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CN-121987711-A - Traditional Chinese medicine composition for improving diabetes cognitive dysfunction and preparation method and application thereof

CN121987711ACN 121987711 ACN121987711 ACN 121987711ACN-121987711-A

Abstract

The invention discloses a traditional Chinese medicine composition for improving diabetes cognitive dysfunction and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials of radix rehmanniae, chinese yam, dogwood, poria cocos, rhizoma alismatis, moutan bark, cassia twig, astragalus mongholicus, codonopsis pilosula, fenugreek and purslane. The invention also discloses a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for improving diabetes cognitive dysfunction. The traditional Chinese medicine composition plays a role in improving diabetes cognitive dysfunction mainly by inhibiting microglial inflammation, protecting the synaptic plasticity of hippocampus nerves and the like.

Inventors

  • NI QING
  • ZHANG SHAN
  • ZHANG YUEYING
  • Wen Zhige
  • XU XINYAO

Assignees

  • 中国中医科学院广安门医院

Dates

Publication Date
20260508
Application Date
20260209

Claims (10)

  1. 1.A traditional Chinese medicine composition for improving diabetes cognitive dysfunction is characterized by comprising raw medicines of radix rehmanniae, chinese yam, dogwood, poria cocos, rhizoma alismatis, moutan bark, cassia twig, astragalus mongholicus, codonopsis pilosula, fenugreek and purslane.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising, by weight, 20-40 parts of radix rehmanniae, 10-20 parts of Chinese yam, 10-15 parts of dogwood, 6-20 parts of poria cocos, 6-15 parts of rhizoma alismatis, 6-20 parts of tree peony bark, 3-9 parts of cassia twig, 10-30 parts of astragalus membranaceus, 6-20 parts of radix codonopsis pilosulae, 3-15 parts of fenugreek and 3-15 parts of purslane.
  3. 3. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, by weight, 24 parts of radix rehmanniae, 12 parts of Chinese yam, 12 parts of dogwood, 9 parts of poria cocos, 9 parts of rhizoma alismatis, 9 parts of cortex moutan, 3 parts of cassia twig, 12 parts of astragalus membranaceus, 9 parts of codonopsis pilosula, 6 parts of fenugreek and 9 parts of purslane.
  4. 4. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, by weight, 20 parts of radix rehmanniae, 10 parts of Chinese yam, 10 parts of dogwood, 6 parts of poria cocos, 6 parts of rhizoma alismatis, 6 parts of cortex moutan, 3 parts of cassia twig, 10 parts of astragalus mongholicus, 6 parts of codonopsis pilosula, 3 parts of fenugreek and 3 parts of purslane.
  5. 5. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises, by weight, 40 parts of radix rehmanniae, 20 parts of Chinese yam, 15 parts of dogwood, 20 parts of poria cocos, 15 parts of rhizoma alismatis, 20 parts of cortex moutan, 9 parts of cassia twig, 30 parts of astragalus mongholicus, 20 parts of codonopsis pilosula, 15 parts of fenugreek and 15 parts of purslane.
  6. 6. The method for preparing a Chinese medicinal composition for improving cognitive impairment of diabetes according to any one of claims 1 to 5, wherein the preparation method comprises pulverizing radix rehmanniae, rhizoma Dioscoreae, corni fructus, poria, alismatis rhizoma, cortex moutan, ramulus Cinnamomi, radix astragali, radix Codonopsis, semen Trigonellae, and herba Portulacae according to formula, mixing, soaking in 6-10 times of water for 0.5-2 hr, decocting for 2-3 times, each time for 30-60 min, mixing decoctions, filtering, concentrating the filtrate under reduced pressure until each milliliter of medicinal liquid is equivalent to 0.2-3g of crude drug, or Pulverizing radix rehmanniae, rhizoma Dioscoreae, corni fructus, poria, alismatis rhizoma, cortex moutan, ramulus Cinnamomi, radix astragali, radix Codonopsis, and semen Trigonellae according to formula, reflux-extracting with 60-80% ethanol water solution of 6-10 times mass for 2-3 times, each time for 1-2 hr, filtering, collecting the combined filtrate, recovering ethanol, concentrating the filtrate under reduced pressure to obtain ethanol extract containing 0.1-2g crude drug per ml of medicinal liquid, mixing the residue after extraction with herba Portulacae of formula, decocting with 6-10 times mass of water for 2-3 times, each time for 40-60 min, mixing decoctions, filtering, mixing the filtrate with ethanol extract, and concentrating further to obtain crude drug 0.2-3g per ml of medicinal liquid.
  7. 7. A traditional Chinese medicine preparation for improving diabetic cognitive impairment, which is characterized in that raw materials of the traditional Chinese medicine preparation comprise the traditional Chinese medicine composition according to any one of claims 1-5.
  8. 8. The traditional Chinese medicine preparation according to claim 7, further comprising pharmaceutically acceptable excipients.
  9. 9. The traditional Chinese medicine preparation according to claim 7 or 8, wherein the traditional Chinese medicine preparation is in the form of decoction, granules, pills, capsules, tablets, powder or oral liquid.
  10. 10. Use of a traditional Chinese medicine composition according to any one of claims 1-5, a traditional Chinese medicine composition prepared by a preparation method according to claim 6 or a traditional Chinese medicine preparation according to any one of claims 7-9 for preparing any one of the following medicaments: 1) Improving blood glucose levels and montreal cognitive assessment scale scores of patients with diabetes cognitive impairment; 2) Inhibiting hippocampal neuritis of diabetic cognitive disorder; 3) Improving the synaptic plasticity of the hippocampal brain region nerve of the diabetic cognitive disorder; 4) Regulating the expression change of different cell type specific genes in hippocampal brain regions of the cognitive disorder of diabetes; 5) Regulating microglial cell AMPK gene expression and inhibiting microglial cell inflammation; 6) Inhibiting accumulation of glycolipid-stimulated microglial lipid droplets in an in vitro environment simulating diabetes; 7) Improving diabetic cognitive impairment.

