts of water. The core of the invention is that the acetylated sodium hyaluronate is introduced into a liquid crystal system as a structure stabilizer, the heat stability of a liquid crystal structure is obviously improved through the anchoring effect of the acetylated sodium hyaluronate and a liquid crystal layer, and the obtained emulsion has the advantages of complete liquid crystal texture after long-term storage at 40 ℃ and excellent long-term moisturizing performance, and can be used as an ideal carrier of high-end cosmetics and external pharmaceutical preparations.

Inventors

• WANG XIAONA
• SHANG YAZHUO
• HAN TINGTING
• LIU YUHUAN
• YANG SUZHEN
• CHEN XIN
• NING HUI
• XU PEIPEI

Assignees

• 山东福瑞达生物股份有限公司
• 华东理工大学

Dates

Publication Date

20260508

Application Date

20260212

Claims (10)

1. 1. The heat-resistant liquid crystal emulsion system based on the sodium hyaluronate is characterized by comprising the following components in parts by weight: 1-6 parts of a liquid crystal emulsifier; 0.01-0.2 parts of acetylated sodium hyaluronate; 5.0-60 parts of grease; 0.1-1 parts of a thickening agent; 0.1-1 parts of preservative; water to 100.0 parts; wherein the acetyl content of the sodium hyaluronate is 20% -30%, and the number average molecular weight is 10000-50000 daltons.
2. 2. The heat-resistant liquid crystal emulsion system based on acetylated sodium hyaluronate as set forth in claim 1, wherein said liquid crystal emulsifier is one or more selected from the group consisting of lecithin-based liquid crystal emulsifiers, olive-based liquid crystal emulsifiers, and glucosidic-based liquid crystal emulsifiers.
3. 3. The heat-resistant liquid crystal emulsion system based on acetylated sodium hyaluronate as set forth in claim 1, wherein the oil is one or more selected from white mineral oil, silicone oil, triglyceride, saturated isopropyl myristate, isooctyl palmitate and squalane.
4. 4. The heat-resistant liquid crystal emulsion system based on acetylated sodium hyaluronate according to claim 1, wherein the thickener is at least one of carbomer type thickener, xanthan gum, acrylate, and alkyl acrylic acid cross-linked copolymer.
5. 5. The heat-resistant liquid crystal emulsion system based on acetylated sodium hyaluronate as set forth in claim 4, wherein the carbomer thickener system further comprises a neutralizing agent for neutralizing carbomer, wherein the neutralizing agent is sodium hydroxide solution, and the mass ratio of the carbomer to the 10% sodium hydroxide solution is 1:2.
6. 6. The heat-resistant liquid crystal emulsion system based on acetylated sodium hyaluronate as set forth in claim 1, wherein the preservative is one or more of phenylphenol, phenoxyethanol, 1, 2-pentanediol and 1, 2-hexanediol.
7. 7. A method for preparing the heat resistant liquid crystal emulsion system according to any one of claims 1 to 6, comprising the steps of: s1, mixing 1-6 parts by weight of liquid crystal emulsifier with 5-60 parts by weight of grease to be used as an oil phase, and heating to 75-80 ℃ to dissolve the oil phase; S2, adding 0.01-0.2 part by weight of acetylated sodium hyaluronate and 0.1-1 part by weight of thickener into water for dissolution to form a water phase, and heating to 75-80 ℃; S3, adding the oil phase into the water phase for emulsification under a homogenizing condition, and homogenizing for 5-8 minutes to obtain a primary emulsion; And S4, stirring and cooling the primary emulsion at the rotation speed of 25-28 ℃ and 300-500 rpm, and when the temperature is reduced to 45-50 ℃, adding 0.1-1 weight part of preservative, and continuously stirring to room temperature to obtain the heat-resistant liquid crystal emulsion system.
8. 8. The method of claim 7, wherein the homogenizing in the step S3 is performed at a rotational speed of 5000 to 9000rpm.
9. 9. Use of a heat-resistant liquid crystal emulsion system as claimed in any one of claims 1 to 6 for the preparation of cosmetic or topical pharmaceutical preparations.
10. 10. The method according to claim 9, wherein the cosmetic is a moisturizing cream, an essential cream, an anti-aging cream or a sun cream, and the topical pharmaceutical preparation is an anti-inflammatory analgesic or a topical skin treatment preparation.

