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CN-121987726-A - Composition for improving coronary blood supply and increasing heart contractility

CN121987726ACN 121987726 ACN121987726 ACN 121987726ACN-121987726-A

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and provides a composition for improving coronary blood supply and increasing heart contractility, which comprises, by weight, 15-20 parts of rhizoma polygonati, 10-15 parts of radix astragali, 5-15 parts of rhizoma polygonati officinalis, 5-10 parts of raspberry, 6-10 parts of dendrobium candidum, 4-8 parts of radix polygonati officinalis, 5-15 parts of poria cocos and 3-5 parts of lotus seeds. By the technical scheme, the problem that the traditional Chinese medicine composition in the related technology is relatively poor in effect in improving coronary blood supply and increasing heart contractility is solved.

Inventors

  • YANG GUANG
  • WANG WENMING
  • GAO CAISHENG
  • TAO JUN
  • YU WENJUAN
  • ZHANG LINGZHAN
  • ZHANG JUNLONG

Assignees

  • 河北肽都生物科技集团有限公司

Dates

Publication Date
20260508
Application Date
20260331

Claims (10)

  1. 1. A composition for improving coronary blood supply and increasing heart contractility, comprising the following components in parts by weight: 15-20 parts of rhizoma polygonati, 10-15 parts of astragalus, 5-15 parts of rhizoma polygonati officinalis, 5-10 parts of raspberry, 6-10 parts of dendrobium candidum, 4-8 parts of radix polygonati officinalis, 5-15 parts of poria cocos and 3-5 parts of lotus seeds.
  2. 2. A method for preparing a composition having the function of improving coronary blood supply and increasing heart contractility, for preparing a composition having the function of improving coronary blood supply and increasing heart contractility according to claim 1, comprising the steps of: s0, blending poria cocos and a solvent, leaching, separating to obtain a filtrate, blending the filtrate with water, extracting, separating to obtain an extracting solution, concentrating the extracting solution to 35% -45% of the original volume to obtain a concentrated solution, adding the concentrated solution into a double-aqueous-phase extraction system, stirring, standing and separating to obtain a lower-phase solution, adding absolute ethyl alcohol into the lower-phase solution, uniformly mixing, standing, separating to obtain a supernatant, concentrating the supernatant, and drying to obtain a pachyman extract; s1, blending and crushing components except poria cocos to obtain a traditional Chinese medicine mixture; S2, mixing the traditional Chinese medicine mixture with water, decocting, filtering to obtain filtrate, concentrating the filtrate, and drying to obtain a premixed traditional Chinese medicine extract; S3, mixing the premixed traditional Chinese medicine extract, the pachyman extract and water, and decocting to obtain the composition with the effects of improving coronary blood supply and increasing heart contractility; in step S0, the solvent includes absolute ethanol; The aqueous two-phase extractant in the aqueous two-phase extraction system comprises an aqueous hydroxypropyl methyl cellulose solution and an aqueous potassium sodium tartrate solution.
  3. 3. The method for preparing the composition for improving coronary blood supply and increasing heart contractility according to claim 2, wherein the mass fraction of the hydroxypropyl methylcellulose aqueous solution is 14% -16%, and the mass fraction of the potassium sodium tartrate aqueous solution is 18% -20%.
  4. 4. The method for preparing the composition for improving coronary blood supply and increasing heart contractility according to claim 2, wherein the volume ratio of the aqueous solution of potassium sodium tartrate to the aqueous solution of hydroxypropyl methylcellulose is 1-1.5:1.
  5. 5. The method for preparing a composition for improving coronary blood supply and increasing heart contractility according to claim 2, wherein the adding amount of the aqueous two-phase extractant is 5-8 times of the volume of the concentrated solution.
  6. 6. The method for preparing a composition for improving coronary blood supply and increasing heart contractility according to claim 2, wherein in step S0, the solvent further comprises sec-butyl acetate; The volume ratio of the ethanol to the sec-butyl acetate is 4-9:1.
  7. 7. The method of claim 6, wherein in step S0, the mass to volume ratio of the Poria to the solvent is 2 g:50-70 ml; and during leaching, the temperature is 45-55 ℃ and the time is 3-4 hours.
  8. 8. The method for preparing a composition for improving coronary blood supply and increasing heart contractility according to claim 2, wherein in step S0, the extraction is reflux extraction for 2-3 times, each time for 1-2 hours; the adding amount of the water is 6-8 times of the filtering material.
  9. 9. The method for preparing a composition for improving coronary blood supply and increasing heart contractility according to claim 2, wherein in step S0, the stirring time is 10-15 min; and when absolute ethyl alcohol is added into the lower phase solution, the addition amount of the absolute ethyl alcohol is 6-8 times of the volume of the lower phase solution.
  10. 10. Use of a composition having an effect of improving coronary blood supply and increasing heart contractility according to claim 1 or a composition prepared by the preparation method of claims 2 to 9 for improving coronary blood supply and increasing heart contractility.

