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CN-121987740-A - A Chinese medicinal composition for treating drug addiction, and its preparation method, application and quality detection method

CN121987740ACN 121987740 ACN121987740 ACN 121987740ACN-121987740-A

Abstract

The invention provides a drug-dropping traditional Chinese medicine composition, which is prepared from the following raw materials, by weight, 9.6-14.4 parts of American ginseng, 17.6-26.4 parts of astragalus root, 10.4-15.6 parts of bighead atractylodes rhizome, 10.4-15.6 parts of poria cocos, 8-12.5 parts of liquorice, 9.6-14.4 parts of angelica, 8-12.5 parts of rhizoma picrorhizae, 12-18 parts of honeysuckle, 8.8-13.2 parts of chestnut shell, 8-12 parts of catechu, 10.4-15.6 parts of all-grass of rehmannia root, 10.4-15.6 parts of gentiana macrophylla, 10.4-15.6 parts of fructus alpiniae oxyphyllae and 17.6-26.4 parts of rhizoma corydalis. The invention also provides a preparation method and application of the traditional Chinese medicine composition, and a quality detection method. Experiments prove that the traditional Chinese medicine composition has small toxic and side effects, stable and controllable curative effect and low re-absorption rate, and has the application points that a large number of tonic medicines are used for rescuing people first, the symptoms are treated by the temporary treatment medicines, the body is recovered as soon as possible under double management, and the compliance of the patients taking the withdrawal symptoms is improved.

Inventors

  • HU CHANGJIANG
  • HU LIN
  • Hu changhe
  • CHEN ZHIMIN

Assignees

  • 青羊区步珍堂中医诊所

Dates

Publication Date
20260508
Application Date
20260210

Claims (12)

