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CN-121987596-A - Hydrogel patch with novel matrix, preparation method and application

CN121987596ACN 121987596 ACN121987596 ACN 121987596ACN-121987596-A

Abstract

The invention relates to the technical field of medicines, in particular to a hydrogel patch with a novel matrix, a preparation method and application thereof, wherein the hydrogel patch comprises the novel matrix and medicines loaded on the matrix, and the novel matrix comprises 5% -6% of sodium polyacrylate, 1% -2% of aluminum glycinate, 20% -25% of glycerol, 60% -64% of water, 1% -3% of propylene glycol, 0.5% -1% of menthol and 1% -2% of eucalyptus oil. The substrate with 6 different formulas can obtain good substrate morphology, good skin feel, seamless connection with non-woven fabrics, good adhesion performance, good repeated adhesion and no water seepage phenomenon, and the prepared glycerinum-sodium polyacrylate gel substrate morphology can be seen to be fine and smooth and white as a whole.

Inventors

  • WEI XIN
  • BIAN BAOJUN
  • JI CHUNFENG
  • ZHU XIAOPING
  • DING LIQIN
  • WANG CHENHAO
  • ZHAN XUEQIANG
  • JIN JIAHUA

Assignees

  • 上海中华药业有限公司

Dates

Publication Date
20260508
Application Date
20241105

Claims (9)

  1. 1. A hydrogel patch having a novel matrix, wherein the hydrogel patch comprises the novel matrix and a drug loaded on the matrix, wherein the novel matrix comprises 5% -6% sodium polyacrylate, 1% -2% aluminum glycinate, 20% -25% glycerin, 60% -64% water, 1% -3% propylene glycol, 0.5% -1% menthol and 1% -2% eucalyptus oil.
  2. 2. The hydrogel patch according to claim 1 wherein said novel matrix further comprises any one of osmanthus oil, rose essential oil, ginger oil, mugwort oil.
  3. 3. The hydrogel patch according to claim 1 wherein said novel matrix further includes osmanthus oil and rose essential oil.
  4. 4. The hydrogel patch according to claim 3, wherein the amounts of osmanthus fragrans oil and rose essential oil added are 0.25% -3, respectively.
  5. 5. The hydrogel patch according to claim 1 wherein said novel matrix further comprises ginger oil and mugwort oil.
  6. 6. The hydrogel patch according to claim 5, wherein the amounts of ginger oil and mugwort oil added are 0.25% -3, respectively.
  7. 7. A method of preparing a hydrogel patch according to any one of claims 1 to 6, comprising the steps of: (1) Respectively preparing water phase and oil phase, namely water, wherein the oil phase comprises the steps of weighing glycerol and propylene glycol according to a proportion, adding menthol into the propylene glycol, dissolving in water bath at 60 ℃, adding ginger oil and/or mugwort leaf oil or sweet osmanthus oil and/or bitter rose essential oil into the mixture, uniformly mixing, pouring the mixture into the glycerol, and uniformly stirring to obtain the oil phase; (2) Adding sodium polyacrylate and aluminum hydroxide into the oil phase obtained in the step (1), and uniformly mixing for later use; (3) Pouring the water phase obtained in the step (1) into a stirring container of an experimental stirrer, and then pouring the oil phase obtained in the step (2), stirring at the rotating speed of F60; (4) Transferring the stirred hydrogel to a coater for coating, wherein the coating thickness is set to be 2.25mm, and the coating speed is F300 at a constant speed; (5) The hydrogel patch obtained after coating is spread and stood for 10-16 hours, so that sodium polyacrylate and aluminum hydroxide are fully crosslinked and cut.
  8. 8. The method of preparing a hydrogel patch according to claim 7 wherein said cutting in step (5) is performed using a laser cutter.
  9. 9. The method of claim 8, wherein the laser cutter parameters are speed of 200.0mm/s, maximum power of 1:90% and maximum power of 2:50%.

