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CN-121987737-A - External preparation for treating pruritic dermatosis and preparation method thereof

CN121987737ACN 121987737 ACN121987737 ACN 121987737ACN-121987737-A

Abstract

The invention provides an external preparation for treating pruritic skin diseases and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The traditional Chinese medicine composition comprises the following components of radix sophorae flavescentis, fructus xanthii, wild chrysanthemum, fructus cnidii, honeysuckle, fructus kochiae, radix stemonae and cortex dictamni. The invention also provides a method for preparing the external preparation by using the traditional Chinese medicine composition, the obtained external preparation has definite clinical localization, is suitable for external treatment of pruritus skin diseases such as eczema, scabies, tinea manus and pedis, dermatitis, skin pruritus and the like, has good effects of relieving itching, resisting inflammation and improving skin damage, and has good clinical application prospect in practical application.

Inventors

  • CHEN JIYING
  • NING WEIMIN
  • MO HUANHAO
  • Wu mou
  • MIAO XIAOLU

Assignees

  • 东莞市中医院

Dates

Publication Date
20260508
Application Date
20260408

Claims (10)

  1. 1. The traditional Chinese medicine composition for treating the pruritic skin diseases is characterized by comprising, by mass, 15-25 parts of radix sophorae flavescentis, 8-15 parts of fructus xanthil, 8-15 parts of wild chrysanthemum flower, 10-18 parts of fructus cnidii, 8-15 parts of honeysuckle, 8-12 parts of fructus kochiae, 6-12 parts of radix stemonae and 10-18 parts of cortex dictamni.
  2. 2. The use of the Chinese medicinal composition according to claim 1 in the preparation of external preparations for treating acute eczema, scabies, tinea manus and pedis, dermatitis and/or skin pruritus.
  3. 3. An external preparation for treating acute eczema, scabies, tinea manus and pedis, dermatitis and/or skin pruritus, which is characterized in that the external preparation is prepared by the traditional Chinese medicine composition of claim 1.
  4. 4. A method for preparing external granules by using the traditional Chinese medicine composition according to claim 1 is characterized by comprising the steps of respectively taking 20-50wt% of fructus cnidii, 20-50wt% of fructus kochiae, 30-70wt% of radix stemonae and 30-70wt% of cortex dictamni, drying, crushing and mixing the obtained mixed powder, mixing the rest of fructus cnidii, fructus kochiae, radix stemonae, cortex dictamni, radix sophorae flavescentis, fructus xanthii, flos chrysanthemi indici and honeysuckle, decocting with water, extracting, filtering an extracting solution, concentrating to obtain clear paste, mixing the mixed powder with the clear paste, and adding auxiliary materials to prepare the external granules.
  5. 5. The method according to claim 4, wherein the drying temperature is 60-70 ℃ and the drying time is 60-90 min, and the crushed materials are sieved by a sieve of 80-100 meshes.
  6. 6. The method according to claim 4, wherein the auxiliary material is selected from one or more of dextrin, starch, lactose, microcrystalline cellulose and maltodextrin, and the auxiliary material is mixed with the fluid extract according to the mass ratio of (0.2-0.8): 1.
  7. 7. A method for preparing a topical ointment by using the traditional Chinese medicine composition as claimed in claim 1, which is characterized by comprising the steps of mixing fructus cnidii, fructus kochiae, radix stemonae, cortex dictamni, radix sophorae flavescentis, fructus xanthii, flos chrysanthemi indici and flos lonicerae, decocting with water, extracting, filtering an extracting solution, concentrating to obtain a clear paste, and mixing the clear paste with auxiliary materials to prepare the topical ointment.
  8. 8. The method according to claim 4 or 7, wherein the water decoction extraction method comprises the steps of adding water which is 5-15 times of the medicinal materials into water for soaking for 20-40 min, heating to boiling, and continuously decocting for 0.5-2 h to obtain an extract, wherein the water decoction extraction is repeated for 1-3 times.
  9. 9. The method according to claim 4 or 7, wherein the concentration method comprises the steps of heating and refluxing the extracting solution at 95-100 ℃ for 20-40 min, and then concentrating the extracting solution at 75-85 ℃ and reduced pressure of-0.06 to-0.08 MPa to a relative density of 1.15-1.25.
  10. 10. The method according to claim 7, wherein the auxiliary material consists of vaseline, glycerol and liquid paraffin, or consists of polyethylene glycol 4000, polyethylene glycol 400 and glycerol; When the auxiliary materials are vaseline, glycerol and liquid paraffin, the mass ratio of the clear paste to the vaseline to the glycerol to the liquid paraffin is 1 (2-4) (0.5-1), and when the auxiliary materials are polyethylene glycol 4000, polyethylene glycol 400 and glycerol, the mass ratio of the clear paste to the polyethylene glycol 4000, the polyethylene glycol 400 to the glycerol is 1 (2-4) (3-8) (0.5-1.5).