  1. 1. The Chinese medicinal composition for treating drug addiction is characterized by being prepared from the following raw materials in parts by weight: 9.6-14.4 parts of American ginseng, 17.6-26.4 parts of astragalus, 10.4-15.6 parts of bighead atractylodes rhizome, 10.4-15.6 parts of poria cocos, 8-12.5 parts of liquorice, 9.6-14.4 parts of Chinese angelica, 8-12.5 parts of rhizoma picrorhizae, 12-18 parts of honeysuckle, 8.8-13.2 parts of chestnut shell, 8-12 parts of catechu, 10.4-15.6 parts of all-grass, 10.4-15.6 parts of dried rehmannia root, 10.4-15.6 parts of gentiana macrophylla, 10.4-15.6 parts of fructus alpiniae oxyphyllae and 17.6-26.4 parts of rhizoma corydalis.
  2. 2. The traditional Chinese medicine composition for drug rehabilitation according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 12 parts of American ginseng, 22 parts of astragalus, 13 parts of bighead atractylodes rhizome, 13 parts of poria cocos, 10 parts of liquorice, 12 parts of Chinese angelica, 10 parts of rhizoma picrorhizae, 15 parts of honeysuckle, 11 parts of chestnut shell, 10 parts of catechu, 13 parts of all-grass of Dula, 13 parts of dried rehmannia root, 13 parts of large-leaf gentian root, 13 parts of fructus alpiniae oxyphyllae and 22 parts of rhizoma corydalis.
  3. 3. The drug-dropping traditional Chinese medicine composition according to claim 1 or 2, which is characterized in that the crude drug powder, water or organic solvent extract of the crude drug is taken as an active ingredient, and pharmaceutically acceptable auxiliary materials or auxiliary ingredients are added to prepare a common oral preparation in pharmacy.
  4. 4. The Chinese medicinal composition for treating drug addiction according to claim 3, wherein said oral preparation is a tablet, capsule, pill, granule, or oral liquid.
  5. 5. The Chinese medicinal composition for treating drug addiction according to claim 4, wherein said pill is honeyed pill, contains Tara sa-min not lower than 0.019 mg/g, contains Cryptochlorogenic acid not lower than 0.082 mg/g, catechin not lower than 0.565 mg/g, picroside II not lower than 0.291 mg/g, isochlorogenic acid C not lower than 0.085 mg/g, picroside I not lower than 0.110 mg/g, and has total content of Cryptochlorogenic acid, catechin, picroside II, isochlorogenic acid C, and picroside I not lower than 1.134 mg/g.
  6. 6. A method for preparing a Chinese medicinal composition for treating drug addiction according to any one of claims 1 to 5, which is characterized by comprising the following steps: a. weighing raw materials in weight proportion; b. decocting radix astragali, radix Angelicae sinensis, flos Lonicerae, rhizoma picrorhizae, radix rehmanniae, radix Gentianae Marcrophyllae, and rhizoma corydalis in water, concentrating; c. Pulverizing the rest materials, adding the concentrated solution obtained in step b, and adding pharmaceutically acceptable adjuvants or auxiliary components to obtain pharmaceutically common oral preparation.
  7. 7. Use of a combination according to any one of claims 1-5 for the preparation of a medicament for the treatment of drug addiction.
  8. 8. The use according to claim 7, wherein the medicament is for treating deficiency of vital energy and exuberance of pathogenic toxin during withdrawal from addiction, or for treating deficiency of vital energy, blood and yin and yang caused by withdrawal symptoms of taking an alpha drug.
  9. 9. A method for detecting a drug addiction treatment traditional Chinese medicine composition according to any one of claims 1-5, which is characterized in that a high performance liquid chromatography is adopted for detecting talassamidine in the composition, and chromatographic conditions are as follows: octadecylsilane chemically bonded silica as filler (column length of 250mm, inner diameter of 4.6mm, particle diameter of 5 μm), acetonitrile as mobile phase A, 0.1% triethylamine solution as mobile phase B, gradient elution according to the following table, flow rate of 1.0ml per minute, column temperature of 35deg.C, detection wavelength of 235nm, theoretical plate number of no less than 5000 as calculated by Taraxamin peak; Time (minutes) Mobile phase a (%) Mobile phase B (%) 0~25 40→60 60→40
  10. 10. The method for detecting the drug addiction treatment traditional Chinese medicine composition according to claim 9, which is characterized by comprising the following steps: a. Preparation of control solution Taking a taraxamamine reference substance, adding methanol to prepare a reference substance solution; b. Preparation of test solutions Adding ammonia water solution and diethyl ether into a proper amount of sample, sealing, soaking for 24 hours, performing ultrasonic treatment after soaking, cooling, shaking uniformly, filtering, and collecting subsequent filtrate; c. A chromatographic condition detection as defined in claim 9.
  11. 11. A method for detecting a Chinese medicinal composition for treating drug addiction according to any one of claims 1-5, wherein the content of cryptochlorogenic acid, catechin, picroside II, isochlorogenic acid C and picroside I is detected by high performance liquid chromatography under the following chromatographic conditions: Octadecylsilane chemically bonded silica is used as a filler (column length is 250mm, inner diameter is 4.6mm, particle size is 5 μm), acetonitrile is used as a mobile phase A, 0.1% formic acid solution (containing 1.62g of ammonium formate per 1000 ml) is used as a mobile phase B, gradient elution is carried out according to the specifications in the following table, flow rate is 1.0ml per minute, column temperature is 30 ℃, detection wavelength is 280nm, and theoretical plate number is not lower than 5000 according to the peak of the hidden chlorogenic acid; Time (minutes) Mobile phase a (%) Mobile phase B (%) 0~3 5 95 3~8 5→10 95→90 8~17 10 90 17~20 10→11.5 90→88.5 20~25 11.5→14 88.5→86 25~32 14→16 86→84 32~36 16→17 84→83 36~42 17→18 83→82 42~48 18→19 82→81 48~54 19→19.5 81→80.5 54~58 19.5 80.5 58~60 5 95
  12. 12. The method for detecting the drug addiction treatment traditional Chinese medicine composition of claim 11, which is characterized by comprising the following steps: a. Preparation of control solution Collecting reference substances of cryptochlorogenic acid, catechin, picroside II, isochlorogenic acid C, and picroside I, adding methanol to obtain reference solution; b. Preparation of test solutions Taking a sample to be detected, adding 70% methanol, and carrying out ultrasonic treatment for 30 minutes to obtain the sample; c. the chromatographic condition detection according to claim 11.

