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CN-121987529-A - Oral care composition and preparation method and application thereof

CN121987529ACN 121987529 ACN121987529 ACN 121987529ACN-121987529-A

Abstract

The invention relates to the technical field of oral care compositions, in particular to an oral care composition, a preparation method and application thereof, and the oral care composition comprises a first composition and a second composition, wherein the first composition comprises an anti-sensitive agent, a cosolvent, a first thickening agent, a surfactant and a first auxiliary agent, the second composition comprises phthalimide peroxycaproic acid, a cosolvent, a second thickening agent, a second auxiliary agent and deionized water, at least one of the cosolvent, the first auxiliary agent and the second auxiliary agent contains a flavoring agent, and the first composition and the second composition are stored separately before use so as to avoid the contact of the anti-sensitive agent and the phthalimide peroxycaproic acid before use. According to the invention, the first composition and the second composition are respectively and independently stored, so that the natural decomposition and activity decay of phthalimide peroxycaproic acid in the shelf life of the product are inhibited, and the product is ensured to still retain higher effective active oxygen content after long-term storage.

Inventors

  • CHEN YINGTAO

Assignees

  • 齿间科技(广州)有限公司

Dates

Publication Date
20260508
Application Date
20260316

Claims (10)

  1. 1. An oral care composition is characterized by comprising a first composition and a second composition, wherein the first composition comprises an anti-sensitive agent, a cosolvent, a first thickening agent, a surfactant and a first auxiliary agent, the second composition comprises phthalimide peroxycaproic acid, a cosolvent, a second thickening agent, a second auxiliary agent and deionized water, at least one of the cosolvent, the first auxiliary agent and the second auxiliary agent contains a flavoring agent, and the first composition and the second composition are stored separately before use so as to avoid the anti-sensitive agent from contacting with the phthalimide peroxycaproic acid before use.
  2. 2. The oral care composition of claim 1 wherein the anti-sensitivity agent comprises one of potassium citrate, potassium nitrate, bioactive glass, hydroxyapatite, and calcium silicate.
  3. 3. The oral care composition of claim 1, wherein the co-solvent comprises one or a combination of glycerin, sorbitol, polyethylene glycol 600, deionized water.
  4. 4. The oral care composition of claim 1 wherein the first thickening agent comprises one or a combination of carbomer, hydroxyethyl cellulose, carrageenan, xanthan gum, carboxymethyl cellulose, polyvinylpyrrolidone, the second thickening agent comprises one or a combination of hydroxyethyl cellulose, carrageenan, xanthan gum, PVM/MA copolymer, the surfactant comprises one of sodium dodecyl sulfate, sodium lauroyl sarcosinate, cocamidopropyl betaine, the first adjunct comprises at least one of flavor, silica, sodium saccharin, hydrated silica, sodium hydroxide, and the second adjunct comprises at least one of flavor, fumed silica, sodium saccharin.
  5. 5. The oral care composition according to claim 1, wherein the first composition comprises, by mass, 0.1 to 10 parts of an anti-sensitive agent, 40 to 100 parts of a cosolvent, 0.5 to 4 parts of a first thickener, 0.5 to 3 parts of a surfactant, and 0.5 to 25 parts of a first auxiliary agent, and the second composition comprises, by mass, 0.05 to 5 parts of phthalimide peroxycaproic acid, 40 to 50 parts of a cosolvent, 0.5 to 4 parts of a second thickener, 0.05 to 10 parts of a second auxiliary agent, and 30 to 55 parts of deionized water.
  6. 6. The oral care composition of claim 1, wherein the pH of the first composition and the second composition is between about 8.0 and about 9.5.
  7. 7. A method of preparing an oral care composition comprising the oral care composition of any one of claims 1-6, comprising the steps of: S1, weighing an anti-sensitive agent, a cosolvent, a first thickening agent, a surfactant and a first auxiliary agent, dispersing the first thickening agent in the cosolvent, heating, adding part of the first auxiliary agent, the surfactant and the anti-sensitive agent, stirring, adding the rest of the first auxiliary agent, and stirring to obtain a first composition; s2, weighing phthalimide peroxycaproic acid, a cosolvent, a second thickening agent, a second auxiliary agent and deionized water, dispersing the second thickening agent in the deionized water and the cosolvent, heating, adding part of the second auxiliary agent and the phthalimide peroxycaproic acid, stirring, adding the rest of the second auxiliary agent, and stirring to obtain a second composition; S3, storing the first composition and the second composition separately so as to avoid the anti-sensitive agent before using contacting with phthalimide peroxycaproic acid.
  8. 8. The method of claim 7, wherein in step S1, the pH of the first composition is adjusted to 7.0 or higher, and in step S2, the pH of the second composition is adjusted to 7.0 or lower, and when the first composition and the second composition are mixed, the pH of the mixture is 8.0-9.5.
  9. 9. Use of an oral care composition characterized by: an oral care composition comprising any one of claims 1 to 6 for oral care, the first composition and the second composition being mixed at the time of use.
  10. 10. The use of an oral care composition according to claim 9, comprising an extrusion container containing a first composition and a second composition, the extrusion container comprising an inner tube and an outer tube concentrically disposed, the inner tube having an inner tube nipple and the outer tube having an outer tube nipple, the second composition being located in the inner tube and the first composition being located in the outer tube.