Description

External preparation for treating pruritic dermatosis and preparation method thereof Technical Field The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an external preparation for treating pruritic skin diseases and a preparation method thereof. Background The skin is used as the largest organ and the first health defense line of the human body, and the functional impairment is easy to cause various skin diseases, wherein the pruritic skin diseases are one of the most common disease categories of clinical dermatology, and comprise various diseases such as acute eczema, scabies, tinea manus, tinea pedis, various dermatitis, skin pruritus and the like. The core clinical characteristics of the diseases are all characterized by skin itch with different degrees, often accompanied by skin damage, erythema, pimple, desquamation, dryness, blisters and other symptoms, and part of the diseases are chronic and recurrent disease course, and are easy to fall into the cycle of diagnosis-treatment-stopping drug-recrudescence-retreatment, which chronically afflicts patients and increases medical burden. At present, the external preparation for treating the pruritic dermatosis mainly clinically, the external administration mode can directly act on a lesion part, the effect is rapid, the adverse reaction of systemic administration can be reduced, and the external preparation is a first-choice treatment mode for treating the light and medium pruritic dermatosis and is an important component of combined treatment of moderately severe patients. The existing external preparation is mainly divided into the following categories, namely, a glucocorticoid preparation which is used as a first-line clinical treatment medicine can quickly inhibit inflammatory reaction and relieve itching and skin injury, but long-term or improper use can easily cause adverse reactions such as skin barrier damage, skin atrophy, telangiectasia, pigmentation and the like, can possibly cause unbalance of skin microflora, increase infection risk, and easily cause 'rebound phenomenon' when stopping medicine suddenly, so that symptom recurrence is aggravated, and meanwhile, patients generally have 'hormone fear' psychological, have poor compliance, and limit the clinical application range and long-term use effect. Secondly, the antihistamine external preparation mainly plays an antipruritic role by blocking histamine receptors, but has a single action mechanism, has limited effect of relieving itching mediated by inflammatory factors, has skin irritation, and is not suitable for damaged skin or sensitive parts. Thirdly, natural component preparations, such as products containing menthol and dipotassium glycyrrhizinate, can only realize instant itching relieving, lack the repair capability of damaged skin barriers, cannot radically solve the problem of itching repetition, have insufficient synergistic effect among components, do not form complete efficacy closed loops of itching relieving-anti-inflammatory-repair, and are difficult to realize long-term symptom control effects. Therefore, the field needs to combine the pathogenesis and clinical treatment requirements of the pruritic dermatosis, and provides the external preparation which has definite curative effect, low recurrence rate, small side effect, stable quality, simple and convenient preparation, convenient use and suitability for various people for treating the pruritic dermatosis. Disclosure of Invention In order to solve the problems in the prior art, a first object of the present invention is to provide a traditional Chinese medicine composition for treating pruritic skin diseases and application thereof in preparing external preparations for treating acute eczema, scabies, tinea manus and pedis, dermatitis and/or skin pruritus. The second purpose of the invention is to provide an external preparation prepared by using the traditional Chinese medicine composition, and a method for preparing external granules and external ointments. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a traditional Chinese medicine composition for treating pruritic skin diseases, which comprises, by mass, 15-25 parts of radix sophorae flavescentis, 8-15 parts of fructus xanthil, 8-15 parts of wild chrysanthemum flower, 10-18 parts of fructus cnidii, 8-15 parts of honeysuckle, 8-12 parts of fructus kochiae, 6-12 parts of radix stemonae and 10-18 parts of cortex dictamni. The invention also provides application of the traditional Chinese medicine composition in preparing external preparations for treating acute eczema, scabies, tinea manus and pedis, dermatitis and/or skin pruritus. The invention also provides an external preparation for treating acute eczema, scabies, tinea manus, tinea pedis, dermatitis and/or skin pruritus, and the external preparation is prepared from the traditional Ch