CN-121987689-A - Traditional Chinese medicine preparation for treating or improving cognitive dysfunction

Abstract

The invention provides a traditional Chinese medicine preparation for treating or improving cognitive dysfunction, and particularly relates to the technical field of traditional Chinese medicine pharmacy. The Chinese medicinal preparation is prepared from rhizoma Atractylodis, radix Pseudostellariae, semen astragali Complanati, oviductus Ranae, oletum Trogopterori, rhizoma Cynanchi Stauntonii, succinum, herba Ardisiae Japonicae, fructus Gleditsiae Abnormalis, artificial bezoar, flos Pruni mume, fructus Trichosanthis, and maltose. In the traditional Chinese medicine preparation, oviductus ranae and artificial bezoar are taken as monarch drugs, semen astragali complanati, gleditsia sinensis lam, rhizoma atractylodis, trogopterus dung and amber are taken as ministerial drugs, radix pseudostellariae, rhizoma cynanchi bungei, japanese ardisia herb, fructus trichosanthis, japanese calyx, and maltose are taken as adjuvant drugs, the whole prescription tonifies the kidney and fills marrow to treat the root, dispels phlegm and opens orifices, activates blood circulation to remove blood stasis, clears heat and eliminates phlegm to treat the symptoms, and the spleen and benefits qi, soothes liver and regulates qi are assisted by synergy between the drugs, supplement each other, and the whole prescription is combined to achieve the effects of marrow filling and nourishing brain, refreshing mind and improving cognition. The traditional Chinese medicine preparation is expected to be further developed and applied as a new medicine for treating or improving cognitive dysfunction.

Inventors

• LI LIGUO
• SU YA
• NING YIMING
• ZHENG YADONG
• DAI XIN

Assignees

• 河南省医学科学院

Dates

Publication Date

20260508

Application Date

20260324

Claims (4)

1. 1. The traditional Chinese medicine preparation for treating or improving cognitive impairment is characterized by being prepared from, by weight, 10-40 parts of rhizoma atractylodis, 10-40 parts of radix pseudostellariae, 10-40 parts of semen astragali complanati, 10-40 parts of oviductus ranae, 10-40 parts of trogopterus dung, 10-40 parts of cynanchum glaucescens, 10-40 parts of amber, 10-40 parts of Japanese ardisia herb, 10-40 parts of gleditsia sinensis lam, 10-40 parts of artificial bezoar, 10-40 parts of green calyx prune, 10-40 parts of fructus trichosanthis and 10-40 parts of maltose.
2. 2. The Chinese medicinal preparation for treating or improving cognitive impairment according to claim 1, wherein the Chinese medicinal preparation is prepared from, by weight, 20-40 parts of rhizoma atractylodis, 15-30 parts of radix pseudostellariae, 20-40 parts of semen astragali complanati, 20-40 parts of oviductus ranae, 20-40 parts of trogopterus dung, 15-30 parts of cynanchum glaucescens, 20-40 parts of amber, 15-30 parts of Japanese ardisia herb, 20-40 parts of gleditsia sinensis, 20-40 parts of calculus bovis factitius, 15-30 parts of green calyx plum, 15-30 parts of snakegourd fruit and 15-30 parts of maltose.
3. 3. The traditional Chinese medicine preparation for treating or improving cognitive impairment according to claim 1, wherein the traditional Chinese medicine preparation is prepared from, by weight, 28 parts of rhizoma atractylodis, 20 parts of radix pseudostellariae, 30 parts of semen astragali complanati, 36 parts of oviductus ranae, 24 parts of trogopterus dung, 18 parts of cynanchum glaucescens, 26 parts of amber, 20 parts of Japanese ardisia herb, 28 parts of gleditsia sinensis lam, 32 parts of artificial bezoar, 22 parts of green calyx prune, 24 parts of fructus trichosanthis and 16 parts of maltose.
4. 4. The Chinese medicinal preparation for treating or improving cognitive impairment according to any one of claims 1 to 3, wherein the Chinese medicinal preparation is prepared from the Chinese medicinal materials in parts by weight, pharmaceutically acceptable auxiliary materials, and is prepared into oral dosage forms for treating or improving cognitive impairment according to conventional preparation methods, wherein the dosage forms comprise any one of decoction, oral liquid, pill, powder, granule, capsule, tablet and paste.

