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CN-121987742-A - Gel patch capable of relieving pain and preparation method and application thereof

CN121987742ACN 121987742 ACN121987742 ACN 121987742ACN-121987742-A

Abstract

The invention relates to the technical field of medicines, in particular to a gel patch capable of relieving pain, a preparation method and application thereof, wherein the gel patch comprises a hydrogel matrix and a traditional Chinese medicine composition loaded on the matrix, and the traditional Chinese medicine composition comprises 10-20 parts of mugwort leaves, 20-30 parts of liquorice, 10-15 parts of angelica, 30-40 parts of frankincense, 10-20 parts of myrrh, 15-20 parts of radix aconiti, 15-30 parts of ligusticum wallichii, 10-20 parts of safflower, 20-25 parts of asarum, 10-25 parts of turmeric, 10-30 parts of astragalus mongholicus and 30-40 parts of lycopodium clavatum. The gel patch can relieve pain of different types, improve local blood circulation, regulate organism function, and relieve pain, and the Chinese medicinal components such as radix Aconiti and herba Lycopodii have effects of dilating blood vessel and promoting blood circulation.

Inventors

  • WEI XIN
  • JI CHUNFENG
  • BIAN BAOJUN
  • ZHU XIAOPING
  • ZHAN XUEQIANG
  • WANG CHENHAO
  • DING LIQIN
  • JIN JIAHUA

Assignees

  • 上海中华药业有限公司

Dates

Publication Date
20260508
Application Date
20241105

Claims (9)

  1. 1. The gel patch capable of relieving pain is characterized by comprising a hydrogel matrix and a traditional Chinese medicine composition loaded on the matrix, wherein the traditional Chinese medicine composition comprises 10-20 parts of mugwort leaf, 20-30 parts of liquorice, 10-15 parts of angelica, 30-40 parts of frankincense, 10-20 parts of myrrh, 15-20 parts of radix aconiti, 15-30 parts of ligusticum wallichii, 10-20 parts of safflower, 20-25 parts of asarum, 10-25 parts of turmeric, 10-30 parts of astragalus and 30-40 parts of lycopodium clavatum.
  2. 2. The gel patch of claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials, by weight, 20 parts of mugwort leaf, 25 parts of liquorice, 10 parts of angelica, 30 parts of frankincense, 10 parts of myrrh, 20 parts of radix aconiti, 20 parts of ligusticum wallichii, 10 parts of safflower, 20 parts of asarum, 15 parts of turmeric, 20 parts of astragalus mongholicus and 30 parts of lycopodium clavatum.
  3. 3. The gel patch of claim 2, wherein the traditional Chinese medicine composition comprises the following raw materials, by weight, 10 parts of mugwort leaf, 20 parts of liquorice, 15 parts of angelica, 40 parts of frankincense, 20 parts of myrrh, 20 parts of radix aconiti, 15 parts of ligusticum wallichii, 20 parts of safflower, 25 parts of asarum, 10 parts of turmeric, 10 parts of astragalus mongholicus and 30 parts of lycopodium clavatum.
  4. 4. The gel patch of claim 3, wherein the Chinese medicinal composition comprises the following raw materials, by weight, 15 parts of mugwort leaf, 30 parts of licorice, 10 parts of Chinese angelica, 30 parts of frankincense, 20 parts of myrrh, 15 parts of radix aconiti, 30 parts of ligusticum wallichii, 10 parts of safflower, 20 parts of asarum, 25 parts of turmeric, 30 parts of astragalus mongholicus and 40 parts of lycopodium clavatum.
  5. 5. The gel patch of claim 1 wherein said hydrogel matrix is prepared from 5% to 6% sodium polyacrylate, 1% to 2% aluminum glycinate, 20% to 25% glycerin, 60% to 64% water, 1% to 3% propylene glycol, 0.5% to 1% menthol, and 1% to 2% eucalyptus oil.
  6. 6. The gel patch of claim 1 wherein the hydrogel matrix is prepared from 6% sodium polyacrylate, 2% aluminum glycidate, 25% glycerin, 64% water, 1% propylene glycol, 0.5% menthol and 1% eucalyptus oil.
  7. 7. A method of preparing a gel patch according to any one of claims 1 to 5, comprising the steps of: (1) Respectively preparing water phase and oil phase, namely water phase, namely weighing 25% of glycerin and 1% of propylene glycol according to a proportion, adding 0.5% of menthol into 1% of propylene glycol, dissolving in water bath at 60 ℃, adding 0.25% of ginger oil into the mixture, uniformly mixing, pouring into glycerin, and uniformly stirring to obtain an oil phase; (2) Adding 6% sodium polyacrylate and 2% aluminum glycinate into the oil phase obtained in the step (1), and uniformly mixing for later use; (3) Pouring the water phase obtained in the step (1) into a stirring container of an experimental stirrer, pouring the oil phase obtained in the step (2), stirring at the rotating speed of F60, pouring the medicinal extract, and stirring to form paste; (4) Transferring the stirred hydrogel to a coater for coating, wherein the coating thickness is set to be 2.25mm, and the coating speed is F300 at a constant speed; (5) The hydrogel patch obtained after coating is spread and stood for 10-16 hours, so that sodium polyacrylate and aluminum hydroxide are fully crosslinked and cut.
  8. 8. The method of preparing a gel patch of claim 6, wherein the cutting in step (5) is performed using a laser cutter.
  9. 9. The method of claim 7, wherein the laser cutting machine has the following parameters of 200.0mm/s, 1:90% maximum power and 2:50% maximum power.

