CN-121987686-A - Pharmaceutical composition for treating diabetic complications and application thereof

Abstract

The invention provides a pharmaceutical composition for treating diabetic complications and application thereof. The invention discovers that after the effective parts of coptis, kudzuvine root and the like are combined, the invention has obvious influence on diabetic complications and has a certain treatment effect. The invention provides an application of a coptis chinensis and radix puerariae composition in preparing a medicine for treating diabetic skin ulcers, wherein the coptis chinensis and radix puerariae composition comprises, by weight, 1-10 parts of coptis chinensis alkaloids, 1-10 parts of coptis chinensis polysaccharides, 1-10 parts of radix puerariae flavone, 1-10 parts of radix puerariae polysaccharides and 1-10 parts of radix puerariae saponins.

Inventors

• Request for anonymity
• Request for anonymity

Assignees

• 成都健升药业有限公司

Dates

Publication Date

20260508

Application Date

20251231

Priority Date

20250114

Claims (9)

1. 1. Application of rhizoma coptidis and radix puerariae composition in preparing medicines for treating diabetic skin ulcers; The coptis root and kudzuvine root composition comprises the following raw materials in parts by weight: 1-10 parts of coptis alkaloid, 1-10 parts of coptis polysaccharide, 1-10 parts of pueraria flavone, 1-10 parts of pueraria polysaccharide and 1-10 parts of pueraria saponin.
2. 2. The use according to claim 1, wherein the coptis extract is 2-4 parts by weight of coptis alkaloid and 2-4 parts by weight of coptis polysaccharide.
3. 3. The use according to claim 1, wherein the pueraria extract is 7-9 parts by weight of pueraria flavone, 7-9 parts by weight of pueraria polysaccharide and 7-9 parts by weight of pueraria saponin.
4. 4. The use according to claim 1, wherein the coptis extract is 3 parts by weight of coptis alkaloid, 3 parts by weight of coptis polysaccharide, and the pueraria extract is 8 parts by weight of pueraria flavone, 8 parts by weight of pueraria polysaccharide and 8 parts by weight of pueraria saponin.
5. 5. The use according to claim 1, wherein said treatment of diabetic skin ulcers is promotion of healing of diabetic skin ulcer wounds.
6. 6. The pharmaceutical composition for treating the diabetic complications is characterized by comprising the following raw materials in parts by weight: 1-10 parts of coptis alkaloid, 1-10 parts of coptis polysaccharide, 1-10 parts of pueraria flavone, 1-10 parts of pueraria polysaccharide and 1-10 parts of pueraria saponin.
7. 7. The pharmaceutical composition of claim 6, wherein the coptis extract is 2-4 parts by weight of coptis alkaloid and 2-4 parts by weight of coptis polysaccharide.
8. 8. The pharmaceutical composition of claim 6, wherein the pueraria extract comprises 7-9 parts by weight of pueraria flavone, 7-9 parts by weight of pueraria polysaccharide and 7-9 parts by weight of pueraria saponin.
9. 9. The pharmaceutical composition of claim 6, wherein the coptis extract comprises 3 parts by weight of coptis alkaloids, 3 parts by weight of coptis polysaccharides, 8 parts by weight of pueraria flavonoids, 8 parts by weight of pueraria polysaccharides and 8 parts by weight of pueraria saponins.

