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CN-121987609-A - Lac-Phe-based composition, health product and application thereof

CN121987609ACN 121987609 ACN121987609 ACN 121987609ACN-121987609-A

Abstract

The invention relates to the field of metabolic disorder treatment medicines, in particular to a Lac-Phe-based composition, a health product and application thereof. The invention adopts proper formula components and corresponding contents, improves the solubility of Lac-Phe, optimizes the absorptivity of the medicine active molecules in vivo, thereby enhancing the bioavailability and being beneficial to improving the curative effect of Lac-Phe in preventing and treating obesity.

Inventors

  • XU ZHIBIN
  • LIU XINAN
  • CHEN ZUXIN

Assignees

  • 深圳先进技术研究院

Dates

Publication Date
20260508
Application Date
20241107

Claims (7)

  1. 1. A Lac-Phe-based composition is characterized by comprising propylene glycol, glycerol, lac-Phe and a synergist in a mass ratio of (0.1-100) (0.1-10) (0.1-2).
  2. 2. The Lac-Phe-based composition according to claim 1, wherein the mass ratio of the propylene glycol to the glycerol is (7-9): 1-2.
  3. 3. The Lac-Phe-based composition according to claim 1, wherein the booster includes vitamin B12.
  4. 4. A health product comprising the Lac-Phe-based composition of any one of claims 1-3, and an atomizing device for atomizing the Lac-Phe-based composition.
  5. 5. The health product according to claim 4, wherein the atomizing device comprises an atomizing circuit, and a storage bin and a battery connected with the atomizing circuit; The storage bin storing the Lac-Phe-based composition to be nebulized; the aerosolization circuit converts the Lac-Phe based composition to an aerosol form; and the battery supplies power for the atomizing circuit.
  6. 6. Use of a Lac-Phe-based composition according to any one of claims 1 to 3 or a health-care product according to claim 4 or 5 for the manufacture of a product for the prevention or treatment of obesity.
  7. 7. A method of preventing or treating obesity comprising administering to a subject in need thereof an effective amount of a Lac-Phe-based composition according to any one of claims 1 to 3 or a nutraceutical according to claim 4 or 5.

Description

Lac-Phe-based composition, health product and application thereof Technical Field The invention relates to the field of metabolic disorder treatment medicines, in particular to a Lac-Phe-based composition, a health product and application thereof. Background The lancet study report indicates that the number of adult obese patients has increased more than twice as much as 1990 and that the number of adult obese patients has increased more than 10 billion by 2022 worldwide, with the number of childhood and adolescent obese patients having increased three times as much as 5 to 19 years old. Furthermore, of 188 countries worldwide, 94% of the countries have an increased age-standardized prevalence of female obesity, and the case of male obesity is also increasing generally, with the exception of only one country. This suggests that obesity places a burden on the public health system, increases medical costs and socioeconomic pressures, and has become a significant public health challenge. For individuals, obesity not only significantly limits mobility and quality of life, causing numerous adverse effects on daily life, but also significantly increases the risk of developing a variety of diseases including cardiovascular disease, diabetes, asthma, osteoarthritis, fertility dysfunction, and certain types of cancer. Therefore, effective measures are needed to reduce the multiple negative effects of obesity. Treatment of obesity generally requires increasing basal metabolic rate, improving cardiopulmonary function, and enhancing muscle strength by controlling diet and maintaining proper exercise amount, which helps maintain healthy body weight for a long period of time. However, controlling appetite requires strong mental power and endurance to overcome the vigorous appetite and feeling of hunger before meals. Exercise weight loss requires a large amount of exercise, not only time consuming, but also long-term tolerance and adherence. Thus, obese patients often face significant challenges in performing these measures. When diet control and exercise effects are not ideal, it is often necessary to assist with medication, even to receive bariatric surgery. However, traditional drug therapies, such as orlistat, bupropion and metformin, are often accompanied by side effects such as diarrhea, headache and nausea. The weight-loss operation may cause complications such as wound infection after operation. In addition, there is still a need to control diet and maintain proper exercise after surgery to prevent recurrence of obesity. In view of the foregoing, although the existing methods for treating obesity are effective to some extent, there is still a need to develop weight-reducing products that have better efficacy and are easy for patients to persist for a long period of time due to significant side effects and persisting difficulties. Only then can the global obesity epidemic trend be more effectively dealt with, the burden of the public health system is lightened, and the global population overall health level is improved. Disclosure of Invention The invention provides a Lac-Phe-based composition, a health product and application thereof by optimizing a composition formula and determining a proper administration mode. In a first aspect of the invention, there is provided a Lac-Phe-based composition comprising (0.1-100): 0.1-10): 0.1-2 propylene glycol, glycerol, lac-Phe and a synergist. In some embodiments, the mass ratio of the propylene glycol to the glycerol is (7-9): 1-2. In some embodiments, the potentiator comprises vitamin B12. In a second aspect of the invention, a health product is provided comprising the Lac-Phe-based composition described above, and an atomizing device for atomizing the Lac-Phe-based composition. In some embodiments, the aerosolization device comprises a aerosolization circuit, a storage bin coupled to the aerosolization circuit, the storage bin storing the Lac-Phe-based composition to be aerosolized, the aerosolization circuit converting the Lac-Phe-based composition to an aerosol form, and a battery to power the aerosolization circuit. In a third aspect, the invention provides an application of the Lac-Phe-based composition or the health product in preparing a product for preventing or treating obesity. In a fourth aspect of the invention, there is provided a method of preventing or treating obesity comprising administering to a subject in need thereof an effective amount of the Lac-Phe-based composition as described above or the nutraceutical as described above. Compared with the prior art, the invention has the beneficial effects that, (1) The medicine active ingredient adopted by the invention is Lac-Phe. As a normal exercise metabolite of human body, lac-Phe has no toxic and side effects and high safety. (2) The Lac-Phe-based composition provided by the invention adopts proper formula components and corresponding contents, improves the solubility of Lac-Phe, optimizes the absorptivity