Search

CN-121987702-A - Medicinal patch needle for preventing and treating allergic rhinitis and preparation method and application thereof

CN121987702ACN 121987702 ACN121987702 ACN 121987702ACN-121987702-A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a medicinal patch needle for preventing and treating allergic rhinitis, and a preparation method and application thereof. The medical patch needle mainly comprises a traditional Chinese medicine composition and a medical patch pressing needle, wherein the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 30-60 parts of astragalus mongholicus, 15-30 parts of Chinese angelica, 10-25 parts of radix sileris, 10-30 parts of rhizoma atractylodis, 10-30 parts of rhizoma acori graminei, 5-15 parts of asarum, 10-30 parts of ligusticum wallichii, 10-20 parts of radix angelicae and 1-5 parts of borneol. The medical needle patch can be used for preventing and treating allergic rhinitis, has mild and durable needling stimulation on the skin part of the acupoints, and can enable medicines to enter the acupoints along with pinholes, namely the acupoints can achieve the effects of activating qi-blood, relieving stuffy nose and removing pathogenic factors under the dual actions of the needling stimulation and the medicines, and has remarkable preventing and treating effects on allergic rhinitis.

Inventors

  • CHEN JINCHENG
  • Zi Mingjie

Assignees

  • 山西中医药大学

Dates

Publication Date
20260508
Application Date
20260327

Claims (10)

  1. 1. A traditional Chinese medicine composition for preventing and treating allergic rhinitis is characterized by comprising, by weight, 30-60 parts of astragalus mongholicus, 15-30 parts of Chinese angelica, 10-25 parts of radix saposhnikoviae, 10-30 parts of rhizoma atractylodis, 10-30 parts of rhizoma acori graminei, 5-15 parts of asarum, 10-30 parts of ligusticum wallichii, 10-20 parts of radix angelicae and 1-5 parts of borneol.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials, by weight, 30 parts of astragalus mongholicus, 20 parts of Chinese angelica, 15 parts of radix saposhnikoviae, 15 parts of rhizoma atractylodis, 20 parts of rhizoma acori graminei, 6 parts of asarum, 20 parts of ligusticum wallichii, 15 parts of radix angelicae and 2 parts of borneol; or 60 parts of astragalus, 30 parts of angelica, 25 parts of divaricate saposhnikovia root, 30 parts of rhizoma atractylodis, 30 parts of grassleaf sweelflag rhizome, 15 parts of manchurian wildginger, 30 parts of szechuan lovage rhizome, 20 parts of dahurian angelica root and 5 parts of borneol; Or 30 parts of astragalus, 15 parts of angelica, 10 parts of divaricate saposhnikovia root, 10 parts of rhizoma atractylodis, 10 parts of grassleaf sweetflag rhizome, 5 parts of asarum, 10 parts of szechuan lovage rhizome, 10 parts of dahurian angelica root and 1 part of borneol.
  3. 3. A method for preparing the traditional Chinese medicine composition according to claim 1 or 2, comprising the following steps: (1) Mixing radix astragali, radix Angelicae sinensis, radix Saposhnikoviae, rhizoma Atractylodis, rhizoma Acori Graminei, herba asari, rhizoma Ligustici Chuanxiong and radix Angelicae Dahuricae, and pulverizing to obtain medicinal powder; (2) Mixing the medicinal powder with Borneolum Syntheticum, and grinding into fine powder.
  4. 4. A process according to claim 3, wherein in step (1) the crushed material is sieved with a 50-70 mesh sieve; And/or, grinding the materials into fine powder in the step (2), and sieving the fine powder with a 70-90-mesh sieve.
  5. 5. A medicine needle patch for preventing and treating allergic rhinitis, which is characterized by comprising the traditional Chinese medicine composition as claimed in claim 1 or 2 and a medicine patch pressing needle, wherein the medicine patch pressing needle comprises a needle body, a medicine containing layer and an adhesive layer.
  6. 6. The medical needle patch according to claim 5, wherein the adhesive layer is located at the periphery of the drug-containing layer, the needle body sequentially passes through the adhesive layer and the drug-delivery layer from bottom to top, and the drug-containing layer comprises an absorbent pad.
  7. 7. The medical needle patch according to claim 6, wherein the absorbent pad is a non-woven fabric attached with a polymer isolation film or a pure cotton ribbon attached with a polymer isolation film, the adhesive layer is a silicone gel tape, a spun-laced non-woven fabric or an elastic spandex cloth coated with glue, the needle body is a needle-like needle body, and the medical layer further comprises a protective film for preventing adhesion and allowing smooth permeation of a medicine.
  8. 8. The medical needle patch according to claim 5, wherein the medical needle patch is classified into a child type and an adult type, the diameter of the child type medical layer is 2-10mm, the diameter of the adult type medical layer is 10-20mm, the length of the child type needle body is 0.8-1.5mm, and the length of the adult type needle body is 1.5-2.5mm.
  9. 9. A method for preparing a medical needle patch according to any one of claims 6 to 8, comprising the steps of uniformly applying the Chinese medicinal composition on an absorbent pad, covering the surface of the pad or the pad with a protective film, fixing a medicated layer containing the Chinese medicinal composition on the adhesive layer, and sequentially passing the needle body through the adhesive layer and the drug administration layer from bottom to top to prepare the medical needle patch.
  10. 10. The use of the traditional Chinese medicine composition according to claim 1 or 2, or the traditional Chinese medicine composition prepared by the preparation method according to claim 3 or 4, or the medicine needle patch according to any one of claims 5-8, or the medicine needle patch prepared by the preparation method according to claim 9, in the preparation of a product for preventing and treating allergic rhinitis.

