CN-121987731-A - Traditional Chinese medicine composition for treating lung nodule precancerous lesions and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating lung nodule precancerous lesions and a preparation method thereof. The composition is prepared from 30 parts of coix seed, 15 parts of astragalus, 30 parts of pyrrosia lingua, 10 parts of raw bighead atractylodes rhizome, 10 parts of fried hawthorn, 10 parts of dyers woad leaf, 30 parts of oyster, 15 parts of suberect spatholobus stem, 30 parts of oldenlandia diffusa, 10 parts of medlar, 10 parts of glossy privet fruit, 15 parts of glehnia root, 3 parts of dragon, 6 parts of liquorice, 15 parts of radix codonopsis pilosulae, 6 parts of cassia twig, 30 parts of lithospermum, 15 parts of semen benincasae, 10 parts of verbena and 10 parts of radix asparagi. The preparation method comprises cleaning and pulverizing the above materials, adding Mel, and making into pill. Clinical researches show that after the preparation is taken for 6 months, the maximum diameter of lung nodules of a patient is obviously reduced, the Meio malignancy probability is reduced from 16.60% to 8.33%, the traditional Chinese medicine syndrome integral is reduced from 10.91 to 6.91, and the serum CEA is reduced from 2.0ng/mL to 1.51ng/mL. Aiming at the lung nodule precancerous lesions with the syndrome of deficiency-positive and phlegm-accumulation, the invention has the effects of tonifying qi and yin, resolving phlegm, detoxifying and eliminating mass, and has definite curative effect and high safety.

Inventors

• ZHANG JIZHOU
• LI YIFAN
• ZHANG DANDAN
• JIN SONG
• PAN MINMIN

Assignees

• 浙江中医药大学附属温州市中医院

Dates

Publication Date

20260508

Application Date

20260327

Claims (4)

1. 1. The traditional Chinese medicine composition for treating lung nodule precancerous lesions is characterized by being prepared from the following raw material medicines in parts by weight: 30 parts of coix seed, 15 parts of astragalus root, 30 parts of pyrrosia lingua, 10 parts of raw bighead atractylodes rhizome, 10 parts of fried hawthorn, 10 parts of dyers woad leaf, 30 parts of oyster, 15 parts of suberect spatholobus stem, 30 parts of oldenlandia diffusa, 10 parts of medlar, 10 parts of glossy privet fruit, 15 parts of glehnia root, 3 parts of dragon, 6 parts of liquorice, 15 parts of codonopsis pilosula, 6 parts of cassia twig, 30 parts of lithospermum, 15 parts of semen benincasae, 10 parts of verbena and 10 parts of radix asparagi.
2. 2. The traditional Chinese medicine composition for treating lung nodule precancerous lesions according to claim 1, wherein the dosage form of the traditional Chinese medicine composition is a pill.
3. 3. A method for preparing the traditional Chinese medicine composition for treating lung nodule precancerous lesions according to claim 1 or 2, which is characterized by comprising the steps of cleaning and selecting the medicinal materials in parts by weight, respectively crushing, uniformly mixing, preparing pills by taking refined honey as an excipient, drying, and packaging after quality inspection is qualified.
4. 4. The use of a traditional Chinese medicine composition for treating lung nodule precancerous lesions according to claim 1 or 2 in the preparation of a medicament for treating lung nodule precancerous lesions of the type of deficiency-positive phlegm nodule.

Description

Traditional Chinese medicine composition for treating lung nodule precancerous lesions and preparation method thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating lung nodule precancerous lesions and a preparation method thereof. Background Lung cancer is one of the most common cancers in our country population, and is the leading cause of cancer death. Early lung cancer is usually manifested as asymptomatic lung nodules, i.e., round-like or irregularly shaped lesions with a diameter of less than or equal to 3cm in the lung, and imaging is manifested as shadows of increased density, which may be single or multiple shots, with clear or unclear boundaries. With the popularization of high-resolution CT, the detection rate of lung nodules is obviously increased, and researches show that the incidence rate of east Asian people is about 35.5%. Although most nodules are benign, some types (e.g., mixed ground glass nodules) can have up to 63% of the risk of malignancy. The lung nodule diameter is closely related to malignancy probability, the lung nodule malignancy ratio of <5mm in diameter is less than 1%, the lung nodule malignancy ratio of 5mm-10mm in diameter is about 6% -8%, and the lung nodule malignancy ratio of 20mm in diameter is as high as 64% -82%. Therefore, early recognition and reasonable intervention of lung nodules become a key link for early prevention and treatment of lung cancer. Modern medical treatment is currently controversial with respect to the management of lung nodules. The main treatment means comprise surgical excision, anti-infection, periodic follow-up observation and the like. For lung nodules which are found accidentally and have no obvious clinical symptoms in physical examination, if the malignant risk is low, a regular follow-up observation strategy is usually adopted, anti-infection drug treatment is given to the suspected inflammatory nodules, and for the nodules which are highly suspected of being malignant or are confirmed to be malignant by puncture biopsy, surgical excision treatment is usually adopted, and some middle and late patients are further interfered by combining means of radiotherapy, chemotherapy, targeted treatment and the like. Clinically, a large number of cases of excessive diagnosis and treatment and excessive operation exist, so that the physical and psychological burden and the medical cost of a patient are increased, and the lung function of the patient is possibly damaged. The lung nodules have no corresponding names in ancient books of traditional Chinese medicine, and most traditional Chinese medical doctors consider that the lung nodules can be classified into cough, accumulation and the like according to clinical symptoms of the lung nodules. The traditional Chinese medicine considers that the etiology and pathogenesis of the lung nodule are mainly that the lung nodule is formed by the mutual pulsation of deficiency, phlegm, blood stasis and toxin and qi movement obstruction. In recent years, the treatment of pulmonary nodules by traditional Chinese medicine has received a great deal of attention, and the number of related patent applications has increased year by year. Research shows that in the disclosed traditional Chinese medicine patent for treating pulmonary nodules, the five medicinal materials before the use frequency are licorice, astragalus, rhizoma pinellinae praeparata, zedoary and oldenlandia respectively, the medicinal properties are mainly sweet and warm, and mainly enter lung, liver and spleen channels, and the effects are mainly clearing heat, drying dampness and resolving phlegm, inducing diuresis and reducing edema. At present, various patent publications of traditional Chinese medicine compositions for treating pulmonary nodules exist. The patent with publication number CN114699502A discloses a traditional Chinese medicine composition for resolving masses, resolving phlegm and promoting blood circulation, which consists of turtle shell, oyster shell, radix bupleuri, radix scutellariae, blackberry lily, stiff silkworm, baked ginger, cassia twig, semen lepidii, pyrrosia lingua, rhizoma pinellinae praeparata, ginseng, honeycomb, white mustard seed, fritillaria thunbergii, catclaw, spina gleditsiae, rhizoma curcumae, wild buckwheat rhizome and honey-fried licorice root and is mainly used for treating phlegm and blood stasis intertwined pulmonary nodules. In another example, the patent with publication number CN113197992A discloses a composition for treating pulmonary nodule, which is prepared from radix bupleuri, rhizoma ligustici wallichii, radix curcumae, green tangerine peel, chinese angelica, white paeony root, dried orange peel, blackberrylily rhizome, prepared pinellia tuber, snakegourd fruit, oyster shell, kelp, seaweed, selfheal, root of red-rooted salvia, ground beetle and radix ranunculi ternate, and has