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CN-121987720-A - A Chinese medicinal concentrated pill for treating cardiovascular and cerebrovascular diseases, and its preparation method

CN121987720ACN 121987720 ACN121987720 ACN 121987720ACN-121987720-A

Abstract

The invention relates to a Chinese medicinal concentrated pill and its preparation technical field, more specifically, the invention discloses a Chinese medicinal concentrated pill for treating cardiovascular and cerebrovascular diseases and its preparation method, the Chinese medicinal concentrated pill is prepared from raw materials such as radix astragali, radix Ginseng under forest, radix Ophiopogonis, fructus Schisandrae chinensis, radix Paeoniae Rubra, semen Persicae, cortex moutan, radix Angelicae sinensis, poria, rhizoma Chuanxiong, stigma croci Sativi, radix Salviae Miltiorrhizae and radix Notoginseng by mixing according to weight portion, wherein radix astragali, radix Salviae Miltiorrhizae and radix Ginseng under forest are prepared into standard fermented Chinese medicinal powder by micro-fermentation process combined with modern times through ancient method; the rest raw materials are subjected to low-temperature full wall breaking superfine grinding to obtain superfine powder. The invention realizes more complete release of active ingredients, more stable absorption, better consistency among batches, more convenient administration and better storage stability through the cooperation of low-temperature wall breaking superfine grinding, controllable micro-fermentation and solid dispersion slow-release molding.

Inventors

  • HUANG LIKUN
  • Feng Sheliang
  • ZHANG TING
  • FENG YIFAN
  • MA HONGLING
  • ZHANG GUOCHAO
  • ZHANG RUIJUN

Assignees

  • 北京九正堂健康科技发展有限公司

Dates

Publication Date
20260508
Application Date
20260408

Claims (9)

  1. 1. A traditional Chinese medicine concentrated pill for treating cardiovascular and cerebrovascular diseases is characterized by comprising the following raw material components in parts by weight: 5-10 parts of radix astragali, 1-2 parts of ginseng under forest, 10-30 parts of dwarf lilyturf tuber, 2-6 parts of schisandra chinensis, 6-15 parts of red paeony root, 5-10 parts of peach seed, 5-10 parts of cortex moutan, 10-20 parts of Chinese angelica, 10-30 parts of poria cocos, 5-10 parts of szechuan lovage rhizome, 3-5 parts of saffron, 30-60 parts of white flower red sage root and 6-8 parts of pseudo-ginseng; The preparation method comprises the steps of respectively treating radix astragali, radix salviae miltiorrhizae and ginseng under forest by a micro-fermentation process combined with the modern technology by an ancient method to obtain corresponding fermented traditional Chinese medicine powder, mixing the fermented traditional Chinese medicine powder with other raw material powder, shaping and uniformly distributing medicine particles in a water-soluble sustained and controlled release carrier by adopting a solid dispersion sustained release technology, and finally preparing the traditional Chinese medicine concentrated pill.
  2. 2. The concentrated Chinese medicinal pill for treating cardiovascular and cerebrovascular diseases according to claim 1, wherein the concentrated Chinese medicinal pill is a watered pill, and the diameter of a single pill is 2 mm-4 mm.
  3. 3. The concentrated Chinese medicinal pill for treating cardiovascular and cerebrovascular diseases according to claim 1, wherein the water content of the dried and solidified concentrated Chinese medicinal pill is less than or equal to 9%.
  4. 4. The concentrated Chinese medicinal pill for treating cardiovascular and cerebrovascular diseases according to claim 1, wherein the micro-fermentation process comprises inoculating strain into the raw material powder of radix astragali, radix Salviae Miltiorrhizae, and radix Ginseng, and adjusting fermentation environment parameters, fermenting at 30-37deg.C for 24-72 h, controlling humidity at 50-60% and pH at 4.5-6.5, stirring, ventilating, and monitoring pH, bacterial count and effective component change.
  5. 5. The concentrated pill for treating cardiovascular and cerebrovascular diseases according to claim 4, wherein the strain used in the micro-fermentation process is CF-37 strain.
  6. 6. The concentrated Chinese medicinal pill for treating cardiovascular and cerebrovascular diseases according to claim 4 or 5, wherein the micro-fermentation process further comprises drying the fermentation product at 40-50deg.C, pulverizing again, and sieving to obtain standard fermented Chinese medicinal powder, wherein the number of the sieved sieve is 80-100 mesh.
  7. 7. The concentrated pill of claim 1, wherein at least part of the raw materials are subjected to full wall-breaking superfine grinding, the full wall-breaking superfine grinding is carried out at-50 ℃ and the low temperature is adopted, so that the average particle size of the obtained superfine powder is 2.5-5 mu m, and the cell wall breaking rate is more than or equal to 99%.
  8. 8. The method for preparing the concentrated Chinese medicinal pill for treating cardiovascular and cerebrovascular diseases according to any one of claims 1 to 7, which is characterized by comprising the following steps: s1, raw material pretreatment, namely removing impurities from all raw material medicines, drying, crushing and mixing for later use; S2, performing wall-breaking superfine grinding, namely performing low-temperature Quan Pobi superfine grinding on each raw material medicinal material to obtain medicinal material superfine powder; S3, micro-fermentation milling, namely adding a fermentation substrate into superfine powder of radix astragali, white flower red sage root and ginseng under forest, inoculating strains, controlling humidity, pH and temperature, performing controllable fermentation, drying at low temperature after fermentation is finished, and secondarily pulverizing and sieving to obtain standard fermented traditional Chinese medicine powder; s4, slow release of the solid dispersion, namely mixing standard fermented traditional Chinese medicine powder with superfine powder of other raw materials, and introducing a water-soluble slow-release carrier to form a solid dispersion system; s5, pill forming and drying, namely preparing soft materials by taking purified water as an adhesive, preparing pills, drying and solidifying to obtain the traditional Chinese medicine concentrated pill.
  9. 9. The method of claim 8, wherein the single pill of the Chinese medicinal concentrated pill prepared in the step S5 has a diameter of 2 mm-4 mm, is dried at 40-60 ℃ until the water content is less than or equal to 9%, and is subjected to pill-sorting, pill weight difference, disintegration time and microorganism limit detection, and is packaged and put in storage after being qualified.