Description

Composition for improving coronary blood supply and increasing heart contractility Technical Field The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a composition for improving coronary blood supply and increasing heart contractility. Background Cardiovascular disease is one of the major diseases that severely threatens human health, with coronary heart disease being particularly common. The main pathological basis of the disease is atherosclerosis of coronary arteries, which causes stenosis or blockage of blood vessel cavities, and further causes myocardial ischemia, hypoxia and even necrosis, and the life quality and the life span of patients are seriously affected. At present, clinical treatment means of coronary heart disease and cardiac insufficiency mainly comprise drug treatment, surgery and the like. In the aspect of drug treatment, nitrate, beta-receptor blocker, calcium channel blocker and antiplatelet drug can relieve symptoms to a certain extent, but drug resistance and adverse reaction are easy to cause after long-term use. While the surgery can effectively improve coronary blood supply, the problems of large trauma, high cost, limited applicable people and the like exist. In recent years, the traditional Chinese medicine has obvious potential in improving coronary blood supply, enhancing myocardial contractility and regulating cardiac function due to the multi-component and multi-target action characteristics. Wherein, the poria cocos is taken as a common traditional Chinese medicine, and the active ingredient pachyman extract of the poria cocos can inhibit excessive activation of myocardial fibroblasts and reduce abnormal deposition of collagen fibers, so that the poria cocos plays a positive role in improving coronary blood supply and enhancing heart contraction function. However, the prior pachyman has poor extraction effect and large loss of active ingredients, so that the application of the pachyman in compound preparations is limited, and meanwhile, the conventional common traditional Chinese medicine composition has the problem that the compatibility is to be improved, and the effects of improving coronary blood supply and increasing heart contractility are to be improved. Therefore, a traditional Chinese medicine component with synergistic effect is provided, and reasonable compatibility can be realized, so that the traditional Chinese medicine component has important significance for effectively treating diseases in cardiovascular and other aspects and improving the health level of people. Disclosure of Invention The invention provides a composition for improving coronary blood supply and increasing heart contractility, which solves the problem that the traditional Chinese medicine composition in the related art has relatively poor effect in improving coronary blood supply and increasing heart contractility. The technical scheme of the invention is as follows: The invention provides a composition for improving coronary blood supply and increasing heart contractility, which comprises the following components in parts by weight: 15-20 parts of rhizoma polygonati, 10-15 parts of astragalus, 5-15 parts of rhizoma polygonati officinalis, 5-10 parts of raspberry, 6-10 parts of dendrobium candidum, 4-8 parts of radix polygonati officinalis, 5-15 parts of poria cocos and 3-5 parts of lotus seeds; As a further technical scheme, a method for preparing a composition with the function of improving coronary blood supply and increasing heart contractility, which is used for preparing the composition with the function of improving coronary blood supply and increasing heart contractility according to claim 1, is characterized by comprising the following steps: s0, blending poria cocos and a solvent, leaching, separating to obtain a filtrate, blending the filtrate with water, extracting, separating to obtain an extracting solution, concentrating the extracting solution to 35% -45% of the original volume to obtain a concentrated solution, adding the concentrated solution into a double-aqueous-phase extraction system, stirring, standing and separating to obtain a lower-phase solution, adding absolute ethyl alcohol into the lower-phase solution, uniformly mixing, standing, separating to obtain a supernatant, concentrating the supernatant, and drying to obtain a pachyman extract; s1, blending and crushing components except poria cocos to obtain a traditional Chinese medicine mixture; S2, mixing the traditional Chinese medicine mixture with water, decocting, filtering to obtain filtrate, concentrating the filtrate, and drying to obtain a premixed traditional Chinese medicine extract; S3, mixing the premixed traditional Chinese medicine extract, the pachyman extract and water, and decocting to obtain the composition with the effects of improving coronary blood supply and increasing heart contractility; in step S0, the solvent includes absolute ethano