CN-121987709-A - Traditional Chinese medicine composition for treating gastroenteropathy and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating gastrointestinal diseases, which is prepared from the following traditional Chinese medicines, by weight, 8-15 parts of selfheal, 20-40 parts of mother-of-pearl, 5-10 parts of radix bupleuri, 3-8 parts of fried fructus aurantii, 3-8 parts of nutgrass galingale rhizome, 6-12 parts of inula flower and 5-9 parts of dried orange peel, and has the effects of clearing liver and lowering adverse qi, soothing liver and regulating qi, and can be used for treating liver and gall heat, gastric qi upward reversing bile reflux gastritis or gastroesophageal reflux disease in a targeted manner.

Inventors

• LI LI
• ZHU SHENGLIANG
• ZHANG FENG
• FENG HUI
• Chang cen
• MA ZHOULI
• LI BIN
• GAO SIYUAN
• WU JUN

Assignees

• 上海市光华中西医结合医院(上海市光华医院)

Dates

Publication Date

20260508

Application Date

20260306

Claims (10)

1. 1. The traditional Chinese medicine composition for treating gastrointestinal diseases is characterized by being prepared from, by weight, 8-15 parts of selfheal, 20-40 parts of mother-of-pearl, 5-10 parts of radix bupleuri, 3-8 parts of fried fructus aurantii, 3-8 parts of nutgrass galingale rhizome, 6-12 parts of inula flower and 5-9 parts of dried orange peel.
2. 2. The traditional Chinese medicine composition for treating gastrointestinal diseases according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight, 9 parts of selfheal, 30 parts of mother-of-pearl, 6 parts of radix bupleuri, 5 parts of fried fructus aurantii, 5 parts of nutgrass galingale rhizome, 9 parts of inula flower and 6 parts of dried orange peel.
3. 3. The traditional Chinese medicine composition for treating gastrointestinal diseases according to claim 1, wherein the gastrointestinal diseases are bile reflux gastritis or gastroesophageal reflux disease.
4. 4. A method for preparing a traditional Chinese medicine composition according to any one of claims 1-2, which is characterized by comprising the following steps of weighing medicines according to the weight ratio, crushing, adding water 3-6 times the mass of the traditional Chinese medicine, decocting for 1-3 times, merging the liquid medicine and concentrating to 1/3-1/2 of the mass of the added water.
5. 5. The method of preparing a pharmaceutical composition according to claim 3, wherein the mother-of-pearl is decocted first.
6. 6. The method for preparing a Chinese medicinal composition according to claim 3, wherein the inula flower is decocted in a bag.
7. 7. A medicament for treating gastrointestinal diseases, which is characterized by comprising the traditional Chinese medicine composition according to any one of claims 1-2 and a pharmaceutically acceptable carrier.
8. 8. The medicament for treating gastrointestinal diseases according to claim 6, wherein the medicament is an oral preparation.
9. 9. The use of the traditional Chinese medicine composition for treating gastrointestinal diseases according to any one of claims 1-2 or the medicine for treating gastrointestinal diseases according to any one of claims 6-7 in preparing the medicine for treating bile reflux gastritis or gastroesophageal reflux disease, wherein the treatment effect is further that the medicine has the effects of reducing inflammation, inhibiting local tissue angiogenesis, preventing pre-cancer lesions and/or canceration.
10. 10. The use according to claim 9, wherein the bile reflux gastritis or gastroesophageal reflux disease is liver and gall heat, gastric qi up-flow bile reflux gastritis or gastroesophageal reflux disease.

Description

Traditional Chinese medicine composition for treating gastroenteropathy and preparation method and application thereof Technical Field The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating gastroenteropathy, a preparation method and application thereof. Background Bile is digestive fluid secreted by liver cells in biliary tract, and is isotonic solution, and comprises bile salt, bile acid, bilirubin, reduced glutathione and its conjugate, oxidized glutathione, etc. During the digestion period, bile can be discharged from liver and gallbladder to duodenum in large quantity, and fat is emulsified into droplets to facilitate digestion, and absorption of fatty acid and fat-soluble vitamins can be promoted. Bile will not flow back into stomach and esophagus under physiological condition, and intestinal tract will not be damaged. Under pathological conditions bile can flow back into the stomach and even reflux into the esophagus to damage the stomach and esophageal mucosa, in some cases bile can even damage the mucosa of the intestinal tract. Bile reflux gastritis (bile reflux gastritis, BRG) is a pathological process involving gastric mucosal atrophy, intestinal metaplasia, dysplasia and the like, in which bile-based duodenal contents flow back into the stomach to cause inflammation, destroy gastric mucosal barrier. Clinically, the stomach pain, the acid regurgitation, the bitter taste, the nausea, the vomiting and the like are taken as main symptoms, the gastric fundus mucus is yellow green under the gastroscope, the gastric wall is polluted by bile and has yellow color, and the gastric mucosa is changed in active inflammation and is marked by edema, erosion, congestion and the like. BRG is common after cholelithiasis, pyloric sphincter dysfunction, cholecystectomy, gastric bulk excision, and gastrointestinal anastomosis. Bile reflux is considered to be an important causative factor of precancerous lesions and gastric cancer. Gastroesophageal reflux disease (gastroesophageal reflux disease, GRED) is an inflammatory lesion of esophagus caused by reflux of gastric and duodenal contents to the esophagus, takes poststernal causalgia, heartburn, pantothenic acid, hypochondriac distending pain and the like as main clinical manifestations, presents esophageal erosion or esophageal ulcer under an endoscope, seriously affects normal work and life of a patient, and can cause complications such as upper gastrointestinal hemorrhage, esophageal stenosis and the like when the illness state is serious. Bile-based alkaline reflux is one of the main reflux types of gastroesophageal reflux disease, and bile reflux may directly cause the destruction of esophageal cell membranes and intercellular tight junctions, damage mucosal barriers, and cause Barrett's esophagus and esophageal adenocarcinoma to occur. At present, no clear and effective treatment scheme for gastroenteropathy caused by bile reflux exists, and first-line western medicines mainly comprising acid-inhibiting medicines cannot relieve and prevent symptoms caused by bile and hidden danger of long-term lesions. Therefore, obtaining a drug capable of treating gastrointestinal diseases, namely bile reflux gastritis and gastroesophageal reflux disease, is a technical problem to be solved in the art. Disclosure of Invention In order to overcome the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating gastrointestinal diseases, a preparation method and application thereof, and in particular relates to a medicine for treating bile reflux gastritis and esophagitis. The invention provides a traditional Chinese medicine composition for treating gastrointestinal diseases, which is prepared from the following traditional Chinese medicines, by weight, 8-15 parts of selfheal, 20-40 parts of mother-of-pearl, 5-10 parts of radix bupleuri, 3-8 parts of fried fructus aurantii, 3-8 parts of nutgrass galingale rhizome, 6-12 parts of inula flower and 5-9 parts of dried orange peel; Further, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight, 9 parts of selfheal, 30 parts of mother-of-pearl, 6 parts of radix bupleuri, 5 parts of fried fructus aurantii, 5 parts of nutgrass galingale rhizome, 9 parts of inula flower and 6 parts of dried orange peel; further, the gastrointestinal disease is bile reflux gastritis or gastroesophageal reflux disease; The second aspect of the invention provides a preparation method of any one of the traditional Chinese medicine compositions, which comprises the following steps of weighing each weight part of medicine according to the weight proportion, adding water 3-6 times of the weight of the traditional Chinese medicine, decocting for 1-3 times, merging the liquid medicine and concentrating to 1/3-1/2 of the weight of the added water to obtain the traditional