Search

CN-121987699-A - Preparation method of Qiqingbaidu granules

CN121987699ACN 121987699 ACN121987699 ACN 121987699ACN-121987699-A

Abstract

The invention provides a preparation method of Qiqing antiphlogistic granule, wherein the Qiqing antiphlogistic granule comprises, by weight, 15-18 parts of radix scutellariae, 15-18 parts of polygonum cuspidatum, 12-15 parts of pulsatilla chinensis, 12-15 parts of radix sophorae flavescentis, 15-18 parts of radix isatidis, 8-10 parts of rhizoma dryopterygii, 6-8 parts of dyers woad leaf, 93-95 parts of sucrose, 4-6 parts of dextrin and 0.2-0.5 part of stabilizer. The product prepared by the method has higher active ingredients, better stability and better curative effect, and can be industrially produced in large scale.

Inventors

  • LI XIN
  • Mei Aoyi
  • LI YANG

Assignees

  • 洛阳瑞华动物保健品有限公司

Dates

Publication Date
20260508
Application Date
20241104

Claims (8)

  1. 1. The Qiqingbaidu granule is characterized by comprising, by weight, 15-18 parts of scutellaria baicalensis, 15-18 parts of polygonum cuspidatum, 12-15 parts of pulsatilla chinensis, 12-15 parts of radix sophorae flavescentis, 15-18 parts of radix isatidis, 8-10 parts of rhizoma dryopterygii, 6-8 parts of dyers woad leaf, 93-95 parts of sucrose, 4-6 parts of dextrin and 0.2-0.5 part of stabilizer.
  2. 2. The Qiqingbaidu granule of claim 1, wherein the stabilizer is beta-cyclodextrin, sodium carboxymethyl cellulose.
  3. 3. The Qiqingbaidu granule of claim 2 wherein the stabilizer is sodium carboxymethyl cellulose.
  4. 4. A preparation method of Qiqingbaidu granule comprises the following steps: step 1, crushing five traditional Chinese medicines of radix scutellariae, pulsatilla chinensis, radix sophorae flavescentis, radix isatidis and rhizoma dryopteris crassirhizomae, and then adding water for extraction to obtain an extract 1 for later use; Step 2, crushing two traditional Chinese medicines of giant knotweed and dyers woad leaf, and then adding alcohol for extraction to obtain an extract 2 for later use; step 3, combining the extracting solution 2 obtained in the step 2) with the extracting solution 1 obtained in the step 1) for standby; Step 4, weighing sucrose, crushing and uniformly mixing with dextrin for later use; Step 5, uniformly spraying the combined extracting solution obtained in the step 3) on the surface of the mixture of the sucrose and the dextrin obtained in the step 4), drying, and granulating for later use; and 6, uniformly mixing the prepared particles, and subpackaging with aluminum foil bags to obtain the finished product.
  5. 5. The method for preparing Qiqingbaidu granule as defined in claim 4, wherein the five flavors of radix Scutellariae, radix Pulsatillae, radix Sophorae Flavescentis, radix Isatidis and rhizoma Dryopteris Crassirhizomatis in step 1) are decocted with water for extraction.
  6. 6. The method for preparing Qiqing baidu granule as defined in claim 4, wherein the two traditional Chinese medicines of giant knotweed and dyers woad leaf in step 2) are crushed, added with 8 times of 60% ethanol at 80 ℃ for reflux extraction for 2 hours, added with 8 times of 60% ethanol at 80 ℃ for reflux extraction for 1 hour, and the extract is obtained by filtering, concentrating and concentrating the extract after merging the extracts.
  7. 7. The method for preparing Qiqingbaidu granule as defined in claim 4, wherein the stabilizer is added into the extract of giant knotweed and dyers woad leaf in the step 2).
  8. 8. The method for preparing Qiqingbaidu granules as claimed in claim 4, wherein the sucrose in the step 4) is crushed and sieved by a 60-mesh sieve.

