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CN-121987713-A - Strong-effect external Chinese herbal medicine composition and preparation method and application thereof

CN121987713ACN 121987713 ACN121987713 ACN 121987713ACN-121987713-A

Abstract

The invention discloses a powerful external Chinese herbal medicine composition, a preparation method and application thereof, and belongs to the technical field of external Chinese herbal medicine preparations. The composition is prepared by compounding active ingredients of traditional Chinese medicinal materials with an external preparation matrix, has reasonable formula compatibility, carefully selects medicinal materials such as safflower oxalis, herba violae, dandelion, rhizoma paridis, radix tinosporae, pseudo-ginseng and the like, and has the effects of clearing heat and detoxicating, promoting blood circulation to remove blood stasis, relieving swelling and pain, removing necrotic tissue and promoting granulation, inhibiting bacteria and repairing. The invention adopts the processes of water extraction, concentration, homogenization and sterile filling, has simple and convenient operation, is suitable for industrial production, and can be prepared into external dosage forms such as gel, cream and the like. The product has good effects on injuries from falls, stasis and swelling induration, burns and scalds, sores and other diseases, has fresh and cool gel and ventilation, is suitable for the liquid-permeable wound surface and summer, has the advantages of moisturizing and slow release of cream, is suitable for deep stasis and swelling, dry wound surface and winter, has wide applicability and mild drug property, and has good clinical practicability.

Inventors

  • Request for anonymity
  • Request for anonymity

Assignees

  • 王谦
  • 贵州佰合商业管理有限公司

Dates

Publication Date
20260508
Application Date
20260401

Claims (17)

