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CN-121987741-A - Preparation method and application of medicinal and edible compound extract for improving bone marrow suppression after tumor chemotherapy

CN121987741ACN 121987741 ACN121987741 ACN 121987741ACN-121987741-A

Abstract

The invention relates to a medicinal and edible compound extract for improving bone marrow suppression of tumor patients after chemotherapy, a preparation method and application thereof. The compound extract is extracted from a raw material medicine composition at least comprising, by weight, 0.9-10 parts of tricholoma matsutake, 0.9-10 parts of mulberry and 0.5-10 parts of rhizoma polygonati. The raw material medicine composition further comprises, by weight, 0.7-10 parts of longan, 0.5-10 parts of dried orange peel, 0.5-10 parts of burnt hawthorn, 0.5-10 parts of fructus amomi, 1.1-10 parts of cordyceps sinensis rice flour and 2.5-15 parts of rice peptide. The selected raw materials are all medicinal and edible components, so that adverse effects on liver and kidney functions and gastrointestinal tracts of eaters are avoided, the safety is high, and the patient acceptance is high. The effect verification result shows that the compound extract of the muriatic fungi has an improvement effect on the side effect of bone marrow depression of a tumor patient, especially in early stage, and no adverse reaction related to the compound extract of the muriatic fungi is found, so that a safe and effective treatment choice is provided for bone marrow depression.

Inventors

  • ZHENG XUAN

Assignees

  • 中国人民解放军海军军医大学

Dates

Publication Date
20260508
Application Date
20260109

Claims (7)

  1. 1. A medicinal and edible compound extract for improving bone marrow suppression of tumor patients after chemotherapy is characterized by being extracted from a raw material medicine composition at least comprising, by weight, 0.9-10 parts of tricholoma matsutake, 0.9-10 parts of mulberry and 0.5-10 parts of rhizoma polygonati.
  2. 2. The medicine and food homologous compound extract for improving bone marrow suppression after chemotherapy of tumor patients according to claim 1, wherein the medicine and food homologous compound extract is characterized by further comprising the following raw materials, by weight, 0.7-10 parts of longan, 0.5-10 parts of dried orange peel, 0.5-10 parts of scorched hawthorn fruit, 0.5-10 parts of fructus amomi, 1.1-10 parts of cordyceps rice flour and 2.5-15 parts of rice peptide.
  3. 3. The medicine and food homologous compound extract for improving bone marrow suppression after chemotherapy of tumor patients according to claim 2, wherein the medicine and food homologous compound extract is characterized by comprising, by weight, 5-5.5 parts of tricholoma matsutake, 5-5.5 parts of mulberries, 5-5.5 parts of rhizoma polygonati, 5-5.5 parts of longan, 5-5.5 parts of dried orange peel, 5-5.5 parts of scorched hawthorns, 5-5.5 parts of sand kernels, 5-6 parts of cordyceps rice flour and 6-8 parts of rice peptides.
  4. 4. A pharmaceutical and edible compound extract for improving bone marrow suppression after chemotherapy of a tumor patient according to any one of claims 1-3, wherein the compound extract is a liquid preparation.
  5. 5. The method for preparing the medicinal and edible compound extract for improving bone marrow suppression after chemotherapy of tumor patients according to claim 4 is characterized by comprising the following steps of mixing the raw material medicaments in parts by weight, soaking the raw material medicaments in a container for a certain time, decocting the raw material medicaments at normal pressure, and filtering out liquid medicine to obtain a water extract for drinking.
  6. 6. The method for preparing the medicinal and edible compound extract for improving bone marrow suppression after chemotherapy of a tumor patient, which is characterized in that 0.9-10 g of mulberry, 0.9-10 g of tricholoma matsutake, 0.7-10 g of longan, 0.5-10 g of dried orange peel, 0.5-10 g of scorched hawthorn fruit, 0.5-10 g of rhizoma polygonati, 0.5-10 g of fructus amomi, 1.1-10 g of cordyceps sinensis rice flour and 2.5-15 g of rice peptide are added into 100ml of water to be soaked or decocted to obtain single extract liquid.
  7. 7. The application of the medicine-food homologous compound extract according to any one of claims 1-3 in preparing a medicine or health food for improving bone marrow suppression of radiotherapy and chemotherapy of tumor patients.

