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CN-121987600-A - Composition containing coenzyme Q10, preparation method and application

CN121987600ACN 121987600 ACN121987600 ACN 121987600ACN-121987600-A

Abstract

The invention discloses a composition containing coenzyme Q10, a preparation method and application thereof, and belongs to the technical field of health products. The invention combines multicomponent synergy of a formula system with high-speed shearing homogenization, vacuum degassing and raw material pretreatment processes, adopts the compounded synergy of a stabilizer, a cosolvent, a carrier and cyclodextrin derivatives, adopts degummed and deacidified refined olive oil as an oil phase matrix, improves the dispersibility and solubility of coenzyme Q10, ensures that the in-vitro dissolution rate of the prepared composition reaches more than 88 percent, realizes the stable storage of the prepared composition for 6 months under the conditions of 25 ℃ and relative humidity of 60 percent by the synergistic effect of the stabilizer system and the pretreatment and degassing processes, ensures that the retention rate of the coenzyme Q10 reaches more than 97 percent, and has no color change, no layering and no precipitation after long-term storage and good uniformity. In addition, the scheme is simple and convenient to operate, can meet the requirement of large-scale industrial production, and has higher practical application value and popularization prospect.

Inventors

  • TANG LINZHI
  • WU TIE
  • HE YAOWEN
  • CHENG FENGSEN
  • WANG ZHENYU
  • SHI AIYUN

Assignees

  • 广东润和生物科技有限公司

Dates

Publication Date
20260508
Application Date
20260226

Claims (10)

  1. 1. A composition containing coenzyme Q10, which is characterized by comprising the following components in parts by weight: 10-20 parts of coenzyme Q, 30-40 parts of olive oil, 3-5 parts of stabilizer, 5-10 parts of cosolvent, 6-10 parts of carrier and 5-6 parts of cyclodextrin derivative; The stabilizer comprises vitamin E and ascorbyl palmitate, the cosolvent comprises polyethylene glycol 400 and tween 80, the carrier comprises stevioside and maltodextrin, and the cyclodextrin derivative is hydroxypropyl-beta-cyclodextrin; the olive oil is the olive oil after degumming and deacidification pretreatment.
  2. 2. The coenzyme Q10-containing composition according to claim 1, wherein the weight ratio of vitamin E to ascorbyl palmitate in the stabilizer is (2-3): 1.
  3. 3. The coenzyme Q10 containing composition according to claim 1, wherein the weight ratio of the polyethylene glycol 400 to the Tween 80 in the cosolvent is (2-4): 1-2.
  4. 4. The coenzyme Q10-containing composition according to claim 1, wherein the weight ratio of steviol glycoside to maltodextrin in the carrier is (1-2): 1.
  5. 5. The method for producing a coenzyme Q10-containing composition according to claim 1, comprising the steps of: (1) Sequentially degumming raw material olive oil and deacidifying, wherein colloid is removed by adopting a mode of hydration stirring combined with centrifugal separation, alkali refining reaction is adopted in the deacidifying treatment under vacuum condition, soapstock is separated, and the pretreated olive oil with the acid value less than or equal to 0.5mg KOH/g and the moisture content less than or equal to 0.1wt% is prepared by washing, dehydrating and drying; (2) Heating the pretreated olive oil in the step (1) to 35-45 ℃, then adding coenzyme Q10 and a stabilizing agent, and stirring at a speed of 500-800r/min for 15-25min to form a uniform oil phase; (3) Adding cosolvent, carrier and cyclodextrin derivative into the obtained oil phase, heating to 45-55deg.C, homogenizing with high-speed shearing dispersing machine at 10000-12000r/min for 15-20min, vacuum degassing for 5-8min under vacuum degree-0.08-0.09 MPa, cooling to 25-30deg.C, and stirring for 10-15min under heat preservation to obtain composition containing coenzyme Q10.
  6. 6. The preparation method according to claim 5, wherein in the step (1), the degumming is performed by heating the olive oil to 60-75 ℃, adding hot water which is 1-3% of the weight of the olive oil, mixing for 20-40 minutes at a stirring speed of 100-300 rpm, removing colloid by centrifugal separation, and collecting the upper layer of the degelatinized olive oil.
  7. 7. The preparation method according to claim 5, wherein in the step (1), the degummed olive oil is heated to 70-85 ℃ under the vacuum condition of-0.05 to-0.07 MPa, naOH alkali solution with the concentration of 2-8-wt% is added, the mixture is mixed for 10-30 minutes at the rotating speed of 300-600 rpm to form soapstock, the soapstock is centrifugally separated at the temperature of 85-95 ℃, and the separated olive oil is washed until washing wastewater is neutral, and then dehydrated and dried to obtain the pretreated olive oil.
  8. 8. The use of the coenzyme Q10-containing composition according to claim 1 for preparing health products having antioxidant or immunity enhancing effects.
  9. 9. A health product containing coenzyme Q10, which is characterized by comprising the composition containing coenzyme Q10 of claim 1 and pharmaceutically acceptable auxiliary materials; the auxiliary materials are selected from one or more of magnesium stearate, micro-powder silica gel, sodium carboxymethyl cellulose and erythritol.
  10. 10. The health product according to claim 9, wherein the preparation form of the health product containing coenzyme Q10 comprises capsule form, granule form and tablet form.

