CN-121987679-A - Composition for relieving vomitoxin harm of weaned pigs as well as preparation method and application thereof

Abstract

The invention relates to the technical field of breeding, in particular to a composition for relieving vomitoxin harm of weaned pigs, and a preparation method and application thereof. The composition comprises, by weight, 50-70 parts of glucurolactone, 10-15 parts of cynaropicrin, 20-40 parts of baicalein, 10-20 parts of stevia rebaudiana extract and 80-120 parts of carrier. The composition can effectively relieve diarrhea, weight loss and intestinal dysfunction symptoms of weaned pigs.

Inventors

• ZHU LIPING
• SUN CHUNHUA
• GAO WEI
• LUO FUXING
• YAN JIABIN
• YAN MINGHUI
• GAO XING
• HOU XIAOHAN
• QI CHANGHAI

Assignees

• 诸城市浩天药业有限公司

Dates

Publication Date

20260508

Application Date

20260227

Claims (5)

1. 1. A composition for relieving the vomit toxin hazard of weaned pigs is characterized by comprising, by weight, 50-70 parts of glucurolactone, 10-15 parts of cynaropicrin, 20-40 parts of baicalein, 10-20 parts of stevia rebaudiana extract and 80-120 parts of a carrier.
2. 2. The composition for alleviating the vomitoxin hazard of weaned pigs of claim 1, wherein said stevia extract comprises chlorogenic acid and analogues thereof in a total content of not less than 40%.
3. 3. The composition for relieving the vomitoxin hazard of weaned pigs according to claim 1, wherein the composition comprises, by weight, 60 parts of glucurolactone, 13 parts of cynaropicrin, 30 parts of baicalein, 15 parts of stevia extract and 100 parts of a carrier.
4. 4. A method of preparing a composition for alleviating the vomitoxin hazard in weaned pigs as claimed in claim 1, comprising the steps of: (1) Weighing the screened glucurolactone, cynaropicrin, baicalein, stevia rebaudiana extract and a carrier in turn according to parts by weight; (2) Taking the stevia rebaudiana extract in the step (1), adding an equal amount of carriers, stirring and mixing uniformly to obtain a first premix for standby, taking the cynaropicrin in the step (1), adding an equal amount of carriers, stirring and mixing uniformly to obtain a second premix for standby, taking the baicalein in the step (1), adding an equal amount of carriers, stirring and mixing uniformly to obtain a third premix for standby; (3) And (3) taking the first premix, the second premix and the third premix in the step (2), stirring and mixing uniformly, adding the rest carrier, continuously stirring and mixing, and then adding the glucurolactone in the step (1), and continuously stirring and mixing.
5. 5. Use of the composition for alleviating the vomitoxin hazard of weaned pigs according to claim 1 in the preparation of a feed product for alleviating the vomitoxin hazard of weaned pigs.

Description

Composition for relieving vomitoxin harm of weaned pigs as well as preparation method and application thereof Technical Field The invention relates to the technical field of breeding, in particular to a composition for relieving vomitoxin harm of weaned pigs, and a preparation method and application thereof. Background Vomitoxin (Deoxynivalenol, DON) is a mycotoxin produced by a variety of fusarium moulds, commonly found in feeds and other organic substrates. DON is a major contaminant of grains such as wheat, barley, and corn, which are present in relatively high proportions in swine diets. In livestock breeding, swine are most sensitive to DON. DON can cause anorexia, vomiting, weight loss, diarrhea and the like of piglets, and seriously damages the healthy development of piglet cultivation. The intestinal tract is the first line of defense against DON, and more studies indicate that DON contamination of feeds can lead to severe disorders of intestinal barrier function and immune function. Therefore, aiming at the technical problems, it is necessary to develop a composition for relieving the vomitoxin hazard of weaned pigs, and a preparation method and application thereof. Disclosure of Invention The first technical problem to be solved by the invention is to provide a composition for relieving the vomitoxin harm of weaned pigs, aiming at the defects of the prior art, and the composition can be used for effectively relieving diarrhea, weight loss and intestinal dysfunction symptoms of the weaned pigs. In order to solve the technical problems, the technical scheme of the invention is as follows: A composition for relieving the vomit toxin harm of weaned pigs comprises, by weight, 50-70 parts of glucurolactone, 10-15 parts of cynaropicrin, 20-40 parts of baicalein, 10-20 parts of stevia rebaudiana extract and 80-120 parts of carrier. As an improved technical scheme, the stevia rebaudiana extract comprises chlorogenic acid and analogues thereof, and the total content of the chlorogenic acid and analogues thereof is not less than 40%. As a further preferred technical scheme, the composition comprises, by weight, 60 parts of glucurolactone, 13 parts of cynaropicrin, 30 parts of baicalein, 15 parts of stevia rebaudiana extract and 100 parts of carrier. Aiming at the defects of the prior art, the invention provides a preparation method of a composition for relieving the vomitoxin harm of weaned pigs, and the composition obtained by the preparation method can effectively relieve diarrhea, weight loss and intestinal dysfunction symptoms of the weaned pigs. A method of preparing a composition for alleviating the vomitoxin hazard of weaned pigs, the method comprising the steps of: (1) Weighing the screened glucurolactone, cynaropicrin, baicalein, stevia rebaudiana extract and a carrier in turn according to parts by weight; (2) Taking the stevia rebaudiana extract in the step (1), adding an equal amount of carriers, stirring and mixing uniformly to obtain a first premix for standby, taking the cynaropicrin in the step (1), adding an equal amount of carriers, stirring and mixing uniformly to obtain a second premix for standby, taking the baicalein in the step (1), adding an equal amount of carriers, stirring and mixing uniformly to obtain a third premix for standby; (3) And (3) taking the first premix, the second premix and the third premix in the step (2), stirring and mixing uniformly, adding the rest carrier, continuously stirring and mixing, and then adding the glucurolactone in the step (1), and continuously stirring and mixing. Aiming at the defects of the prior art, the invention provides the application of the composition for relieving the vomitoxin harm of the weaned pigs in preparing the feed product for relieving the vomitoxin harm of the weaned pigs, and the diarrhea, weight loss and intestinal dysfunction symptoms of the weaned pigs can be effectively relieved by utilizing the feed containing the composition. The composition for relieving the vomitoxin harm of the weaned pigs is added in the preparation of feed products for relieving the vomitoxin harm of the weaned pigs according to the dosage of 200-500 mg/kg. After the technical scheme is adopted, the invention has the beneficial effects that: In the composition of the invention, glucurolactone is used as a precursor substance of glucuronic acid, and can obviously enhance the activity of UDP-glucuronyl transferase (UGT) in liver. DON and its metabolite combine with glucuronic acid in liver to produce DON-glucuronic acid conjugate with greater polarity and higher water solubility, so as to accelerate the discharge of DON-glucuronic acid conjugate out of body through bile and urine, and directly reduce the concentration of free DON in blood and intestinal tract. The baicalein can effectively inhibit NF- κB and MAPK inflammatory signal pathways activated by DON, and reduce the expression of intestinal inflammatory factors (such as TNF-alpha, IL-1β and IL-