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CN-121987698-A - Traditional Chinese medicine composition for treating erysipelas and preparation method thereof

CN121987698ACN 121987698 ACN121987698 ACN 121987698ACN-121987698-A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating erysipelas and a preparation method thereof. The Chinese medicinal composition comprises radix astragali, herba Artemisiae Anomalae, lignum sappan, folium Callicarpae Formosanae, ramulus Euonymi, flos Lonicerae, herba Portulacae, radix Arnebiae, radix Sangusorbae, folium Platycladi and cortex Phellodendri. The pharmacodynamics experiment shows that the traditional Chinese medicine composition provided by the invention obviously relieves the swelling of lower limbs of erysipelas rats, reduces the NO content in serum, increases the TNF-alpha content in serum, reduces lesion scores of lesion parts, and effectively improves related symptoms of erysipelas. The traditional Chinese medicine composition disclosed by the invention is wide in raw material source, easy to collect, simple in preparation process, high in safety, free of obvious adverse effects and free of adverse effects on the environment.

Inventors

  • LIU QI
  • YU XINXIN

Assignees

  • 黑龙江中医药大学

Dates

Publication Date
20260508
Application Date
20260316

Claims (9)

  1. 1. A traditional Chinese medicine composition for treating erysipelas is characterized by comprising, by weight, 20-25 parts of astragalus membranaceus, 16-20 parts of diverse wormwood herb, 18-22 parts of sappan wood, 16-20 parts of callicarpa megaphylla, 18-22 parts of winged euonymus twig, 18-22 parts of honeysuckle, 18-22 parts of purslane, 8-12 parts of lithospermum, 8-12 parts of garden burnet, 12-18 parts of biota orientalis and 18-22 parts of phellodendron.
  2. 2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following components, by weight, 22 parts of astragalus membranaceus, 18 parts of diverse wormwood herb, 20 parts of sappan wood, 18 parts of callicarpa macrophylla, 20 parts of winged euonymus twig, 20 parts of honeysuckle, 20 parts of purslane, 10 parts of lithospermum, 10 parts of sanguisorba officinalis, 15 parts of biota orientalis and 20 parts of phellodendron amurense.
  3. 3. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, by weight, 25 parts of astragalus membranaceus, 16 parts of diverse wormwood herb, 18 parts of sappan wood, 20 parts of callicarpa megaphylla, 22 parts of winged euonymus twig, 22 parts of honeysuckle, 18 parts of purslane, 12 parts of lithospermum, 8 parts of sanguisorba officinalis, 12 parts of biota orientalis and 22 parts of phellodendron amurense.
  4. 4. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following components, by weight, 22 parts of astragalus membranaceus, 18 parts of diverse wormwood herb, 22 parts of sappan wood, 16 parts of callicarpa megaphylla, 18 parts of winged euonymus twig, 20 parts of honeysuckle, 22 parts of purslane, 8 parts of lithospermum, 10 parts of garden burnet, 15 parts of biota orientalis and 20 parts of phellodendron amurense.
  5. 5. A method for preparing a Chinese medicinal composition according to any one of claims 1& # x2011 and 4, which is characterized by comprising the steps of weighing astragalus membranaceus, diverse wormwood herb, sappan wood, callicarpa macrophylla, winged euonymus twig, honeysuckle flower, purslane, lithospermum, sanguisorba officinalis, biota orientalis and phellodendron, mixing, adding 7-10 times of water into the mixture for the first time, decocting for 1-1.5h, filtering to obtain filtrate, adding 5-8 times of water into filter residues into the filter residues, decocting for 0.5-1h, filtering to obtain filtrate, and combining the filtrate obtained by the first decoction with the filtrate.
  6. 6. The method for preparing a Chinese medicinal composition according to claim 5, wherein the method comprises the steps of weighing radix astragali, herba Artemisiae Anomalae, lignum sappan, folium Callicarpae Formosanae, ramulus Euonymi, flos Lonicerae, herba Portulacae, radix Arnebiae, radix Sangusorbae, folium Platycladi and cortex Phellodendri, mixing, adding 8 times of water, decocting for 1 hr, filtering to obtain filtrate, adding 6 times of water, decocting for 1 hr, filtering to obtain filtrate, and mixing with the filtrate obtained by the first decoction.
  7. 7. The method for preparing a traditional Chinese medicine composition according to claim 5, wherein the preparation method comprises the steps of weighing astragalus membranaceus, diverse wormwood herb, sappan wood, callicarpa megaphylla, winged euonymus twig, honeysuckle, purslane, lithospermum, sanguisorba officinalis, cacumen biotae and phellodendron amurense, mixing, adding 10 times of water into the mixture for the first time, decocting for 1 hour, filtering to obtain filtrate, adding 5 times of water into filter residues into the filter residues, decocting for 0.5 hour, filtering to obtain filtrate, and combining the filtrate obtained by the first decoction.
  8. 8. The method for preparing a traditional Chinese medicine composition according to claim 5, wherein the preparation method comprises the steps of weighing astragalus membranaceus, diverse wormwood herb, sappan wood, callicarpa megaphylla, winged euonymus twig, honeysuckle, purslane, lithospermum, sanguisorba officinalis, cacumen biotae and phellodendron, mixing, adding 8 times of water into the mixture for the first time, decocting for 1.5 hours, filtering to obtain filtrate, adding 6 times of water into filter residues into the filter residues, decocting for 1 hour, filtering to obtain filtrate, and combining the filtrate obtained by the first decoction.
  9. 9. The application of the traditional Chinese medicine composition according to any one of claims 1& # x2011 and 4 in preparing medicines for preventing or treating erysipelas.

