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CN-121987685-A - Nose patch with nose-smoothing and relieving functions and preparation method thereof

CN121987685ACN 121987685 ACN121987685 ACN 121987685ACN-121987685-A

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a nose patch with a nose relieving function and a preparation method thereof, wherein the nose patch comprises a backing material and a medicine-containing layer compounded on the backing material, the medicine-containing layer consists of a first medicine extract composition, a second medicine extract composition, sodium polyacrylate, gelatin, glycerin, ethylparaben and Tween 80, the preparation method comprises the steps of S1 pretreatment of auxiliary materials for standby, S2 preparation of the first medicine extract composition and the second medicine extract composition respectively, S3 mixing of the first medicine extract composition and the auxiliary materials, adding of the second medicine extract composition and the residual auxiliary materials, stirring at a controlled temperature to prepare ointment, S4 tabletting the ointment to form a medicine-containing layer, and S5 compounding of the medicine-containing layer with the backing material and release paper.

Inventors

  • CHEN JIANZHOU

Assignees

  • 贵州盛世泰合医药科技有限公司

Dates

Publication Date
20260508
Application Date
20260127

Claims (8)

  1. 1. The nasal patch with the nasal smoothing function comprises a backing material and a medicine-containing layer compounded on the backing material, and is characterized in that the medicine-containing layer comprises 15-25 parts of a first medicinal material extract composition, 8-10 parts of a second medicinal material extract composition, 6-9 parts of sodium polyacrylate, 5-7 parts of gelatin, 28-32 parts of glycerol, 1-2 parts of ethylparaben and 2-4 parts of tween 80; Wherein the first medicinal material extract composition comprises, by weight, 0.1-0.5 part of aconite extract, 3-4 parts of baical skullcap root extract, 3-4 parts of liquoric root extract, 2-3 parts of dahurian angelica root extract, 1-2 parts of szechuan lovage rhizome extract, 3-4 parts of centipeda herb extract, 1-2 parts of ricepaper pith extract, 1-2 parts of cocklebur fruit extract, 1-2 parts of towel gourd root extract, 0.5-1 part of pedicellus melo extract, 0.3-0.8 part of manchurian wildginger extract and 0.1-0.3 part of kansui root extract; The second medicinal material extract composition comprises, by weight, 20-25% of centipeda minima volatile oil, 18-20% of magnolia flower volatile oil, 9-12% of peppermint volatile oil, 5-8% of fructus xanthil volatile oil, 9-12% of schizonepeta volatile oil, 14-17% of cassia bark volatile oil and 14-17% of ligusticum volatile oil, wherein the sum of the components is 100%.
  2. 2. A nasal patch with nose relieving function according to claim 1 is characterized in that the preparation method of the centipeda minima volatile oil, the magnolia flower volatile oil, the xanthium fruit volatile oil, the cassia bark volatile oil, the ligusticum volatile oil, the peppermint volatile oil and the schizonepeta volatile oil comprises the steps of respectively crushing dry centipeda minima, the magnolia flower, the xanthium fruit, the cassia bark, the ligusticum, the peppermint and the schizonepeta medicinal materials into coarse powder of 10-20 meshes, adding water with the weight of 8 times of medicinal materials, soaking for 3 hours at room temperature, loading into a steam distillation device for heating and distilling for 5 hours, collecting distillate, extracting with diethyl ether for 3 times, combining diethyl ether layers, adding anhydrous sodium sulfate for drying and filtering, and recovering diethyl ether under reduced pressure to obtain the volatile oil of each medicinal material.
  3. 3. The nasal patch with the nasal soothing function according to claim 1, wherein the preparation method of the angelica dahurica extract, the ligusticum chuanxiong extract, the centipeda minima extract, the ricepaper pith extract, the fructus xanthii extract, the luffa root extract, the pedicellus melo extract, the herba asari extract and the radix kansui extract comprises the steps of respectively crushing dry angelica dahurica, ligusticum chuanxiong, centipeda minima, ricepaper pith, fructus xanthii, luffa root, pedicellus melo, herba asari and radix kansui into 40-60 mesh coarse powder, adding 70% ethanol with the weight of 10 times, heating and refluxing for 2 times, each time for 1.5 hours, combining extract liquid, filtering, recovering ethanol under reduced pressure, concentrating under reduced pressure, drying at 30 ℃, crushing and sieving with 80 mesh sieve to obtain the extracts of the corresponding medicinal materials respectively.
