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CN-121987708-A - Traditional Chinese medicine composition for improving ovarian function

CN121987708ACN 121987708 ACN121987708 ACN 121987708ACN-121987708-A

Abstract

The invention provides a traditional Chinese medicine composition for improving ovarian function, which comprises, by weight, 1-5 parts of ginseng, 8-20 parts of semen cuscutae, 3-14 parts of Chinese angelica, 8-20 parts of radix salviae miltiorrhizae, 4-14 parts of morinda officinalis, 6-15 parts of prepared rehmannia root, 6-14 parts of medlar, 6-18 parts of glossy privet fruit, 3-13 parts of dogwood, 3-13 parts of nutgrass galingale rhizome, 3-12 parts of epimedium and 1-10 parts of liquorice. The whole prescription has the synergistic effect of the medicines, and can tonify kidney, invigorate spleen, sooth liver, activate blood, coordinate yin and yang, smooth qi and blood, fill kidney essence and restore menstrual flow, thereby achieving the treatment aim of improving ovarian function.

Inventors

  • SHI YUN

Assignees

  • 北京中医药大学东直门医院

Dates

Publication Date
20260508
Application Date
20260210

Claims (10)

  1. 1. The traditional Chinese medicine composition for improving the ovarian function is characterized by comprising, by weight, 1-5 parts of ginseng, 8-20 parts of semen cuscutae, 3-14 parts of Chinese angelica, 8-20 parts of radix salviae miltiorrhizae, 4-14 parts of morinda officinalis, 6-15 parts of prepared rehmannia root, 6-14 parts of medlar, 6-18 parts of glossy privet fruit, 3-13 parts of dogwood, 3-13 parts of nutgrass galingale rhizome, 3-12 parts of epimedium and 1-10 parts of liquorice.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising, by weight, 1-4 parts of ginseng, 9-17 parts of semen cuscutae, 4-12 parts of Chinese angelica, 9-17 parts of radix salviae miltiorrhizae, 5-13 parts of morinda officinalis, 8-13 parts of prepared rehmannia root, 7-13 parts of medlar, 7-16 parts of glossy privet fruit, 4-12 parts of dogwood, 4-12 parts of nutgrass galingale rhizome, 5-11 parts of epimedium herb and 1-8 parts of liquorice.
  3. 3. The traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following raw materials, by weight, 3 parts of ginseng, 12 parts of semen cuscutae, 6 parts of Chinese angelica, 12 parts of radix salviae miltiorrhizae, 9 parts of morinda officinalis, 9 parts of prepared rehmannia root, 9 parts of medlar, 9 parts of glossy privet fruit, 6 parts of dogwood, 6 parts of nutgrass galingale rhizome, 9 parts of epimedium herb and 6 parts of liquorice; preferably, the traditional Chinese medicine composition comprises the following raw materials, by weight, 3 parts of ginseng, 15 parts of semen cuscutae, 10 parts of Chinese angelica, 15 parts of radix salviae miltiorrhizae, 12 parts of morinda officinalis, 12 parts of prepared rehmannia root, 12 parts of medlar, 15 parts of glossy privet fruit, 10 parts of dogwood, 10 parts of nutgrass galingale rhizome, 9 parts of epimedium and 6 parts of liquorice; Preferably, the traditional Chinese medicine composition comprises the following raw materials of 2 parts by weight of ginseng, 10 parts by weight of semen cuscutae, 8 parts by weight of Chinese angelica, 10 parts by weight of radix salviae miltiorrhizae, 6 parts by weight of morinda officinalis, 9 parts by weight of prepared rehmannia root, 9 parts by weight of medlar, 9 parts by weight of glossy privet fruit, 6 parts by weight of dogwood, 6 parts by weight of nutgrass galingale rhizome, 6 parts by weight of epimedium and 2 parts by weight of liquorice.
  4. 4. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that said morinda officinalis is a processed morinda officinalis; Preferably, the glossy privet fruit is wine glossy privet fruit; preferably, the dogwood is cornus officinalis; Preferably, the licorice is honey-fried licorice.
  5. 5. The method for preparing the traditional Chinese medicine composition according to claim 1, which is characterized by comprising the steps of weighing ginseng, semen cuscutae, chinese angelica, radix salviae miltiorrhizae, morinda officinalis, prepared rehmannia root, medlar, glossy privet fruit, dogwood, nutgrass galingale rhizome, epimedium herb and liquorice according to the selected parts by weight, mixing and extracting.
  6. 6. The method according to claim 5, wherein the extraction method comprises one or more of decoction extraction, maceration extraction, percolation extraction, reflux extraction and ultrasonic extraction, in particular decoction extraction; preferably, the number of extractions is at least 1, more preferably 1 to 5, still more preferably 1 to 3; Preferably, the extraction time is at least 20min, more preferably 20-120min, and even more preferably 20-90min.
  7. 7. A Chinese medicinal preparation for improving ovarian function, wherein the active ingredients in the Chinese medicinal preparation comprise the Chinese medicinal composition according to any one of claims 1 to 4 or the Chinese medicinal composition obtained by the preparation method according to claim 5.
  8. 8. The traditional Chinese medicine preparation according to claim 7, wherein the traditional Chinese medicine preparation comprises decoction, pill, capsule, granule, tablet, ointment, dripping pill, patch or lotion, preferably decoction; preferably, the Chinese medicinal preparation further comprises pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials are selected from one or more of solubilizers, cosolvent, emulsifying agents, colorants, adhesives, disintegrating agents, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adhesive agents, integrating agents, permeation promoters, pH value regulators, buffers, plasticizers, surfactants, thickeners, coating agents, moisturizers, absorbents, diluents, flocculating and deflocculating agents, filter aids, release retarders, high molecular framework materials and film forming materials.
  9. 9. A method of preparing the traditional Chinese medicine preparation according to claim 7, comprising the steps of: 1) The Chinese medicinal composition is prepared by weighing Ginseng radix, semen Cuscutae, radix Angelicae sinensis, saviae Miltiorrhizae radix, radix Morindae officinalis, radix rehmanniae Preparata, fructus Lycii, fructus Ligustri Lucidi, corni fructus, rhizoma Cyperi, herba Epimedii and Glycyrrhrizae radix according to the selected weight ratio, mixing, extracting, filtering, and concentrating to obtain Chinese medicinal composition extract; 2) Adding adjuvants into the Chinese medicinal composition extract, and making into clinically acceptable dosage forms.
  10. 10. Use of a traditional Chinese medicine composition according to any one of claims 1-4 or obtained by the preparation method according to claim 5 or a traditional Chinese medicine preparation according to claim 7 or obtained by the preparation method according to claim 9 for the preparation of a medicament for improving ovarian function; Preferably, the reduced ovarian function disorder comprises premature ovarian dysfunction (POI), reduced ovarian reserve, ovarian hyporesponsiveness, perimenopausal syndrome, and secondary ovarian damage.

