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CN-121987696-A - Pharmaceutical composition for relieving physical fatigue and preparation method and application thereof

CN121987696ACN 121987696 ACN121987696 ACN 121987696ACN-121987696-A

Abstract

The invention discloses a pharmaceutical composition for relieving physical fatigue, a preparation method and application thereof, wherein the pharmaceutical composition is prepared from the following raw materials, by weight, 1-3 parts of hairy antler, 1.6-3 parts of ginseng, 2-6 parts of medlar, 2-6 parts of shizandra berry and 1-3 parts of tortoise shell. The preparation method adopts the extraction process of firstly decocting tortoise shell, then extracting ginseng and the like, and combines spray drying and 85% ethanol granulating technologies, thereby effectively retaining active ingredients. The pharmacodynamics experiment result shows that the composition can obviously prolong the mouse load swimming time, improve the liver glycogen storage, reduce the blood lactic acid and serum urea nitrogen level, and the effect is obviously superior to the simple superposition of the single medicinal materials. The invention has scientific formula, remarkable synergy, stable process and high safety, and is suitable for long-term conditioning and relieving physical fatigue.

Inventors

  • ZHANG SIXI
  • SUN JINGMENG
  • ZHAI JINGHUI
  • ZHANG YUEMING

Assignees

  • 张四喜

Dates

Publication Date
20260508
Application Date
20260325

Claims (9)

  1. 1. A pharmaceutical composition for relieving physical fatigue is characterized by comprising, by weight, 1-3 parts of cervus elaphus linnaeus, 1.6-3 parts of ginseng, 2-6 parts of wolfberry fruit, 2-6 parts of schisandra chinensis and 1-3 parts of tortoise shell.
  2. 2. The pharmaceutical composition for relieving physical fatigue according to claim 1, which is characterized by comprising the following raw materials, by weight, 1 part of red deer antler, 1.6 parts of ginseng, 4 parts of medlar, 4 parts of shizandra berry and 3 parts of tortoise shell.
  3. 3. The pharmaceutical composition according to claim 1 or 2, wherein the pharmaceutical composition is an oral solid formulation.
  4. 4. The pharmaceutical composition according to claim 3, wherein the oral solid formulation is a tablet, granule or capsule.
  5. 5. A method of preparing a pharmaceutical composition for alleviating physical fatigue according to claim 1 or 2, comprising the steps of: S1, smashing and sterilizing antler of red deer for standby; s2, taking tortoise shells, adding water with the amount of 6-10 times that of the medicinal materials, and decocting for 1-2 hours to obtain tortoise shell decoction; s3, adding ginseng, medlar and schisandra chinensis into the tortoise shell decoction in the step 2, continuously adding water with the quantity of 6-10 times of that of the medicinal materials, extracting for three times, each time for 1-2 hours, filtering, and combining the filtrates; S4, concentrating the filtrate obtained in the step S3 to a relative density of 1.05-1.10, and spray drying to obtain dry paste powder; s5, adding the dry extract powder obtained in the step S4 into the hairy antler fine powder, uniformly mixing, adding pharmaceutically acceptable auxiliary materials, and preparing the pharmaceutical composition.
  6. 6. The method for preparing the pharmaceutical composition for relieving physical fatigue according to claim 5, wherein the step S5 specifically comprises mixing fine powder and dry paste of cornu Cervi Pantotrichum with white granulated sugar powder, preparing soft materials with 85% edible alcohol as wetting agent, granulating with 16 mesh sieve, and drying at 50-60deg.C to obtain powder with water content less than or equal to 7.0%.
  7. 7. The method for preparing a pharmaceutical composition for alleviating physical fatigue according to claim 6, wherein the tablet is obtained by taking the dried powder with the water content less than or equal to 7.0%, adding magnesium stearate, mixing well, and tabletting.
  8. 8. The method for preparing a pharmaceutical composition for alleviating physical fatigue according to claim 6, wherein the powder with a water content of 7.0% or less after drying is encapsulated to obtain a capsule.
  9. 9. Use of a pharmaceutical composition for alleviating physical fatigue according to any of claims 1-4 or obtainable by a method according to any of claims 5-8 for the preparation of a product for alleviating physical fatigue.