Description

A Chinese medicinal concentrated pill for treating cardiovascular and cerebrovascular diseases, and its preparation method Technical Field The invention relates to the technical field of traditional Chinese medicine concentrated pills and preparation thereof, in particular to a traditional Chinese medicine concentrated pill for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background The cardiovascular and cerebrovascular diseases have the characteristics of long disease course, high recurrence rate, long-term intervention requirement and the like. The traditional Chinese medicine has application foundation in the aspects of supplementing qi and nourishing yin, promoting blood circulation and removing blood stasis, and the like, and various traditional Chinese medicine pills/concentrated pill preparations exist on the market. However, the prior art still has the following disadvantages in terms of "formulation synergy, process control, dissolution absorption and dosing compliance", inter-batch consistency, etc: in the prior art, the conventional crushing or extraction and concentration is generally adopted for pelleting, the cell wall of the medicinal material is insufficiently crushed, the particle size distribution of the powder is wider, and the release and dissolution rates of the active ingredients are limited, so that the problems of slow effect taking, low absorption and utilization rate, large dosage and the like occur. The concentrated pill in the prior art adopts the traditional watered pill and honeyed pill processes, and is easy to be treated at higher temperature or for longer time in the links of concentration, drying and the like, so that partial heat sensitivity, volatility or easily oxidized components are lost, and the stability of the drug effect and consistency among batches are affected. In the prior art, although a scheme for treating traditional Chinese medicinal materials by fermentation exists, a controllable micro-fermentation parameter system (such as temperature, humidity, pH, duration, ventilation stirring, monitoring indexes and the like) aiming at specific medicinal materials is often lacking, the fermentation process is easily influenced by environmental fluctuation, even the risk of mixed bacteria exists, so that the fermentation conversion is unstable, and the fluctuation of the content of active ingredients is large. In the prior art, the fermentation treatment and the preparation sustained-release are usually split, even if fermentation is carried out, the fermentation treatment and the preparation sustained-release are molded in a conventional powder mixing and pelleting mode, and even the uniform dispersion and sustained-release control of a fermentation product and other powder in a carrier are difficult to realize, so that the problems of in vivo exposure fluctuation, high administration frequency, gastrointestinal irritation and the like occur. When the existing pill is not fine in particle size, pill weight, water content and drying and curing, the problems of adhesion, cracking, uneven hardness, inconsistent disintegration, increased microbial risk and the like are easy to occur, so that the storage stability and clinical use experience are affected. Therefore, a traditional Chinese medicine concentrated pill which can realize more sufficient release of active ingredients, more stable absorption, more consistent quality and more convenient administration by further realizing low-temperature full-wall-breaking superfine grinding, controllable micro-fermentation of specific medicinal materials and slow-release forming of solid dispersion on the basis of a formula and a preparation method thereof are needed. Disclosure of Invention In order to overcome the defects in the prior art, the embodiment of the invention provides a traditional Chinese medicine concentrated pill for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, so as to solve the problems in the prior art. The invention provides a traditional Chinese medicine concentrated pill for treating cardiovascular and cerebrovascular diseases, which comprises the following raw material components in parts by weight: 5-10 parts of radix astragali, 1-2 parts of ginseng under forest, 10-30 parts of dwarf lilyturf tuber, 2-6 parts of schisandra chinensis, 6-15 parts of red paeony root, 5-10 parts of peach seed, 5-10 parts of cortex moutan, 10-20 parts of Chinese angelica, 10-30 parts of poria cocos, 5-10 parts of szechuan lovage rhizome, 3-5 parts of saffron, 30-60 parts of white flower red sage root and 6-8 parts of pseudo-ginseng; The preparation method comprises the steps of respectively treating radix astragali, radix salviae miltiorrhizae and ginseng under forest by a micro-fermentation process combined with the modern technology by an ancient method to obtain corresponding fermented traditional Chinese medicine powder, mixing the ferment