Description

Composition containing coenzyme Q10, preparation method and application Technical Field The invention relates to the technical field of health products, in particular to a composition containing coenzyme Q10, a preparation method and application thereof. Background Coenzyme Q10 is a core component of human cell mitochondrial respiratory chain, has physiological activities of resisting oxidation, enhancing cell energy metabolism, protecting myocardial function and the like, and is widely applied to the field of health care products. However, coenzyme Q10 has a large molecular weight, strong fat solubility, extremely poor water solubility and extremely low dissolution rate, which severely restricts the full play of its efficacy. In the prior art, the solubility of coenzyme Q10 is often improved by adding grease carriers such as olive oil, and the dissolution performance is optimized by adding surfactants in part of schemes, but the problems of insufficient product stability, layering precipitation in the storage process and the like are easily caused. Therefore, development of a coenzyme Q10 composition which can synchronously improve dissolution and stability and can be industrially produced is an urgent need in the field of current health care products. Disclosure of Invention In order to solve the existing problems, the invention provides a coenzyme Q10-containing composition, a preparation method and application, and adopts the following technical scheme: The invention provides a composition containing coenzyme Q10, which comprises, by weight, 10-20 parts of coenzyme Q10, 30-40 parts of olive oil, 3-5 parts of a stabilizer, 5-10 parts of a cosolvent, 6-10 parts of a carrier and 5-6 parts of a cyclodextrin derivative; The stabilizer comprises vitamin E and ascorbyl palmitate, the cosolvent comprises polyethylene glycol 400 and tween 80, the carrier comprises stevioside and maltodextrin, and the cyclodextrin derivative is hydroxypropyl-beta-cyclodextrin; The olive oil is the olive oil after degumming and deacidification pretreatment. The acid value of the pretreated olive oil is less than or equal to 0.5mg KOH/g, and the moisture content is less than or equal to 0.1wt%. Further, the weight ratio of the vitamin E to the ascorbyl palmitate in the stabilizer is (2-3): 1. Further, the weight ratio of the polyethylene glycol 400 to the tween 80 in the cosolvent is (2-4): 1-2. Further, the weight ratio of the steviol glycoside to the maltodextrin in the carrier is (1-2): 1. In still another aspect, the present invention provides a method for preparing the coenzyme Q10-containing composition, comprising the steps of: (1) Sequentially degumming raw material olive oil and deacidifying, wherein colloid is removed by adopting a mode of hydration stirring combined with centrifugal separation, alkali refining reaction is adopted in the deacidifying treatment under vacuum condition, soapstock is separated, and the pretreated olive oil with the acid value less than or equal to 0.5mg KOH/g and the moisture content less than or equal to 0.1wt% is prepared by washing, dehydrating and drying; (2) Heating the pretreated olive oil in the step (1) to 35-45 ℃, then adding coenzyme Q10 and a stabilizing agent, and stirring at a speed of 500-800r/min for 15-25min until the raw materials are completely dissolved to form a uniform oil phase; (3) Adding cosolvent, carrier and hydroxypropyl-beta-cyclodextrin into the obtained oil phase, heating to 45-55deg.C, homogenizing with high-speed shearing disperser at 10000-12000r/min for 15-20min, vacuum degassing under vacuum degree-0.08-0.09 MPa for 5-8min, cooling to 25-30deg.C, and stirring for 10-15min to obtain composition containing coenzyme Q10. Further, in the step (1), the degumming method specifically comprises heating olive oil to 60-75deg.C, adding 70-85deg.C hot water which is 1-3% of the weight of the olive oil, mixing at stirring speed of 100-300 rpm for 20-40min, centrifuging to remove colloid, and collecting upper layer of de-glued olive oil. Further, in the step (1), the specific method of deacidification comprises heating degummed olive oil to 70-85 ℃ under the vacuum condition of-0.05 to-0.07 MPa, adding NaOH alkali solution with the concentration of 2-8 wt%, mixing for 10-30 minutes at the rotating speed of 300-600 rpm to form soapstock, then centrifugally separating the soapstock at the temperature of 85-95 ℃, washing the separated oil until washing wastewater is neutral, and then dehydrating and drying to obtain pretreated olive oil. In still another aspect, the invention provides the use of the coenzyme Q10-containing composition in the preparation of a health product having antioxidant or immunity enhancing effects. The invention also provides a health product containing coenzyme Q10, which comprises the composition containing coenzyme Q10 and pharmaceutically acceptable auxiliary materials; the auxiliary materials are selected from one or more of magnesium stearate,