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CN-121987541-A - Composition for promoting collagen regeneration and inhibiting expression lines of sensitive muscles and application thereof

CN121987541ACN 121987541 ACN121987541 ACN 121987541ACN-121987541-A

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a composition for promoting collagen regeneration of sensitive muscles and inhibiting expression lines and application thereof. The invention provides a composition for promoting collagen regeneration and inhibiting expression lines of sensitive muscles, which is prepared by compounding a small fruit coffee seed extract, a selaginella extract, a sargassum horneri extract and acetyl hexapeptide-1, and the four components form a complete regulation and control network from inhibiting collagen degradation and promoting synthesis to barrier repair through signal cooperation of a pharmacodynamics level, so that the efficiency of multi-target synergistic effect is obviously improved, the full-path regulation and control from inhibiting facial wrinkles and promoting collagen regeneration to repairing barrier functions is realized, the limitation that the action mechanism of the prior art is single, the limitation of lack of long-term and systematic repairing effects is effectively overcome, and meanwhile, the mildness of a formula and the applicability of the sensitive muscles are obviously improved.

Inventors

  • ZHANG JIANHUA
  • LIU SHICHAO
  • GUO WENJIAO

Assignees

  • 溪木源生物科技集团有限公司

Dates

Publication Date
20260508
Application Date
20260319

Claims (8)

  1. 1. A composition for promoting collagen regeneration and inhibiting expression lines of sensitive muscles is characterized by comprising, by weight, 0.01-1 part of small fruit coffee seed extract, 0.01-0.1 part of selaginella extract, 0.01-0.5 part of stonewort extract and 0.01-0.5 part of acetyl hexapeptide; Wherein, the extract of the Cladosiphon-californica is extracted by an alkaline method, and the preparation method comprises the following steps: w1, pretreatment, namely weighing 100g of dried algae powder with the california cerealis, and rapidly rinsing and filtering with distilled water to obtain pretreated algae powder I with the california cerealis; Extracting by an alkaline method, namely preparing 1L of 0.1M sodium hydroxide solution by using distilled water, adding the stonewort powder I prepared in the step W1 into the sodium hydroxide solution, uniformly stirring, placing the mixture into a constant-temperature water bath kettle at the temperature of 78-82 ℃, and stirring and extracting for 1.5-2.5 hours at the rotating speed of 300-400 rpm; Purifying the extracting solution, namely slowly adding 4.5-5.5% (v/v) dilute hydrochloric acid solution into the filtrate I to adjust the pH to 7.0, adding active carbon accounting for 1-2% of the mass of the filtrate I, stirring and decoloring for 25-35min at 55-65 ℃ and 200-300rpm, carrying out suction filtration again, and collecting filtrate II; w4, ethanol precipitation, namely heating and concentrating filtrate II to 1/4 of the original volume at 60-70 ℃, slowly adding 3 times of absolute ethanol at 3-5 ℃ and 100-200 rpm, and standing for precipitation for 1-1.5h; And W5, collecting and treating the precipitate, namely carrying out suction filtration by using a Buchner funnel, collecting the precipitate, washing the precipitate for 2-3 times by using absolute ethyl alcohol, adding distilled water into the precipitate to prepare a solution with the concentration of 1-3%, and carrying out spray drying, crushing and sieving by using a 100-mesh sieve to obtain the algae extract with the distance of stonewort, wherein the inlet temperature of spray drying is 160-170 ℃ and the outlet temperature of spray drying is 80-90 ℃.
  2. 2. The composition for promoting collagen regeneration and inhibiting expression lines for sensitive muscle according to claim 1, which comprises, by weight, 0.1 to 0.6 part of coffee cherry seed extract, 0.04 to 0.08 part of selaginella extract, 0.1 to 0.4 part of stonewort extract, and 0.1 to 0.4 part of acetyl hexapeptide-1.
  3. 3. The composition for promoting collagen regeneration and inhibiting expression lines for sensitive muscle according to claim 1, which comprises, by weight, 0.2 to 0.4 part of coffee cherry seed extract, 0.05 to 0.07 part of selaginella extract, 0.28 to 0.32 part of stonewort extract, and 0.28 to 0.32 part of acetyl hexapeptide-1.
  4. 4. Use of a composition for promoting collagen regeneration and inhibiting expression lines of sensitive muscles according to any one of claims 1 to 3 in a skin care product having anti-aging, antioxidant, repairing, moisturizing effects and suitable for sensitive skin.
  5. 5. The use according to claim 4, wherein the skin care product is one or more of a lotion, an emulsion, a cream, a mask, a spray.
  6. 6. An emulsion is characterized by comprising, by weight, 5% -20% of the composition of any one of claims 1-3, 0.05% -0.5% of a thickener, 1% -10% of a humectant, 0.01% -0.3% of a pH regulator, 1% -6% of an emulsifier, 5% -15% of grease, 0.5% -3% of a preservative, and the balance deionized water.
  7. 7. The emulsion of claim 6, wherein the starting material is selected from at least one of (a) - (f): (a) The thickener comprises at least one of xanthan gum, carbomer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate/VP copolymer, hydroxyethyl cellulose and cetyl alcohol; (b) The humectant comprises at least one of allantoin, sodium polyacrylate, panthenol, beta-glucan, trehalose, octaethylene glycol, dipropylene glycol, sodium hyaluronate, 1, 2-butanediol, glycerol and tremella polysaccharide; (c) The pH regulator comprises at least one of arginine, citric acid and sodium hydroxide; (d) The emulsifier comprises at least one of PEG-100 glycerol stearate, glycerol stearate citrate, cetostearyl glucoside, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, PEG-20 methyl glucose sesquistearate, potassium cetyl phosphate and sodium stearyl glutamate; (e) The oil comprises at least one of caprylic/capric triglyceride, polydimethylsiloxane, jojoba oil, grape seed oil, white pool flower seed oil, squalane, macadamia nut oil and camellia oil; (f) The preservative comprises at least one of 1, 2-hexanediol, 1, 2-pentanediol, ethylhexyl glycerol, p-hydroxyacetophenone, phenoxyethanol and sodium benzoate.
  8. 8. A method of preparing an emulsion according to claim 6 or 7, comprising the steps of: S1, uniformly mixing a thickener and a humectant, adding deionized water, heating at 70-80 ℃ for 8-12min, homogenizing at 3500-4500rpm for 4-7min, and preserving heat for later use after homogenization to obtain a prefabricated component A; S2, mixing grease and an emulsifying agent, heating to 70-80 ℃, uniformly dissolving, and preserving heat for later use to obtain a prefabricated component B; S3, heating the prefabricated component A to 70-80 ℃, adding the prefabricated component B at 3500-4500rpm, and homogenizing for 4-7min to obtain an emulsified base material; s4, stirring and cooling the emulsified base material to 48-52 ℃, adding the components of the composition according to any one of claims 1-3, stirring uniformly, adding a preservative and a pH regulator, stopping stirring, and discharging to obtain the emulsion.

