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CN-121987654-A - External scalp preparation, composition, preparation method and application

CN121987654ACN 121987654 ACN121987654 ACN 121987654ACN-121987654-A

Abstract

The embodiment of the application discloses an external scalp preparation, a composition, a preparation method and application thereof, which can realize the effect of protecting hair. The composition comprises 0.1-0.8% of caffeine, 0.003-0.08% of biotin and 0.02-0.8% of glucosyl hesperidin by mass.

Inventors

  • XU PENG
  • WU MAN
  • DENG GUIFENG
  • ZHONG JIANGMING
  • SHU PENG
  • ZHAO CHUNXIANG

Assignees

  • 深圳护家科技(集团)股份有限公司

Dates

Publication Date
20260508
Application Date
20260210

Claims (12)

  1. 1. A composition, characterized by comprising: caffeine, biotin, and glucosyl hesperidin; Wherein the mass ratio of caffeine, biotin and glucosyl hesperidin is as follows (0.1~0.8): (0.003~0.08): (0.02~0.8)。
  2. 2. The composition of claim 1, wherein the composition comprises, The mass fraction of caffeine is 0.1-0.8%, the mass fraction of biotin is 0.003-0.08%, and the mass fraction of glucosyl hesperidin is 0.02-0.8%.
  3. 3. The composition as set forth in claim 1, further comprising: a substrate comprising a solvent comprising water; The matrix also comprises one or more of sodium laureth sulfate, ammonium laureth sulfate, cocamidomethyl MEA, cocamidopropyl betaine, sodium chloride, sodium benzoate, phenoxyethanol, essence, hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and citric acid.
  4. 4. The composition of claim 1, wherein the composition comprises, The weight ratio of the sodium laureth sulfate, the ammonium laureth sulfate, the cocamidomethyl MEA, the cocamidopropyl betaine, the sodium chloride, the sodium benzoate, the phenoxyethanol, the essence, the hydroxypropyl guar gum and the hydroxypropyl trimethyl ammonium chloride to the citric acid is (10-20): (1-5): (1-3): (2-10): (0.3-0.5): (0.5-0.7): (0.3-0.5): (0.1-0.3): (0.01-0.2).
  5. 5. A method of preparing a composition comprising: mixing caffeine, biotin, and glucosyl hesperidin to obtain the composition; Wherein the mass ratio of caffeine, biotin and glucosyl hesperidin is as follows (0.1~0.8): (0.003~0.08): (0.02~0.8)。
  6. 6. A process for preparing a composition according to claim 5, The mixing of caffeine, biotin, and glucosyl hesperidin to obtain the composition comprises: Adding caffeine into a matrix at a first temperature, and dissolving under stirring to obtain a caffeine mixture, wherein the first temperature is 75-90 ℃; The composition is obtained by adding biotin and glucosyl hesperidin to the mixture of caffeine at a second temperature, and dissolving under stirring, wherein the second temperature is not higher than 50 ℃.
  7. 7. A process for preparing a composition as claimed in claim 6, wherein, The preparation method of the matrix comprises the following steps: Adding polyquaternium-10 and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride into water, and uniformly dispersing under stirring to obtain a first mixture; Adding sodium laureth sulfate and ammonium laureth sulfate into the first mixture, heating to 75-90 ℃ under stirring, and completely dissolving to obtain a second mixture; Adding cocoamidomethyl MEA, cocoamidopropyl betaine, sodium chloride, citric acid and sodium benzoate to the second mixture, and completely dissolving under stirring to obtain a third mixture; and cooling the third mixture to below 50 ℃, adding phenoxyethanol and essence, and uniformly stirring to obtain the matrix.
  8. 8. The composition prepared by the preparation method according to any one of claims 5 to 7.
  9. 9. Use of a composition according to any one of claims 1 to 4,8 in the preparation of a hair care formulation.
  10. 10. Use of the composition according to any one of claims 1 to 4,8 for the preparation of a topical scalp formulation.
  11. 11. Use of a composition according to any one of claims 1 to 4,8 for the preparation of an EGF expression promoter and/or a VEGF expression promoter.
  12. 12. A scalp preparation for external use, which is characterized by comprising the composition according to any one of claims 1 to 4 and 8.