Description

Preparation method of Qiqingbaidu granules Technical Field The invention belongs to the field of veterinary medicines in the field of biological medicines, and relates to a preparation method of Qiqing toxin-vanquishing particles. Background The formula of the Qiqingbaidu granule is taken in the second edition of the animal pharmacopoeia of the people's republic of China in 2020 edition, and comprises 100g of radix scutellariae, 100g of polygonum cuspidatum, 80g of pulsatilla chinensis, 80g of radix sophorae flavescentis, 100g of radix isatidis, 60g of rhizoma dryopterygii and 40g of dyers woad leaf. Decocting the above 7 materials with water for 2 times, the first time for 2 hours and the second time for 1 hour, filtering decoction, mixing filtrates, concentrating under reduced pressure below 80 ℃ to a relative density of 1.30-1.35 (55 ℃) to obtain fluid extract, adding appropriate amount of sucrose and dextrin, mixing, granulating, drying, and making 560 g. The product is mainly used for treating damp-heat diarrhea and pullorum disease. However, the effective components in the giant knotweed and the dyers woad leaf can not be extracted well from the finished product extracted by the method. The active ingredients such as emodin and chrysophanol in the giant knotweed are extracted by ethanol more than that obtained by water decoction, but the indigo indirubin in the main ingredients in the dyers woad leaf is almost insoluble in water and slightly soluble in ethanol, and the active ingredients in the giant knotweed and dyers woad leaf can be extracted by ethanol. Therefore, a new preparation method is developed, and the effective components in the giant knotweed and the dyers woad leaf are better extracted under the condition of not reducing or improving the original drug effect. Disclosure of Invention The invention adopts the following technical scheme: The invention provides a preparation method of Qiqing antiphlogistic granules, which has good stability and can obtain Qiqing antiphlogistic granules with better efficacy. Extracting folium Isatidis and rhizoma Polygoni Cuspidati with ethanol, concentrating, adding stabilizer to ensure no loss of effective components, mixing with water extractive solutions of other medicinal materials, adding appropriate amount of sucrose and dextrin, mixing, granulating, drying, and granulating. The technical scheme adopted by the invention for achieving the aim is that the traditional Chinese medicine comprises, by weight, 15-18 parts of radix scutellariae, 15-18 parts of polygonum cuspidatum, 12-15 parts of pulsatilla chinensis, 12-15 parts of radix sophorae flavescentis, 15-18 parts of radix isatidis, 8-10 parts of rhizoma dryopteris crassirhizomae, 6-8 parts of dyers woad leaf, 93-95 parts of sucrose, 4-6 parts of dextrin and 0.2-0.5 part of stabilizer. The invention relates to a preparation method of Qiqing antiphlogistic granules, which comprises the following steps: step 1, crushing five traditional Chinese medicines of radix scutellariae, pulsatilla chinensis, radix sophorae flavescentis, radix isatidis and rhizoma dryopteris crassirhizomae, adding 8 times of water extract for 1 hour, decocting for 2 hours, adding 8 times of water for decocting for 1 hour, mixing decoctions, filtering, concentrating and collecting extract to obtain extract for later use; Step 2, crushing two traditional Chinese medicines of polygonum cuspidatum and dyers woad leaf, adding 8 times of 60% ethanol at 80 ℃ for reflux extraction for 2 hours, adding 8 times of 60% ethanol at 80 ℃ for reflux extraction for 1 hour, mixing the extracting solutions, filtering, concentrating and collecting paste to obtain an extracting solution for later use; step 3, adding the stabilizer into the extracting solution in the step 2, and then combining the stabilizer with the extracting solution 1 for standby; step 4, weighing sucrose, crushing, sieving with a 60-mesh sieve, and uniformly mixing with dextrin for later use; step 5, uniformly spraying the extracting solution on the surface of the mixture, drying, and granulating for later use; and 6, uniformly mixing the prepared particles, and subpackaging with aluminum foil bags to obtain the finished product. Detailed Description Example 1 Step 1, crushing 15-18 parts of radix scutellariae, 12-15 parts of pulsatilla chinensis, 12-15 parts of radix sophorae flavescentis and 15-18 parts of radix isatidis, 8-10 parts of rhizoma dryopteris crassirhizomae, adding 8 times of water, soaking for 1 hour, decocting for 2 hours, adding 8 times of water, decocting for 1 hour, mixing decoctions, filtering, concentrating and collecting extract to obtain an extract for later use. And 2, crushing 15-18 parts of giant knotweed rhizome and 6-8 parts of dyers woad leaf, adding 8 times of 60% ethanol at 80 ℃ for reflux extraction for 2 hours, adding 8 times of 60% ethanol at 80 ℃ for reflux extraction for 1 hour, combining the extracting solutions, filtering, concentrating and c