CN-121987693-A - Traditional Chinese medicine composition for resisting chicken coccidiosis as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for resisting chicken coccidiosis, a preparation method and application thereof, and relates to the technical field of livestock breeding. The Chinese medicinal composition for resisting chicken coccidiosis comprises, by mass, 20-60 parts of dried orange peel, 10-30 parts of dark plum, 10-30 parts of hairyvein agrimony and 5-20 parts of hawthorn. The invention takes a chicken as an experimental object, and researches the effect of the traditional Chinese medicine composition on the coccidiosis of the chicken from the directions of general conditions, bloody stool conditions, coccidian oocyst discharge conditions, cecum tissue pathological changes, pathological detection, serum biochemistry, oxidation resistance detection and the like of the chicken by establishing a chicken coccidiosis model. The traditional Chinese medicine composition has the effects of resisting insects, diminishing inflammation, stopping dysentery, stopping diarrhea, stopping bleeding, resisting diseases and the like, all medicinal materials are common traditional medicinal materials, the cost of required raw materials is low, the preparation process is simple, no toxic or side effect is caused on chickens, hormone and antibiotics are not contained, and a new choice is provided for replacing chemicals for preventing and treating coccidium.

Inventors

• SI HONGBIN
• Cheng Junze
• WANG CHENCHEN
• ZHANG QI
• LI YEHONG
• XIE ZONGGU
• LU JUNZHI
• ZHANG TING
• FU YI

Assignees

• 广西大学

Dates

Publication Date

20260508

Application Date

20241107

Claims (10)

1. 1. A Chinese medicinal composition for treating chicken coccidiosis comprises (by weight parts) pericarpium Citri Tangerinae 20-60, mume fructus 10-30, herba et Gemma Agrimoniae 10-30, and fructus crataegi 5-20.
2. 2. The traditional Chinese medicine composition for resisting chicken coccidiosis according to claim 1, which is characterized by comprising the following raw materials, by mass, 30 parts of dried orange peel, 20 parts of dark plum, 20 parts of hairyvein agrimony and 10 parts of hawthorn.
3. 3. A Chinese medicinal composition for resisting chicken coccidiosis is characterized by comprising medicinal powder of the Chinese medicinal composition in claim 1 or 2 or water or organic solvent extract of raw materials as an active ingredient and pharmaceutically acceptable auxiliary materials.
4. 4. The Chinese medicinal composition for resisting chicken coccidiosis according to any one of claims 1 to 3, wherein the Chinese medicinal composition is powder, decoction, oral liquid, granules, pills and tablets.
5. 5. A method for preparing the chicken coccidiosis-resistant traditional Chinese medicine composition according to any one of claims 1-4, comprising the following steps: (1) Weighing the raw materials of 20-60 parts by weight of dried orange peel, 10-30 parts by weight of dark plum fruit, 10-30 parts by weight of hairyvein agrimony and 5-20 parts by weight of hawthorn, cleaning, drying, cutting into segments, crushing, sieving, uniformly mixing, putting into an extraction tank, adding a proper amount of water to immerse the medicinal materials; (2) Heating the soaked traditional Chinese medicinal materials in the step (1), adding cellulase, regulating pH, and continuously stirring during enzymolysis; (3) After enzymolysis, adding water, decocting and boiling, and then decocting with slow fire; (4) Filtering the traditional Chinese medicine in the step (3), and adding water into filter residues for decocting with slow fire; (5) Filtering the traditional Chinese medicine in the step (4), and then adding water for decocting with slow fire; (6) Mixing the three decoctions obtained in the steps (3), (4) and (5), concentrating under reduced pressure, spray drying to obtain a material 1, vacuum freeze drying the filter residue obtained after enzymolysis, pulverizing and sieving to obtain a material 2, uniformly mixing the material 1 and the material 2, sterilizing, and packaging to obtain the traditional Chinese medicine composition.
6. 6. The preparation method of the Chinese medicinal preparation according to claim 5, wherein the mesh number of the sieving sieve in the step (1) is 80-120 meshes, the soaking time of the myrrh material surface is 2-10cm, the heating temperature in the step (2) is 30-60 ℃, the cellulase content in the step (2) is 0.2-1.0%, the pH is regulated to 4.5-6.0, the enzymolysis time is 3-7 hours, the weight ratio of the total weight of all medicinal materials to the water in the step (3) is 1:10-1:12, the slow fire decocting time is 1.5-2 hours, the weight ratio of the total weight of all medicinal materials to the water in the step (4) is 1:8-1:10, the slow fire decocting time is 1-1.5 hours, the weight ratio of the total weight of all medicinal materials to the water in the step (5) is 1:7-1:9, the slow fire decocting time is 1-1.5 hours, the concentration in the step (6) is 1.07-1.12, and the mesh number of the sieving sieve in the step (4) is 80-100 meshes.
7. 7. Use of the anti-coccidiosis traditional Chinese medicine composition according to any one of claims 1-4 in the preparation of feed or feed additives or drinking water additives.
8. 8. The use of the chicken coccidiosis-resistant traditional Chinese medicine composition according to claim 7 in preparing feed, wherein the additive amount of the chicken coccidiosis-resistant traditional Chinese medicine composition in the feed is 5-15 kg/ton of feed by mixing.
9. 9. Use according to claim 7 or 8, characterized in that: the application of the traditional Chinese medicine composition in preparing feed or feed additive or drinking water additive for resisting coccidiosis of chickens and treating at least one of coccidiosis of chickens.
10. 10. The use according to claim 9, characterized in that: the anticoccidial is anticoccidial eimeria tenella; The chicken coccidiosis is chicken coccidiosis caused by eimeria tenella.

