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CN-121987706-A - Clam, cassia twig and poria cocos pill for resolving hard mass as well as preparation method and application thereof

CN121987706ACN 121987706 ACN121987706 ACN 121987706ACN-121987706-A

Abstract

The invention provides a clam, cassia twig, poria cocos and poria cocos pill for resolving hard mass, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition comprises, by mass, 10-20 parts of clamshells, 20-30 parts of oysters, 8-12 parts of cassia twig, 10-20 parts of poria cocos, 10-20 parts of selfheal, 10-15 parts of lychee seeds, 10-15 parts of dried orange peel, 8-12 parts of rhizoma pinellinae praeparata, 10-20 parts of mango leaves, 10-15 parts of radix polygoni multiflori, 1-5 parts of leeches, 25-35 parts of Ficus hirsuta and 10-15 parts of bighead atractylodes rhizome. The traditional Chinese medicine composition provided by the invention can be used for treating nodular goiter.

Inventors

  • DENG JIAGANG
  • HOU XIAOTAO
  • HAO ERWEI
  • DU ZHENGCAI
  • WANG XIANGYING
  • ZHONG WEN
  • QIN XIN
  • LI XIAO
  • Weng Daliang

Assignees

  • 广西中医药大学

Dates

Publication Date
20260508
Application Date
20260409

Claims (10)

  1. 1. The traditional Chinese medicine composition is characterized by comprising the following raw material components in parts by mass: 10-20 parts of clamshell, 20-30 parts of oyster, 8-12 parts of cassia twig, 10-20 parts of poria cocos, 10-20 parts of selfheal, 10-15 parts of lychee seed, 10-15 parts of dried orange peel, 8-12 parts of rhizoma pinellinae praeparata, 10-20 parts of mango leaf, 10-15 parts of radix scutellariae, 1-5 parts of leech, 25-35 parts of Ficus simplicissima and 10-15 parts of bighead atractylodes rhizome.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material components in parts by mass: 14-18 parts of clamshell, 24-28 parts of oyster, 9-11 parts of cassia twig, 14-18 parts of poria cocos, 14-18 parts of selfheal, 12-14 parts of lychee seed, 12-14 parts of dried orange peel, 9-11 parts of rhizoma pinellinae praeparata, 14-18 parts of mango leaf, 12-14 parts of radix scutellariae, 2-4 parts of leech, 28-34 parts of Ficus simplicissima and 12-14 parts of bighead atractylodes rhizome.
  3. 3. The traditional Chinese medicine composition according to claim 1, wherein the dosage form of the traditional Chinese medicine composition comprises one of a pill, a granule, a tablet, a capsule, a paste, an oral solution and a mixture.
  4. 4. A method of preparing a pill of a traditional Chinese medicine composition as claimed in claim 3, comprising the steps of: (1) Mixing 4/5 of total parts of clamshell, oyster and cassia twig, selfheal, lychee seed, dried orange peel, rhizoma pinellinae praeparata, mango leaf, radix scutellariae, leech, fimbriae fimbriata and bighead atractylodes rhizome, adding water for extraction, and concentrating to obtain an extract with the relative density of 1.16-1.20; (2) Mixing Poria and the rest ramulus Cinnamomi, pulverizing, sieving with 80-100 mesh sieve, mixing with the extract obtained in step (1), preparing soft material by molding method, making pill, drying, spraying ethanol-Mel mixture, polishing, and oven drying to obtain the final product.
  5. 5. The preparation method of claim 4, wherein the water in the step (1) is added in an amount of 10-14 times of the total mass of the mixed medicinal materials.
  6. 6. The preparation method according to claim 4, wherein the extraction time in the step (1) is 0.8-1.2 h, the extraction temperature is 90-100 ℃, and the extraction times are 2-3.
  7. 7. The method according to claim 4, wherein the drying temperature in the step (2) is 50-60 ℃, and the drying time is 22-25 hours.
  8. 8. The method according to claim 4, wherein the ethanol-honey mixture in the step (2) has a volume percentage of 94-96%, and the ethanol-honey mixture has a volume ratio of 2-4:1.
  9. 9. The method according to claim 4, wherein the temperature of the drying in the step (2) is 50-60 ℃, and the drying time is 10-15 hours.
  10. 10. The use of the traditional Chinese medicine composition according to any one of claims 1-3 in preparing a medicament for treating nodular goiter.

