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CN-121987535-A - Breast repair patch with whitening and antioxidation effects

CN121987535ACN 121987535 ACN121987535 ACN 121987535ACN-121987535-A

Abstract

The invention relates to the technical field of breast repair, in particular to a breast repair patch with whitening and antioxidation effects, which comprises the following components by weight percent of nicotinamide 45%, VE and derivatives 45%, repairing agent 5%, cream 2%, thickening agent 1%, penetration enhancer 1% and essential oil 1%. The invention determines the formula by workers, and determines that the cream thickener, the permeation promoter and the essential oil are 45 percent of nicotinamide, 45 percent of VE and derivative, 5 percent of repairing agent, 2 percent of cream, 1 percent of thickener, 1 percent of permeation promoter and 1 percent of essential oil, then uses hydrogel paste and paste as base materials, can lead the repairing paste to have various functions of repairing a stress barrier, relieving allergy, whitening and resisting oxidation, improves the repairing quality, thereby improving the functionality and applicability of the repairing paste, accurately weighing raw materials according to the formula, respectively dissolving and heating an oil phase and a water phase, emulsifying and mixing, and adding the active ingredients usually at a proper temperature.

Inventors

  • WEI DONGMEI

Assignees

  • 四川大学华西第二医院

Dates

Publication Date
20260508
Application Date
20251209

Claims (10)

  1. 1. A breast repair patch with whitening and antioxidation effects comprises the following components in percentage by weight: 45% of nicotinamide; VE and derivative 45%; 5% of repairing agent; 2% of cream; 1% of thickener; 1% of penetration enhancer; 1% of essential oil.
  2. 2. The breast repair patch with whitening and antioxidation effects according to claim 1, wherein the penetration enhancer is azone, and the cream is prepared by adopting an emulsifying system oil phase + water phase + emulsifying agent.
  3. 3. The breast repair patch with whitening and antioxidation effects according to claim 1, wherein the repair agent adopts ceramide and centella asiatica extract.
  4. 4. A method for preparing a breast repair patch with whitening and antioxidation effects, based on the breast repair patch with whitening and antioxidation effects of any one of claims 1-3, characterized by comprising the following steps: S1, formula design S1.1, determining the component ratio, namely 45 percent of nicotinamide, 45 percent of VE and derivatives, 5 percent of repairing agent, 2 percent of cream, 1 percent of thickening agent, 1 percent of permeation enhancer, 1 percent of essential oil, S1.2 and matrix, and ① percent of hydrogel patch and ② percent of paste; S2, selecting and processing the base material S2.1, selecting a base material, carrying out ① non-woven fabrics, ② biological fibers, ③ spunlaced fabrics and gel films, wherein the S2.2 cutting design accords with breast curves, ① semilunar shapes, ② butterfly shapes, S2.3, carrying out base material treatment, carrying out ① base material disinfection, carrying out ② base material hydrophilization treatment and carrying out ③ base material special coating treatment; S3, production process S3.1, proportioning and mixing, accurately weighing raw materials according to a formula, respectively dissolving/heating ① oil phase and water phase, emulsifying and mixing, adding active ingredients at a proper temperature, avoiding high-temperature damage, strictly controlling temperature, stirring speed and time, ensuring homogenization, ② degassing, removing bubbles generated in the stirring process, ensuring the appearance and coating uniformity of a product, S3.2 and ‌ coating and coating, ① uniformly coating mixed gel on a substrate, covering a layer of anti-sticking release film, quantitatively and uniformly coating paste on the substrate by ②, covering the release film, S3.3, cutting and packaging, cutting ①, cutting a large piece of coating material into a designed single patch shape, packaging in ②, loading the single patch into a packaging bag with good barrier property such as an aluminum foil bag, sealing in a ③ environment, cold sealing, ensuring the sealing property of the packaging bag, preventing volatilization, pollution and oxidation of essence, ④, performing 60 irradiation sterilization on a final product, reducing the critical risk of microorganisms, sterilizing and packaging in a clean box, and packaging the inner and outer packaging with ⑤ ‌; s4, quality inspection S4.1, raw material detection, namely, checking the appearance, physicochemical indexes, microorganism limit and the like of each batch of raw materials, meeting the standard, and using the raw materials, S4.2, checking semi-finished products, wherein in the production process, the pH value, viscosity, color and smell of the mixture are checked, S4.3, checking the finished products, and ① physicochemical indexes, the appearance, smell, pH value, viscosity, coating amount/net content, cold resistance and heat resistance, ② microorganism indexes, namely, ‌ bacteria total number, mould and saccharomycete total number, heat-resistant coliform, staphylococcus aureus, pseudomonas aeruginosa, ③ active ingredient content ‌, and the actual content of key whitening agent and antioxidant are checked, so that the raw materials are consistent and stable with claims, and a ④ ‌ corrosion prevention challenge test, namely, ‌ is performed on the finished products, the microbial growth is effectively inhibited in the shelf life, and ⑤ skin irritation/allergy test, namely, the repeated injury spot patch test of people is proved.
  5. 5. The method for preparing the breast repair patch with the whitening and antioxidation effects of claim 4, wherein the microbial index adopts a plate counting method and enrichment culture and identification, the active ingredient content adopts a high performance liquid chromatography method, and ‌ antiseptic challenge test adopts ‌ inoculation microorganism ‌.
  6. 6. The method for preparing the breast repair patch with whitening and antioxidation effects according to claim 4, wherein the stability test of the breast repair patch is carried out, wherein the accelerated stability test comprises 40 ℃ plus or minus 1 ℃,75% RH plus or minus 5% RH,3-6 months, and the long-term stability test comprises 25 ℃ plus or minus 2 ℃ and 60% RH plus or minus 5% RH, the whole shelf life is covered, and the changes of the appearance, smell, pH value, viscosity, active ingredient content and microorganism index of the product during the storage period are examined, and the shelf life is determined.
  7. 7. The method for preparing a breast repair patch with whitening and antioxidation effects according to claim 4, wherein Co60 irradiation Cobalt-60 irradication is a technique of performing ‌ sterilization, disinfection and material modification ‌ by utilizing gamma rays released by radioisotope Cobalt-60.
  8. 8. The method for preparing a breast repair patch with whitening and antioxidation effects according to claim 4, wherein the degassing in the step S3 is performed by ultrasonic degassing.
  9. 9. The method of claim 8 wherein the ultrasonic degassing means that ultrasonic waves generate high-frequency vibration when the ultrasonic waves are transmitted in the liquid to form micro bubbles, the bubbles are expanded and collapsed under the action of sound pressure, local high pressure and shock waves are generated to break the dissolution balance of gas in the liquid, and the dissolved gas is precipitated and accumulated into large bubbles to escape.
  10. 10. The application of the breast repair patch with the whitening and antioxidation effects based on the breast repair patch with the whitening and antioxidation effects and the preparation method of the breast repair patch with the whitening and antioxidation effects, which are characterized in that the breast repair patch is directly applied to a breast part and reacts and repairs the skin through nicotinamide, VE and derivatives under photoelectric treatment.