Description

Composition for promoting collagen regeneration and inhibiting expression lines of sensitive muscles and application thereof Technical Field The invention belongs to the technical field of cosmetics, and particularly relates to a composition for promoting collagen regeneration of sensitive muscles and inhibiting expression lines and application thereof. Background Aging is a progressive physiological process and is also affected by a variety of factors such as environment, lifestyle, diseases, etc., and is characterized by a gradual decrease in the ability of cells and molecules to maintain homeostasis, apoptosis, and an increase in aging. At the same time, these factors cause cumulative damage to the skin, resulting in skin aging such as wrinkling, loss of elasticity, dullness, etc. Skin aging can be classified into endogenous aging and exogenous aging, the latter being mainly caused by environmental factors such as ultraviolet radiation, smoking, blowing, sun drying, exposure to harmful chemicals, and the like. The existing cosmetic industry mainly adopts the following technical paths that firstly, single plant extracts (such as centella asiatica, green tea, ginseng and the like) are used as cores, skin is improved through antioxidation and anti-inflammatory effects, secondly, oligopeptide components directly act on neuromuscular signal transduction to inhibit wrinkle formation, and thirdly, cutin update is promoted through chemical cutin stripping components, so that the instant effect is improved. However, these schemes generally have the problems of single action mechanism, lack of systematic regulation and control, weak component compounding logic and the like, are difficult to cover the whole chain of the aging cascade reaction of nerve signal transduction-MMPs activation-collagen degradation-barrier damage, and partial chemical stripping means easily damage skin barriers, so that the long-term use safety is insufficient. Along with the progress of technology and the improvement of living standard of people, the requirements for efficacy type skin care products are increasing, and especially the requirements for products with anti-aging function are urgent. Therefore, it is of great importance to develop a composition with multi-target synergism. Disclosure of Invention Aiming at the defects or improvement demands of the prior art, the invention provides a composition for promoting collagen regeneration and inhibiting expression lines of sensitive muscles, so as to solve the problems of single action mechanism, lack of long-term and systematic repair effects of the existing anti-aging products. The aim of the invention can be achieved by the following technical scheme: the invention provides a composition for promoting collagen regeneration and inhibiting expression lines of sensitive muscles, which comprises, by weight, 0.01-1 part of small fruit coffee seed extract, 0.01-0.1 part of selaginella extract, 0.01-0.5 part of stonewort extract and 0.01-0.5 part of acetyl hexapeptide; Wherein, the extract of the amygdalina is extracted by an alkaline method, which comprises the following steps: w1, pretreatment, namely weighing 100g of dried algae powder with the california cerealis, and rapidly rinsing and filtering with distilled water to obtain pretreated algae powder I with the california cerealis; Extracting by an alkaline method, namely preparing 1L of 0.1M sodium hydroxide solution by using distilled water, adding the stonewort powder I prepared in the step W1 into the sodium hydroxide solution, uniformly stirring, placing the mixture into a constant-temperature water bath kettle at the temperature of 78-82 ℃, and stirring and extracting for 1.5-2.5 hours at the rotating speed of 300-400 rpm; Purifying the extracting solution, namely slowly adding 4.5-5.5% (v/v) dilute hydrochloric acid solution into the filtrate I to adjust the pH to 7.0, adding active carbon accounting for 1-2% of the mass of the filtrate I, stirring and decoloring for 25-35min at 55-65 ℃ and 200-300rpm, carrying out suction filtration again, and collecting filtrate II; w4, ethanol precipitation, namely heating and concentrating filtrate II to 1/4 of the original volume at 60-70 ℃, slowly adding 3 times of absolute ethanol at 3-5 ℃ and 100-200 rpm, and standing for precipitation for 1-1.5h; And W5, collecting and treating the precipitate, namely carrying out suction filtration by using a Buchner funnel, collecting the precipitate, washing the precipitate for 2-3 times by using absolute ethyl alcohol, adding distilled water into the precipitate to prepare a solution with the concentration of 1-3%, and carrying out spray drying, crushing and sieving by using a 100-mesh sieve to obtain the algae extract with the distance of stonewort, wherein the inlet temperature of spray drying is 160-170 ℃ and the outlet temperature of spray drying is 80-90 ℃. Preferably, the composition for promoting collagen regeneration and inhibiting expressi