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CN-121987734-A - Traditional Chinese medicine preparation for treating metabolic syndrome

CN121987734ACN 121987734 ACN121987734 ACN 121987734ACN-121987734-A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine preparation for treating metabolic syndrome, which is prepared from, by weight, 10-20 parts of lotus leaf, 5-15 parts of hawthorn, 5-15 parts of red sage root, 10-20 parts of semen cassiae, 5-15 parts of chrysanthemum, 20-40 parts of corn silk, 5-15 parts of mulberry leaf, 10-20 parts of poria cocos, 5-15 parts of rhizoma alismatis, 5-15 parts of burdock root, 15-25 parts of fried radish seed and 20-40 parts of raw malt. The recipe takes the methods of clearing heat and promoting diuresis, and promoting digestion and removing stagnation as well as the effects of clearing heat and promoting diuresis, promoting digestion and removing stagnation and promoting blood circulation and removing blood stasis for damp-heat accumulation type metabolic syndrome. Clinical researches show that the total effective rate of the invention is 75.93% in combination with conventional western medicines for treating metabolic syndrome, which is obviously superior to that of a pure western medicine control group (53.70%), can obviously reduce the blood pressure, body mass index, waist-hip ratio, fasting blood glucose, fasting insulin, insulin resistance index and blood lipid level of patients, and increases high-density lipoprotein cholesterol without obvious adverse reaction. The traditional Chinese medicine composition has the advantages of precise and appropriate formula, definite curative effect, high safety and good clinical application prospect.

Inventors

  • LIN XIAOSHENG
  • WANG HAIYAN

Assignees

  • 林晓生

Dates

Publication Date
20260508
Application Date
20260402

Claims (9)

  1. 1. A traditional Chinese medicine preparation for treating metabolic syndrome is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of lotus leaves, 5-15 parts of hawthorns, 5-15 parts of root of red-rooted salvia, 10-20 parts of semen cassiae, 5-15 parts of chrysanthemum, 20-40 parts of corn silk, 5-15 parts of mulberry leaves, 10-20 parts of poria cocos, 5-15 parts of rhizoma alismatis, 5-15 parts of burdock roots, 15-25 parts of fried radish seeds and 20-40 parts of raw malt.
  2. 2. The traditional Chinese medicine preparation for treating metabolic syndrome according to claim 1, which is characterized by being prepared from the following raw materials, by weight, 12-18 parts of lotus leaves, 8-12 parts of hawthorns, 8-12 parts of red sage roots, 12-18 parts of cassia seeds, 8-12 parts of chrysanthemums, 25-35 parts of corn silk, 8-12 parts of mulberry leaves, 12-18 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of burdock roots, 18-22 parts of fried radish seeds and 25-35 parts of raw malt.
  3. 3. The traditional Chinese medicine preparation for treating metabolic syndrome according to claim 2, which is characterized by being prepared from the following raw materials, by weight, 15 parts of lotus leaves, 10 parts of hawthorns, 10 parts of red-rooted salvia roots, 15 parts of cassia seeds, 10 parts of chrysanthemums, 30 parts of corn silk, 10 parts of mulberry leaves, 15 parts of poria cocos, 10 parts of rhizoma alismatis, 10 parts of burdock roots, 20 parts of stir-fried radish seeds and 30 parts of raw malt.
  4. 4. A Chinese medicinal preparation for treating metabolic syndrome according to any one of claims 1-3, wherein the Chinese medicinal preparation is in the form of decoction, granule, capsule, tablet, oral liquid, pill, powder or mixture.
  5. 5. The Chinese medicinal preparation for treating metabolic syndrome according to claim 4, wherein the decoction is prepared by weighing raw materials according to the prescription, decocting with water for extraction, adding 6-10 times of water for the first time, decocting for 1-2 hours, filtering to obtain a first filtrate, adding 4-8 times of water for the second time, decocting for 0.5-1.5 hours, filtering to obtain a second filtrate, mixing the two filtrates, and concentrating to obtain a decoction containing 0.5-2g of crude drug per milliliter.
  6. 6. The Chinese medicinal preparation for treating metabolic syndrome according to claim 4, wherein the granule is prepared by the following method: Weighing the raw materials according to the prescription, decocting in water, concentrating the extractive solution to obtain fluid extract with relative density of 1.10-1.30, adding adjuvants, granulating, drying, and grading to obtain granule.
  7. 7. The traditional Chinese medicine preparation for treating metabolic syndrome according to claim 4, wherein the capsule is prepared by the following method: Weighing the raw materials according to the prescription, decocting in water, concentrating the extractive solution into soft extract, drying, pulverizing into fine powder, and making into capsule.
  8. 8. The Chinese medicinal preparation for treating metabolic syndrome according to any one of claims 1 to 7, wherein the preparation method of the Chinese medicinal preparation comprises the following steps of: Step 1, weighing lotus leaf, hawthorn, red sage root, cassia seed, chrysanthemum, corn silk, mulberry leaf, poria cocos, rhizoma alismatis, burdock root, fried radish seed and raw malt according to the prescription; Step 2, mixing the above raw materials, decocting in water, filtering, and collecting filtrate; And 3, concentrating the filtrate, adding pharmaceutically acceptable auxiliary materials, and preparing a clinically acceptable dosage form.
  9. 9. The Chinese medicinal preparation for treating metabolic syndrome according to claim 8, wherein the specific conditions of the decoction in the step 2 are that the water added for 8 times is decocted for 1.5 hours for the first time, the filtrate is filtered, the water added for 6 times is decocted for 1 hour for the second time, the filtrate is filtered, and the two filtrates are combined.