Description

Traditional Chinese medicine composition for resisting chicken coccidiosis as well as preparation method and application thereof Technical Field The invention belongs to the technical field of livestock breeding, and particularly relates to a traditional Chinese medicine composition for resisting chicken coccidiosis, and a preparation method and application thereof. Background Coccidiosis is a common parasitic disease caused by a series of coccidia in Eimeria, and is characterized by hemorrhagic pathological changes in the intestinal tract of chickens, and causes a series of clinical symptoms of listlessness, messy and mattness of feathers, reduced appetite, even waste blood and the like in the affected chickens. The disease is frequently generated in chickens, especially threatens the growth and development of 8-20-day-old chickens, the incidence rate after coccidium infection is generally more than seven, and the death rate can reach 50% or more. Except for chicks, the chicks of other ages are also susceptible, but have higher overage resistance, and the phenomena of delay in growth, malnutrition, listlessness and the like can appear after the overage resistance, so that the economic benefit of raising is directly reduced. After the infection of the laying hen, the egg yield is gradually reduced, even the egg production is stopped, and the production function of the laying hen is reduced or lost, so that the laying hen becomes a main disease which endangers the chicken industry. After sexual reproduction, the oocysts of the coccidian are discharged out of the body along with the excrement, so that the living environment of the oocysts is polluted, and further, other chickens can be infected through indirect transmission. If the disease is not found and measures are taken in time, the process is repeated continuously, the disease is finally caused to be popular in the region, and great threat and loss are caused to the poultry industry. Furthermore, it has been reported that the useful life of a new drug is usually only 3 to 5 years due to drug resistance. Those skilled in the art are aware of the dangers of coccidiosis in chickens and therefore, excessive control is often performed during the breeding process, especially to allow the chickens to ingest a large amount of anticoccidial drugs for a long period of time, which undoubtedly aggravates the problems of coccidian resistance and drug residues in chicken products. Due to the ubiquitous drug resistance, common chemical drugs gradually lose anticoccidial effect, so that chicken coccidiosis is more difficult to control. It is estimated conservatively that our country spends more than 30 million dollars on chicken coccidiosis control each year and economic losses due to this disease. In order to effectively control chicken coccidiosis, besides improving the quality of farmers and breeding enterprises, improving the immunity of chicken flocks and improving the health level of chicken flocks, more importantly, natural medicines for replacing anticoccidial medicines are actively searched in response to national 'forbidden' and 'substituted' calls, and the chicken coccidiosis is effectively prevented and treated on the premise of ensuring the health of chicken flocks, environment, human beings and society. In order to ensure the health of animals, environment, human beings and other aspects to the greatest extent and avoid over-dependence on chemical medicines and vaccines, natural medicines become the most ideal choice. The Chinese medicine is taken as the origin of the traditional Chinese medicine, has rich traditional Chinese medicine resources, and is our congenital advantage. Effective development of anticoccidial traditional Chinese medicine resources and improvement of anticoccidial effect and chicken food safety level are promising. Based on the principle of syndrome differentiation and treatment of traditional Chinese medicine, chicken coccidiosis belongs to the category of insect accumulation, and pathogenic toxin is generated by exogenous damp-heat, so that the phenomenon of internal accumulation and non-dispersion in chicken bodies is formed. The accumulation of damp-heat causes symptoms such as diarrhea, even bloody stool and the like of chickens. Therefore, the method is a good point of entry in the treatment of chicken coccidiosis. Dried ripe pericarp of orange and its cultivated variety of Rutaceae family is used as a qi-regulating medicine, has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and resolving phlegm, and can effectively relieve symptoms of damp-heat accumulation and internal stagnation in sick chicken. Dark plum is a dry and near-mature fruit of Prunus mume belonging to Rosaceae, has effects of astringing intestine, promoting fluid production, and relieving ascariasis, and is commonly used for treating chronic diarrhea, chronic dysentery, deficiency heat diabetes, and emesis and abdominal pain due to