Description

External scalp preparation, composition, preparation method and application Technical Field The invention relates to the technical field of hair care, in particular to an external scalp preparation, a composition, a preparation method and application thereof. Background Alopecia is a common hair abnormality problem, and occurrence of the hair abnormality is closely related to various factors such as genetic factors, endocrine level changes, immune abnormality, hair follicle microenvironment imbalance, external physicochemical stimulation and the like. The prior study shows that the growth cycle of the hair follicle is finely regulated by various signal paths and bioactive factors, and when the anagen phase of the hair follicle is shortened, the catagen phase is advanced or the hair follicle is miniaturized, the hair can be gradually thinned or even shed. Currently, the intervention means for alopecia mainly depend on the composition forms of external or oral medicines, bioactive component preparations, functional cosmetics and the like, and the purposes of preventing alopecia or promoting hair growth are achieved by inhibiting androgen action, improving scalp microcirculation, regulating inflammatory reaction or promoting hair follicle cell proliferation. However, the common hair loss prevention and treatment composition mainly comprises a single active ingredient or two ingredients which are simply compounded, and the problem of insufficient hair care effect is generally existed. Accordingly, there is a need to provide a composition for preventing hair loss. Disclosure of Invention It is an aim of embodiments of the present application to address at least one of the above-mentioned problems with the background and to provide corresponding advantages. Another object of the embodiments of the present application is to provide an external scalp preparation, composition, and preparation method and use thereof, which can achieve the effect of protecting hair, for solving the problem of preventing hair loss. The embodiment of the application mainly realizes the aim through the following technical scheme. In a first aspect, embodiments of the present application provide a composition comprising: caffeine, biotin, and glucosyl hesperidin; wherein the mass ratio of caffeine, biotin and glucosyl hesperidin is (0.1-0.8): 0.003-0.08): 0.02-0.8. In some embodiments, in the composition, The mass fraction of caffeine is 0.1-0.8%, the mass fraction of biotin is 0.003-0.08%, and the mass fraction of glucosyl hesperidin is 0.02-0.8%. In some embodiments, the composition further comprises a matrix comprising a solvent. In some embodiments, the composition wherein the solvent comprises water; in some embodiments, the matrix further comprises one or more of sodium laureth sulfate, ammonium laureth sulfate, cocamidomethyl MEA, cocamidopropyl betaine, sodium chloride, sodium benzoate, phenoxyethanol, essence, hydroxypropyl guar hydroxypropyl trimethylchloride, polyquaternium-10, and citric acid. In some embodiments, in the composition, The weight ratio of the sodium laureth sulfate, the ammonium laureth sulfate, the cocamidomethyl MEA, the cocamidopropyl betaine, the sodium chloride, the sodium benzoate, the phenoxyethanol, the essence, the hydroxypropyl guar gum and the hydroxypropyl trimethyl ammonium chloride to the citric acid is (10-20): (1-5): (1-3): (2-10): (0.3-0.5): (0.5-0.7): (0.3-0.5): (0.1-0.3): (0.01-0.2). In a second aspect, embodiments of the present application provide a method of preparing a composition comprising: Caffeine, biotin, and glucosyl hesperidin were mixed to obtain the composition. According to this method, the composition of the first aspect can be prepared. In some embodiments, according to the method of preparing the composition, The mixing of caffeine, biotin, and glucosyl hesperidin to obtain the composition comprises: Adding caffeine into a matrix at a first temperature, and dissolving under stirring to obtain a caffeine mixture, wherein the first temperature is 75-90 ℃; adding biotin and glucosyl hesperidin to the mixture of caffeine at a second temperature, and dissolving under stirring to obtain the composition, wherein the second temperature is not more than 50 ℃; wherein the mass ratio of caffeine, biotin and glucosyl hesperidin is (0.1-0.8): 0.003-0.08): 0.02-0.8. In some embodiments, the method of preparing the matrix comprises: adding polyquaternium-10 and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride into deionized water, and uniformly dispersing under stirring to obtain a first mixture; Adding sodium laureth sulfate and ammonium laureth sulfate into the first mixture, heating to 75-90 ℃ under stirring, and completely dissolving to obtain a second mixture; Adding cocoamidomethyl MEA, cocoamidopropyl betaine, sodium chloride, citric acid and sodium benzoate to the second mixture, and completely dissolving under stirring to obtain a third mixture; and cooling the third mix