Description

Pharmaceutical composition for treating diabetic complications and application thereof Technical Field The invention relates to the fields of traditional Chinese medicines and natural medicine extracts. Background Diabetic complications refer to various complications that may occur after long-term diabetes, including cardiovascular disease, neuropathy, ocular disease, kidney disease, and the like. Diabetic patients can damage various tissues and organs due to long-term instability of blood sugar, resulting in complications. Huang Lian (Coptis chinensis) is bitter and cold in nature and enters heart, spleen and stomach meridians. Has the effects of clearing heat, drying dampness, purging pathogenic fire and removing toxin. It is used for the syndrome of "middle warmer" due to excessive stomach fire. The main component is coptis alkaloid. Can activate PKC, increase insulin receptor expression, repair damaged islet cells, promote insulin secretion, reduce lipid deposition, regulate intestinal flora, and delay carbohydrate hydrolysis and absorption. Pueraria (Puerariae Lobatae Radix) is sweet, pungent and cool in nature and enters spleen, stomach and lung meridians. Has effects of relieving muscle and fever, promoting salivation, and quenching thirst. It is used for treating diabetes due to dryness-heat caused by yin deficiency. The main ingredient is pueraria flavone (or isoflavone). Can improve insulin resistance, protect islet cells, and resist inflammation and oxidation. The compatibility of the two components is the core component of the classic formula of the decoction of kudzuvine root, baicalin and coptis. The compatibility of medicines conforms to the treatment principle of clearing heat and promoting fluid production, the radix puerariae can promote fluid production and quench thirst to treat the principal and subordinate symptoms, and the rhizoma coptidis can clear heat and purge fire to treat the principal and subordinate symptoms, so that the medicine is especially suitable for treating type 2 diabetes of damp-heat type in intestinal tracts or yin deficiency and dryness-heat type. The compatibility of kudzuvine root and coptis root has been reported for treating diabetes, and how to develop a pharmaceutical composition for treating diabetic complications on the basis of the compatibility of kudzuvine root and coptis root, and further research is needed. Disclosure of Invention In one aspect, the invention provides a pharmaceutical composition for treating diabetic complications, which comprises the following components: (1) 1-10 parts of coptis alkaloid; (2) 1-10 parts of pueraria flavone, 1-10 parts of pueraria polysaccharide, or/and 1-10 parts of pueraria saponin. The invention also provides a pharmaceutical composition for treating diabetic complications, which is characterized by comprising the following components: (1) 1-10 parts of coptis polysaccharide; (2) 1-10 parts of pueraria flavone, 1-10 parts of pueraria polysaccharide, or/and 1-10 parts of pueraria saponin. In one aspect, the invention also provides a pharmaceutical composition for treating diabetic complications, which comprises the following components: (1) 1-10 parts of coptis flavone; (2) 1-10 parts of pueraria flavone, 1-10 parts of pueraria polysaccharide, or/and 1-10 parts of pueraria saponin. In one aspect, the invention also provides a pharmaceutical composition for treating diabetic complications, which comprises the following components: (1) 1-10 parts of pueraria flavones; (2) 1-10 parts of coptis alkaloid, 1-10 parts of coptis polysaccharide, or/and 1-10 parts of coptis flavone. In one aspect, the invention also provides a pharmaceutical composition for treating diabetic complications, which comprises the following components: (1) 1-10 parts of pueraria polysaccharide; (2) 1-10 parts of coptis alkaloid, 1-10 parts of coptis polysaccharide, or/and 1-10 parts of coptis flavone. In one aspect, the invention also provides a pharmaceutical composition for treating diabetic complications, which comprises the following components: (1) 1-10 parts of pueraria saponin; (2) 1-10 parts of coptis alkaloid, 1-10 parts of coptis polysaccharide, or/and 1-10 parts of coptis flavone. In one aspect, the invention also provides a pharmaceutical composition for treating diabetic complications, which comprises the following components: (1) 1-10 parts of coptis alkaloid and 1-10 parts of coptis polysaccharide; (2) 1-10 parts of pueraria flavone, 1-10 parts of pueraria polysaccharide, or 1-10 parts of pueraria flavone and 1-10 parts of pueraria saponin, or 1-10 parts of pueraria polysaccharide and 1-10 parts of pueraria saponin. In one aspect, the invention also provides a pharmaceutical composition for treating diabetic complications, which comprises the following components: (1) 1-10 parts of coptis alkaloid and 1-10 parts of coptis flavone; (2) 1-10 parts of pueraria flavone, 1-10 parts of pueraria polysaccharide, or 1-10 parts of pueraria f