Description

Heat-resistant liquid crystal emulsion system based on sodium hyaluronate and preparation method and application thereof Technical Field The invention relates to the technical field of cosmetics and preparations thereof, in particular to a heat-resistant liquid crystal emulsion system based on sodium hyaluronate, and a preparation method and application thereof. Background Liquid crystal structured emulsions are generally a novel emulsion system based on self-assembly of surfactants at the oil-water interface to form lamellar lyotropic liquid crystal phases. The micro-characteristics of the emulsion are that the emulsifier molecules are not arranged randomly on the interface, but form a lamellar liquid crystal structure with long-range order. The highly ordered molecular arrangement gives the liquid crystal emulsion a series of excellent performances beyond the traditional common emulsion (1) excellent physical stability, a liquid crystal network is used as a firm three-dimensional barrier, can effectively prevent coalescence and Orderian ripening of liquid drops, (2) a unique carrier function, the lamellar structure of the liquid crystal emulsion can be used as a micro reservoir to realize efficient entrapment and controllable slow release of active ingredients (such as whitening agents, anti-aging ingredients and medicines), so that the efficacy is improved and the stimulation risk is reduced, and (3) excellent biocompatibility and moisture retention are realized, the structure of the liquid crystal emulsion can simulate a skin cuticle lipid bilayer, the skin affinity of a product is enhanced, and long-acting moisture retention is realized by forming ordered moisture retention films. However, the performance of liquid crystal emulsion systems is highly dependent on the formation and maintenance of their microscopic liquid crystal structure. The formation of the structure is closely related to the type of the emulsifier (such as lecithin, olive ester and other amphiphilic molecules), and is strictly controlled by the cooperative regulation of complex factors such as formulation composition (such as oil phase property, water phase polarity and component proportion) and preparation process (such as temperature, shearing force and feeding sequence). The complexity of such structures also results in their inherent thermodynamic metastable nature. In practical application scenes, when the liquid crystal is subjected to high-temperature environments (such as storage in summer, long-distance transportation and use in tropical areas) or technological thermal stress (such as hot filling and sterilization), the ordered structure of the liquid crystal is extremely easy to damage, melt or phase change, so that the system is unstable. The method is characterized in that layering, demulsification and texture degradation of emulsion occur on the macro scale, characteristic liquid crystal textures disappear on the micro scale, core advantages of the liquid crystal textures serving as a stable framework and a functional carrier are lost, the slow release function is invalid on the efficacy, and the long-acting moisturizing performance is remarkably attenuated. Although the industry attempts to improve by optimizing the formulation or adding auxiliary stabilizers, it is often difficult to achieve a desirable balance of maintaining the structural integrity of the liquid crystal, maintaining the light skin feel of the system, and achieving long-term stability. Meanwhile, sodium hyaluronate (AcHA) has been widely used in cosmetics as a chemically modified hyaluronic acid derivative for the purpose of enhancing moisturizing properties due to its excellent skin-friendly and film-forming moisturizing properties. However, its practical paradigm is currently limited primarily to dissolution in the aqueous phase as an "effective moisturizing additive" and its functional value is not fully explored. In the prior art, research and practice for actively introducing and stabilizing the microstructure of a liquid crystal emulsion by taking acetylated sodium hyaluronate as a structural functional component are not available, so that the double challenges of heat stability and moisturizing durability of the liquid crystal emulsion are fundamentally and synergistically solved. Therefore, aiming at the current situation that the existing liquid crystal emulsion has insufficient heat stability and the current situation that the application scene of the acetylated sodium hyaluronate is single, an innovative technical scheme is urgently needed in the field. In particular, it is highly desirable to provide a heat-resistant liquid crystal emulsion system based on sodium hyaluronate, and a corresponding preparation method and a wide application path thereof. By converting the role of the traditional additive into the key construction unit participating in and stabilizing the liquid crystal structure, the acetylated sodium hyaluronate is hopeful to