Search

CN-121987536-A - Preparation method and application of acanthopanax extract for cosmetics

CN121987536ACN 121987536 ACN121987536 ACN 121987536ACN-121987536-A

Abstract

The invention discloses a preparation method and application of an acanthopanax extract for cosmetics, and relates to the technical field of acanthopanax extraction, wherein the acanthopanax extract comprises water, an acanthopanax composition, a preservative, a stabilizer, a thickener, a flavoring agent, a coloring agent and an auxiliary drug mixture; the stabilizer, the preservative and the like added in the preparation process and the specific step-by-step mixing and air-drying standing process effectively protect active ingredients, reduce degradation, manage, visualize and store relevant data and corresponding analysis results of the preparation of the acanthopanax extract, facilitate the preparation and management of the acanthopanax extract through internet cloud management and control, and improve the intelligent level of the preparation and management of the acanthopanax extract.

Inventors

  • SUN YEJUN
  • ZHANG SHUNJIE
  • WANG KAILIANG
  • SUN CHENGYU

Assignees

  • 中科先丰(宝清县)中药材科技有限公司

Dates

Publication Date
20260508
Application Date
20251225

Claims (10)

  1. 1. A preparation method of an acanthopanax extract for cosmetics is characterized in that the acanthopanax extract comprises water, an acanthopanax composition, a preservative, a stabilizer, a thickener, a aromatic, a coloring agent and an auxiliary drug mixture.
  2. 2. The method for preparing the acanthopanax extract for cosmetics according to claim 1, wherein the acanthopanax extract comprises, by weight, 100-1000 parts of water, 10-200 parts of acanthopanax composition, 2-10 parts of preservative, 1-10 parts of stabilizer, 4-10 parts of thickener, 1-5 parts of aromatic, 1-3 parts of coloring agent and 5-10 parts of auxiliary drug mixture.
  3. 3. The method for preparing the acanthopanax senticosus extract for cosmetics according to claim 1, wherein the method for preparing the acanthopanax senticosus extract comprises the following specific steps: s1, preparing raw materials, namely selecting dry roots or root barks of acanthopanax, cleaning the dry roots or root barks of acanthopanax according to a conventional method to remove impurities, cutting the dry roots or root barks into small sections or powder, and preparing a plurality of reagents for auxiliary operation; S2, selecting and soaking a solvent, namely weighing a plurality of solvents which are required to be suitable according to parts by weight, mixing to obtain a mixed solvent, and mixing the dry acanthopanax powder and the mixed solvent according to a weight ratio of 1:5 to 1:10 for soaking; s3, performing ultrasonic assisted extraction, controlling the frequency by using an ultrasonic cleaner or ultrasonic extraction equipment, filtering to remove residues after the extraction is completed, collecting an extracting solution, and concentrating the extracting solution to a required concentration by adopting a rotary evaporation method or a vacuum concentration method, wherein the concentration of the concentrated solution is 5-10 times that of the stock solution; s4, further drying the concentrated solution to obtain acanthopanax extract powder, and judging whether purification and separation are needed according to the requirement; s5, analyzing the components of the acanthopanax extract, analyzing the main active components in the extract by using methods such as high performance liquid chromatography and gas chromatography, confirming the content and stability of the main active components, randomly drawing test products on the extract meeting the requirements, observing the concrete performance in the period after use, and passing the test products when all detection values meet the standards to obtain the acanthopanax extract finished product.
  4. 4. The method for preparing acanthopanax extract for cosmetics according to claim 3, wherein the specific preparation process of the mixed solvent in the step S2 is as follows: S201, weighing the required preservative, stabilizer and thickener according to parts by weight, stirring for the first time by stirring equipment, pouring water while heating and stirring, and performing air drying and standing for the first time; s202, weighing a mixture of the required aromatic, the required coloring agent and the required auxiliary medicine according to parts by weight, carrying out secondary stirring through stirring equipment, pouring water while heating and stirring, and carrying out secondary air drying and standing; s203, re-mixing the two mixed solvents, stirring for three times by stirring equipment, pouring water while heating and stirring, adding the acanthopanax composition, and performing tertiary air drying and standing.
  5. 5. The method for preparing acanthopanax senticosus extract for cosmetics according to claim 4, wherein the control frequency in the step S3 is 20kHz-40kHz, and the extraction is performed for 30-60min.
  6. 6. The method for preparing acanthopanax senticosus extract for cosmetics according to claim 4, wherein the soaking temperature in S2 is 30-50 ℃ and the soaking time is 12-48h.
  7. 7. The method for preparing acanthopanax senticosus extract for cosmetics according to claim 4, wherein the drying in the step S4 is spray drying or vacuum freeze drying; When spray drying is adopted, the air inlet temperature is 150-180 ℃ and the air outlet temperature is 80-100 ℃; when vacuum freeze-drying is used, the method comprises three stages of pre-freezing, sublimation drying and analysis drying, wherein the pre-freezing temperature is lower than-40 ℃.
  8. 8. The method for preparing acanthopanax senticosus extract for cosmetics according to claim 4 and application thereof, wherein the quality control method of the acanthopanax senticosus extract is characterized by comprising the following steps: (1) Preparing a sample solution, namely taking a proper amount of acanthopanax extract powder, precisely weighing, dissolving with methanol and fixing the volume; (2) Preparing reference substance solution, taking a proper amount of syringin reference substance, precisely weighing, dissolving with methanol, and preparing into a series of concentration solutions; (3) Performing high performance liquid chromatography, gradient eluting with acetonitrile-water or methanol-water as mobile phase at flow rate of 0.8-1.2mL/min and column temperature of 25-35deg.C at detection wavelength of 210-270nm, respectively injecting sample solution and reference solution, and recording chromatogram; (4) And calculating the result, namely calculating the content of syringin in the sample by an external standard method, and judging that the batch of extract is qualified when the content meets the preset quality standard.
  9. 9. The method for preparing acanthopanax extract for cosmetics according to claim 8, wherein the mobile phase in the step (3) is acetonitrile-0.1% phosphoric acid aqueous solution, the gradient elution procedure is 0-10min,5% -15% acetonitrile, 10-30min,15% -25% acetonitrile, and the detection wavelength is 265nm.
  10. 10. A cosmetic use of an extract of Acanthopanax senticosus according to any one of claims 1 to 9, wherein the extract of Acanthopanax senticosus is used in a skin care composition.

