CN-121987710-A - Medicine for treating depression, traditional Chinese medicine acupoint patch and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and in particular relates to a medicine for treating depression, a traditional Chinese medicine acupoint patch and a preparation method thereof. The medicine is suitable for a acupoint application, and comprises a traditional Chinese medicine composition and a traditional Chinese medicine composition extract, wherein the traditional Chinese medicine composition comprises, by weight, 10-20 parts of radix bupleuri, 10-20 parts of nutgrass galingale rhizome, 10-20 parts of combined spicebush root, 10-20 parts of saffron, 5-10 parts of flos Albiziae, 5-10 parts of coptis chinensis and 5-10 parts of poria cocos. The invention adopts all Chinese herbal medicine formulas, has no toxic and side effects caused by long-term application of western medicines, adopts the same amount of crude drugs and Chinese herbal medicine extracts, concentrates high-activity components, ensures that the crude drugs can retain the synergistic effect of the crude drugs more greatly on the basis of increasing the curative effect, solves the problem of the volume of the patch caused by overlarge dosage of the crude drugs, and has more remarkable meridian and acupoint effects through transdermal administration, lower side effects and higher compliance of users compared with oral administration of Chinese medicines.

Inventors

• ZHANG HAOMIN
• YU XIAOQI
• RONG YUFENG
• ZHAO XIANG
• SUN JUNYU
• ZHAO TONG
• WANG NA
• LI FENGQI

Assignees

• 长春中医药大学

Dates

Publication Date

20260508

Application Date

20260319

Claims (10)

1. 1. The medicine for treating depression is characterized by being suitable for a acupoint application, and comprises a traditional Chinese medicine composition and a traditional Chinese medicine composition extract, wherein the traditional Chinese medicine composition comprises, by weight, 10-20 parts of radix bupleuri, 10-20 parts of nutgrass galingale rhizome, 10-20 parts of combined spicebush root, 10-20 parts of saffron, 5-10 parts of flos albiziae, 5-10 parts of coptis chinensis and 5-10 parts of poria cocos, and the traditional Chinese medicine composition extract is extracted from the traditional Chinese medicine composition.
2. 2. The medicine according to claim 1, wherein the mass ratio of bupleurum, nutgrass galingale rhizome, combined spicebush root, saffron, silktree albizia flower, coptis root and poria cocos is 2:2:2:1:1:1.
3. 3. The medicament according to claim 2, wherein the mass ratio of the Chinese medicinal composition to the Chinese medicinal composition extract is 1:1.
4. 4. A medicament according to any of claims 1 to 3, characterized in that it further comprises a transdermal agent, which is a 2% volume fraction aqueous solution of laurocapram.
5. 5. The medicament according to claim 4, wherein the volume to mass ratio of the 2% volume fraction aqueous solution of laurocapram to the total mass of the Chinese medicinal composition and the extract of the Chinese medicinal composition is 15ml:16.5g.
6. 6. A traditional Chinese medicine acupoint patch for treating depression, characterized in that the traditional Chinese medicine acupoint patch comprises the medicine according to any one of claims 1 to 5.
7. 7. The patch of claim 6, wherein the drug is in the form of a drug cake, and the drug cake is placed in a non-woven breathable adhesive tape.
8. 8. The patch of claim 7, wherein the non-woven breathable adhesive comprises release paper, impermeable film, impermeable collar, non-woven fabric, easy tear strip, and hot melt adhesive, and the medicated cake is placed in the impermeable collar.
9. 9. The traditional Chinese medicine patch according to any one of claims 6 to 8, wherein the diameter of the drug cake is 0.4cm-0.6cm.
10. 10. The method for preparing the traditional Chinese medicine acupoint patch according to any one of claims 6 to 9, which is characterized in that the method comprises the steps of preparing a medicine into a medicine cake, and placing the medicine cake in a non-woven breathable adhesive tape to obtain the traditional Chinese medicine acupoint patch.