Description

Traditional Chinese medicine composition for treating erysipelas and preparation method thereof Technical Field The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating erysipelas and a preparation method thereof. Background Erysipelas are acute lymphangitis caused by group a group b hemolytic streptococcus infection, and the pathogenic bacteria invade when skin or mucous membrane is inflamed or damaged, and also caused by blood infection. Erysipelas are common diseases in surgery, often occur on the face, legs, abdomen of babies and the like, often appear as clearly-defined flaky erythema, slightly bulge, fade due to light pressure, spread around easily, and cause burning pain on the skin surface and discomfort such as Gao Rewei cold and headache. The disease can repeatedly occur in the original focus, and is called recurrent erysipelas. Prolonged disease progression can lead to chronic lymphedema of the lower extremities, known as trunk, and even to streptococcal toxic shock syndrome. The traditional Chinese medicine considers that the etiology and pathogenesis of erysipelas are that the body and blood system have heat, and the erysipelas are caused by external fire toxin, accumulation of heat toxin and stagnation of skin, or are caused by skin mucous membrane damage and invasion of toxin by gaps. The occurrence and development of the disease are related to damp-heat and fire toxin, especially fire toxin. The holy Ji general records that "the main cause of heat toxin is outbreak between the skin and the heat accumulation is erysipelas". The theory of disease sources and symptoms of erysipelas, the term "Yun Zhan (pill) means that the person suddenly turns red, such as Dan Zhi, so called Dan. It is also indicated for wind-heat type malignant toxicity when it is applied to the feet or abdomen, such as the palm. Severe cases also include cellulitis, etc., and pain is not enough due to the urgent treatment, and the pain is bad and rotten for a long time. The pathogenesis of erysipelas on lower limbs is mainly downward flow of damp-heat, which is caused by the repeated feeling of exogenous pathogenic factors, the stagnation of damp-heat pathogenic factors on lower limbs, skin stagnation and blockage of channels and collaterals, and the erysipelas on lower limbs are easy to repeatedly attack due to damp viscosity and cementing with heat toxin. In short, erysipelas on the lower extremities are caused by damp-heat and pathogenic-toxin are indistinguishable. Therefore, the treatment mainly takes heat clearing and fire relieving as well as blood circulation activating, dampness removing, swelling eliminating and stagnation eliminating as auxiliary materials. At present, for erysipelas treatment, modern medicine uses penicillin medicines for resisting G+ cocci to carry out systemic anti-infection treatment, and is matched with local application of 50% magnesium sulfate wet dressing, so that the method has definite clinical curative effect and quick effect, but the long-term application of antibiotics is extremely easy to generate antibiotic resistance, and the phenomenon of 'stiffness' appears after the treatment of a plurality of patients, and researches show that the simple antibiotic treatment has the problems of unstable curative effect, long treatment course, easy disease recurrence and the like. The Western medicine development still has limitations and defects in the treatment of some diseases until now, but the advantages of traditional Chinese medicine are gradually revealed, and the rapid development of traditional Chinese medicine can make up the limitations and defects of the pure Western medicine treatment to a certain extent and promote the development of medicine to a certain extent. Therefore, there is a need to develop a safe and effective therapeutic drug, which provides a new thought method for treating surgical diseases such as erysipelas of lower limbs, etc., reduces pain of patients and improves life treatment of patients. Disclosure of Invention In view of the above, the invention provides a traditional Chinese medicine composition for treating erysipelas and a preparation method thereof. The invention also provides a preparation method of the traditional Chinese medicine composition for treating erysipelas. The invention also provides application of the traditional Chinese medicine composition for treating erysipelas in preparing medicines for treating erysipelas. The technical scheme adopted by the invention for achieving the purpose is as follows: The invention provides a traditional Chinese medicine composition for treating erysipelas, which comprises the following components of astragalus mongholicus, diverse wormwood herb, sappan wood, callicarpa megaphylla, winged euonymus twig, honeysuckle flower, purslane, lithospermum, garden burnet root, biota orientalis and phellodendron bark. According to