Description

Gel patch capable of relieving pain and preparation method and application thereof Technical Field The invention relates to the technical field of medicines, in particular to a gel patch capable of relieving pain, a preparation method and application thereof. Background The Chinese medicine considers that the pain symptoms belong to the category of arthralgia syndrome, namely the arthralgia syndrome refers to the meaning of obstruction and obstruction, and generally refers to symptoms caused by obstruction of the channels and collaterals of the body or viscera by pathogenic qi, obstruction of the channels and collaterals, qi stagnation and blood stasis, and pain caused by obstruction. In summary, pain is an intolerable sensory and emotional experience, associated with actual or potential tissue damage. Neck pain is also known as neck-shoulder syndrome, and is manifested by pain in neck and shoulder, stiffness in muscles, difficulty in stretching, pain or numbness in upper limbs, persistent or indirect muscular soreness of upper back, and limited range of head movement. In recent years, along with the living tension of modern people, the popularization of computers and mobile phones and the change of working modes, the reduction of physical labor and the long-time bad case-setting work lead to the gradual rise of the occurrence rate of neck and shoulder pain and the trend of younger. The neck pain belongs to the category of 'arthralgia syndrome' in traditional Chinese medicine, the pain part is positioned on the neck, the traditional Chinese medicine considers that the etiology of neck and shoulder pain is that the neck is affected by wind-cold dampness evil, external injury or strain and the like, so that qi and blood are not smooth, and the qi and blood of channels and collaterals are stagnated, and the wind-cold dampness evil blocks the neck and back channels and collaterals to cause the disease, so called 'non-general pain', and the pathogenesis is according to the theory of 'spirit of spirit and spirit of pulse house' and 'spirit of heart and heart' in spirit of spirit and heart, and the main pathogenesis of neck and shoulder pain is 1 invasion of wind-cold dampness, 2 of liver and kidney deficiency and 3 of overfatigue. Therefore, the treatment of neck pain can remove the pulse by means of acupoint pressing and the like so as to restore qi and blood, yin and yang balance and qi movement, so that the body shape, qi and spirit are all improved and the symptoms are self-eliminated. The waist pain is more frequent in young and old people, and the male patients are more than the female patients, because the labor intensity is reduced along with the change of the working mode, and the waist pain is gradually increased and is in a younger trend due to the long-time bad work of the table. Lumbago belongs to the category of arthralgia syndrome in traditional Chinese medicine, and liver and kidney govern bones in the book of Su Wen Xuan Ming Wu Qi hybrid disease. Kidney stores essence, which is the congenital principal bone to generate marrow, kidney essence is filled and kidney qi is exuberant, which promotes growth and development, and has the effects of strengthening body, strengthening bones, storing blood in liver, nourishing blood and feet, nourishing tendons and vessels, strengthening tendons and vessels, and the traditional Chinese medicine considers that lumbago is related to deficiency of liver and kidney. The pain of one or both sides of the waist caused by external evil feeling, or qi and blood dysfunction due to trauma or kidney deficiency, and malnutrition of the waist are the main clinical syndromes. Moxibustion and traditional Chinese medicine application are one of the common traditional Chinese medicine pain relief means, and the medicine is externally applied to the body surface of a focus or related acupuncture points to relieve pain, so that the medicine directly acts on a lesion part, the first pass effect of the liver after oral administration of the medicine is effectively avoided, the relief effect is improved, and the effects of activating blood circulation to dissipate blood stasis and dredging collaterals to relieve pain are achieved. The traditional Chinese medicine-containing neck plaster and waist plaster which are commercially available mainly comprise the following raw materials of Chinese mugwort leaf cervical plaster which are mainly prepared by mixing Chinese mugwort leaf oil, peppermint oil, magnetic powder, osmanthus fragrans oil, eucalyptus oil and the like, the Nanjing Tongren-Tang Chinese mugwort leaf cervical plaster which is used for eliminating rich and expensive bags, hot compress the shoulder and cervical vertebra to dredge and correct, the kernel and mugwort neck plaster, the Dingsheng cervical plaster which is composed of a backing layer, medical resin, a main layer natural plant extract, chilli extract, glycerol, a penetrating agent, aromatic oil, dimethyl sulfoxi