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CN-121987707-A - Multi-target external application traditional Chinese medicine for cold-dampness arthralgia and preparation process thereof

CN121987707ACN 121987707 ACN121987707 ACN 121987707ACN-121987707-A

Abstract

The invention discloses a multi-target external application traditional Chinese medicine for treating cold-dampness arthralgia and a preparation process thereof, which is characterized in that the composition comprises, by weight, 8-15 g of prepared radix aconiti kusnezoffii, 1-5 g of dragon's blood, 3-8 g of vinegar prepared frankincense, 3-8 g of myrrh, 2-4 g of chitosan, 1-3 g of safflower, 3-8 g of ligusticum wallichii, 3-8 g of pseudo-ginseng, 3-8 g of radix salviae miltiorrhizae, 3-8 g of caulis spatholobi, 3-8 g of angelica sinensis, 3-8 g of radix angelicae pubescentis, 1-3 g of centipede, 3-8 g of caulis polygoni multiflori and 0.5-1 g of menthol.

Inventors

  • ZHU HUIAN

Assignees

  • 厦门润泽玥药业有限公司

Dates

Publication Date
20260508
Application Date
20260331

Claims (10)

  1. 1. The multi-target externally-applied traditional Chinese medicine for treating cold-dampness arthralgia is characterized by comprising the following components, by weight, 8-15 g of prepared radix aconiti kusnezoffii, 1-5 g of dragon's blood, 3-8 g of vinegar-prepared frankincense, 3-8 g of myrrh, 2-4 g of chitosan, 1-3 g of safflower, 3-8 g of ligusticum wallichii, 3-8 g of pseudo-ginseng, 3-8 g of radix salviae miltiorrhizae, 3-8 g of caulis spatholobi, 3-8 g of Chinese angelica, 3-8 g of radix angelicae pubescentis, 1-3 g of centipede, 3-8 g of caulis polygoni multiflori and 0.5-1 g of menthol.
  2. 2. The externally applied traditional Chinese medicine for treating multi-target cold-dampness arthralgia according to claim 1, wherein the composition is superfine powder, and the composition is packaged in a light-proof breathable composite bag.
  3. 3. A preparation process of a multi-target externally applied traditional Chinese medicine for treating cold-dampness arthralgia is characterized by comprising the following steps: The targeted modification pretreatment step comprises the steps of carrying out low-temperature ultrasonic pretreatment at-10 ℃ for 30 minutes on the prepared radix aconiti and the prepared radix aconiti kusnezoffii, carrying out secondary vinegar processing process treatment on vinegar processed frankincense, and carrying out vacuum freeze drying and degreasing treatment on centipedes; the step of graded crushing and superfine treatment, which is to subject the prepared radix aconiti, the prepared radix aconiti kusnezoffii, the vinegar prepared frankincense and the myrrh subjected to the low-temperature ultrasonic pretreatment to low-temperature freezing superfine crushing at the temperature of minus 20 ℃ until the particle size is not more than 75 microns, subject safflower, szechuan lovage rhizome, sanchi, red sage root, suberect spatholobus stem, chinese angelica, radix angelicae pubescentis and black bone vine to low-temperature air current crushing at the temperature of not more than 30 ℃ until the particle size is not more than 125 microns, and subject the centipede subjected to the vacuum freeze drying and degreasing treatment to superfine crushing until the particle size is not more than 75 microns; The accurate extraction step comprises extracting sanguis Draxonis and Saviae Miltiorrhizae radix by supercritical CO 2 gradient extraction technique; The layering mixing and homogenizing step comprises the steps of carrying out staged mixing by adopting a three-dimensional motion mixer, wherein chitosan is mixed with the dragon's blood extract micro powder, the vinegar processed frankincense micro powder and the myrrh micro powder in the first stage, the Sichuan Wu Chao micro powder and the grass Wu Chao micro powder are added in the second stage, menthol and the safflower micro powder are added in the third stage, the Ligusticum chuanxiong micro powder, the pseudo-ginseng micro powder, the red sage root extract micro powder, the spatholobus stem micro powder, the Chinese angelica micro powder, the radix angelicae pubescentis micro powder, the black bone vine micro powder and the centipede micro powder are mixed by adopting a compound homogenizing technology combining low-frequency vibration and high-speed stirring.
  4. 4. The preparation process of the externally applied traditional Chinese medicine for treating the multi-target cold-dampness arthralgia syndrome according to claim 3, wherein in the step of layered mixing and homogenizing, the mixing rotating speed of the first stage is 150 revolutions per minute, the mixing time is 20 minutes, the mixing rotating speed of the second stage is 120 revolutions per minute, the mixing time is 30 minutes, the composite homogenizing technical parameter of the third stage is the vibration frequency of 50Hz, the stirring rotating speed of 200 revolutions per minute, and the homogenizing time of 15 minutes.
  5. 5. The external application Chinese medicine for treating multi-target cold-dampness arthralgia and its preparation process according to claim 4, wherein the external application Chinese medicine for treating cold-dampness arthralgia is characterized by further comprising an extraction residue recovery step of crushing residues generated after the supercritical CO 2 gradient extraction to 100 meshes, wherein the obtained residue powder is used as a matrix filler for subsequent mixing.
  6. 6. The external application traditional Chinese medicine for treating multi-target cold-dampness arthralgia and the preparation process thereof according to claim 5, wherein the external application traditional Chinese medicine for treating multi-target cold-dampness arthralgia is characterized by further comprising a dynamic film forming regulation step after the layered mixing and homogenizing step, wherein the dynamic film forming regulation step comprises the steps of sampling and detecting mixed and homogenized powder, and forming a complete medicine film within 20 to 30 minutes after the powder is mixed into paste by using a solvent by adjusting the addition amount of chitosan or the proportion of vinegar-processed frankincense and myrrh, wherein the tensile strength of the medicine film is not lower than 1.2 megapascals.
  7. 7. The external application traditional Chinese medicine for treating multi-target cold-dampness arthralgia and the preparation process thereof according to claim 6, wherein in the dynamic film-forming regulation step, the adjustment range of the chitosan addition amount is +/-0.5 g.
  8. 8. The external application traditional Chinese medicine for treating multi-target cold-dampness arthralgia and the preparation process thereof according to claim 7, wherein the external application traditional Chinese medicine for treating multi-target cold-dampness arthralgia is characterized by further comprising a low-temperature aging step of aging the powder for 24 hours under the environment of 10-15 ℃ and 40-50% of relative humidity after the step of layered mixing and homogenizing or the step of dynamic film formation regulation.
  9. 9. The external application traditional Chinese medicine for treating multi-target cold-dampness arthralgia and the preparation process thereof, which are disclosed in claim 8, are characterized in that the secondary vinegar preparation process comprises the steps of soaking rice vinegar according to the proportion of 1:5 by weight of vinegar, standing for 2 hours, and then drying at a low temperature of 60 ℃.
  10. 10. The external application traditional Chinese medicine for treating multi-target cold-dampness arthralgia and the preparation process thereof according to claim 9, wherein the gradient extraction comprises the steps of extracting fat-soluble components under 15MPa pressure, extracting water-soluble active components under 25MPa pressure, and performing low-temperature spray drying on the obtained extract to obtain micro powder, wherein the air inlet temperature of the low-temperature spray drying is 80 ℃, and the air outlet temperature is 40 ℃.

