CN-121987628-A - Medicine for repairing ovarian function

Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a medicine for repairing ovarian function and application thereof. The invention discovers NMDPEF (also called S29434) that the ovarian function of a psychogenic stress individual can be repaired, the primordial follicle induced by the psychogenic stress is prevented from being activated in advance, the quality of the oocyte is improved, and the fertilization capacity and the embryo development potential of the oocyte are improved. NMDPEF to protect primordial follicle library of psychogenic stressed mice, preserve fertility, MDPEF to improve oocyte quality of psychogenic stressed mice, NMDPEF to improve fertilization capacity and blastocyst development rate of the psychogenic stressed mice. The medicine has the advantages of simple acquisition, low cost, mass production, obvious effect, quick response, shortened medicine taking period, reduced toxic and side effects of the medicine and improved compliance of patients.

Inventors

• MA WEI
• WANG BICHENG
• XU XIANGNING

Assignees

• 首都医科大学

Dates

Publication Date

20260508

Application Date

20260408

Priority Date

20251119

Claims (9)

1. Application of NMDPEF in preparing medicine for repairing ovary function.
2. 2. The method according to claim 1, wherein the ovarian function is that of a stressed subject, and wherein the stressed subject is a psychologically stressed subject.
3. 3. The use as claimed in claim 1, wherein NMDPEF includes pharmaceutically acceptable salts, solvates and derivatives thereof, and wherein NMDPEF is administered at a dose of 4.5 mg/kg/d.
4. 4. The use of claim 1, wherein the repair of ovarian function comprises protecting primordial follicular libraries in the ovary, improving oocyte quality, improving fertility of the oocyte, and improving blastocyst development rate after fertilization of the oocyte.
5. 5. The use according to claim 1, wherein one or more pharmaceutically acceptable carriers are further added to the pharmaceutical composition.
6. 6. A pharmaceutical composition comprising NMDPEF and another agent that repairs ovarian function, the pharmaceutical composition having at least one of the following effects: 1) Protecting the primordial follicular bank in the ovary; 2) Improving oocyte quality; 3) Improving the fertilization capacity of the oocyte; 4) Improving the blastocyst development rate after oocyte fertilization.
7. 7. The pharmaceutical composition of claim 6, wherein the ovarian function is that of a stressed subject, and wherein the stressed subject is a psychologically stressed subject.
8. 8. The pharmaceutical composition of claim 6, wherein NMDPEF comprises pharmaceutically acceptable salts, solvates and derivatives thereof, and wherein NMDPEF is administered at a dose of 4.5 mg/kg/d.
9. 9. The pharmaceutical composition of claim 6, wherein one or more pharmaceutically acceptable carriers can be added, and the pharmaceutical composition can be made into various dosage forms, including tablet, capsule, aerosol, pill, powder, solution, suspension, granule and suppository.

Description

Medicine for repairing ovarian function Technical Field The invention belongs to the technical field of biological medicines, and particularly relates to a medicine for repairing ovarian function and application thereof. Background The hypofunction of ovarian reserve (DIMINISHED OVARIAN RESERVE, DOR) refers to the decrease of the number of follicles in the ovary and the decrease of the quality of oocytes, which causes the insufficient ovarian function, resulting in the decrease of fertility, accompanied by the decrease of the level of anti-mullerian hormone (AMH), the decrease of the number of follicles in the sinus (AFC), and the increase of the level of basic Follicle Stimulating Hormone (FSH) （Practice Committee of the American Society for Reproductive Medicine; Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2020; 114(6): 1151-1157）., which are clinically manifested mainly as menstrual disorder, abnormal ovulation, infertility, etc. At present, clinical medicine has no unified judging standard for DOR, and because different examination institutions have different judging of the same examination items, the pathogenesis of DOR is difficult to determine, and age, genetic factors, life style, radiotherapy/chemotherapy, surgery and other factors are mainly considered as main dangerous factors (Ge Renjie, hu Rongkui, chen, and the like; the progress of diagnosis of traditional Chinese medicine with reduced ovarian reserve function [ J ]. J.Chinese medicine, 2020,35 (1): 322-325.). Stress refers to the combined response （Boudarene M, Legros JJ, Timsit-Berthier M. Study of the stress response: role of anxiety, cortisol and DHEAs. Encephale. 2002; 28(2): 139-46）. psychological stress that occurs when the body is exposed to a stress source (the factor that causes the body to develop a state of physical and mental stress) is very closely related to human disease. When psychological stress occurs, the body undergoes a combined response of the nervous, endocrine, and immune systems, etc. And the cognition of the stress of the human body can further influence the response reaction of the human body. When the body is in a strongly stimulated environment, the cerebral cortex is subjected to comprehensive analysis, and a series of nonspecific response reactions such as nerve excitation, hormone secretion increase, blood pressure increase, heart rate acceleration and the like are caused. Extensive investigation has found that there is a direct correlation between hypofertility and anxiety, and that women who are known to be difficult or full-term to pregnancy exhibit much more pronounced （King RB. Subfecundity and anxiety in a nationally representative sample. Soc Sci Med. 2003; 56(4): 739-751）. anxiety than women with normal fertility, while women with poor fertility have a stronger desire to own their children than normal women, but the lower fertility further aggravates the anxiety mood of such women. A strong psychological stress or long-term psychological stress can affect the physical and psychological health of humans, and can have adverse effects on the reproductive endocrine system, resulting in a variety of fertility-related diseases including dysfunctional uterine bleeding, infertility, amenorrhea, sexual dysfunction, etc. (Cheng Xiang, chen Zhengqiong, xie Rongkai, etc.. Fluoxetine hydrochloride combines the clinical observations of estrogens for menopausal depression, chongqing medicine, 2005, 34 (5): 721-722; lu Li, li Jianping, xue Yunzhen, etc.. Emotional response, personality characteristics, relationships with menstrual disorders, journal of Chinese psychological health, 2005, 19 (3): 156-158). Psychological stress can affect follicular development and survival, eventually leading to a decline in ovarian function （Zhai QY, Wang JJ, Tian Y, Liu X, Song Z. Review of psychological stress on oocyte and early embryonic development in female mice. Reprod Biol Endocrinol. 2020; 18(1): 101）. ovaries can produce ovaries and secrete hormones, the development processes in ovaries include primordial follicles, pre-sinus follicles, sinus follicles and mature follicles in turn, wherein chronic psychological stress in pre-sinus follicles and sinus follicles, termed growth follicles （Shah JS, Sabouni R, Cayton Vaught KC, et al. Biomechanics and mechanical signaling in the ovary: a systematic review. J Assist Reprod Genet. 2018; 35(7): 1135-1148; Gruhn JR, Zielinska AP, Shukla V, et al. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science. 2019; 365(6460): 1466-1469）., can accelerate activation of primordial follicles and destroy growth follicles development, harm oocyte quality, lead to premature depletion of ovarian reserves （Xu YP, Fu JC, Hong ZL, et al. Psychological stressors involved in the pathogenesis of premature ovarian insufficiency and potential intervention