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CN-121987674-A - Synbiotic composition capable of promoting intestinal flora proliferation and preparation method and application thereof

CN121987674ACN 121987674 ACN121987674 ACN 121987674ACN-121987674-A

Abstract

The invention provides a synbiotics composition capable of promoting intestinal flora proliferation, a preparation method and application thereof, and relates to the technical field of microorganisms. The synbiotic composition comprises probiotics and prebiotics, wherein the probiotics are a mixture of lactobacillus crispatus, lactobacillus acidophilus and bifidobacterium animalis, the mass ratio of the probiotics is (0.1-2), the mass ratio of the probiotics is (2-4), the mixture of lactobacillus crispatus, lactobacillus acidophilus and bifidobacterium animalis is (5-7), and the prebiotics are a mixture of ‌ xylo-oligosaccharide, oat beta-glucan, arabinoxylan and 2' -fucosyllactose, the mass ratio of the prebiotics is (3-5), the mass ratio of the prebiotics is (1-2), the mass ratio of the prebiotics is (3-4), and the mass ratio of the prebiotics is (0.1-1). The invention obviously promotes the proliferation of beneficial bacteria in intestinal tracts through the interaction between specific probiotics and specific prebiotics.

Inventors

  • XU JIAN
  • BAI YUXUAN
  • TU QIANG
  • QIAN JINXING

Assignees

  • 江苏汉典生物科技股份有限公司

Dates

Publication Date
20260508
Application Date
20260410

Claims (10)

  1. 1. A synbiotic composition capable of promoting intestinal flora proliferation is characterized by comprising the following raw materials of probiotics and prebiotics, wherein the probiotics are a mixture of lactobacillus crispatus, lactobacillus acidophilus and bifidobacterium animalis in a mass ratio of (0.1-2) to (5-7), and the prebiotics are a mixture of ‌ xylooligosaccharide, oat beta-glucan, arabinoxylan and 2' -fucosyllactose in a mass ratio of (3-5) to (1-2) to (3-4) to (0.1-1).
  2. 2. The synbiotic composition according to claim 1, wherein the probiotics are a mixture of lactobacillus crispatus, lactobacillus acidophilus and bifidobacterium animalis in a mass ratio of 1:3:6.
  3. 3. The synbiotic composition according to claim 2, wherein the lactobacillus crispatus is lactobacillus crispatus LCR15 with a preservation number of ‌ CGMCC No.6406, the lactobacillus acidophilus is lactobacillus acidophilus NCFM with a preservation number of ATCC 700396, and the bifidobacterium animalis is bifidobacterium animalis cic 21711 with a preservation number of cic 21711 ‌.
  4. 4. The synbiotic composition according to claim 2, wherein the viable count of lactobacillus crispatus LCR15 is ‌ x10 6 - 1×10 7 CFU/g, the viable count of lactobacillus acidophilus NCFM is ‌ x 10 9 - 1×10 10 CFU/g, and the viable count of bifidobacterium animalis cic 21711 is ‌ 1 x 10 8 - 1×10 10 CFU/g.
  5. 5. The synbiotic composition according to claim 1, wherein the mass ratio of prebiotics to probiotics is 4-9:1.
  6. 6. The synbiotic composition according to claim 1, wherein the prebiotic is a mixture of ‌ xylo-oligosaccharide, oat β -glucan, arabinoxylan and 2' -fucosyllactose in a mass ratio of 4:1.5:3.5:1.
  7. 7. A method of preparing a synbiotic composition as claimed in any of claims 1 to 6 comprising the step of mixing the prebiotic and probiotic.
  8. 8. Use of a synbiotic composition according to any one of claims 1-6, for the preparation of a product that promotes proliferation of intestinal beneficial flora.
  9. 9. The use according to claim 8, wherein the products include pharmaceuticals and foods.
  10. 10. The use according to claim 9, wherein the pharmaceutical dosage form is selected from the group consisting of pills, capsules, granules, oral liquids, powders, tablets, troches, suspensions, syrups, injections or elixirs.