Description

Multi-target external application traditional Chinese medicine for cold-dampness arthralgia and preparation process thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a multi-target external traditional Chinese medicine for treating cold-dampness arthralgia and a preparation process thereof. Background The cold-dampness arthralgia is a common clinical condition of traditional Chinese medicine, is mainly caused by blockage of channels and collaterals and unsmooth qi and blood circulation due to invasion of cold evil and dampness evil, and is mainly characterized by pain, numbness and limited movement of joints of neck, shoulder, waist, legs and knees, and associated symptoms such as dysmenorrhea, cold womb and the like of part of female patients, and seriously influences the life quality of the patients. Along with the change of modern life style, such as long-term table work, air-conditioning environment exposure, lack of exercise and the like, the incidence of neck, shoulder, waist and leg pain in sub-healthy people is remarkably improved, and the demand for safe and efficient external conditioning products is increasingly urgent. At present, the externally applied traditional Chinese medicine products aiming at cold-dampness arthralgia syndrome are more in variety and mainly comprise paste, powder, tincture and the like, but a plurality of short plates still exist in practical application, namely, firstly, the targeting of functional components is poor, most of the products adopt the traditional crushing process, the cell wall structure of medicinal materials is not effectively destroyed, the dissolution rate of fat-soluble and water-soluble effective components is low, and the synergistic effect of eliminating cold evil and dampness evil and dredging channels and collaterals is insufficient, so that the effects are slow, the duration of curative effect is short, the long-acting relieving requirements of patients are difficult to meet, secondly, the film forming performance is poor, partial powder products are easy to fall off after being regulated and the drug property is not uniformly released, the paste products mainly adopt synthetic adhesives, the discomfort such as skin smoldering, allergy and the like are easy to be caused, the biocompatibility is poor, thirdly, the preparation process is rough, the toxic components of prepared radix aconiti, the centipede and other animal medicinal materials are not effectively removed through the accurate process regulation and control, and the potential safety hazards exist, meanwhile, the existing process has low utilization rate of extracted residues, the green production rate is not met, the effect of cold-damp arthralgia syndrome is relieved, the cold-dampness syndrome is only limited, and the cold-damp arthralgia syndrome is relieved, and the cold-caused by the correlative cold-dampness syndrome is only is relieved, and the cold-caused by the correlative effect is only, and cold-caused by the cold-dampness disease. Therefore, we need to propose a multi-target external application traditional Chinese medicine for treating cold-dampness arthralgia and a preparation process thereof. Disclosure of Invention The invention aims to provide a multi-target external application traditional Chinese medicine for treating cold-dampness arthralgia and a preparation process thereof, so as to solve the problems in the background technology. In order to achieve the above purpose, the present invention provides the following technical solutions: the multi-target externally-applied traditional Chinese medicine for treating cold-dampness arthralgia comprises, by weight, 8-15 g of prepared radix aconiti kusnezoffii, 1-5 g of dragon's blood, 3-8 g of vinegar-prepared frankincense, 3-8 g of myrrh, 2-4 g of chitosan, 1-3 g of safflower, 3-8 g of ligusticum wallichii, 3-8 g of pseudo-ginseng, 3-8 g of radix salviae miltiorrhizae, 3-8 g of caulis spatholobi, 3-8 g of angelica, 3-8 g of radix angelicae pubescentis, 1-3 g of centipede, 3-8 g of caulis polygoni multiflori and 0.5-1 g of menthol. Preferably, the composition is ultrafine powder, and the composition is packaged in a light-proof breathable composite bag. A preparation process of a multi-target externally applied traditional Chinese medicine for treating cold-dampness arthralgia comprises the following steps: The targeted modification pretreatment step comprises the steps of carrying out low-temperature ultrasonic pretreatment at-10 ℃ for 30 minutes on the prepared radix aconiti and the prepared radix aconiti kusnezoffii, carrying out secondary vinegar processing process treatment on vinegar processed frankincense, and carrying out vacuum freeze drying and degreasing treatment on centipedes; the step of graded crushing and superfine treatment, which is to subject the prepared radix aconiti, the prepared radix aconiti kusnezoffii, the vinegar prepared frank