CN-121987670-A - Application of bacteroides faecalis PM01 in preparation of medicines for preventing or treating inflammatory diseases

Abstract

The invention discloses application of bacteroides faecalis PM01 in preparation of a medicament for preventing or treating inflammatory diseases, and belongs to the technical field of microorganisms. The application of the bacteroides faecalis PM01 in preparing a medicament for preventing or treating inflammatory diseases disclosed by the invention can inhibit neutrophils and macrophages from aggregating to the inflammation of the zebra fish tail fin in an in-vivo inflammation model, and the bacteroides faecalis PM01 can inhibit the increase of the contents of inflammatory factors IL-1 beta, IL-6 and TNF-alpha induced by LPS, so that theoretical reference and guiding basis are provided for developing medicaments for preventing or treating inflammatory diseases by utilizing the bacteroides faecalis PM 01.

Inventors

• CHEN TAO
• LIU YAN
• ZHENG KANGDI
• ZHANG ZHAO

Assignees

• 广东南芯医疗科技有限公司
• 广东一元兰欣生物科技有限公司

Dates

Publication Date

20260508

Application Date

20230515

Claims (6)

1. 1. The application of the bacteroides faecalis PM01 in preparing a medicament for preventing or treating inflammatory diseases is characterized in that the preservation number of the bacteroides faecalis PM01 is CGMCC No.22983.
2. 2. The use of parabacteroides faecalis PM01 according to claim 1 for the preparation of a medicament for preventing or treating an inflammatory disease, wherein the parabacteroides faecalis PM01 is a bacterial suspension.
3. 3. The use of paramamoeba faecalis PM01 as claimed in claim 1 for the manufacture of a medicament for inhibiting the aggregation of neutrophils and macrophages to the inflammation of the tail fin of zebra fish.
4. 4. The use of parabacteroides coproduct PM01 according to claim 3 for the preparation of a medicament for inhibiting the aggregation of neutrophils and macrophages to the inflammation of the tail fin of zebra fish, wherein the parabacteroides coproduct PM01 is a bacterial suspension.
5. 5. The application of the parabacteroides faecalis PM01 in claim 1 in preparing medicines for inhibiting inflammatory factors IL-1 beta, IL-6 and TNF-alpha.
6. 6. The application of the parabacteroides faecalis PM01 according to claim 5 in preparing medicines for inhibiting inflammatory factors IL-1 beta, IL-6 and TNF-alpha, wherein the parabacteroides faecalis PM01 is a bacterial suspension.

Description

Application of bacteroides faecalis PM01 in preparation of medicines for preventing or treating inflammatory diseases Technical Field The invention relates to the technical field of microorganisms, in particular to application of bacteroides faecalis PM01 in preparation of medicines for preventing or treating inflammatory diseases. Background Inflammation is what is commonly called "inflammation" and is a basic pathological process mainly based on defense reaction, which occurs when biological tissues are stimulated by a certain stimulation factor such as trauma, infection and the like. The local manifestations of inflammation are redness, swelling, heat, pain and dysfunction, and systemic reactions such as fever and changes in peripheral blood leukocyte count are also accompanied. Inflammation is often beneficial and is an automatic defensive response in humans. However, inflammation is sometimes also detrimental, such as attack on the body's own tissues, inflammation occurring in transparent tissues, and the like. The traditional treatment mode comprises the use of antibiotics and anti-inflammatory drugs, wherein in case of infectious inflammation caused by infection, the anti-inflammatory drugs or anti-inflammatory needles can be used, which are generally known as antibiotics, and the antibiotics are actually used for killing or inhibiting bacteria and reducing the inflammation caused by infection. If not inflammation caused by infection, non-steroidal anti-inflammatory agents or steroids are used in medicine to suppress the inflammatory response, often referred to as "anti-inflammatory agents". However, the continued use of the agents described above presents significant drawbacks and side effects, such as those associated with continued steroid use, including gastric ulcers and bleeding. Probiotics are used as a type of microorganism beneficial to human health, and when a certain number of living probiotics are planted in the intestinal tracts of a host, beneficial health effects can be exerted by changing the intestinal microecology and other ways. Therefore, providing an application of bacteroides faecalis PM01 in preparing a medicament for preventing or treating inflammatory diseases is a problem which needs to be solved by a person skilled in the art. Disclosure of Invention In view of the above, the invention provides application of Paramycolatopsis PM01 in preparing medicines for preventing or treating inflammatory diseases. Inflammation is a reaction of the immune system to tissue injury and infection and is mainly characterized by the accumulation of leukocytes (granulocytes, macrophages) around the infected tissue. The immune system of zebra fish is very similar to mammals. When trauma occurs, neutrophils, macrophages respond to traumatic inflammation almost simultaneously, and macrophages and neutrophils recruit to the site of injury. Cutting off the tail fin of the zebra fish by a scalpel, inducing acute injury and promoting the zebra fish neutrophil to generate immune response. The transgenic neutrophil fluorescent fish (green) is adopted, and the number of the zebra fish wound neutrophil truncated by the tail fin can be obviously increased compared with that of a normal zebra fish under a fluorescent microscope. In order to achieve the above purpose, the present invention adopts the following technical scheme: The application of the bacteroides faecalis PM (Parabacteroidesmerdae) PM01 in preparing a medicament for preventing or treating inflammatory diseases is that the preservation number of the bacteroides faecalis PM01 is CGMCC No.22983, and the bacteroides faecalis PM01 is preserved in China general microbiological culture Collection center (CGMCC), namely CGMCC), the institute of microbiological research, national academy of China, no. 3, north Star, the Korean area of Beijing, and the classification name of the bacteroides faecalis Parabacteroidesmerdae, wherein the preservation date is 2021, 07, 30. Furthermore, the parabacteroides merdae PM01 is applied to preparation of medicines for inhibiting neutrophils and macrophages from gathering at inflammation positions of zebra fish tail fins. Furthermore, the bacteroides faecalis PM01 is applied to the preparation of medicines for inhibiting inflammatory factors IL-1 beta, IL-6 and TNF-alpha. Furthermore, the parabacteroides faecalis PM01 is a bacterial suspension. The parabacteroides merdae PM01 can obviously inhibit neutrophils and macrophages from gathering to inflammation of the zebra fish tail fin in vivo, and has good effect of preventing or treating inflammatory diseases. The bacteroides faecalis PM01 can obviously inhibit LPS to improve the content of inflammatory factors IL-1 beta, IL-6 and TNF-alpha in the zebra fish body, and has the potential of preventing or treating inflammatory diseases. Compared with the prior art, the invention discloses application of the bacteroides faecalis PM01 in preparing a medicament for preventi