Description

A Chinese medicinal composition for treating drug addiction, and its preparation method, application and quality detection method Technical Field The invention relates to a traditional Chinese medicine composition for drug rehabilitation, a preparation method, application and a quality detection method thereof, belonging to the field of traditional Chinese medicines. Background The current mainstream drug rehabilitation treatment scheme adopts the substitution therapy of the chemical synthetic drugs such as methadone, buprenorphine and the like, and is assisted with symptomatic support treatment. However, this strategy has significant limitations in that alternative drugs are addictive in nature, secondary dependence may result from prolonged use, and at the same time, such drugs often accompany adverse reactions such as respiratory depression, constipation, etc., and have limited intervention effects on psychological craving and prolonged withdrawal symptoms. The application history of traditional Chinese medicine in the field of drug rehabilitation is long, and the traditional Chinese medicine shows unique advantages with the deep research of modern researches. Studies have shown that scopolamine, a traditional Chinese medicine component, can promote morphine subcutaneous absorption by enhancing morphine metabolism, thereby accelerating morphine excretion (Zhou Wenhua, zhu Bo, chen Qijun, etc. scopolamine affects rat serum and urine morphine concentrations [ J ]. J.Chinese medicine, 1995, (01): 5-7+60.). Single Chinese medicinal materials such as henbane, datura flower, belladonna herb and the like have proved to be effective in resisting morphine withdrawal. The traditional Chinese medicines such as rhizoma corydalis, herba Chelidonii, caulis sinomenii, radix sileris, stephania sinica Diels, radix sophorae flavescentis, radix paeoniae alba, cinnamon and the like have analgesic effects, and also have good effects in improving adverse reactions after drug addiction. In addition, the alcohol extract of the Chinese medicine jasmine root has the effects of central sedation, hypnosis and analgesia, and can relieve or eliminate the main withdrawal symptoms such as anxiety, dysphoria, pain, insomnia and the like in the withdrawal process. In summary, the current Chinese herbal medicines for drug rehabilitation mainly comprise the following categories [6 ], ① tranquillization category, ② strengthening body resistance and tonifying deficiency category, ③ detoxification and pathogen attack category and ④ symptomatic treatment category. However, drug addiction can lead to complex pathological changes of multiple systems and viscera of the organism, and cause acute and protracted withdrawal symptoms. Compared with single medicinal materials, the traditional Chinese medicine compound preparation can exert the synergistic effect of multiple components and multiple targets through the compatibility of monarch, minister, assistant and guide, and has more outstanding potential in the aspects of comprehensive curative effect and medication safety. The application number 201810743205.7 is a Chinese medicinal composition for treating drug addiction and its preparation method, wherein the Chinese medicinal composition comprises American ginseng 1-100 parts, white atractylodes rhizome 1-100 parts, chinese angelica root 1-100 parts, corktree bark 1-100 parts, coptis root 1-100 parts, astragalus root 1-200 parts, licorice root 1-100 parts, dried orange peel 1-100 parts, bupleurum root 1-100 parts, gastrodia tuber 1-100 parts, banksia rose 1-50 parts, cimicifuga rhizome 0.5-50 parts, datura flower 0.1-10 parts, corydalis tuber 1-100 parts, wild jujube seed 1-100 parts, eaglewood 0.1-50 parts and prepared aconite root 0.1-100 parts. The prescription is mainly used for treating spleen and kidney deficiency, qi deficiency and yang collapse due to long-term opioid addiction. Disclosure of Invention The invention provides a Chinese medicinal composition for treating drug addiction, and a preparation method, application and a quality detection method thereof. The invention provides a traditional Chinese medicine composition for drug rehabilitation, which is prepared from the following raw materials in parts by weight: 9.6-14.4 parts of American ginseng, 17.6-26.4 parts of astragalus, 10.4-15.6 parts of bighead atractylodes rhizome, 10.4-15.6 parts of poria cocos, 8-12.5 parts of liquorice, 9.6-14.4 parts of Chinese angelica, 8-12 parts of rhizoma picrorhizae, 12-18 parts of honeysuckle, 8.8-13.2 parts of chestnut shell, 8-12 parts of catechu, 10.4-15.6 parts of all-grass, 10.4-15.6 parts of dried rehmannia root, 10.4-15.6 parts of gentiana macrophylla, 10.4-15.6 parts of fructus alpiniae oxyphyllae and 17.6-26.4 parts of rhizoma corydalis. Wherein, the raw material medicine is Aconitum episcopale Leveille tubers of Aconitum carmichaeli (such as document, yan Zhuyun, etc.), yi nationality medicine is variety investigation and identifica