Description

Traditional Chinese medicine composition for improving diabetes cognitive dysfunction and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines. More particularly relates to a traditional Chinese medicine composition for improving diabetes cognitive dysfunction and a preparation method and application thereof. Background Type 2 diabetes mellitus is a chronic metabolic disorder disease, and is a disorder of glycolipid metabolism and chronic low-grade inflammation caused by insulin resistance or deficiency, and widely damages organs and tissues including the central nervous system. A large number of epidemiologic grounds support cognitive impairment as a common but severely underestimated complication of diabetes. The journal of Lancet reports that merely controlling blood glucose can only improve cognitive function in part of clinical studies, and at present, no medicine capable of effectively delaying or reversing the progress of diabetes-related cognitive dysfunction is available. Neuroinflammation is an important factor in degenerative nervous system diseases such as cognitive dysfunction. Studies have demonstrated that obesity, insulin resistance, and diabetic conditions can promote the conversion of microglial cells from a neuroprotective phenotype to a neurotoxic phenotype, thereby exacerbating central inflammation and compromising cognitive function. Therefore, developing an intervention strategy for microglial-mediated neuroinflammatory pathways has become an important research direction for improving diabetic cognitive impairment and breaking through the current treatment bottleneck. Disclosure of Invention Aiming at the technical problems, the invention aims to provide a novel traditional Chinese medicine composition which can effectively inhibit microglial neuroinflammation so as to effectively improve diabetic cognitive impairment. The invention also aims at providing a preparation method of the traditional Chinese medicine composition. Still another object of the present invention is to provide various Chinese medicinal preparations of the above-mentioned Chinese medicinal composition. The invention also aims to provide the application of the traditional Chinese medicine composition and the traditional Chinese medicine preparation in preparing medicines for improving diabetic cognitive impairment. In order to achieve the above purpose, the invention adopts the following technical scheme: In a first aspect, the invention provides a traditional Chinese medicine composition for improving diabetic cognitive impairment, which comprises the following raw materials of radix rehmanniae, chinese yam, dogwood, poria cocos, rhizoma alismatis, moutan bark, cassia twig, astragalus mongholicus, codonopsis pilosula, fenugreek and purslane. Preferably, the traditional Chinese medicine composition comprises, by weight, 20-40 parts of radix rehmanniae, 10-20 parts of Chinese yam, 10-15 parts of dogwood, 6-20 parts of poria cocos, 6-15 parts of rhizoma alismatis, 6-20 parts of cortex moutan, 3-9 parts of cassia twig, 10-30 parts of astragalus membranaceus, 6-20 parts of codonopsis pilosula, 3-15 parts of fenugreek and 3-15 parts of purslane. The traditional Chinese medicine composition is mainly used for patients with diabetes and cognitive impairment, and has the symptoms of hypomnesis, inattention, soreness of waist and knees, frequent nocturia, hypodynamia, sexual hypofunction and the like. According to the invention, through systematic animal experiments and preliminary clinical observation, the developed traditional Chinese medicine composition not only can effectively regulate and control the blood sugar level of diabetic cognitive impairment model animals, but also can play a role in cognitive protection through a unique neuroimmune regulation mechanism. The core mechanism of the composition is that the composition can obviously inhibit the accumulation of pathological lipid droplets in microglial cells, further prevent the conversion of the pathological lipid droplets into pro-inflammatory neurotoxic phenotypes, and finally reduce the neuroinflammation and protect the neuron functions. The disease is located in the brain (the medullary sea), which is in the kidneys. For diabetes, it consumes qi to damage yin, poor and kidney to cause kidney qi to decline, as in Yizongbi read, kidney is the root of viscera, root of twelve vessels, root of respiration and triple energizer, and the source of raw materials is also the source of raw materials. The kidney qi deficiency, the first one of which is the inability to transpire and gasify, the second one of which is the lack of promotion of qi, the second one of which is the stagnation of blood, and the stagnation of blood. Phlegm and blood stasis are mutually combined, and stagnation transforms heat, and the accumulation of phlegm and blood is known as turbid toxin. Turbid toxin invadi