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CN-121987728-A - Traditional Chinese medicine composition capable of reducing blood pressure, blood lipid and blood sugar and application

CN121987728ACN 121987728 ACN121987728 ACN 121987728ACN-121987728-A

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition capable of reducing blood pressure, blood fat and blood sugar and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines, by weight, 10-20 parts of red ginseng, 10-20 parts of raw white atractylodes rhizome, 20-40 parts of poria cocos, 20-40 parts of radix rehmanniae, 20-40 parts of radix scrophulariae, 20-40 parts of medlar, 10-20 parts of rhizoma anemarrhenae, 10-20 parts of radix trichosanthis, 20-40 parts of ligusticum wallichii, 10-20 parts of gastrodia elata, 10-20 parts of uncaria, 10-20 parts of salvia miltiorrhiza, 5-15 parts of raw liquorice and 5-15 parts of pseudo-ginseng; the invention is based on the traditional Chinese medicine composition, prepares the medicine particles, has the function of reducing blood pressure, blood fat and blood sugar, breaks through the limitation of single index regulation of the existing medicine, follows the compatibility principle of the traditional Chinese medicine, is prepared by phase-making of the medicines, solves the problems of unbalanced compatibility, easy initiation of spleen and stomach discomfort and the like of part of traditional prescription, has small adverse reaction after long-term administration and is applicable to wider crowds.

Inventors

  • LV YANG

Assignees

  • 吕杨

Dates

Publication Date
20260508
Application Date
20260402

Claims (9)

  1. 1. The traditional Chinese medicine composition capable of reducing blood pressure, blood lipid and blood sugar is characterized by being prepared from the following raw material medicines, by weight, 10-20 parts of red ginseng, 10-20 parts of raw white atractylodes rhizome, 20-40 parts of poria cocos, 20-40 parts of radix rehmanniae, 20-40 parts of radix scrophulariae, 20-40 parts of wolfberry fruit, 10-20 parts of rhizoma anemarrhenae, 10-20 parts of radix trichosanthis, 20-40 parts of ligusticum wallichii, 10-20 parts of rhizoma gastrodiae, 10-20 parts of uncaria, 10-20 parts of radix salviae miltiorrhizae, 5-15 parts of raw liquorice and 5-15 parts of pseudo-ginseng, wherein the pseudo-ginseng is independently prepared into fine powder, and the rest raw material medicines are raw materials for water decoction.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials, by weight, 15 parts of red ginseng, 15 parts of raw bighead atractylodes rhizome, 30 parts of poria cocos, 30 parts of raw rehmannia, 30 parts of radix scrophulariae, 30 parts of wolfberry fruit, 15 parts of rhizoma anemarrhenae, 15 parts of radix trichosanthis, 30 parts of ligusticum wallichii, 15 parts of gastrodia elata, 15 parts of uncaria, 15 parts of red sage root, 10 parts of raw licorice root and 10 parts of pseudo-ginseng.
  3. 3. A method of preparing a Chinese medicinal composition according to any one of claims 1-2, comprising the steps of: S1, preparing materials: weighing red ginseng, raw bighead atractylodes rhizome, poria cocos, raw rehmannia root, radix scrophulariae, medlar, rhizoma anemarrhenae, radix trichosanthis, ligusticum wallichii, rhizoma gastrodiae, uncaria, radix salviae miltiorrhizae and raw liquorice according to parts by weight, mixing and crushing into coarse powder to obtain mixed medicinal powder; S2, extracting with water: Decocting the mixed medicinal powder of the S1 with water twice, adding 8-12 times of water for soaking for 30-60 min for 1.5-2 h, adding 6-8 times of water for 1-1.5 h for the second time, mixing the two decoctions, standing for 12-24 h, and taking a supernatant; s3, concentrating: Concentrating the supernatant of the S2 under reduced pressure to obtain clear paste with the relative density of 1.10-1.20 at 60 ℃; s4, granulating, namely adding auxiliary materials into the clear paste of the S3, preparing a soft material, sieving, granulating, drying and finishing to obtain traditional Chinese medicine extract granules; And S5, mixing, namely uniformly mixing the traditional Chinese medicine extract particles of the step S4 with the pseudo-ginseng fine powder of the step S1.
  4. 4. The preparation method of the traditional Chinese medicine extract granule, according to claim 3, wherein in S4, sieving is performed to obtain wet granules through a 16-20-mesh sieve, drying is performed at 60-70 ℃ until the water content is less than or equal to 8.0%, the auxiliary materials are dextrin and stevioside, wherein the dextrin is 1-2 times of the dry paste weight of the ointment, and the stevioside is 0.1% -0.3% of the total weight of the traditional Chinese medicine extract granule.
  5. 5. The method according to claim 3, wherein in S5, the obtained mixture is packaged in bags with a content of 5-10 g, wherein the content of the fine powder of pseudo-ginseng is 0.5-1.5 g.
  6. 6. The use of the Chinese medicinal composition according to claim 2 in preparing a medicament for treating primary hypertension with symptoms of liver-kidney yin deficiency, liver-yang hyperactivity and blood stasis.
  7. 7. The use of the Chinese medicinal composition according to claim 2 in preparing a medicament for treating type 2 diabetes mellitus with deficiency of both qi and yin and its complications, angina pectoris, terminal microvascular circulatory disorder or cataract.
  8. 8. The use of the Chinese medicinal composition according to claim 2 in preparing a medicament for treating spleen deficiency phlegm-dampness, blood stasis and collateral obstruction type hyperlipidemia.
  9. 9. Use of a traditional Chinese medicine composition according to claim 1 or 2 for preparing a medicament for assisting in stabilizing blood pressure, blood fat or blood sugar of a primary hypertension, hyperlipidemia or type 2 diabetes patient.