Description

Preparation method and application of medicinal and edible compound extract for improving bone marrow suppression after tumor chemotherapy Technical Field The invention relates to the field of traditional Chinese medicine compositions, in particular to a compound extract for improving the side effect of chemoradiotherapy bone marrow depression of a tumor patient, a preparation method and application thereof in preparing a pharmaceutical preparation for improving the side effect of chemoradiotherapy bone marrow depression of the tumor patient. Background Tumor incidence continues to rise, and has become one of the first diseases that jeopardize human health. Chemoradiotherapy is an important means for treating tumors, and can damage normal cells of human bodies, especially cause serious hematopoietic system injury such as bone marrow suppression and the like, while playing a positive role. Bone marrow suppression is taken as a main side effect of radiotherapy or chemotherapy, and is mainly characterized by leucocyte and platelet count reduction, resulting in anemia, hemorrhage, immunosuppression and even fatal infection, thereby interrupting the treatment progress of tumors, seriously affecting the life quality and prognosis of patients, not only delaying the treatment progress and affecting the treatment effect, but also endangering the lives of the patients and becoming a main cause of death. Therefore, the treatment of bone marrow depression is becoming more and more important, and the rational and effective treatment of bone marrow depression is an important link in tumor treatment. The clinical treatment method of bone marrow suppression comprises traditional leukogenic drugs such as reserpine, scyllitol, bai Anpian and the like, which have slow and insignificant effects, and injection drugs such as leukogenic drugs, recombinant human granulocyte stimulating factors and the like have the defects of rapid effect, short duration and easy fall back. Methods such as component transfusion, bone marrow transplantation, peripheral hematopoietic stem cell transplantation and the like have definite curative effects but are expensive. In fact, patients with malignant tumors and family members prefer a safer, more effective, and longer lasting treatment regimen. At present, most of nutrition support takes total nutrient preparation, special total nutrient preparation and non-total nutrient component preparation as nutrient substrates, and the effect of improving bone marrow suppression is not seen. The medicinal and edible plants are of great origin in China, and play a great role in health care of people in China. In recent years, more and more scientific literature suggests the health efficacy of pharmaceutically and dietetically homologous bioactive substances. According to the original national commission of health, a list of 101 kinds of articles with homology of medicine and food is issued, the articles are between health care products and medicines, and the biological active substances are considered to have the treatment effect of medicines and the safety and stability of foods. However, research and discovery are focused on the field of medicines, wherein the research on relieving bone marrow depression is mainly focused on the field of medicines, for example, the Chinese patent with the patent number of CN105343198A discloses a medicine composition for preventing and treating bone marrow depression, which is prepared from 29-46 parts by weight of polygala japonica and 30-60 parts by weight of Chinese medicinal materials of paper mulberry root-bark, the Chinese patent with the patent number of CN110025674A discloses a Chinese medicine composition for treating bone marrow depression during chemotherapy, which is prepared from the following Chinese medicinal materials of 6-150 parts by weight of raw astragalus root, 2-50 parts by weight of angelica, 2-50 parts by weight of eclipta, 2-50 parts by weight of glossy privet fruit, 2-50 parts by weight of fructus psoraleae, 2-30 parts by weight of semen cuscutae, 10-30 parts by weight of Chinese medicinal composition for treating bone marrow depression after radiotherapy and chemotherapy disclosed by the Chinese patent with the patent number of CN114306564A consists of 10-30 parts by weight of radix codonopsis pilosulae, 60 parts by weight of astragalus root, 10-30 parts by weight of fried rhizoma atractylodis, 10-20 parts by weight of rhizoma cimicifugae, 10-20 parts by weight of radix bupleuri, 10-20 parts by weight of donkey-hide gelatin, 10-20 parts by weight of angelica sinensis, 10-20 parts by weight of ginseng, 10-20 parts by weight of fructus cannabis, 10-20 parts by weight of cornu cervi, 10-40 parts by weight of processed by weight of fructus cervi, 10-by decocting by weight of fructus cervi, 10-by weight of glossy privet, etc. Disclosure of Invention The invention is carried out by relying on the research, and aims to provide the compound extract of th