Description

Breast repair patch with whitening and antioxidation effects Technical Field The invention relates to the technical field of breast repair, in particular to a breast repair patch with whitening and antioxidation effects. Background ‌ Breast repair requires selection of a proper scheme according to personal conditions, common reasons include prosthesis displacement, postoperative morphological dissatisfaction or tissue atrophy, repair means are generally divided into prosthesis adjustment, autologous fat filling, scar repair or combined treatment, a doctor needs to evaluate breast tissue conditions, skin elasticity and health requirements and then plan, if the prosthesis has envelope contracture, displacement or rupture, the prosthesis can need to be taken out or replaced, and implantation levels are adjusted, so that fat survival rate and possibility of multiple filling are considered for autologous fat repair. Regarding ‌ breast patch ‌, which is an external patch product for female breast care, is generally used for ‌ to relieve breast distending pain, dredge the breast, promote blood circulation or assist post-operative repair, however, the following problems are encountered during the normal production of patches: In the production process of the repair patch, the functions of the repair patch are single due to single components, so that the use functionality and applicability of the repair patch are reduced; the method comprises the steps of (1) carrying out a repair paste production process, wherein internal bubbles are easy to be removed when raw materials are mixed, so that the production quality and coating uniformity of a product are reduced, and (2) carrying out inspection on a final finished product when the finished product is detected, so that the raw materials and semi-finished products in the production process are not inspected, and the safety and environmental protection of the whole production process are reduced. Disclosure of Invention The invention aims to provide a breast repair patch with whitening and antioxidation effects, which aims to solve the problems that (1) in the production process of the repair patch proposed in the background technology, the functions of the repair patch are single due to single components, so that the using functionality and applicability of the repair patch are reduced, (2) in the production process of the repair patch, internal bubbles are easily not removed when raw materials are mixed, so that the production quality and coating uniformity of a product are reduced, and (3) in the detection of a finished product, only the final finished product is detected, so that the raw materials and semi-finished products in the production process are not detected, and the safety and environmental friendliness of the whole production process are reduced. In order to achieve the purpose, the invention provides the following technical scheme that the breast repair patch with the whitening and antioxidation effects comprises the following components in percentage by weight: 45% of nicotinamide; VE and derivative 45%; 5% of repairing agent; 2% of cream; 1% of thickener; 1% of penetration enhancer; 1% of essential oil. Preferably, the penetration enhancer is azone, and the cream is prepared from oil phase, water phase and emulsifier of an emulsifying system. Preferably, the repairing agent adopts ceramide and centella asiatica extract. A preparation method of a breast repair patch with whitening and antioxidation effects comprises the following production steps: S1, formula design S1.1, determining the component ratio, namely 45 percent of nicotinamide, 45 percent of VE and derivatives, 5 percent of repairing agent, 2 percent of cream, 1 percent of thickening agent, 1 percent of permeation enhancer, 1 percent of essential oil, S1.2 and matrix, and ① percent of hydrogel patch and ② percent of paste; S2, selecting and processing the base material S2.1, selecting a base material, carrying out ① non-woven fabrics, ② biological fibers, ③ spunlaced fabrics and gel films, wherein the S2.2 cutting design accords with breast curves, ① semilunar shapes, ② butterfly shapes, S2.3, carrying out base material treatment, carrying out ① base material disinfection, carrying out ② base material hydrophilization treatment and carrying out ③ base material special coating treatment; S3, production process S3.1, proportioning and mixing, accurately weighing raw materials according to a formula, respectively dissolving/heating ① oil phase and water phase, emulsifying and mixing, adding active ingredients at a proper temperature, avoiding high-temperature damage, strictly controlling temperature, stirring speed and time, ensuring homogenization, ② degassing, removing bubbles generated in the stirring process, ensuring the appearance and coating uniformity of a product, S3.2 and ‌ coating and coating, ① uniformly coating mixed gel on a substrate, covering a layer of anti-sticking release film,