Description

Synbiotic composition capable of promoting intestinal flora proliferation and preparation method and application thereof Technical Field The invention relates to the technical field of microorganisms, in particular to a synbiotics composition capable of promoting intestinal flora proliferation, a preparation method and application thereof. Background The number of microorganisms living in the intestinal tract of a human body exceeds 1000, and is about 1014 which is ten times as many as that of cells of the human body. These microorganisms can adhere to intestinal mucosa to form a barrier to prevent the colonization of pathogenic bacteria, secrete various enzymes to help digestion and absorption of nutrients such as saccharides and proteins, and synthesize various vitamins necessary for human body. In addition, more and more studies indicate that intestinal microorganisms are closely related to the occurrence and development of obesity, diabetes, immunity, and the like. Also, as such, the human body is considered to be a super organism consisting of self-cellular and in vivo symbiotic microflora. According to the biochemical reaction of intestinal flora in a host body and the action effect of the intestinal flora on the host, the intestinal flora can be divided into two major categories of beneficial bacteria and harmful bacteria. Harmful bacteria can cause intestinal mucosa destruction, infection, tumor generation, and influence on visceral functions by generating toxins. The beneficial bacteria not only can supply or promote the absorption of nutrient substances through the metabolism activity of the beneficial bacteria and promote the excretion of harmful substances, but also can prevent the invasion of pathogenic bacteria through the metabolism of the beneficial bacteria, such as the generation of a large amount of organic acids, secretion of proteins and other activities. Under normal conditions, intestinal flora, hosts and the external environment establish a dynamic ecological balance, which plays an important role in human health. However, due to aging, environmental pollution, diet change, and abuse of antibiotics, the intestinal microecological system is often destroyed, thereby causing dysbacteriosis, and the normal physiological combination is destroyed, and a pathological combination is generated, thereby causing clinical symptoms, which are called intestinal dysbacteriosis. Clinically, patients with dysbacteriosis often have a reduced bifidobacteria number with reduced or increased other intestinal microbiota. Thus the probiotic bacteria amount in the body of the patient can be proliferated to improve the intestinal microecology state of the patient. At present, the means for adjusting the intestinal flora mainly comprise living bacteria and supplementing bacteria (namely, probiotics and supplementing bacteria) and self intestinal bacteria and multiplying (namely, prebiotics and supplementing bacteria). Prebiotics are soluble dietary fibers that are broken down by intestinal microorganisms into short chain fatty acids that provide energy for intestinal epithelial cells. Probiotics are living microorganisms that produce substances in the intestine that are beneficial to human health by colonization. The use of probiotics or prebiotics to regulate intestinal flora is a research hotspot of researchers in the field, and for example, chinese patent application No. CN102138594A discloses a compound seabuckthorn tea preparation with the function of regulating intestinal flora. The tea beverage is prepared by compounding fructo-oligosaccharide, isomaltooligosaccharide and other oligosaccharides with sea buckthorn fruit powder and black tea powder, and is used for proliferating beneficial intestinal bacteria and inhibiting harmful intestinal bacteria. However, the regulation of intestinal flora by means of prebiotics alone takes a long time and the effect is unstable. The Chinese patent application CN109700033A discloses a probiotic composition for regulating intestinal tracts and preventing constipation and a preparation method thereof, the probiotic composition takes lactobacillus plantarum fungus powder and lactobacillus plantarum metabolite powder as active ingredients, the lactobacillus plantarum is preserved in China center for type culture collection, the preservation number of the lactobacillus plantarum is CCTCCNO: M2018042, the probiotic composition also comprises a fungus powder carrier, the fungus powder carrier comprises microcrystalline cellulose, medicinal corn starch, inulin and magnesium stearate, wherein the probiotic composition comprises, by mass, 9-11 parts of lactobacillus plantarum fungus powder, 4-6 parts of lactobacillus plantarum metabolite powder, 18-22 parts of microcrystalline cellulose, 80-120 parts of medicinal corn starch, 8-12 parts of inulin and 8-12 parts of magnesium stearate. However, the viable bacteria supplementing has many shortcomings at the current level, such