Description

Preparation method and application of acanthopanax extract for cosmetics Technical Field The invention relates to the technical field of acanthopanax root extraction, in particular to a preparation method and application of an acanthopanax root extract for cosmetics. Background Acanthopanax is a perennial plant and belongs to the Araliaceae. Acanthopanax is also called siberian ginseng because it belongs to the family araliaceae as ginseng, and in traditional medicine, acanthopanax is often used for enhancing immunity and improving physical strength, and also is often used in the cosmetic field. In the cosmetic field, plant extracts are favored for their natural and safe properties. The acanthopanax is rich in active ingredients such as syringin and the like, and has good effects of resisting oxidization and relieving skin. However, existing extraction methods (e.g., hot water extraction, simple alcohol extraction) have significant drawbacks. The invention discloses a nano acanthopanax preparation medicine, which is prepared by taking nano acanthopanax as a raw material according to a proportion, and has the particle fineness of 1200-1500 meshes and the particle diameter of 0.1-200nm, wherein most of the particle diameters are smaller than 100nm, and the nano acanthopanax preparation medicine has new physical properties. Is prepared by the steps of microwave extraction, decompression concentration, spray drying with supersonic jet technology, and the like. The medicine has high bioavailability and remarkable therapeutic effect. However, the following problems still remain in the above scheme: The extraction efficiency is low, the yield of active ingredients is low, and the heat-sensitive ingredients are easy to damage in the extraction process; The extraction flow cannot be subjected to real-time supervision treatment, and the distance between partial links is long, so that the manual frequent running is required, and the whole extraction period is prolonged; The obtained crude extract has poor stability, is easy to change color and inactivate in the formula of the cosmetics, and is difficult to meet the production requirement of high-quality cosmetics, thereby bringing a plurality of inconveniences. Therefore, the invention needs to design a preparation method and application of the acanthopanax senticosus extract for cosmetics to solve the problems. Disclosure of Invention The invention aims to provide a preparation method which can efficiently and stably extract the acanthopanax active ingredient and can be directly applied to high-end skin care products, has important industrial value, and solves the problems in the background art. In order to solve the problems, the invention provides a technical scheme that: A preparation method of an acanthopanax extract for cosmetics comprises the steps of water, an acanthopanax composition, a preservative, a stabilizer, a thickener, a flavoring agent, a coloring agent and an auxiliary drug mixture. As a preferred implementation mode of the invention, the acanthopanax extract comprises, by weight, 100-1000 parts of water, 10-200 parts of acanthopanax composition, 2-10 parts of preservative, 1-10 parts of stabilizer, 4-10 parts of thickener, 1-5 parts of aromatic, 1-3 parts of coloring agent and 5-10 parts of auxiliary drug mixture. As a preferred embodiment of the invention, the preparation method of the acanthopanax senticosus extract comprises the following specific steps: s1, preparing raw materials, namely selecting dry roots or root barks of acanthopanax, cleaning the dry roots or root barks of acanthopanax according to a conventional method to remove impurities, cutting the dry roots or root barks into small sections or powder, and preparing a plurality of reagents for auxiliary operation; S2, selecting and soaking a solvent, namely weighing a plurality of solvents which are required to be suitable according to parts by weight, mixing to obtain a mixed solvent, and mixing the dry acanthopanax powder and the mixed solvent according to a weight ratio of 1:5 to 1:10 for soaking; s3, performing ultrasonic assisted extraction, controlling the frequency by using an ultrasonic cleaner or ultrasonic extraction equipment, filtering to remove residues after the extraction is completed, collecting an extracting solution, and concentrating the extracting solution to a required concentration by adopting a rotary evaporation method or a vacuum concentration method, wherein the concentration of the concentrated solution is 5-10 times that of the stock solution; s4, further drying the concentrated solution to obtain acanthopanax extract powder, and judging whether purification and separation are needed according to the requirement; S5, analyzing the components of the acanthopanax extract, analyzing the main active components in the extract by using methods such as high performance liquid chromatography and gas chromatography, confirming the content and stability of the extrac