Description

Medicine for treating depression, traditional Chinese medicine acupoint patch and preparation method thereof Technical Field The invention belongs to the technical field of medicines, and in particular relates to a medicine for treating depression, a traditional Chinese medicine acupoint patch and a preparation method thereof. Background Depression is a common emotional disorder, and its core symptoms include persistent emotional depression, impaired interest, slow thinking, often accompanied by physical discomfort, sleep disorder, weight abnormality, and reduced self-evaluation, and the serious patients may have self-disabled behavior, which causes great harm to physical and mental health and social functions of the patients. With the increase of social pressure and the change of life style, the incidence rate of depression rises year by year, and the depression becomes a serious public health problem affecting human health in the global scope. Research shows that the long-term depression state not only directly reduces the life quality of patients, but also is closely related to the occurrence and development of various somatic diseases such as cardiovascular diseases, metabolic syndrome, cancers and the like, and the death risk is obviously increased, so that the development of safe and effective depression treatment means has important clinical significance and social value. The current main clinical antidepressant treatment is mainly based on chemical synthetic drugs (such as 5-hydroxytryptamine reuptake inhibitors and the like), and can relieve symptoms to a certain extent, but has obvious limitations that on one hand, the drugs are easy to cause adverse reactions of nerve, digestive and endocrine systems, such as nausea, vomiting, dizziness, somnolence, sexual dysfunction and the like, and can cause drug dependence after long-term use, on the other hand, patients need to take the drugs orally for a long time, the treatment compliance is poor, and especially for patients with gastrointestinal discomfort or dysphagia, the treatment persistence is difficult to ensure. These problems result in limited clinical utility of existing therapies, and there is a need to explore safer, more convenient, and more acceptable alternatives for patients. The traditional Chinese medicine has unique advantages in the field of depression treatment, is based on the theory of 'overall concept' and 'dialectical treatment', regulates qi, blood and yin and yang balance of an organism through the synergistic effect of multiple components and multiple targets, improves emotional symptoms, and simultaneously gives attention to physical function recovery, and has relatively low toxic and side effects. The Chinese medicine acupoint plaster therapy is used as an important component of the external Chinese medicine therapy, integrates the advantages of Chinese medicine effect, meridian acupoint stimulation and acupuncture therapy, has the characteristics of simple operation, direct action, no wound and the like, can effectively avoid the stimulation of oral administration to the gastrointestinal tract, and improves the compliance of patients. Therefore, the development of the Chinese medicinal acupoint patch has important significance for improving the external treatment effect of the traditional Chinese medicine for depression. Disclosure of Invention Based on the above, the invention aims to provide a medicament for treating depression, a traditional Chinese medicine acupoint patch and a preparation method thereof. In order to achieve the above purpose, the present invention may adopt the following technical scheme: The invention provides a medicament for treating depression, which is suitable for acupoint application, and comprises, by weight, 10-20 parts of radix bupleuri, 10-20 parts of nutgrass galingale rhizome, 10-20 parts of combined spicebush root, 10-20 parts of saffron, 5-10 parts of flos Albiziae, 5-10 parts of coptis chinensis and 5-10 parts of poria cocos, wherein the Chinese medicinal composition extract is extracted from the Chinese medicinal composition. Preferably, in the medicine, the mass ratio of bupleurum, nutgrass galingale rhizome, combined spicebush root, saffron, flos albiziae, coptis and poria cocos is 2:2:2:1:1:1. Preferably, in the medicine, the mass ratio of the traditional Chinese medicine composition to the traditional Chinese medicine composition extract is 1:1. Preferably, in the above medicine, the medicine further comprises a transdermal agent, and the transdermal agent is 2% volume fraction laurocapram aqueous solution. Preferably, in the medicine, the volume-mass ratio of the 2% volume fraction laurocapram aqueous solution to the total mass of the traditional Chinese medicine composition and the traditional Chinese medicine composition extract is 15mL:16.5g. The invention also provides a traditional Chinese medicine acupoint patch for treating depression, which comprises the medicines. Preferab