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CN-121987724-A - Traditional Chinese medicine preparation, alkaline preparation, phospholipid-based drug-carrying preparation and preparation method

CN121987724ACN 121987724 ACN121987724 ACN 121987724ACN-121987724-A

Abstract

The invention relates to a traditional Chinese medicine preparation, an alkaline preparation, a medicine carrying preparation based on phospholipid and a preparation method thereof. The traditional Chinese medicine preparation comprises 3-5 parts of anoectochilus formosanus, 3-5 parts of prepared rehmannia root, 10-15 parts of Korean ginseng, 1-3 parts of angelica keiskei koidzumi, 5-10 parts of cornus officinalis, 5-10 parts of rose, 7-12 parts of ganoderma lucidum, 3-5 parts of poria cocos, 3-5 parts of rhizoma alismatis, 7-10 parts of dendrobium, 70-100 parts of sodium hydroxide and 5-15 parts of egg white. The traditional Chinese medicine preparation based on phospholipid compound medicine carrying technology comprises, by weight, 3-5 parts of anoectochilus formosanus, 3-5 parts of prepared rehmannia root, 10-15 parts of Korean ginseng, 1-3 parts of angelica keiskei koidzumi, 5-10 parts of cornus officinalis, and 70-100 parts of sodium hydroxide, wherein the phospholipid compound is formed by a traditional Chinese medicine extract and phospholipid according to a mass ratio of 0.5-2:1, the particle size of the compound is 100-500 nm, the osmotic pressure of the traditional Chinese medicine preparation is 280-310 mOsm/L, and the pH value is 4.5-10.

Inventors

  • ZHANG QINGZHU

Assignees

  • 中国中医药发展研究院有限公司

Dates

Publication Date
20260508
Application Date
20250617

Claims (13)