  1. 1. The powerful externally-applied Chinese herbal medicine composition is characterized by comprising, by weight, 400-440 parts of safflower oxalis, 160-200 parts of viola philippica, 160-200 parts of dandelion, 90-110 parts of rheum officinale, 70-90 parts of radix polygoni multiflori, 50-70 parts of vinegar-prepared rhizoma corydalis, 50-70 parts of garden burnet root charcoal, 20-40 parts of dragon's blood and 15-25 parts of natural borneol, wherein the matrix auxiliary material is an external preparation matrix.
  2. 2. The Chinese herbal medicine composition according to claim 1, wherein the active ingredients comprise, by weight, 420 parts of safflower oxalis, 180 parts of herba violae, 180 parts of dandelion, 100 parts of rheum officinale, 80 parts of radix polygoni multiflori, 60 parts of vinegar-processed rhizoma corydalis, 60 parts of garden burnet charcoal, 30 parts of dragon's blood and 20 parts of natural borneol.
  3. 3. The herbal composition according to claim 1, wherein the natural borneol is natural borneol with a content of not less than 96%, the vinegar-processed rhizoma corydalis is decoction pieces processed with rice vinegar, the charred radix Sanguisorbae is decoction pieces processed with charred radix Sanguisorbae, and the dried root of the Rutaceae plant Feilong palm blood is obtained.
  4. 4. The herbal composition according to any one of claims 1 to 3, wherein the external preparation base is preferably but not limited to a gel base or a cream base, wherein the gel base comprises 8 to 12 parts of carbomer, 3 to 7 parts of sodium hyaluronate, 4 to 8 parts of chitosan, 5 to 15 parts of triethanolamine, 180 parts of purified water, and the cream base comprises 12 to 18 parts of glyceryl monostearate, 8 to 12 parts of stearic acid, 25 to 35 parts of white vaseline, 10 to 15 parts of liquid paraffin, 15 to 25 parts of glycerin, 3 to 8 parts of triethanolamine, 0.2 to 0.5 part of ethylparaben, and 120 to 150 parts of purified water.
  5. 5. The herbal composition of claim 4, wherein the gel matrix comprises carbomer 940 10 parts, sodium hyaluronate 5 parts, chitosan 6 parts, triethanolamine 10 parts, and purified water 180 parts, and the cream matrix comprises glyceryl monostearate 15 parts, stearic acid 10 parts, white vaseline 30 parts, liquid paraffin 12 parts, glycerin 20 parts, triethanolamine 5 parts, ethylparaben 0.3 parts, and purified water 135 parts.
  6. 6. A method for preparing the Chinese herbal medicine composition according to any one of claims 1 to 5 is characterized by comprising the following steps of (1) extracting medicinal materials, namely cleaning and crushing active medicinal materials except natural borneol, adding water for heating and extracting, combining extract liquid, filtering and concentrating to obtain thick extract, (2) preparing a matrix, namely uniformly preparing an external preparation matrix according to a proportion, and (3) mixing and shaping, namely uniformly mixing the thick extract and the matrix, adding natural borneol for dispersing, homogenizing and then aseptically filling to obtain the external Chinese herbal medicine preparation.
  7. 7. The method of claim 6, wherein the step (1) is specifically to crush the medicinal materials into coarse powder of 20-40 meshes, add water of 8-10 times of the total weight of the medicinal materials, heat and decoct for 2 times, decoct for 1-2 hours for the first time, decoct for 0.5-1.5 hours for the second time, combine the two extracting solutions, concentrate the filtrate into thick extract with the relative density of 1.25-1.35, cool for standby.
  8. 8. The use of the herbal composition according to any one of claims 1 to 5 for the preparation of a medicament for external use, wherein the medicament is used for treating traumatic stasis swelling, acute sprain swelling pain, old joint induration swelling pain, burns and scalds, sores, red swelling and pain, insect bite, red swelling and ulceration, innominate skin swelling and pain, and inflammation of superficial damaged wound surfaces.
  9. 9. The Chinese herbal medicine composition suitable for the light and medium acute traumatic injury is characterized by comprising, by weight, 200 parts of lycopodium clavatum, 180 parts of garden balsam stem, 120 parts of Chinese angelica, 100 parts of szechuan lovage rhizome, 60 parts of prepared frankincense, 60 parts of prepared myrrh, 80 parts of sappan wood, 60 parts of safflower, 50 parts of Chinese mugwort leaf and 30 parts of wild pepper, wherein the composition is matched with an external preparation matrix for use.
  10. 10. The Chinese herbal medicine composition suitable for severe closed traumatic injury is characterized by comprising, by weight, 100 parts of pseudo-ginseng, 80 parts of ground beetle, 70 parts of calcined native copper, 120 parts of drynaria rhizome, 100 parts of teasel root, 80 parts of safflower, 60 parts of peach kernel, 90 parts of red paeony root, 80 parts of herba lycopi and 70 parts of radix clematidis, wherein the composition is matched with an external preparation matrix for use.
  11. 11. A Chinese herbal medicine composition suitable for old traumatic injury is characterized by comprising, by weight, 150 parts of spatholobus stem, 150 parts of Chinese starjasmine stem, 120 parts of mistletoe, 80 parts of cassia twig, 90 parts of turmeric, 40 parts of prepared radix aconiti, 40 parts of prepared kusnezoff monkshood root, 100 parts of Chinese angelica, 100 parts of red sage root and 120 parts of kadsura pepper stem, wherein the composition is matched with an external preparation matrix for use.
  12. 12. The Chinese herbal medicine composition suitable for pyocutaneous disease and swelling is characterized by comprising, by weight, 125-135 parts of rhizoma paridis, 95-105 parts of radix tinosporae, 155-165 parts of herba houttuyniae, 105-115 parts of wild chrysanthemum, 85-95 parts of cortex phellodendri, 85-95 parts of radix sophorae flavescentis, 85-95 parts of garden burnet, 33-37 parts of dragon's blood, 20-24 parts of natural borneol and 125-135 parts of dandelion, wherein the composition is matched with an external preparation matrix for use.
  13. 13. The Chinese herbal medicine composition according to claim 12, wherein the active ingredients comprise, by weight, 130 parts of rhizoma paridis, 100 parts of radix tinosporae, 160 parts of cordate houttuynia, 110 parts of wild chrysanthemum flower, 90 parts of amur corktree bark, 90 parts of lightyellow sophora root, 90 parts of garden burnet root, 35 parts of dragon's blood, 22 parts of natural borneol and 130 parts of dandelion.
  14. 14. The use of a herbal composition according to any one of claims 12 to 13 for the preparation of a medicament for the treatment of heat toxin accumulation type sores and ulcers, deep skin abscesses, sores and ulcers without extinction, sores and ulcers with liquid penetration, damp-heat type innominate, cellulitis, mosquito bite ulcer suppuration, and sores and ulcers with inflammation and inflammation due to redness.
  15. 15. The external preparation special for the pyocutaneous disease with the excessive dampness-heat is characterized by comprising, by weight, 70 parts of dandelion, 65 parts of viola yedoensis makino, 50 parts of kuh-seng, 40 parts of fried gardenia, 35 parts of red halloysite, 35 parts of cortex moutan, 5 parts of menthol and 690 parts of matrix auxiliary materials, wherein the matrix auxiliary materials are external preparation matrixes.
  16. 16. The external preparation special for the blood stasis stagnation type pyocutaneous disease is characterized by comprising, by weight, 60 parts of wine-baked angelica sinensis, 55 parts of ligusticum wallichii, 45 parts of prepared frankincense, 20 parts of dragon's blood, 40 parts of radix angelicae, 30 parts of wine-baked rheum officinale, 6 parts of borneol and 704 parts of matrix auxiliary materials, wherein the matrix auxiliary materials are external preparation matrixes.
  17. 17. The general powerful external preparation for treating pyocutaneous disease is characterized by comprising, by weight, 75 parts of honeysuckle, 65 parts of weeping forsythiae capsule, 50 parts of rhizoma bletillae, 45 parts of raw garden burnet, 7 parts of a mixture of menthol and borneol in a ratio of 1:1, and 758 parts of a general matrix, wherein the general matrix is an external preparation matrix.