Description

Traditional Chinese medicine composition for improving ovarian function Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving ovarian function. Background Premature ovarian failure (Premature Ovarian Insufficiency, POI) refers to the decrease of ovarian function of females before age 40, serious ovarian failure, perimenopausal symptoms, infertility and other manifestations, serious influence on endocrine and reproductive functions of patients, and the prevalence rate of the premature ovarian failure is increased and the female is tended to be younger. However, the etiology of POI is not completely defined, and its pathogenesis is still under exploration. The clinical symptoms of POI are highly matched with symptoms such as hypomenorrhea, amenorrhea, blood withered, infertility, pre-menopause and post-menopause in traditional Chinese medicine, and are discussed in relevant ancient books, for example, the functions and the anatomical positions of the traditional Chinese medicine such as 'uterus', 'cell vein' are basically similar to those of the ovary in the traditional Chinese medicine, the "yellow emperor 'inner channel [ M ]: sian: sanqin publishing company, 2018.) points out that the position of the cell vein is' in the heart and is in the middle of the cell ', and the viewpoint of the main setback and lunate channel rhythm of the cell vein is proposed, and the' not in the moon 'cell vein is also blocked', and the core symptoms of the POI are directly related. The concept of "premature senility" is also related to "Huangdi's interior meridian", and "know seven losses and eight benefits" can be regulated, and the node of premature senility is also not known. Forty years, while yin qi is self-half and life is sufficient, the cause of the purgation and premature failure is yin qi self-half, which emphasizes the core role of yin essence deficiency in premature ovarian failure. Modern traditional Chinese medicine considers kidney deficiency as a main cause of premature ovarian failure, and is closely related to viscera dysfunction such as liver, spleen and the like. The pathogenesis of the disease mainly comprises deficiency and stasis, and qi and blood are not regulated, so that the functional disorder of the kidney-tendiness-Chong-ren-uterus axis is caused, and POI manifestations such as hypoovariance, abnormal menstruation and the like finally appear. Therefore, the traditional Chinese medicine provides a diagnosis and treatment thought with unique characteristics and definite curative effect for POI treatment through dialectical treatment. In combination with related ancient books and the existing traditional Chinese medicine theory, a prescription of a traditional Chinese medicine composition is provided for symptoms such as ovarian dysfunction. The patent CN101919963B discloses a traditional Chinese medicine composition for treating hypoovate and perimenopausal syndrome, which comprises the following raw materials of glossy privet fruit, mulberry fruit, cistanche salsa, red sage root, medicinal cyathula root, nutgrass galingale rhizome, white peony root, rhizoma anemarrhenae and lily. The core pathogenesis of the disease is liver depression, kidney deficiency and blood stasis, and the yin of the whole prescription has yang and the yang has yin, so that the disease mainly has the effects of tonifying kidney and activating blood, soothing liver and regulating qi, relieving depression and tranquillizing, balancing yin and yang and regulating thoroughfare and conception vessels. The patent CN101850016B discloses a traditional Chinese medicine composition for treating premature ovarian failure, which comprises the following raw materials of prepared rehmannia root, dogwood, angelica, white paeony root, epimedium herb and red sage root. The recipe is mainly used for treating premature ovarian failure due to yin deficiency of liver and kidney, prepared rehmannia root and dogwood in the recipe nourish yin and tonify liver and kidney are monarch drugs, chinese angelica, white paeony root and red sage root are used for enriching blood, activating blood and dredging channels, epimedium is used for tonifying kidney yang, and red sage root is also used for clearing heart and relieving restlessness. Disclosure of Invention The invention provides a traditional Chinese medicine composition for improving ovarian function, which takes ginseng and semen cuscutae as principal drugs, treats the essence of first and second days, lays the core efficacy of the basis for repairing the ovarian function, takes prepared rehmannia root, medlar, glossy privet fruit, epimedium herb, morinda officinalis, angelica and cornus officinalis as ministerial drugs, and has the effects of coordinating yin and yang and tonifying qi and blood, synergistic interaction with the principal drugs, generating water source by symbiotic mens