  1. 1. The traditional Chinese medicine preparation is characterized by comprising, by weight, 3-5 parts of anoectochilus formosanus, 3-5 parts of prepared rehmannia root, 10-15 parts of Korean ginseng, 1-3 parts of angelica keiskei, 5-10 parts of cornus officinalis, 5-10 parts of rose, 7-12 parts of lucid ganoderma, 3-5 parts of poria cocos, 3-5 parts of rhizoma alismatis, 7-10 parts of dendrobium nobile, 70-100 parts of sodium hydroxide and 5-15 parts of animal egg white.
  2. 2. The traditional Chinese medicine preparation according to claim 1, further comprising 1-3 parts of platycodon grandiflorum and 3-5 parts of fritillaria thunbergii, wherein platycodin promotes the deposition of medicines in respiratory tracts, and fritillaria thunbergii alkaloids synergistically enhance phlegm-resolving and anti-inflammatory effects.
  3. 3. A method for preparing the Chinese medicinal preparation according to claim 1, comprising the following steps: ⑴ The fermentation treatment, namely, soaking and grinding the raw materials into powder, adding 70-100 parts of sodium hydroxide and 5-15 parts of animal egg white by weight of the raw materials, and hermetically fermenting for more than or equal to 3 days, wherein the addition amount of the animal egg white is 20-30 parts by weight of the raw materials, the animal egg white provides protease for assisting in degrading macromolecular components, and the macromolecular components are degraded into micromolecular active fragments with molecular weight less than or equal to 5kDa through microbial fermentation; ⑵ Step of graded filtration, namely adding sodium hydroxide into fermentation liquor, standing, and sequentially carrying out graded filtration through a G1-G6 sand core funnel with the aperture gradually of 16-30 mu m; ⑶ The preparation is adapted by adding distilled water into the filtrate to adjust the pH value to 4.5-14.0; ⑷ Is prepared into a traditional Chinese medicine preparation.
  4. 4. A Chinese medicinal preparation according to any one of claims 1 to 3, wherein the Chinese medicinal preparation is in any one of the pharmaceutically acceptable dosage forms.
  5. 5. A traditional Chinese medicine preparation based on phospholipid complex drug loading is characterized by being prepared from the following raw materials in parts by weight through a phospholipid complex drug loading technology: 3-5 parts of anoectochilus formosanus, 3-5 parts of prepared rehmannia root, 10-15 parts of Korean ginseng, 1-3 parts of angelica keiskei, 5-10 parts of cornus officinalis and 70-100 parts of sodium hydroxide; The phospholipid complex is formed by a traditional Chinese medicine extract and phospholipid according to a mass ratio of 0.5-2:1, and the particle size of the complex is 100-500 nm; the osmotic pressure of the traditional Chinese medicine preparation is 280-310 mOsm/L, and the pH value is 4.5-10.
  6. 6. The traditional Chinese medicine preparation based on phospholipid complex drug delivery according to claim 5, wherein the phospholipid is hydrogenated soybean phospholipid with a phase transition temperature of 50 ℃ or more, and further comprises platycodin-phospholipid complex.
  7. 7. A method for preparing the traditional Chinese medicine preparation based on phospholipid complex drug delivery according to claim 5, which is characterized by comprising the following steps: ⑴ Extracting active ingredients by supercritical CO 2 under the pressure of 25-35 MPa and the temperature of 40-50 ℃; ⑵ The phospholipid complex is formed by reacting the extract, the soybean phospholipid and the sodium hydroxide for 2 hours according to the mass ratio of 1:1:8; ⑶ Nanocrystallization, namely circulating for 3 times under 150MPa by a micro-jet homogenizer to obtain a nanosuspension with an average particle size of 200 nm; ⑷ And (3) isotonic regulation, namely adding distilled water to regulate the osmotic pressure to 290+/-5 mOsm/L, and preparing the traditional Chinese medicine preparation.
  8. 8. The method for preparing a phospholipid complex drug loaded Chinese medicinal preparation according to claim 7, wherein sodium hydroxide is added as an acid-base balance regulator in the step ⑵.
  9. 9. The Chinese medicinal preparation according to any one of claims 5 to 8, wherein the Chinese medicinal preparation is any one of pharmaceutically acceptable dosage forms.
  10. 10. The preparation method of the traditional Chinese medicine preparation is characterized by comprising the following steps: ⑴ Adding 10-20 parts of animal egg white and 3-5 parts of ganoderma lucidum into 70-100 parts of high-purity liquid caustic soda, and standing for several days, wherein the high-purity liquid caustic soda is formed by adding distilled water into high-purity sodium hydroxide; ⑵ Fermenting, namely fermenting and converting macromolecular components by utilizing animal egg white and microorganisms of a protein carrier to enhance permeability; ⑶ Filtering, namely, removing impurities from a G1-G6 sand core funnel with the aperture of 16-30 mu m and retaining small molecular active ingredients, wherein the molecular weight of the preparation is less than 500Da and is qualified; ⑷ Bottling the filtered medicine to obtain injection medicine; ⑸ The pH value of the injection medicament is adjusted to be 4.5-10 by distilled water, and the adjusted injection medicament is used together with glucose water.
  11. 11. The method for preparing the Chinese medicinal preparation according to claim 10, wherein the Chinese medicinal preparation is any one of the dosage forms in pharmacy.
  12. 12. The preparation method of the alkaline preparation for regulating the acid-base balance of the body is characterized by comprising the following steps: ⑴ Adding 10-20 parts of animal egg white into 70-90 parts of high-purity liquid caustic soda, wherein the high-purity liquid caustic soda consists of high-purity sodium hydroxide and distilled water, and standing for several days; ⑵ Fermenting, namely fermenting and converting macromolecular components by using animal egg white of a protein carrier and microorganisms to enhance permeability; ⑶ Filtering, namely, a G1-G6 sand core funnel, wherein the aperture of the funnel is 16-30 mu m, impurities are removed, and small molecular active ingredients are reserved, wherein the molecular weight of the preparation is less than 500Da and is qualified; ⑷ Making into liquid preparation.
  13. 13. The method for preparing an alkaline preparation for regulating acid-base balance of human body according to claim 12, wherein said liquid medicament is any one of the dosage forms.

