CN-121987690-A - Use of lung-heat clearing and cough relieving composition for treating chronic obstructive pulmonary disease

Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a novel application of a composition for clearing lung and relieving cough in treating chronic obstructive pulmonary disease. Animal experimental study shows that the composition for clearing lung and relieving cough can obviously improve the lung function of COPD mice and inhibit abnormal reconstruction of bronchi. The action mechanism of the composition is related to inhibiting apoptosis of lung tissue cells, reducing infiltration of inflammatory cells and improving abnormal reconstruction of bronchi, and the composition has obvious pharmacological activity of resisting COPD.

Inventors

• HAN FENGYU
• YU XIULING
• FAN SHENGCI
• SHANGGUAN TONGQIANG
• SHE YIHUAN

Assignees

• 内蒙古天奇中蒙制药股份有限公司

Dates

Publication Date

20260508

Application Date

20241107

Claims (6)

1. 1. Use of a lung heat clearing and cough relieving composition of Sai Nile in the preparation of a medicament for treating chronic obstructive pulmonary disease.
2. 2. The use of claim 1, wherein the composition for clearing lung-heat and relieving cough comprises 550-650 parts of glehnia root, 80-120 parts of myrobalan, 50-80 parts of szechwan chinaberry fruit, 80-120 parts of cape jasmine, 80-120 parts of shikonin, 80-120 parts of lithospermum and 80-120 parts of madder.
3. 3. The use according to claim 2, wherein the composition for clearing lung-heat and relieving cough comprises 600 parts of glehnia root, 100 parts of myrobalan, 60 parts of szechwan chinaberry fruit, 100 parts of gardenia, 100 parts of shikonin, 100 parts of lithospermum, and 100 parts of madder.
4. 4. The use according to claim 3, wherein the composition for clearing lung-heat and relieving cough is in the form of decoction, capsule, granule, tablet or pill.
5. 5. The use according to claim 4, wherein the formulation is in the form of a capsule.
6. 6. The use according to any one of claims 1 to 5, wherein the lung clearing and cough relieving composition reduces inflammatory cell infiltration and/or improves abnormal reconstruction of the bronchi.

Description

Use of lung-heat clearing and cough relieving composition for treating chronic obstructive pulmonary disease Technical Field The invention relates to the field of traditional Chinese medicines, in particular to a novel application of a composition for clearing lung and relieving cough in treating chronic obstructive pulmonary disease. Background Chronic obstructive pulmonary disease, abbreviated as Chronic Obstructive Pulmonary (COPD), is a destructive pulmonary disease characterized by incompletely reversible airflow limitation. Airflow limitation is often progressive and associated with abnormal inflammatory responses of the lungs to harmful particles or gases. Acute exacerbations and complications affect the severity of the disease and prognosis of the individual. COPD is a disease of the airways, but also has a considerable systemic impact on the whole body. The main symptoms are chronic cough, expectoration, short breath or dyspnea, wheezing, chest distress, etc. Incompletely reversible airflow limitation is a prerequisite for COPD diagnosis. The predicted values of FEV1/FVC <70% and FEV1<80% after inhalation of bronchodilators can be determined as incompletely reversible airflow limitation, few patients have no cough, expectoration symptoms, FEV1/FVC <70% only at the time of lung function examination, and FEV1 is not less than 80% of the predicted values, and COPD can be diagnosed after other diseases are excluded. The composition for clearing lung and relieving cough is derived from Mongolian medicine Jing Fang Jiuzuolao-7 decoction powder, and is used as a main prescription for treating lung heat diseases by Mongolian medicine, and has been used for thousands of years and has obvious curative effect. The recipe consists of glehnia root, myrobalan fruit, chinaberry fruit, madder root, cape jasmine, shikonin and gromwell. The radix glehniae has the effects of clearing lung heat, relieving cough and moistening lung by adopting the Mongolian medicinal theory, and the radix rubiae, the shikonin and the radix arnebiae are added to strengthen the efficacy of clearing lung heat, so that the unique knowledge of the Mongolian medicinal effect on the radix glehniae and the specificity of the formula are reflected. In view of the symptoms of chronic obstructive pulmonary disease, the field of traditional Chinese medicine is actively involved in the prevention and treatment of COPD, and a symptomatic prescription is developed. The invention adopts the composition for clearing lung and relieving cough to conduct antagonism effect research to find a control method of COPD and a capsule for clearing lung and relieving cough. Disclosure of Invention The invention provides a new application of a composition for clearing lung and relieving cough in treating chronic obstructive pulmonary disease. The composition for clearing lung and relieving cough comprises 550-650 parts of glehnia root, 80-120 parts of myrobalan, 50-80 parts of szechwan chinaberry fruit, 80-120 parts of gardenia, 80-120 parts of shikonin and 80-120 parts of madder. Preferably, the composition for clearing lung and relieving cough comprises 600 parts of glehnia root, 100 parts of myrobalan, 60 parts of szechwan chinaberry fruit, 100 parts of gardenia, 100 parts of shikonin, 100 parts of lithospermum and 100 parts of madder. The preparation form of the composition for clearing lung and relieving cough provided by the invention is decoction, capsules, granules, tablets or pills. Preferably, the preparation form of the composition for clearing lung and relieving cough is capsules. The seven medicinal materials are extracted, concentrated, dried, crushed, granulated and encapsulated to obtain the Chinese medicinal composition. The capsule content is 0.4 g. The dosage of the Shaoli lung-heat clearing and cough relieving capsule is 3 granules per time and 3 times per day. The Qinghui Qingfei cough relieving capsule has the effects of clearing lung heat, relieving cough and eliminating phlegm, and is clinically used for treating acute episode of chronic tracheitis. Creatively, the invention adopts the Qinghui cough relieving capsule for preventing and curing COPD. Animal experimental researches show that the administration of 400mg/kg and 800mg/kg of the Yiniao lung heat clearing and cough relieving capsule can significantly improve lung function indexes of COPD mice, including significantly reducing deep inhalation amount (Inspiratory capacity, IC, ml) of COPD mice, measuring static compliance (Static compliance, cst, ml/cmH 2 O) by a lung function instrument, significantly reducing lung index (mg/g), improving airway wall thickness of COPD, significantly inhibiting inflammatory cell infiltration, significantly reducing collagen deposition of lung tissue of model mice caused by COPD, significantly inhibiting excessive mucus secretion of bronchus wall of COPD model mice, inhibiting apoptosis caused by COPD, significantly reducing down-regulation of bronchoa