Description

Traditional Chinese medicine preparation for treating or improving cognitive dysfunction Technical Field The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine preparation for treating or improving cognitive dysfunction. Background Alzheimer's Disease (AD) is a chronic progressive neurological degenerative disease characterized by a latent onset of disease, the preclinical stage of which can last for decades, during which patients often do not exhibit significant neurological symptoms. This asymptomatic long preclinical phase means that the pathophysiological processes of AD change silently and continue to progress before the clinical symptoms manifest. Mild cognitive impairment (Mildcognitive impairment, MCI), which is a transitional state of normal aging and dementia, manifests as memory impairment and/or other cognitive dysfunction such as episodic memory, executive power, attention, etc., is considered as a window for early intervention in AD, if not timely, and would impose a huge economic burden on the home and society. In current clinical therapies, improving cognitive function is primarily dependent on the use of cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists. However, these drugs only temporarily relieve symptoms, cannot effectively prevent the progression of the disease, and may cause various side effects upon long-term use. The cognition source of the traditional Chinese medicine on the cognition disorder disease is far and long, and the traditional Chinese medicine has unique advantages in improving the clinical symptoms of MCI and delaying the disease development due to the characteristics of multiple targets and low toxicity. Disclosure of Invention (One) solving the technical problems Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine preparation for treating or improving cognitive dysfunction. (II) technical scheme In order to achieve the above purpose, the invention is realized by the following technical scheme: In a first aspect, the invention provides a traditional Chinese medicine preparation for treating or improving cognitive impairment, which is prepared from, by weight, 10-40 parts of rhizoma atractylodis, 10-40 parts of radix pseudostellariae, 10-40 parts of semen astragali complanati, 10-40 parts of oviductus ranae, 10-40 parts of trogopterus dung, 10-40 parts of cynanchum glaucescens, 10-40 parts of amber, 10-40 parts of Japanese ardisia herb, 10-40 parts of gleditsia sinensis, 10-40 parts of calculus bovis factitius, 10-40 parts of green calyx prune, 10-40 parts of fructus trichosanthis and 10-40 parts of maltose. Further, the traditional Chinese medicine preparation is prepared from the following traditional Chinese medicinal materials, by weight, 20-40 parts of rhizoma atractylodis, 15-30 parts of radix pseudostellariae, 20-40 parts of semen astragali complanati, 20-40 parts of oviductus ranae, 20-40 parts of trogopterus dung, 15-30 parts of rhizoma cynanchi, 20-40 parts of amber, 15-30 parts of Japanese ardisia herb, 20-40 parts of gleditsia sinensis lam, 20-40 parts of artificial bezoar, 15-30 parts of green calyx plum, 15-30 parts of snakegourd fruit and 15-30 parts of maltose. Further, the traditional Chinese medicine preparation is prepared from the following traditional Chinese medicinal materials, by weight, 28 parts of rhizoma atractylodis, 20 parts of radix pseudostellariae, 30 parts of semen astragali complanati, 36 parts of oviductus ranae, 24 parts of trogopterus dung, 18 parts of rhizoma cynanchi, 26 parts of amber, 20 parts of Japanese ardisia herb, 28 parts of gleditsia sinensis lam, 32 parts of artificial bezoar, 22 parts of green calyx prune, 24 parts of snakegourd fruit and 16 parts of maltose. Further, the traditional Chinese medicine preparation is prepared from the traditional Chinese medicine materials in parts by weight, pharmaceutically acceptable auxiliary materials and a conventional preparation method into an oral dosage form medicament for treating or improving cognitive impairment, wherein the dosage form comprises any one of decoction, oral liquid, pills, powder, granules, capsules, tablets and ointment. In a second aspect, the invention provides a preparation method of a water decoction as a traditional Chinese medicine preparation for treating or improving cognitive dysfunction, wherein the traditional Chinese medicine oral liquid is prepared according to the following steps: (1) Weighing the following traditional Chinese medicinal materials, namely 10-40 parts of rhizoma atractylodis, 10-40 parts of radix pseudostellariae, 10-40 parts of semen astragali complanati, 10-40 parts of oviductus ranae, 10-40 parts of trogopterus dung, 10-40 parts of rhizoma cynanchi, 10-40 parts of amber, 10-40 parts of Japanese ardisia herb, 10-40 parts of gleditsia sinensis lam, 10-40 parts of calculus bovis factitius, 1