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CN-121987719-A - Traditional Chinese medicine composition for treating pneumonia

CN121987719ACN 121987719 ACN121987719 ACN 121987719ACN-121987719-A

Abstract

The invention relates to a traditional Chinese medicine composition for treating pneumonia, which comprises, by weight, 7.2-10.8 parts of radix scutellariae, 12.0-18.0 parts of fructus trichosanthis, 9.6-14.4 parts of fructus forsythiae, 7.2-10.8 parts of fritillaria thunbergii, 7.2-10.8 parts of purified pinellia ternate, 7.2-10.8 parts of radix peucedani, 9.6-14.4 parts of pulsatilla chinensis, 9.6-14.4 parts of radix salviae miltiorrhizae, 4.8-7.2 parts of ginseng, 7.2-10.8 parts of radix ophiopogonis, 9.6-14.4 parts of pericarpium citri reticulatae and 7.2-10.8 parts of radix platycodi. The lung heat clearing prescription has the effects of clearing away lung heat, resolving phlegm and relieving cough, and can be used for treating pneumonia, especially pneumonia or acute lung injury caused by klebsiella, and especially community-acquired pneumonia phlegm-heat obstructing lung.

Inventors

  • LI JIANSHENG
  • ZHAO PENG
  • WANG MINGHANG
  • TIAN YANGE
  • FENG SUXIANG
  • JIANG YUHANG

Assignees

  • 河南中医药大学

Dates

Publication Date
20260508
Application Date
20260326

Claims (9)

  1. 1. The traditional Chinese medicine composition for treating pneumonia comprises, by weight, 7.2-10.8 parts of radix scutellariae, 12.0-18.0 parts of fructus trichosanthis, 9.6-14.4 parts of fructus forsythiae, 7.2-10.8 parts of fritillaria thunbergii, 7.2-10.8 parts of purified pinellia ternate, 7.2-10.8 parts of radix peucedani, 9.6-14.4 parts of pulsatillae, 9.6-14.4 parts of radix salviae miltiorrhizae, 4.8-7.2 parts of ginseng, 7.2-10.8 parts of radix ophiopogonis, 9.6-14.4 parts of dried orange peel and 7.2-10.8 parts of platycodon grandiflorum.
  2. 2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine raw materials comprise, by weight, 8.1-9.9 parts of radix scutellariae, 13.5-16.5 parts of fructus trichosanthis, 10.8-13.2 parts of fructus forsythiae, 8.1-9.9 parts of fritillaria thunbergii, 8.1-9.9 parts of rhizoma pinelliae preparata, 8.1-9.9 parts of radix peucedani, 10.8-13.2 parts of radix pulsatillae, 10.8-13.2 parts of radix salviae miltiorrhizae, 5.4-6.6 parts of ginseng, 8.1-9.9 parts of radix ophiopogonis, 10.8-13.2 parts of pericarpium citri reticulatae and 8.1-9.9 parts of radix platycodi.
  3. 3. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine raw materials comprise, by weight, 9 parts of radix scutellariae, 15 parts of fructus trichosanthis, 12 parts of fructus forsythiae, 9 parts of fritillaria thunbergii, 9 parts of purified pinellia ternate, 9 parts of radix peucedani, 12 parts of Chinese pulsatilla root, 12 parts of radix salviae miltiorrhizae, 6 parts of ginseng, 9 parts of radix ophiopogonis, 12 parts of pericarpium citri reticulatae and 9 parts of radix platycodi.
  4. 4. A traditional Chinese medicine extract for treating pneumonia, which is an aqueous extract of the traditional Chinese medicine composition of any one of claims 1-3.
  5. 5. The extract of Chinese medicine according to claim 4, which is selected from the group consisting of water decoction and a product prepared by concentrating the water decoction.
  6. 6. Use of the traditional Chinese medicine composition according to any one of claims 1-3 or the traditional Chinese medicine extract according to claim 4 or 5 for preparing a medicament for treating pneumonia.
  7. 7. The use according to claim 6, wherein the pneumonia is klebsiella-caused pneumonia or acute lung injury.
  8. 8. The use of claim 6, wherein the pneumonia is community-acquired pneumonia phlegm-heat obstructing the lung.
  9. 9. A medicament for treating pneumonia, comprising the traditional Chinese medicine extract of claim 4 or 5.