Description

Oral care composition and preparation method and application thereof Technical Field The invention relates to the technical field of oral care compositions, in particular to an oral care composition, a preparation method and application thereof. Background In the existing oral care technology, the oral care gel or paste is usually stored in a special container, and is extruded onto a dental tray, a tooth beautifying instrument or a toothbrush by a user when in use, so that the care effects of whitening, anti-allergy and the like are realized. The anti-allergic component in the oral care product needs to adapt to neutral to alkalescent pH environment of the oral cavity, and the action mechanism of the anti-allergic component mainly comprises two types, namely, forming a protective film on the surface of teeth or in dentinal tubules to block the conduction of external stimuli such as cold, hot, sour and sweet to dental pulp nerves, and reducing the sensitivity of dental pulp nerve endings through ion action to inhibit nerve signal transmission, thereby relieving the dental sensitivity. As a main-stream tooth whitening active ingredient, phthalimide Peroxycaproic Acid (PAP) has advantages of low tooth sensitivity, small gum irritation, and less damage to enamel compared with conventional hydrogen peroxide and carbamide peroxide. However, if PAP is added into a general anti-sensitive gel or anti-sensitive toothpaste formula, the unpleasant taste of PAP raw materials such as bitter taste, metallic taste and the like can be reduced or eliminated to a great extent, but the phthalimide peroxy caproic acid is used as organic peroxy acid and is highly sensitive to system pH, metallic ions and nucleophilic substances, and the anti-sensitive ingredients are easy to release alkaline ions in an aqueous phase or change local microenvironment, if the two ingredients are placed in the same phase or in a single formula, the decomposition of the phthalimide peroxy caproic acid can be accelerated, the activity of the phthalimide peroxy caproic acid is reduced in a long-term storage process, and the expected whitening care effect cannot be realized. Therefore, there is a need in the market for an oral care composition containing phthalimide peroxycaproic acid, which can solve the problem of coexistence stability of the phthalimide peroxycaproic acid and the anti-allergic component, improve the taste of the product, thereby improving the use preference of consumers and further better meeting the use demands of users. Disclosure of Invention Aiming at the technical problems that the prior oral care composition containing the phthalimide peroxycaproic acid has poor taste, and the activity of the phthalimide peroxycaproic acid is reduced in the long-term storage process of the PAP and the anti-sensitive component in the same phase or the same formula, so that the expected whitening care effect can not be realized. The technical scheme adopted for solving the technical problems is as follows: an oral care composition is characterized by comprising a first composition and a second composition, wherein the first composition comprises an anti-sensitive agent, a cosolvent, a first thickening agent, a surfactant and a first auxiliary agent, the second composition comprises phthalimide peroxycaproic acid, a second thickening agent, a second auxiliary agent and deionized water, at least one of the cosolvent, the first auxiliary agent and the second auxiliary agent contains a flavoring agent, and the first composition and the second composition are stored separately before use so as to avoid the anti-sensitive agent from contacting the phthalimide peroxycaproic acid before use. According to the invention, the first composition containing the anti-sensitive agent and the second composition containing the phthalimide peroxycaproic acid are respectively and independently stored, so that the direct contact between the anti-sensitive agent and the phthalimide peroxycaproic acid during the simultaneous mixed storage period of the first composition and the second composition is blocked, the adverse effects on the stability of the phthalimide peroxycaproic acid caused by pH environmental change, metal ion interference or nucleophilic attack of the anti-sensitive agent are avoided, the natural decomposition and activity attenuation of the phthalimide peroxycaproic acid in the shelf life of the product are inhibited, and the product is ensured to still retain higher effective active oxygen content after long-term storage. Based on the foregoing, the anti-sensitivity agent in the first composition and the whitening agent in the second composition can both be maintained in their respective optimal stable systems. When the high-activity phthalimide peroxycaproic acid is used for mixing, the high-activity phthalimide peroxycaproic acid can decompose tooth pigment through oxidization to achieve the expected whitening effect, and meanwhile, the anti-sensit