CN-121987730-A - Traditional Chinese medicine composition suitable for type II diabetes and preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition suitable for type II diabetes mellitus, and a preparation method and application thereof. The traditional Chinese medicine composition comprises, by weight, 30-45 parts of astragalus mongholicus, 20-30 parts of dendrobe, 30-45 parts of rhizoma polygonati, 20-30 parts of radix ophiopogonis and 20-30 parts of corn silk. The traditional Chinese medicine composition effectively regulates the sugar metabolism balance and improves insulin resistance through the synergistic effect of core components such as astragalus root for tonifying qi and yang, promoting the production of body fluid and nourishing blood, dendrobium nobile for tonifying stomach and promoting the production of body fluid, rhizoma polygonati for tonifying qi and nourishing yin, moistening lung and tonifying kidney, ophiopogon root for nourishing yin and promoting the production of body fluid and the like, thereby realizing the effect of reducing blood sugar and/or blood lipid.

Inventors

• HU AIHONG
• TANG BO
• TANG YUNDI
• Ruan Qiongyan
• SHI FENG

Assignees

• 上海市浦东新区光明中医医院

Dates

Publication Date

20260508

Application Date

20260320

Claims (10)

1. 1. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 30-45 parts of astragalus membranaceus, 20-30 parts of dendrobium nobile, 30-45 parts of rhizoma polygonati, 20-30 parts of radix ophiopogonis and 20-30 parts of corn silk.
2. 2. The method for preparing a traditional Chinese medicine composition according to claim 1, wherein 30-45 parts by weight of astragalus membranaceus, 20-30 parts by weight of dendrobium nobile, 30-45 parts by weight of rhizoma polygonati, 20-30 parts by weight of radix ophiopogonis and 20-30 parts by weight of corn silk are mixed to obtain the traditional Chinese medicine composition according to claim 1.
3. 3. An application of a Chinese medicinal composition in preparing medicine for lowering blood sugar and/or blood lipid is provided.
4. 4. The use of a traditional Chinese medicine composition according to claim 3, wherein the traditional Chinese medicine composition is used for preparing a medicament for reducing hyperglycemia and/or hyperlipidemia caused by type II diabetes.
5. 5. The use of the traditional Chinese medicine composition according to claim 4, wherein the type II diabetes is type II diabetes with qi and yin impairment.
6. 6. The use of the traditional Chinese medicine composition according to claim 4, wherein the use of the traditional Chinese medicine composition in the preparation of a medicament for reducing liver lipid accumulation of type II diabetes is provided.
7. 7. The use of the traditional Chinese medicine composition according to claim 4, wherein the traditional Chinese medicine composition is used for preparing a medicine for reducing fasting blood glucose level of type II diabetics.
8. 8. The use of the traditional Chinese medicine composition according to claim 4, wherein the use of the traditional Chinese medicine composition in preparing a medicament for regulating type II diabetes blood lipid metabolic disorder.
9. 9. The use of the traditional Chinese medicine composition according to claim 4, wherein the use of the traditional Chinese medicine composition in preparing a medicament for improving insulin resistance and repairing islet function of type II diabetes.
10. 10. The use of the traditional Chinese medicine composition according to claim 4, wherein the use of the traditional Chinese medicine composition in the preparation of a medicament for protecting pancreatic tissue of type II diabetes is provided.

Description

Traditional Chinese medicine composition suitable for type II diabetes and preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition suitable for type II diabetes mellitus, and a preparation method and application thereof. Background Diabetes Mellitus (DM) is an endocrine and metabolic disorder characterized by absolute or relative inadequate insulin secretion and/or reduced response of the body to insulin under the combined action of two major genetic and environmental factors, and is manifested as a persistent hyperglycemic state. Diabetes is the 3 rd disease following cardiovascular and cerebrovascular diseases and tumors, and is a public problem that impairs human health. Currently, diabetes mellitus has an explosive epidemic trend, and no radical treatment means exists in the treatment of diabetes mellitus in modern medicine, and the existing clinical medicine treatment methods comprise insulin (such as quick-acting insulin and long-acting insulin), oral hypoglycemic agents (such as metformin, sulfonylurea, glinide, thiazolidinedione, alpha-glycosidase inhibitor, DPP-4 inhibitor and SGLT-2 inhibitor), GLP-1 receptor agonists and the like. Non-drug therapies include diet control (optimizing carbohydrate intake, controlling total calories, balancing nutrition), exercise intervention (endurance exercise, strength training, daily activities), blood glucose monitoring and health management (regular monitoring of blood glucose, periodic review of glycosylated hemoglobin). However, the above-mentioned therapies cannot radically cure diabetes, and long-term administration of chemical drugs may be accompanied by side effects such as gastrointestinal reaction, liver and kidney function injury, hypoglycemia risk, and weight gain, and some patients are reluctant to take western hypoglycemic drugs at the critical value of hyperglycemia, but do not effectively control sugar intake in healthy eating habits, thereby leading to rise of blood sugar, and poor medication compliance of patients. The traditional Chinese medicine is an effective treatment measure for treating diabetes and complications thereof, the traditional Chinese medicine is discussed in yellow emperor's internal channels for the understanding and prevention of diabetes, and the traditional Chinese medicine considers that the characteristics of the diabetes symptoms are ' deficiency ', and the early symptoms are more marked by yin deficiency. Then, with the prolonged course of disease, it can develop into deficiency of both qi and yin, which leads to deficiency of both yin and yang. The heart of the pathogenesis of diabetes is heat, and diabetes patients can often show gastrointestinal heat, damp-heat in spleen and stomach, stagnated heat in liver channel, phlegm fire, stagnant heat, heart fire, liver fire, stomach fire and other different forms. With the deep scientific research, the Chinese medicine has remarkable effects on treating diabetes in recent years, the Chinese medicine has remarkable effects on improving symptoms, preventing and treating complications and the like, the Chinese medicine is used for controlling hyperglycemia critical value and diabetes light symptoms, and assisting the western medicine in controlling the serious diabetes blood sugar level in the hypoglycemic medicine control, so the method is practical, simple and convenient, has small side effects and is high in general acceptance in patients. However, the traditional Chinese medicine compound for treating diabetes disclosed at present still has the following defects: 1. the traditional Chinese medicine composition disclosed in the prior art comprises a plurality of traditional Chinese medicine components, wherein the traditional Chinese medicine composition disclosed in the traditional Chinese patent CN108339060A comprises more than 20 medicinal flavors, and the traditional Chinese medicine composition disclosed in the traditional Chinese patent CN108324852A and the traditional Chinese medicine composition disclosed in the traditional Chinese patent CN106581492A also comprises a plurality of traditional Chinese medicine components. The prescription is too numerous and complicated, which not only increases the difficulty of research on the action mechanism, but also causes the undefined effective substance basis, and the establishment of stable and controllable quality standard is difficult, thereby affecting the consistency among batches of the preparation and the stability of clinical curative effect. 2. The traditional Chinese medicine compound is single in dosage form and poor in patient compliance, most of traditional Chinese medicine compounds are still applied in the form of traditional decoction or medicinal liquor, and the problems of time consumption in decoction, inconvenience in carrying, inaccurate dosage and the like exist,