Description

Medicinal patch needle for preventing and treating allergic rhinitis and preparation method and application thereof Technical Field The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a medicinal patch needle for preventing and treating allergic rhinitis, and a preparation method and application thereof. Background Allergic rhinitis (ALLERGICRHINITIS), also known as allergic rhinitis, is a chronic nonspecific inflammatory disease of the nasal mucosa mediated by immunoglobulin E (IgE) and type 2 helper T cells (Th 2), which is mainly characterized by nasal itching, nasal obstruction, sneeze, runny nose, etc. The symptoms of nose and eyes of the patient can cause a series of problems such as sleep disorder, dysphoria, depression, attention and memory decline, so that the physical and psychological conditions of the patient are seriously influenced, and the economic burden of individuals and society is increased. The pathological characteristics of allergic rhinitis show that gland secretion is increased or blood vessel leakage is increased under the pathological state of nasal mucosa, and particularly, the long-term contact with the allergen can induce insensitivity or resistance to fat-soluble glucocorticoid, which also enables the modern medicine to take local administration as the first-line preferred drug administration mode, and avoids various defects of oral administration for treating the disease. The acupoints act in a manner similar to the "window" of viscera on the body surface, and reflect the pathological conditions. Under the guidance of the theory of traditional Chinese medicine, the Chinese medicine scholars try to apply the medicine to the acupoints, namely the local administration by injecting through the acupoints, and the therapy not only enriches the treatment methods of the traditional Chinese medicine, but also provides a new administration way for the modern medicine. Through searching, the Chinese patent CN117018126A discloses a traditional Chinese medicine formula for treating allergic rhinitis, nasosinusitis, nasal polyp, adenoid hypertrophy and turbinate hypertrophy, which is characterized by comprising the following raw materials in parts by weight: 2-6g of artificial musk, 10-20g of flos magnoliae, 20-35g of cocklebur fruit, 10-15g of ligusticum wallichii, 10-18g of combined spicebush root, 10-18g of chrysanthemum, 20-25g of folium artemisiae argyi, 10-25g of radix scutellariae, 10-25g of rhizoma acori graminei, 10-25g of radix angelicae, 20-35g of cottonrose hibiscus leaves, 10-25g of platycodon grandiflorum, 10-15g of tabasheer, 10-15g of rhizoma dioscoreae nipponicae, 10-15g of inula seed, 10-35 g of inula flower, 10-25g of herba artemisiae capillaris, 10-25g of eupatorium, 25-40g of radix codonopsis pilosulae, 10-15g of frankincense, 10-15g of myrrh, 10-25g of bletilla striata, 10-15g of dragon's blood, 25-40g of radix pseudostellariae, 25-40g of ginseng, 55-65g of astragalus mongholicus, 5-12g of fructus gleditsiae 5-12g of asarum, 25-40g of red sage root, 20-35g of red paeony root, 8-12g of safflower, 25-40g of angelica, 20-35g of cassia twig, 20-35g of divaricate saposhnikovia root, 20-35g of dendrobium, 10-15g of dalbergia wood, 25-40g of herba polygonati officinalis, 15-25g of underground pearl, 10-25g of seedling of pig, 8-12g of antrodia camphorata, 8-12g of cortex dictamni, 8-12g of edible tulip, 10-25g of calyx seu fructus physalis, 12-18g of broom cypress root, 10-15g of singwang, 25-40g of American cockroach, 5-12g of kava, 20-35g of marsdenia tenacissima, 20-35g of common clubmoss herb, 10-25g of white drug-seed, 10-25g of common yam rhizome, 18-25g of typhonine, 5-8g of snake, 2-5g of toad venom, 20-35g of dragon bone, 20-35g of oyster, 20-35g of purple tip flower, 5-12g of sea dragon, 5-12g of leech, 4-8g of scorpion, 4-8 centipedes, 20-35g of fried jujube kernels, 8-12g of mantis egg-case, 10-15g of borneol and 8-12g of menthol. The invention can effectively treat nasal polyp, allergic rhinitis, nasosinusitis, adenoid hypertrophy and other diseases, and has a plurality of functions of resisting allergy, resisting inflammation, dilating blood vessels, reducing swelling, stopping bleeding, regulating immune system, easing pain, relieving nerves and the like. The Chinese patent ZL202222964788.0 discloses a medicine patch pressing needle which is a blank medicine patch containing vitamin B12 or according to the specific illness requirement. In order to improve the clinical effect and simultaneously highlight the clinical advantages of acupuncture and acupoint administration, so that the acupuncture needle can generate stable and durable acupuncture stimulation and pharmacological actions of medicines, the qi and blood of channels and collaterals are stimulated to the maximum extent, the viscera functions are regulated, and scientific and organic combination of the acupuncture needle and the acupoints is necessar