Description

Strong-effect external Chinese herbal medicine composition and preparation method and application thereof Technical Field The invention belongs to the technical field of Chinese herbal medicine external preparations, and in particular relates to a powerful external Chinese herbal medicine composition with the effects of clearing heat and detoxicating, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, removing necrotic tissue and promoting tissue regeneration, which can be prepared into water-soluble gel, moisturizing cream and various external preparations, is suitable for different wound scenes, is suitable for external treatment of traumatic injury, burns and scalds and skin swelling and toxin, and simultaneously relates to a preparation process of the composition and application thereof in the field of pharmacy. Background Traumatic injury, burn and scald, and pyocutaneous disease and swelling are common clinical high-frequency surgical diseases, and serious patients often have severe swelling and pain, deep blood stasis and stagnation, slow wound healing, easy leaving of hard joints or scars, and the like, which seriously affect the normal functions of limbs of patients. Currently, the external medicines for treating the diseases on the market are mainly divided into western medicine preparations and traditional Chinese medicine preparations, and the two kinds of products have prominent technical defects. The western medicine external preparation contains hormone, antibiotics or chemical analgesic components, can relieve pain symptoms in a short period, but cannot realize the effects of promoting blood circulation to remove blood stasis and repairing damaged tissues from root sources, is easy to cause adverse reactions such as skin allergy, red swelling stimulation and the like after long-term use or application on damaged skin, is easy to generate drug resistance, and is difficult to solve the core problems of slow wound healing and difficult dissipation of blood stasis. The traditional Chinese medicine external preparation mostly adopts single vaseline and grease matrix, has sticky and heavy texture, poor medicine permeability and slow effect, is only suitable for light symptoms such as mild collision, muscular soreness and the like, has poor curative effect on serious symptoms, does not consider the requirements of bacteriostasis and repair of damaged wounds in part of the formula, has higher infection risk during wound administration, greatly prolongs the healing period, easily leaves scars and induration after healing, and has limited applicability because the traditional product is mostly single dosage form and cannot be suitable for use scenes such as permeable wounds, dry wounds, different seasons and the like. Aiming at a plurality of defects existing in the prior art, the preparation method is based on the traditional Chinese medicine compatibility theory, combines clinical practice experience, selects traditional Chinese medicines, can prepare various external preparations, adapts to different wound surfaces and use scenes, fills the blank of the prior art, and meets the clinical diagnosis and treatment and daily medicine requirements. Disclosure of Invention 3.1 Object of the invention The invention aims to overcome the defects of poor curative effect, strong matrix irritation, poor wound suitability, slow effect and single dosage form of the existing external medicine for treating traumatic injury, burn and scald and sores and ulcers and sores and swelling and to provide the external Chinese herbal medicine composition which has the effects of strong detumescence and analgesia, blood circulation promoting and stasis dispelling, bacteriostasis repairing, and putrefaction removing and granulation promoting, can be prepared into various dosage forms for complementary adaptation, has fresh and breathable gel, moisture absorption and sore healing, and can moisten and adhere cream, realize long-acting slow release, not only can relieve swelling and pain, but also can remove stasis and block up hard knots, simultaneously adapt to damaged wound surfaces and burn and scald affected parts, has scientific formula and mild medicine property, controllable preparation process specification, and is suitable for industrialized batch production and clinical popularization. The invention discloses a powerful external Chinese herbal medicine composition which is prepared by compounding Chinese herbal medicine active ingredients and matrix auxiliary materials, has strict compatibility of the prescription, and combines the synergistic effect of the medicinal material ingredients and the matrix auxiliary materials, and combines the medicinal effect activity and the skin safety. The core traumatic injury and general wound surface prescription are compatible, the principal drugs are selected from safflower oxalis, herba violae and dandelion, the effects of clearing heat a