CN-121987664-A - Application of ferrous ion compound in preparation of medicine for treating perianal diseases and medicine

Abstract

The invention relates to the technical field of biological medicines, in particular to application of a ferrous ion compound in preparation of a medicine for treating perianal diseases and the medicine. The comprehensive effect of the ferrous ion compound in the treatment of perianal inflammation and the like is obviously better than the treatment effect of the existing positive medicament and high or low concentration ferrous ion, and the comprehensive effects of resisting inflammation, improving perianal circulation, inhibiting bacteria and promoting tissue repair can be realized in a rabbit model.

Inventors

• WANG PAN
• HU LIANGBIN
• TIAN LU
• MO HAIZHEN
• LI HONGBO
• ZHOU XIAOHUI
• BAI YU

Assignees

• 烟台爱恩生命科技有限公司

Dates

Publication Date

20260508

Application Date

20260306

Claims (10)

1. 1. Application of ferrous ion compound in preparing medicine for treating perianal diseases is provided.
2. 2. The use according to claim 1, wherein the ferrous compound is any one or a combination of several of ferrous sulphate, ferrous lactate, ferrous chloride and ferrous gluconate.
3. 3. The use according to claim 2, wherein the perianal disease is hemorrhoids, chronic perianal inflammation or anal inflammation.
4. 4. The use according to claim 3, wherein the medicament is for alleviating perianal redness and swelling, promoting perianal cyst absorption, or ameliorating local discomfort during the inflammatory phase of hemorrhoids.
5. 5. The use according to claim 4, wherein the pharmaceutical dosage form is in the form of a solution, gel, suspension, emulsion or hydrogel.
6. 6. The use according to claim 5, wherein the hydrogel is prepared from ferrous salt as effective component, and adjuvants such as nicotinamide, vitamin B 2 , sodium alginate, hyaluronic acid and carbomer.
7. 7. The use according to claim 6, wherein the concentration of the ferrous compound in the hydrogel drug is 2mM to 3mM.
8. 8. The application of the hydrogel type medicine according to claim 7, wherein the preparation method is characterized in that the ferrous ion compound is dissolved in sterile ultrapure water to a final concentration of 2 mM-3 mM to obtain a 2 mM-3 mM ferrous ion compound solution, and the preparation method comprises the steps of adding auxiliary materials and stirring until a stable colloid is formed to obtain the 2 mM-3 mM ferrous ion compound hydrogel.
9. 9. The use according to claim 8, wherein the added auxiliary materials are 1.5% -2% sorbitol, 0.2% -0.3% allantoin, 0.01% -0.02% vitamin B2, 2% -3% panthenol, 0.02% -0.03% shikonin, 0.6% -1% polyethylene glycol-200, 0.5% -0.7% carbomer and 0.2% -0.3% sodium alginate, based on the mass fraction of the 2 mM-3 mM ferrous compound solution.
10. 10. A medicament for treating hemorrhoids, characterized in that the medicament is the hydrogel-type medicament according to claim 5, which is prepared by the steps of: dissolving a ferrous ion compound in sterile ultrapure water to a final concentration of 2 mM-3 mM to prepare a2 mM-3 mM ferrous ion compound solution; And sequentially adding 1.5% -2% of sorbitol, 0.2% -0.3% of allantoin, 0.01% -0.02% of vitamin B2, 2% -3% of panthenol, 0.02% -0.03% of shikonin, 0.6% -1% of polyethylene glycol-200, 0.5% -0.7% of carbomer and 0.2% -0.3% of sodium alginate into a 2 mM-3 mM ferrous compound solution according to the mass fraction of the 2 mM-3 mM ferrous compound solution, stirring at 200 rpm~300 rpm,20 ℃ to 23 for 3 h-4 h to form a stable colloid, and adjusting the pH to 5.6-70 by using triethanolamine to obtain the 2 mM-3 mM ferrous compound hydrogel.