  4. 4. The nasal patch with the nasal cavity soothing function according to claim 1, wherein the preparation method of the baical skullcap root extract and the liquoric root extract is characterized in that the baical skullcap root extract and the liquoric root extract are crushed into coarse powder with 20-40 meshes, 60% ethanol with the weight being 12 times of that of the coarse powder is added, the mixture is heated and refluxed for 2 times, each time for 2 hours, the extract is combined, filtered and squeezed, the ethanol is recovered under reduced pressure until no obvious alcohol smell exists, then the mixture is concentrated to obtain thick pastes with the relative density of 1.2-1.3, the thick pastes are respectively prepared into aqueous solutions with the concentration of 10%, cellulase is respectively added, enzymolysis is carried out for 150min at 50 ℃, the enzymolysis solution is dried at 30 ℃, and the mixture is crushed and sieved with a 80-mesh sieve to obtain the baical skullcap root extract and the liquoric root extract respectively.
  5. 5. The nasal patch with nose-relieving function according to claim 4, wherein the cellulase is added into the aqueous solutions of the two kinds of thick pastes according to the proportion of 1.8% of the mass of the two kinds of thick pastes, and the enzyme activity of the solid enzyme preparation of the cellulase is more than or equal to 1000U/g.
  6. 6. The nasal patch with nasal cavity soothing function according to claim 1, wherein the preparation method of the aconite extract comprises the steps of crushing the aconite into coarse powder of 20-40 meshes, soaking the coarse powder in 0.5% hydrochloric acid solution for 24 hours, percolating the coarse powder in a percolating cylinder at a flow rate of 4mL/kg per hour, collecting percolate with a volume of 8 times of medicinal materials, adjusting the pH of the percolate to 9-10 by ammonia water, extracting the percolate with chloroform for 4 times, wherein the consumption of chloroform is 1/3 of the volume of the percolate each time, merging chloroform layers, and recovering chloroform under reduced pressure to obtain the aconite extract.
  7. 7. A method for preparing a nasal patch with nasal relief function according to any one of claims 1 to 6, characterized by comprising the following steps: S1, placing sodium polyacrylate in a stirring device, adding glycerol and stirring to obtain glycerol suspension for standby, adding gelatin into a proper amount of purified water, heating and stirring until the gelatin is completely dissolved to obtain gelatin solution for standby, and dissolving ethyl hydroxy benzoate with ethanol to obtain ethyl hydroxy benzoate solution for standby; S2, uniformly mixing the aconite extract, the baical skullcap root extract, the liquoric root extract, the dahurian angelica root extract, the szechuan lovage rhizome extract, the centipeda minima extract, the ricepaper pith extract, the cocklebur fruit extract, the towel gourd root extract, the melon pedicel extract, the manchurian wildginger extract and the kansui root extract to obtain a first medicinal material extract composition, and mixing the centipeda minima volatile oil, the magnolia flower volatile oil, the siberian cocklebur fruit volatile oil, the cassia bark volatile oil, the ligusticum volatile oil, the peppermint volatile oil and the schizonepeta volatile oil according to a proportion to obtain a second medicinal material extract composition; s3, adding the first medicinal material extract composition into a stirrer, adding glycerol suspension, stirring at a speed of 100-150r/min for 5-10min, then mixing the second medicinal material extract composition with Tween 80, adding into the stirrer, stirring for 10-15min, adding gelatin solution and ethylparaben solution, fully and uniformly stirring, and controlling the material temperature to be not more than 35 ℃ in the stirring process to form an ointment with a bright surface; s4, placing the ointment in the stirrer in a trough of an automatic tablet press, and pressing into an M-shaped nasal patch to form a drug-containing layer of 0.9-1.0 g; s5, compounding the medicine-containing layer with a backing material, and then compounding release paper on the surface of the medicine-containing layer to obtain the nasal patch with the function of relieving nose.
  8. 8. The method for preparing a nasal patch with nasal cavity soothing function according to claim 7, wherein in the step S1, after glycerin is added into the sodium polyacrylate, the mixture is stirred for 20-30min at a rotation speed of 45-55 ℃ and 200-300r/min to obtain glycerin suspension, the proportion of purified water added into the gelatin is 1:5-1:8 (w/v), the heating temperature is 60-70 ℃, and the mixture is stirred until the mixture is completely dissolved and then cooled to 30-35 ℃ for standby.