Description

Hydrogel patch with novel matrix, preparation method and application Technical Field The invention relates to the technical field of medicines, in particular to a hydrogel patch with a novel matrix, a preparation method and application thereof. Background The patch matrix is an important component of the patch that provides a carrier and release medium for the drug. The patch matrix serves as a carrier for the drug, uniformly dispersing or dissolving the drug therein, so that the drug can be stably present in the patch. Different matrixes have different carrying capacities on medicines, the oil-based matrix has better carrying effect on the fat-soluble medicines, and the water-soluble matrix is more suitable for the water-soluble medicines. The composition and the property of the matrix can influence the release speed of the medicine from the patch, and the medicine can be controlled to be released at a constant speed within a certain time by selecting different types of matrixes and adjusting the formula of the matrix, so that the aim of long-acting administration is fulfilled. The matrix has certain viscosity, so that the patch can be firmly stuck on the surface of the skin, the medicine is ensured to be fully contacted with the skin, and the absorption efficiency of the medicine is improved. Part of the matrix also has the function of moisturizing, so that the skin can keep certain moisture, and the permeation of medicines is facilitated. The matrix comprises oleaginous matrix, water-soluble matrix and emulsion matrix, wherein oleaginous matrix comprises adeps ragmitis, lanolin, cera flava, etc. Lanolin has good water absorbability, can absorb about 2 times of water, is beneficial to dissolution and dispersion of medicine, and beeswax is solid at normal temperature, and can increase hardness and stability of patch. The water-soluble matrix comprises cellulose derivatives such as methyl cellulose and sodium carboxymethyl cellulose and water-soluble polymer compound polyethylene glycol prepared by gradually adding and polymerizing ethylene oxide and water or ethylene glycol, and the emulsion matrix comprises oil-in-water type and water-in-oil type, wherein the oil-in-water type can be mixed with water, and the emulsion is easy to clean and has high drug release rate. The water-in-oil matrix is less greasy than the oil-in-water matrix, and the drug release rate is relatively slow. The matrix required by different drug properties is different, and the proper matrix can be selected according to the solubility of the drug, if the drug is fat-soluble, the fat-based matrix is preferentially selected, so that the dissolution and the stabilization of the drug are facilitated, and if the drug is water-soluble, the water-soluble matrix is more proper. Still other drugs are unstable in certain circumstances and it is desirable to select a matrix that maintains its stability. For drugs requiring rapid onset of action, a matrix with a faster drug release rate, such as an oil-in-water emulsion type matrix, may be selected, and for drugs requiring long-acting action, a matrix capable of slow drug release may be selected. The substrate with small skin irritation is selected, so that adverse reactions such as skin allergy, red swelling and the like are avoided. Some substrates can increase the permeability of the skin and promote the absorption of the drug, while some substrates can form a barrier to the skin and affect the permeation of the drug. For example, invention patent CN101785864B discloses a post-crosslinking hydrophilic patch matrix, which has simple production process, can absorb skin sweat, has large drug loading, stable and durable drug release and convenient use. The invention patent CN1065428C discloses a matrix type patch which can improve the percutaneous absorbability of physiologically active substances and completely reduce the skin irritation. Disclosure of Invention The primary object of the present invention is to provide a hydrogel patch having a novel matrix comprising 5% -6% sodium polyacrylate, 1% -2% aluminum glycinate, 20-25% glycerin, 60% -64% water, 1% -3% propylene glycol, 0.5% -1% menthol and 1% -2% eucalyptus oil, and a drug supported on the matrix. Preferably, the novel matrix further comprises any one of osmanthus fragrans oil, rose essential oil, ginger oil and mugwort leaf oil. Preferably, the novel matrix also comprises osmanthus fragrans oil and rose essential oil. Preferably, the addition amounts of the osmanthus fragrans oil and the rose essential oil are respectively 0.25% -3. Preferably, the novel matrix further comprises ginger oil and mugwort leaf oil. Preferably, the addition amounts of the ginger oil and the blumea oil are respectively 0.25% -3. The second object of the present invention is to provide a method for preparing the hydrogel patch, comprising the steps of: (1) Respectively preparing water phase and oil phase, namely water, wherein the oil phase comprises the step