Description

Traditional Chinese medicine composition capable of reducing blood pressure, blood lipid and blood sugar and application Technical Field The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition capable of reducing blood pressure, blood lipid and blood sugar and application thereof. Background The incidence of primary hypertension, hyperlipidemia and type2 diabetes mellitus tends to rise year by year and younger, and the three frequently occur together, which is called as 'three highs', and becomes a main chronic disease threatening cardiovascular health of the national population. The disease course of three highs is prolonged, serious complications such as coronary heart disease, cerebral infarction, diabetic nephropathy, retinopathy and the like are easily caused by poor long-term control, the life quality of patients is reduced, and the burden of a medical system is increased, so that the research and development of safe and effective therapeutic drugs capable of achieving multi-target regulation and control has important clinical value and social significance. At present, the treatment of 'three highs' is mainly based on chemical medicines, but various western medicines can pertinently regulate and control blood pressure, blood fat or blood sugar, but have certain limitations, wherein single western medicine generally only has remarkable effect on one index, patients combining 'three highs' need to take multiple medicines in a combined way, the problem of poor medication compliance is easy to occur, adverse reactions such as gastrointestinal discomfort, liver and kidney function injury, hypotension and the like can be generated when part of western medicines are taken for a long time, and systemic symptoms such as dizziness, limb numbness, hypodynamia and the like caused by diseases of the patients are difficult to improve. The traditional Chinese medicine has the advantages of multiple targets, multiple ways and small adverse reaction in the treatment of chronic metabolic diseases by taking the principle of overall concept and dialectical treatment, and becomes an important supplement for the treatment of three highs. The traditional Chinese medicine prescription or the traditional Chinese medicine preparation is partially used for regulating and controlling blood pressure, blood fat and blood sugar, but most prescriptions are designed only aiming at single symptoms, and are difficult to consider the pathological characteristics of 'three highs' combined occurrence, and the prescriptions partially consider the multiple symptoms, have the problem of narrow adaptability of traditional Chinese medicine symptoms, fail to be attached to the common complex symptoms of liver-kidney yin deficiency, liver-yang hyperactivity, qi-yin deficiency, spleen deficiency and phlegm dampness, blood stasis and obstruction of collaterals and the like of patients suffering from the three highs in clinic, and meanwhile, the prescriptions of the traditional prescriptions are not fully combined with the modern traditional Chinese medicine pharmacological research results, and the combination degree of the medicinal materials with the modern pharmacological effects of reducing blood pressure, blood fat and blood sugar is insufficient, so that the stability of clinical curative effects is affected. Based on the defects of the prior art, the traditional Chinese medicine composition combines the traditional Chinese medicine classical theory and the modern traditional Chinese medicine pharmacological research results, screens the traditional Chinese medicines with the effects of tonifying qi and nourishing yin, suppressing hyperactive liver and subsiding yang, activating blood and dissolving stasis, and strengthening spleen and eliminating dampness aiming at the core traditional Chinese medicine syndrome and pathological mechanism of patients with high blood pressure, high blood lipid and low blood glucose, and the modern research proves that the traditional Chinese medicine composition with the functions of reducing blood pressure, blood lipid and blood glucose is prepared, and can be used for treating primary hypertension, hyperlipidemia and type 2 diabetes. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition capable of reducing blood pressure, blood lipid and blood sugar and application thereof, so as to solve the problems in the background technology. In order to achieve the above purpose, the present invention provides the following technical solutions: The traditional Chinese medicine composition capable of reducing blood pressure, blood lipid and blood sugar is prepared from the following raw materials, by weight, 10-20 parts of red ginseng, 10-20 parts of raw white atractylodes rhizome, 20-40 parts of poria cocos, 20-40 parts of radix rehmanniae, 20-40 parts of radix scrophulariae, 20-40 p