Description

Nose patch with nose-smoothing and relieving functions and preparation method thereof Technical Field The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a nose patch with a nose-smoothing and relieving function and a preparation method thereof. Background Allergic rhinitis and cold are usually accompanied with symptoms such as nasal obstruction, watery nasal discharge and the like at the initial stage, the pathological mechanism of the allergic rhinitis and cold is closely related to the release of inflammatory substances such as histamine and the like, and the inflammatory substances cause the expansion of blood vessels in the nasal cavity and the edema of mucous membrane, so that discomfort such as nasal obstruction, watery nasal discharge and the like is caused. The skin horny layer on the surface of nose bridge and nose wing is relatively thin, the blood supply is rich, which provides favorable condition for transdermal absorption of medicine, therefore, the essential oil or extract with the effect of relieving nose is prepared into external patch, and is directly applied on nose, thus being a convenient and noninvasive relieving mode. Based on the above situation, related attempts in the prior art, for example, in the prior art, a preparation method (CN 202210295518.7) of a nose-penetrating essential oil patch is disclosed, which comprises the steps of firstly preparing silica microspheres as carriers through a complex process, including hydrothermal synthesis of porous carbon microspheres, surface modification, silicate coating and the like, then mixing camphor, menthol with lavender essential oil and eucalyptus oil, adding polyvinylpyrrolidone and silica microspheres to form essential oil microspheres, then treating non-woven fabrics with dopamine hydrochloride solution, loading the essential oil microspheres, and compounding with an impermeable film and an adhesive layer to prepare the patch. However, the nose-smoothing essential oil patch in the prior art still has the defects that, specifically, only essential oil is added as a component for relieving nasal obstruction, the component types are single, the synergistic relieving of the mucous membrane edema is difficult, and the effect of relieving the nasal obstruction is poor. Disclosure of Invention Aiming at the technical defects in the background technology, the invention provides a nose patch with a nose-smoothing and relieving function and a preparation method thereof, which solve the technical problems and meet the actual demands, and the specific technical scheme is as follows: The nasal patch with the nasal smoothing function comprises a backing material and a medicine-containing layer compounded on the backing material, wherein the medicine-containing layer comprises 15-25 parts of a first medicinal material extract composition, 8-10 parts of a second medicinal material extract composition, 6-9 parts of sodium polyacrylate, 5-7 parts of gelatin, 28-32 parts of glycerol, 1-2 parts of ethylparaben and 2-4 parts of tween 80; Wherein the first medicinal material extract composition comprises, by weight, 0.1-0.5 part of aconite extract, 3-4 parts of baical skullcap root extract, 3-4 parts of liquoric root extract, 2-3 parts of dahurian angelica root extract, 1-2 parts of szechuan lovage rhizome extract, 3-4 parts of centipeda herb extract, 1-2 parts of ricepaper pith extract, 1-2 parts of cocklebur fruit extract, 1-2 parts of towel gourd root extract, 0.5-1 part of pedicellus melo extract, 0.3-0.8 part of manchurian wildginger extract and 0.1-0.3 part of kansui root extract; The second medicinal material extract composition comprises, by weight, 20-25% of centipeda minima volatile oil, 18-20% of magnolia flower volatile oil, 9-12% of peppermint volatile oil, 5-8% of fructus xanthil volatile oil, 9-12% of schizonepeta volatile oil, 14-17% of cassia bark volatile oil and 14-17% of ligusticum volatile oil, wherein the sum of the components is 100%. According to a further technical scheme, the preparation method of the centipeda minima volatile oil, the magnolia liliflora volatile oil, the xanthium sibiricum volatile oil, the cassia bark volatile oil, the ligusticum volatile oil, the mint volatile oil and the schizonepeta volatile oil comprises the steps of respectively crushing dry centipeda minima, magnolia liliflora, the xanthium sibiricum, the cassia bark heart, ligusticum, mint and schizonepeta into coarse powder of 10-20 meshes, adding water with the weight of 8 times of the medicinal materials, soaking for 3 hours at room temperature, loading into a steam distillation device for heating and distilling for 5 hours, collecting distillate, extracting for 3 times by diethyl ether, combining diethyl ether layers, adding anhydrous sodium sulfate for drying and filtering, and recovering diethyl ether under reduced pressure to obtain the volatile oil of each medicinal material. According to a