Description

Traditional Chinese medicine composition for treating pneumonia Technical Field The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating pneumonia. Background Pneumonia is still one of the leading causes of global hospitalization and death, and is the fourth leading risk of death worldwide. The infected population is distributed in all ages, and the pneumonia is counted to cause 75 to 120 thousands of neonatal deaths each year, accounting for 10% of the global childhood mortality rate. Pneumonia is manifested as acute lower respiratory tract infection, typical symptoms are fever, cough, expectoration, pleurisy, dyspnea and the like, and the occurrence of pneumonia complications and repeated infection after discharge are important reasons for influencing prognosis. Acute lung injury and its severe form acute respiratory distress syndrome are the most prominent pathological lesions and severe complications of pneumonia, and the excessive inflammatory response induced by the causative agent of pneumonia and its toxins is the core mechanism responsible for acute lung injury. From the aspect of the infection acquisition mode of patients, the pneumonia is divided into community-acquired pneumonia and hospital-acquired pneumonia, and infection strains of the pneumonia have a certain difference. Among them, klebsiella pneumoniae is the most common pathogen in community-infected groups. Lipopolysaccharide is a critical toxic component of the pathogenesis of gram-negative bacteria (such as klebsiella pneumoniae), and its induced acute lung injury is a critical pathological link of pneumonia. At present, anti-infection treatment and prevention of complications are mainly used in the treatment of pneumonia, penicillin and cephalosporin are main medicines for treating bacterial pneumonia, and problems of increased pathogen resistance rate, increased drug-resistant strains, strain variation and the like are increasingly prominent due to abuse of antibiotic medicines, so that the risk of mortality of patients suffering from pneumonia is greatly increased. A large number of researches show that the traditional Chinese medicine has positive effects on reducing the expression of inflammatory mediators in lung, improving immunity, improving pulmonary ventilation function and hemodynamic disorder, relieving the degree of lung infection, relieving clinical symptoms, promoting recovery of complications and the like, has obvious curative effect and has great advantages in clinical treatment. Disclosure of Invention The theory of traditional Chinese medicine holds that exogenous pathogenic factors attack and pathological product accumulation cause deficiency of healthy qi and internal deficiency, and weak resistance to pathogenic factors. Wind-heat invasion of the lung through the mouth and nose or pathogenic wind-cold invasion of the interior to transform heat, phlegm-fluid being produced, phlegm-heat obstructing the lung "is the main pathogenesis of pneumonia, and in clinical practice, the syndrome of phlegm-heat obstructing the lung is the main common condition. Aiming at the pathogenesis of the pneumonia, based on the traditional Chinese medicine theory, the inventor provides a traditional Chinese medicine composition (also called lung heat clearing prescription, and the following is the same) for treating the pneumonia, wherein the traditional Chinese medicine composition comprises, by weight, 7.2-10.8 parts of radix scutellariae, 12.0-18.0 parts of fructus trichosanthis, 9.6-14.4 parts of fructus forsythiae, 7.2-10.8 parts of fritillaria thunbergii, 7.2-10.8 parts of rhizoma pinelliae preparata, 7.2-10.8 parts of radix peucedani, 9.6-14.4 parts of radix pulsatillae, 9.6-14.4 parts of radix salviae miltiorrhizae, 4.8-7.2 parts of ginseng, 7.2-10.8 parts of radix ophiopogonis, 9.6-14.4 parts of pericarpium citri reticulatae and 7.2-10.8 parts of radix platycodi. Particularly, the traditional Chinese medicine raw materials of the traditional Chinese medicine composition comprise, by weight, 8.1-9.9 parts of radix scutellariae, 13.5-16.5 parts of fructus trichosanthis, 10.8-13.2 parts of fructus forsythiae, 8.1-9.9 parts of fritillaria thunbergii, 8.1-9.9 parts of purified pinellia ternate, 8.1-9.9 parts of radix peucedani, 10.8-13.2 parts of pulsatillae, 10.8-13.2 parts of radix salviae miltiorrhizae, 5.4-6.6 parts of ginseng, 8.1-9.9 parts of radix ophiopogonis, 10.8-13.2 parts of pericarpium citri reticulatae and 8.1-9.9 parts of radix platycodi. More particularly, the traditional Chinese medicine composition comprises, by weight, 9 parts of baikal skullcap root, 15 parts of snakegourd fruit, 12 parts of weeping forsythiae capsule, 9 parts of thunberg fritillary bulb, 9 parts of purified pinellia tuber, 9 parts of peucedanum root, 12 parts of Chinese pulsatilla root, 12 parts of red sage root, 6 parts of ginseng, 9 parts of dwarf lily