CN-121987692-A - Dachengqi decoction tablet and preparation method thereof

Abstract

The invention provides a modified tablet of Dachengqi decoction and a preparation method thereof. Compared with decoction prepared from the original prescription, the tablet provided by the invention is convenient to take and can better control dosage. Can be used for increasing gastrointestinal tract propulsion function and volume, and treating local intestinal obstruction and constipation.

Inventors

• LI JIAQI
• ZHENG CAN
• WANG ZIQI
• LIANG YUJIAO
• YIN YONGMEI

Assignees

• 南开大学

Dates

Publication Date

20260508

Application Date

20241101

Claims (3)

1. 1. A modified tablet of DACHENGQI decoction comprises radix et rhizoma Rhei preparata 12-20g, cortex Magnolia officinalis 24-50g, fructus Aurantii Immaturus parched with bran 11-30g, natrii sulfas 9-20g, appropriate amount of dry starch, and disintegrating agent 3-9%.
2. 2. The tablet of claim 1, wherein the disintegrating agent is selected from the group consisting of dry starch, crospovidone, sodium carboxymethyl starch, and combinations thereof, and wherein water or ethanol is used as a wetting agent and magnesium stearate is used as a lubricant during the preparation process.
3. 3. A process for the preparation of a tablet according to claims 1-2, comprising the steps of: ① The preparation method of the Chinese medicinal extract comprises weighing cortex Magnolia officinalis and fructus Aurantii Immaturus, soaking in distilled water, decocting with slow fire, filtering with two layers of gauze, adding distilled water without residue, decocting under heating, filtering, mixing the filtrates, adding Natrii sulfas, dissolving, boiling, and concentrating. ② The preparation method of radix et rhizoma Rhei powder comprises weighing radix et rhizoma Rhei Preparata, drying at 60deg.C, and grinding into powder. ③ The granule is prepared by mixing radix et rhizoma Rhei powder and Chinese medicinal extract, adding appropriate amount of dry starch and absolute ethanol, making into soft material, sieving with 16 mesh sieve, granulating, drying at 40-70deg.C, sieving with 16 mesh sieve, and grading. ④ Adding disintegrating agent or surfactant, adding 1% lubricant, mixing, and tabletting.

Description

Dachengqi decoction tablet and preparation method thereof Technical Field The invention relates to the technical field of pharmaceutical preparations, in particular to a modified tablet of Dachengqi decoction and a preparation method thereof. Background Dachengqi decoction, the name of the Chinese medicine prescription. It is a purgative, cold-descending and heat-accumulation type, and has the actions of treating yang-purgation syndrome, constipation, frequent and transient qi, epigastric fullness, abdominal distention and fullness, hard pressing, even hot flushes and delirium, sweats in hands and feet, yellow and dry tongue coating with thorny, deep and dry pulse, heat-accumulation and side-flow syndrome, lower Li Qing cereal, pure blue color, foul smell, pain in umbilicus and abdomen, hard pressing with lumps, dry mouth and tongue, slippery pulse, heat syncope, spasmodic or mania of the interior heat-accumulation syndrome. The recipe is used in treating acute simple intestinal obstruction, acute cholecystitis, respiratory distress syndrome, extrusion syndrome, acute appendicitis, etc. The Dachengqi decoction is derived from Shang Han Lun (typhoid fever treatise), and the prescription composition of the Dachengqi decoction comprises rheum officinale (12 g), magnolia officinalis (24 g), immature bitter orange (12 g) and mirabilite (9 g). The decoction is prepared by decocting with water. Decocting cortex Magnolia officinalis and fructus Aurantii Immaturus, adding radix et rhizoma Rhei, and dissolving Natrii sulfas. The recipe is taken with warm water for 2 times to achieve the effect of benefiting the middle-aged. The raw material prescription is decoction, and the decoction is often used for emergency treatment, so that the decoction is inconvenient to carry and take. The development of a novel preparation which has the same drug effect as the original dosage form and is convenient to take has important medicinal and industrial values. Drawings FIG. 1, disintegration time of the resulting tablets was checked. Disclosure of Invention The invention aims to provide a modified Dachengqi decoction tablet, which comprises the following components of 12-20g of cooked rhubarb, 24-50g of mangnolia officinalis, 11-30g of bran-fried immature bitter orange, 9-20g of mirabilite, a proper amount of dry starch and 3-9% of disintegrating agent. In a preferred embodiment of the present invention, the disintegrant is selected from any one of crospovidone, sodium carboxymethyl starch, dry starch or a combination thereof. In a preferred embodiment of the invention, the binder is selected from any one of water or ethanol or a combination thereof. In a preferred embodiment of the invention, the lubricant is selected from magnesium stearate. The invention further provides a preparation method of the modified Dachengqi decoction tablet, which comprises the following steps of weighing 24g of magnolia officinalis and 12g of immature bitter orange in a beaker, adding 250mL of distilled water, soaking for 30min, decocting for 30min with small fire, filtering with two layers of gauze, adding 250mL of distilled water, soaking residues, decocting for 30min with heating, filtering, combining the two filtrates, adding mirabilite, dissolving, boiling and concentrating to 20mL. ② The preparation method of radix et rhizoma Rhei powder comprises weighing 12g of radix et rhizoma Rhei Preparata, drying at 60deg.C, and grinding into powder. ③ The granule is prepared by mixing radix et rhizoma Rhei powder 12g and Chinese medicinal extract 10.5g, adding appropriate amount of dry starch and absolute ethanol, making into soft mass, sieving with 16 mesh sieve, granulating, drying at 60deg.C, and sieving with 16 mesh sieve. ④ Adding disintegrating agent or surfactant, adding 1% magnesium stearate, mixing, and tabletting. Unless otherwise indicated, the invention relates to percentages between liquids which are volume/volume percentages, between liquids which are volume/weight percentages, between solids which are weight/volume percentages, between solids and liquids which are weight/volume percentages, and the balance being weight/weight percentages. Compared with the prior art, the invention has the beneficial effects that the invention develops a novel modified tablet of the Dachengqi decoction, and compared with the decoction, the modified tablet of the Dachengqi decoction is simple to use and obviously improves the medication accessibility of patients. The preparation method of the tablet composition has simple process and low production cost, and is especially suitable for large-scale industrial production. Detailed Description The invention is illustrated by the following examples, which are given solely for the purpose of further illustration and are not intended to limit the scope of the invention. Some insubstantial modifications and adaptations of the invention by others are within the scope of the invention. The reagents used in the followi