Description

Application of ferrous ion compound in preparation of medicine for treating perianal diseases and medicine Technical Field The invention relates to the technical field of biological medicines, in particular to application of a ferrous ion compound in preparation of a medicine for treating perianal diseases and the medicine. Background Perianal diseases refer to diseases occurring in the anus and its surrounding areas, and commonly include perianal abscess, anal fistula, rectal prolapse, anal fissure, and hemorrhoids. Perianal abscess refers to bacterial infection of perianal tissues to form abscess, and symptoms such as severe perianal pain, lump and fever usually appear, anal fistula refers to complications of perianal abscess, namely that an abnormal channel is formed between an anal canal and perianal skin after the abscess is broken, common symptoms are secretion discharge at anus and sometimes accompanied by pain, rectal prolapse refers to that rectum partially or completely protrudes from anus, common symptoms comprise difficult defecation, discomfort at anus and secretion discharge, anal fissure refers to anal skin laceration usually caused by constipation, and is manifested as severe anus pain and possibly accompanied by bleeding when defecation, hemorrhoids are the most common perianal diseases and are divided into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids. Internal hemorrhoids occur inside the anus and external hemorrhoids occur outside the anus, with common symptoms including pain in the anus, bleeding, itching, etc. The pathogenesis of perianal diseases is mainly related to the combined actions of the factors such as the local anatomical characteristics of anus, blood circulation, infection, defecation habit, immune response and the like. Hemorrhoids are mostly caused by the factors of the relaxation of anal cushion supporting tissues, venous reflux disorder, forced defecation and the like, anal fissure is often caused by abrasion of hard stool, local blood supply is insufficient due to sphincter cramp, the breach is difficult to heal, perianal abscess mainly originates from bacterial infection after anal gland opening blockage and spreads to the periphery, anal fistula is an abnormal channel formed by unoccluded anal gland opening after abscess is broken or incised, and rectal prolapse is caused by pelvic floor muscle relaxation, weakening of supporting structure and rising of abdominal pressure. These diseases are often caused or exacerbated by multiple factors such as constipation, sedentary, local inflammation, and lifestyle. At present, comprehensive strategies such as conservation, medicines, minimally invasive surgery and the like are adopted according to different types of diseases in clinical treatment of perianal diseases, but each method has certain limitations. Hemorrhoid treatment starts with adjustment and defecation, hip bath and local medicines, and minimally invasive such as rubber band ligation, hardening injection and infrared solidification have the advantages of small wound and quick recovery, but have limited effect on prolapse hemorrhoids with heavy weight and higher recurrence rate, and surgery such as traditional hemorrhoid excision or PPH can radically cure, but has large wound and long recovery period, and can cause pain, bleeding or anal stenosis. The conservative treatment of anal fissure can relieve symptoms, but chronic anal fissure is difficult to completely heal, and the internal sphincterotomy has high cure rate, but can bring about the risk of reducing the anal control force to different degrees. Perianal abscess must be incised for drainage, but may still develop into anal fistula after surgery, and antibiotics have limited effect on simple abscesses. Anal fistula requires operation treatment, and fistulotomy is suitable for low-level fistula but is vulnerable to sphincter injury, and wire hanging, LIFT and other sphincter protection operations are safer but have low recurrence rate. The pelvic floor training effect of rectal prolapse is limited, and the operation can correct prolapse, but recurrence or defecation dysfunction can still occur. Overall, perianal disease treatment requires a tradeoff between efficacy, safety, risk of recurrence, and functional protection. Therefore, the existing perianal disease treatment means still have the problems of unstable curative effect, high recurrence rate, more side effects, poor patient compliance and the like. The existing external medicine (including hormone, antibiotics, plant extract and hemostatic astringents) for treating perianal diseases still has the problems of large irritation, easy recurrence or insufficient repair capability. Thus, a new strategy for treating perianal diseases is urgently needed. Disclosure of Invention The invention provides application of a ferrous ion compound in preparing a medicament for treating hemorrhoids and a medicament for developing a novel strategy for