Description

Traditional Chinese medicine preparation, alkaline preparation, phospholipid-based drug-carrying preparation and preparation method Technical Field The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine preparation, a traditional Chinese medicine preparation based on phospholipid complex drug loading, an alkaline preparation for regulating body acid-base balance and a preparation method thereof. Background Some diseases caused by bad life style of modern people are shown by data, which are all caused by acidic physique, such as sub-health, joint and muscle problems, skin problems, digestive system and immune system problems, endocrine and metabolic disorders, male impotence, female hormonal disorders, cardiovascular diseases, and major diseases such as cancer, diabetes and hypertension. In western medicine of the prior art, the problems of neglecting the acid-base balance of the body, treating the symptoms and the root cause, drug resistance, toxic and side effects and the like, cancer metastasis and recurrence and the like still exist in treating chronic diseases (such as diabetes and hypertension), neglecting where the diseases come from and paying attention to how to treat the diseases. Most of the western medicines for treating chronic diseases only depend on hormone therapy, and the hormone therapy can only control symptoms, and cannot radically treat chronic respiratory tract inflammation (such as sphagitis, chronic obstructive pulmonary disease, lung bulla and asthma), the traditional Chinese medicine preparation is difficult to penetrate through respiratory tract mucous membrane barriers, has low bioavailability, and is large in atomized liquid irritation and easy to cause airway spasm. The hormone atomization only inhibits inflammatory reaction, but cannot regulate the pathogenesis of 'spleen-kidney yang deficiency'. The conversion rate of active ingredients in the enzymolysis process in the prior art is less than or equal to 35.2mg/g flavone), and the atomized residues are higher than 12%. Disclosure of Invention The invention aims to provide a traditional Chinese medicine atomization preparation for treating full-respiratory tract inflammation, which is capable of enabling alkaline solution to enter a human body, regulating acid-base balance, achieving the purpose of curing diseases and relieving people, and is inhaled for administration, wherein the medicine is atomized into the pharynx, is rapidly absorbed into blood through abundant capillaries in the lung, has rapid onset of action, realizes cooperative treatment of full-respiratory tract (nose, pharynx and lung) inflammation, breaks through a permeable barrier of medicine components, and reduces irritation of atomized liquid to the airway. The first technical scheme is that the traditional Chinese medicine preparation is characterized by comprising, by weight, 3-5 parts of anoectochilus formosanus, 3-5 parts of prepared rehmannia root, 10-15 parts of Korean ginseng, 1-3 parts of angelica keiskei, 5-10 parts of cornus officinalis, 5-10 parts of rose, 7-12 parts of ganoderma lucidum, 3-5 parts of poria cocos, 3-5 parts of rhizoma alismatis, 7-10 parts of dendrobium nobile, 70-100 parts of sodium hydroxide and 5-15 parts of animal egg white. The medicine also comprises 1-3 parts of platycodon grandiflorum and 3-5 parts of fritillary bulb, wherein platycodin promotes the medicine to be deposited on the respiratory tract, and fritillary bulb alkaloids synergistically enhance the phlegm-resolving and anti-inflammatory effects. The second technical proposal of the invention is a preparation method of the traditional Chinese medicine preparation, which is characterized by comprising the following steps: ⑴ The fermentation treatment, namely, soaking and grinding the raw materials into powder, adding 70-100 parts of sodium hydroxide and 5-15 parts of animal egg white by weight of the raw materials, and hermetically fermenting for more than or equal to 3 days, wherein the addition amount of the animal egg white is 20-30 parts by weight of the raw materials, the animal egg white provides protease for assisting in degrading macromolecular components, and the macromolecular components are degraded into micromolecular active fragments with molecular weight less than or equal to 5kDa through microbial fermentation; ⑵ Step of graded filtration, namely adding sodium hydroxide into fermentation liquor, standing, and sequentially carrying out graded filtration through a G1-G6 sand core funnel with the aperture gradually of 16-30 mu m; ⑶ The preparation is adapted by adding distilled water into the filtrate to adjust the pH value to 4.5-14.0; ⑷ Is prepared into a traditional Chinese medicine preparation. Preferably, the Chinese medicinal preparation is any one of the dosage forms in pharmacy. The Chinese medicinal preparation is any one of the dosage forms in pharmacy