Description

Clam, cassia twig and poria cocos pill for resolving hard mass as well as preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a clam, cassia twig, poria cocos and poria cocos pill for resolving hard mass, and a preparation method and application thereof. Background Most of nodular goiter is based on simple diffuse goiter, and the follicular epithelium is changed from diffuse hyperplasia into focal hyperplasia due to repeated disease progression, and degeneration occurs in partial areas, and finally, nodules in different development stages appear in glands due to repeated alternation of long-term hyperplasia and degeneration. Its lesions are actually an advanced manifestation of simple goiter. The incidence rate of the nodular goiter is high, and the larger nodular goiter can cause compression symptoms, and dyspnea, dysphagia, hoarseness and the like occur. Existing methods of treating nodular goiter include surgical and pharmaceutical treatments. The operation treatment can cause great trauma to patients, and the existing medicine treatment is generally carried out by taking thyroid medicines and hormones or by an operation method, but has high recurrence rate, large toxic and side effects and unsatisfactory treatment effect. The traditional Chinese medicine has the advantages of remarkable effect, less toxic and side effects and the like, and therefore, the traditional Chinese medicine attracts attention of researchers. Therefore, it is very important to provide a traditional Chinese medicine for treating nodular goiter. Disclosure of Invention The invention aims to provide a clam Guiling resolving hard mass pill, a preparation method and application thereof, wherein the clam Guiling resolving hard mass pill can be used for treating nodular goiter. In order to achieve the above object, the present invention provides the following technical solutions: the invention provides a traditional Chinese medicine composition which comprises the following raw material components in parts by mass: 10-20 parts of clamshell, 20-30 parts of oyster, 8-12 parts of cassia twig, 10-20 parts of poria cocos, 10-20 parts of selfheal, 10-15 parts of lychee seed, 10-15 parts of dried orange peel, 8-12 parts of rhizoma pinellinae praeparata, 10-20 parts of mango leaf, 10-15 parts of radix scutellariae, 1-5 parts of leech, 25-35 parts of Ficus simplicissima and 10-15 parts of bighead atractylodes rhizome. Preferably, the material comprises the following raw material components in parts by mass: 14-18 parts of clamshell, 24-28 parts of oyster, 9-11 parts of cassia twig, 14-18 parts of poria cocos, 14-18 parts of selfheal, 12-14 parts of lychee seed, 12-14 parts of dried orange peel, 9-11 parts of rhizoma pinellinae praeparata, 14-18 parts of mango leaf, 12-14 parts of radix scutellariae, 2-4 parts of leech, 28-34 parts of Ficus simplicissima and 12-14 parts of bighead atractylodes rhizome. Preferably, the dosage form of the traditional Chinese medicine composition comprises one of pills, granules, tablets, capsules, ointment, oral solution and mixture. The invention also provides a preparation method of the traditional Chinese medicine composition pill, which comprises the following steps: (1) Mixing 4/5 of total parts of clamshell, oyster and cassia twig, selfheal, lychee seed, dried orange peel, rhizoma pinellinae praeparata, mango leaf, radix scutellariae, leech, fimbriae fimbriata and bighead atractylodes rhizome, adding water for extraction, and concentrating to obtain an extract with the relative density of 1.16-1.20; (2) Mixing Poria and the rest ramulus Cinnamomi, pulverizing, sieving with 80-100 mesh sieve, mixing with the extract obtained in step (1), preparing soft material by molding method, making pill, drying, spraying ethanol-Mel mixture, polishing, and oven drying to obtain the final product. Preferably, the adding amount of the water in the step (1) is 10-14 times of the total mass of the mixed medicinal materials. Preferably, the time of the extraction in the step (1) is 0.8-1.2 h, the temperature of the extraction is 90-100 ℃, and the times of the extraction are 2-3 times. Preferably, the drying temperature in the step (2) is 50-60 ℃, and the drying time is 22-25 hours. Preferably, the volume percentage of the ethanol in the ethanol-honey mixed solution in the step (2) is 94-96%, and the volume ratio of the ethanol to the honey in the ethanol-honey mixed solution is 2-4:1. Preferably, the temperature of the drying in the step (2) is 50-60 ℃, and the drying time is 10-15 hours. The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating nodular goiter. Compared with the prior art, the invention has the beneficial effects that: The invention provides a clam Guiling pill for resolving hard mass and a preparation method and application there