CN-121987618-A - Pharmaceutical composition with synergistic anti-aging effect and preparation method and application thereof

Abstract

The invention relates to the technical field of biological medicines, in particular to a pharmaceutical composition with a synergistic anti-aging effect, and a preparation method and application thereof. The composition specifically comprises dihydroquercetin and fisetin. According to the invention, two core anti-aging mechanisms of anti-oxidation and aging cell removal are organically integrated for the first time, so that multi-target cooperative intervention on aging process is realized. Compared with single components, the composition not only can effectively repair oxidative damage, but also can selectively remove accumulated aging cells, simultaneously plays roles from two aspects of source and result, overcomes the defects of single action path and limited effect of the traditional single strategy, and provides a more comprehensive and efficient new scheme for delaying aging and preventing and treating aging-related diseases.

Inventors

• ZHOU ZHONGGUANG
• LUAN XIAOMIN

Assignees

• 北京延寿健康科技有限公司
• 海南儒泰科技有限公司

Dates

Publication Date

20260508

Application Date

20260328

Claims (9)

1. 1. A pharmaceutical composition with synergistic anti-aging effect is characterized by comprising dihydroquercetin and fisetin.
2. 2. The pharmaceutical composition according to claim 1, wherein the mass ratio of dihydroquercetin to fisetin is 1-10:1-10.
3. 3. The pharmaceutical composition according to claim 2, wherein the mass ratio is 1-5:1-5.
4. 4. A pharmaceutical composition according to claim 3, wherein the mass ratio is 1:1.
5. 5. The pharmaceutical composition according to any one of claims 1 to 4, wherein the pharmaceutical composition is in the form of an oral preparation, an injection or a topical preparation.
6. 6. The pharmaceutical composition of claim 5, wherein the oral formulation is a tablet, capsule, granule, powder, or oral liquid.
7. 7. The pharmaceutical composition of any one of claims 1-4, further comprising a pharmaceutically, dietetic, or cosmetically acceptable carrier, excipient, or diluent.
8. 8. A method for preparing the pharmaceutical composition according to any one of claims 1 to 7, characterized in that dihydroquercetin and fisetin are mixed, pharmaceutically acceptable auxiliary materials are added, and corresponding dosage forms are prepared.
9. 9. Use of the pharmaceutical composition according to any one of claims 1 to 7 for the preparation of a medicament for anti-aging, preventing or treating aging-related diseases.

Description

Pharmaceutical composition with synergistic anti-aging effect and preparation method and application thereof Technical Field The invention relates to the technical field of biological medicines, in particular to a pharmaceutical composition with a synergistic anti-aging effect, and a preparation method and application thereof. Background Senescence is a multifactorial, multifaceted, progressive biological process characterized by genomic instability, telomere loss, epigenetic changes, loss of protein homeostasis, mitochondrial dysfunction, cellular senescence, and chronic inflammation. These interrelated "aging markers" together drive the decline of body function and significantly increase the risk of onset of age-related chronic diseases such as cardiovascular disease, neurodegenerative disease, metabolic syndrome, malignancy, and the like. Therefore, searching for strategies that can effectively interfere with the aging process, delay or ameliorate age-related diseases has become an important direction in modern biomedical research. In recent years, natural products are used for anti-aging intervention, and attention is paid to the natural products due to wide sources, multi-target effect and relatively high safety. Dihydroquercetin (Dihydroquercetin, also known as douglas fir element, taxifolin) is a dihydroflavonol compound extracted mainly from larch and other plants. A large number of researches prove that the dihydroquercetin has strong antioxidant activity, and can effectively remove free radicals, chelate metal ions, activate endogenous antioxidant enzymes and protect mitochondrial functions. In addition, it has been found to have various pharmacological activities such as anti-inflammatory, microcirculation improving, cardiovascular protection, and lipid metabolism regulating. At present, dietary supplements and medicines containing dihydroquercetin as a main component are widely applied in multiple countries and are mainly used for protecting and improving the functions of a cardiovascular system. However, its single use of anti-aging effect is mainly limited to the level of anti-oxidative stress, with limited effect on clearing the key anti-aging target of existing aging cells. Fisetin (Fisetin) is a flavonol compound naturally existing in fruits and vegetables such as strawberry, apple, onion, etc. Recent studies indicate that fisetin is a potential Senolytic drug, i.e., can selectively induce apoptosis of senescent cells, thereby alleviating tissue microenvironment damage caused by senescence-associated secretion phenotypes consisting of pro-inflammatory factors secreted by senescent cells, growth factors, matrix remodelling enzymes and the like. By eliminating senescent cells, fisetin has been shown to alleviate pathological changes in a variety of age-related disease models and improve the health status of elderly individuals. However, fisetin, when used alone, although targeting senescent cells, is relatively inadequate in the ability to repair oxidative stress damage that persists in the body, and it is difficult to fundamentally prevent the production of new senescent cells. Currently, although there have been many reports of dihydroquercetin applied to cardiovascular protection or removal of senescent cells using fisetin, aging is a complex process driven by the accumulation of oxidative damage together with an increase in load on senescent cells. Strategies that target antioxidant or scavenge senescent cells singly often have difficulty blocking this process comprehensively, resulting in limitations in anti-aging effects. In the prior art, the related research report or application of multi-target collaborative intervention aging is not yet realized by combining the dihydroquercetin with fisetin and utilizing the unique advantages of the dihydroquercetin in the aspects of antioxidation protection and aging cell elimination. In view of the foregoing, there is still a need in the art to develop a novel composition that can simultaneously act on different key links in the aging process, and achieve a more comprehensive and efficient anti-aging effect through a multi-target synergistic mechanism. Disclosure of Invention The invention aims to provide a pharmaceutical composition with synergistic anti-aging effect, and a preparation method and application thereof. In order to achieve the above object, the present invention provides the following technical solutions: the invention provides a pharmaceutical composition with synergistic anti-aging effect, which consists of dihydroquercetin and fisetin. Preferably, the mass ratio of the dihydroquercetin to the fisetin is 1-10:1-10. Preferably, the mass ratio is 1-5:1-5. Preferably, the mass ratio is 1:1. Preferably, the dosage form of the pharmaceutical composition is an oral preparation, an injection or a topical preparation. Preferably, the oral preparation is a tablet, a capsule, a granule, a powder or an oral liquid. Preferably, a pharmaceuti