Description

Traditional Chinese medicine preparation for treating metabolic syndrome Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating metabolic syndrome. Background The metabolic syndrome is a group of clinical syndrome which is caused by aggregation of various metabolic abnormalities such as obesity, hyperglycemia, dyslipidemia, hypertension and the like, and is an important risk factor for causing type 2 diabetes and cardiovascular and cerebrovascular diseases. The prevalence of metabolic syndrome is on an increasing trend year by year with changes in lifestyle and acceleration of the aging process of the population. Epidemiological investigation shows that the prevalence rate of adult metabolic syndrome in China is over 30 percent, the healthy life quality of people is seriously threatened, and a heavy burden is brought to social medical resources. Modern medicine considers that the core pathological basis of metabolic syndrome is insulin resistance, and comprehensive intervention strategies are mainly adopted in treatment, including life style intervention (diet control and exercise increase) and drug treatment. The currently common clinical therapeutic drugs mainly comprise ① hypoglycemic drugs such as metformin, which can reduce blood sugar by inhibiting hepatic glucose output and improving peripheral insulin resistance, ② antihypertensive drugs such as irbesartan which is an angiotensin II receptor Antagonist (ARB) and can reduce blood pressure by blocking the vasoconstrictor effect of angiotensin II, and ③ lipid-lowering drugs such as statin atorvastatin and can reduce cholesterol synthesis by inhibiting HMG-CoA reductase. The western medicine treatment scheme can control metabolic indexes to a certain extent, but has the defects that firstly, a plurality of medicines are required to be taken for a long time, patient compliance is poor, secondly, the western medicine has a single acting target point and is difficult to comprehensively interfere with multiple pathological links of metabolic syndrome, thirdly, adverse reactions such as liver and kidney function damage, gastrointestinal tract reaction and muscular soreness can be generated after long-term administration, and thirdly, traditional Chinese medicine symptoms such as physical heaviness, abdominal distention, constipation and the like of a patient are difficult to improve by pure western medicine treatment, and life quality of the patient is influenced. Therefore, development of a traditional Chinese medicine preparation which has definite curative effect and high safety and can comprehensively improve multiple pathological links of metabolic syndrome is urgently needed. Disclosure of Invention In order to overcome the technical defects in the prior art, the invention provides a traditional Chinese medicine preparation for treating metabolic syndrome, which is prepared from the following raw materials in parts by weight: 10-20 parts of lotus leaves, 5-15 parts of hawthorns, 5-15 parts of root of red-rooted salvia, 10-20 parts of semen cassiae, 5-15 parts of chrysanthemum, 20-40 parts of corn silk, 5-15 parts of mulberry leaves, 10-20 parts of poria cocos, 5-15 parts of rhizoma alismatis, 5-15 parts of burdock roots, 15-25 parts of fried radish seeds and 20-40 parts of raw malt. Preferably, the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 12-18 parts of lotus leaves, 8-12 parts of hawthorns, 8-12 parts of red sage roots, 12-18 parts of semen cassiae, 8-12 parts of chrysanthemums, 25-35 parts of corn silk, 8-12 parts of mulberry leaves, 12-18 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of burdock roots, 18-22 parts of stir-fried radish seeds and 25-35 parts of raw malt. Preferably, the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 15 parts of lotus leaves, 10 parts of hawthorns, 10 parts of red sage roots, 15 parts of cassia seeds, 10 parts of chrysanthemum, 30 parts of corn silk, 10 parts of mulberry leaves, 15 parts of poria cocos, 10 parts of rhizoma alismatis, 10 parts of burdock roots, 20 parts of fried radish seeds and 30 parts of raw malt. Preferably, the Chinese medicinal preparation is in the form of decoction, granule, capsule, tablet, oral liquid, pill, powder or mixture. Preferably, the decoction is prepared by weighing raw materials according to the prescription, decocting with water for extraction, adding 6-10 times of water for 1-2 hours for the first time, filtering to obtain a first filtrate, adding 4-8 times of water for 0.5-1.5 hours for the second time, filtering to obtain a second filtrate, mixing the two filtrates, and concentrating to obtain the decoction containing 0.5-2g of crude drug per milliliter. Preferably, the granule is prepared by the following method: Weighing the raw materials ac