Description

Pharmaceutical composition for relieving physical fatigue and preparation method and application thereof Technical Field The invention relates to the technical field of pharmacy, in particular to a pharmaceutical composition for relieving physical fatigue and application thereof. Background Along with the acceleration of the life rhythm and the increase of the working pressure of the modern society, the population of the chronic fatigue syndrome and physical fatigue presents a tendency of younger and generalized. Physical fatigue is manifested by muscle soreness, energy exhaustion, and multiple pathophysiological mechanisms such as mitochondrial dysfunction, oxidative stress injury and neuroendocrine regulation imbalance. At present, products for relieving physical fatigue are mainly divided into two types of chemical medicines and traditional Chinese medicines or natural products. Although chemical drugs (such as phenylpropanoids, modafinil, etc.) can promote central excitability in a short period of time, the chemical drugs are often accompanied with dependence, drug resistance and side effects of cardiovascular systems, and are not suitable for daily conditioning of long-term or sub-healthy people. The traditional anti-fatigue products mainly comprising traditional Chinese medicines or natural products in the market mostly use the traditional thought of 'tonifying qi and strengthening yang' or 'nourishing yin and replenishing essence', and the formula is relatively fixed and serious in homogenization. The product has the following technical defects that firstly, the action mechanism is single, most of the product is only focused on supplementing energy substrates or removing lactic acid, the synergistic intervention is difficult to perform aiming at multiple targets of energy metabolism-oxidative stress-neuroprotection, secondly, the bioavailability of active ingredients is low, the synergistic proportion of key active ingredients is destroyed by the water decoction or crude extraction process of all traditional medicinal materials, and thirdly, the compatibility optimization based on modern evidence-based medicine is lacked, so that the effect is slow and the individual difference of curative effects is large. With the development of modern nutrition and molecular pharmacology, the industry has increasingly recognized that physical fatigue occurs as a result of multiple system interactions. The traditional single mode of 'tonifying' or 'exciting' is simply relied on, so that the requirements of modern people on an anti-fatigue product which is accurate, efficient and safe and has a repairing function are difficult to meet. Therefore, based on modern fatigue mechanism research, a pharmaceutical composition with definite components, mechanism synergy and multi-dimensional comprehensive intervention from 'energy supplement-mitochondrial function repair-antioxidant defense-metabolic steady state regulation' is developed, and the pharmaceutical composition has important clinical significance and market value for filling the technical blank of the existing product in the aspects of curative effect depth and safety. Disclosure of Invention The invention provides a pharmaceutical composition for relieving physical fatigue, which has the advantages of clear components, scientific compatibility and synergistic effect, and a preparation method thereof. The composition takes yin and yang dual-tonifying and vital essence and qi generating as a formula principle, and the anti-fatigue effect is remarkably improved through multi-target intervention on energy metabolism and oxidative stress. In the first aspect, the invention provides a pharmaceutical composition for relieving physical fatigue, which comprises the following raw materials, by weight, 1-3 parts of cervus elaphus linnaeus, 1.6-3 parts of ginseng, 2-6 parts of wolfberry fruit, 2-6 parts of shizandra berry and 1-3 parts of tortoise shell. Preferably, the pharmaceutical composition for relieving physical fatigue comprises the following raw materials in parts by weight: 1 part of red deer antler, 1.6 parts of ginseng, 4 parts of medlar, 4 parts of shizandra berry and 3 parts of tortoise shell. Preferably, the pharmaceutical composition is an oral solid preparation. Preferably, the oral solid preparation is a tablet, a granule or a capsule. In a second aspect, the present invention provides a method for preparing the above pharmaceutical composition for alleviating physical fatigue, comprising the steps of: S1, smashing and sterilizing antler of red deer for standby; s2, taking tortoise shells, adding water with the amount of 6-10 times that of the medicinal materials, and decocting for 1-2 hours to obtain tortoise shell decoction; s3, adding ginseng, medlar and schisandra chinensis into the tortoise shell decoction in the step 2, continuously adding water with the quantity of 6-10 times of that of the medicinal materials, extracting for three times, each time