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CN-121987745-A - Plaster for treating neck, shoulder, waist and leg pain

CN121987745ACN 121987745 ACN121987745 ACN 121987745ACN-121987745-A

Abstract

The application relates to the technical field of traditional Chinese medicine preparations, and discloses a plaster for treating neck, shoulder, waist and leg pain, which comprises a volatile and heat-sensitive medicinal material group, a heat-resistant medicinal material group with toxic components, a floating medicinal material group, sesame oil, a composite micro-coating matrix and a physical excitant. The preparation method comprises pretreating volatile and thermosensitive medicinal materials with composite micro-coating matrix, micro-wetting toxic medicinal materials with physical activator, adding mixed powder to be added into high-temperature sesame oil for reaction, transferring to a closed mechanical molding cavity, and molding by moderate temperature normal pressure, high Wen Zhengya strong permeation and moderate temperature negative pressure suddenly dropping. According to the application, by utilizing the phase change heat insulation of the coating matrix and the vaporization micro-boiling mechanism of the exciting agent, the degradation of toxic diester alkaloids and the retention of thermosensitive components are synchronously realized, and the physical topological structure of the plaster is remodeled through warm-pressing coupling, so that the leaching amount of active ingredients, the transdermal release efficiency and the product forming stability are improved.

Inventors

  • XIE SHUYUN

Assignees

  • 谢书云

Dates

Publication Date
20260508
Application Date
20260326

Claims (10)

  1. 1. The plaster for treating the neck, shoulder, waist and leg pain is characterized by being prepared from the following raw materials in parts by weight: The medicine group for providing volatile and thermosensitive active ingredients comprises 30g of ephedra herb, 20g of Chinese angelica, 10g of safflower, 20g of divaricate saposhnikovia root, 30g of frankincense and 30g of myrrh; providing a medicinal material group with heat resistance, main pain relieving effect and toxic components, wherein the medicinal material group comprises 30g of radix aconiti, 30g of radix aconiti kusnezoffii, 30g of raw arisaema tuber, 20g of pinellia tuber, 30g of ground beetle, 30g of eucommia bark, 20g of rhizoma sparganii, 20g of rhizoma zedoariae, 50g of lycopodium clavatum and 100g of radix angelicae pubescentis; Providing a floating medicinal material group for bone penetration and blood circulation promoting and stiffness removing, wherein the floating medicinal material group comprises 60-100g of white mustard seed, 60-100g of garden balsam stem, 80-100g of suberect spatholobus stem and 60-100g of clematis root; 1140-2700g of sesame oil for providing an extraction solvent and a shaped substrate; 7-14g of composite micro-cladding matrix for forming a physical heat insulation buffer layer in a high-temperature environment; 18.6-60.8g of physical activator for inducing the phase change vaporization and micro-boiling effect of the internal fluid.
  2. 2. The plaster for treating neck, shoulder, waist and leg pain according to claim 1, wherein the physical activator is yellow wine with an alcoholicity of 15-20% by volume or rice vinegar with a total acidity of 5.0-9.0%.
  3. 3. The plaster for treating neck, shoulder, waist and leg pain according to claim 1, wherein the composite micro-coating matrix is composed of yellow wax, polyethylene glycol 4000 and stearic acid.
  4. 4. A plaster for treating pain in neck, shoulder, waist and leg according to claim 3, wherein the weight ratio of yellow wax, polyethylene glycol 4000 and stearic acid is (50-60): 30-40): 5-10; The preparation method of the composite micro-coating matrix comprises the steps of melting yellow wax and stearic acid at 75-85 ℃, adding polyethylene glycol 4000 in the molten state, starting mechanical stirring, stirring at a constant temperature of 300-500rpm for 15-30min, and cooling to 45-55 ℃ to obtain the matrix in a semi-fluid state.
  5. 5. The plaster for treating neck, shoulder, waist and leg pain according to claim 1, wherein in the preparation process of the plaster, the following treatment is carried out on the medicinal material group providing volatile and thermosensitive active ingredients in advance: Pulverizing the medicinal material group providing volatile and heat-sensitive active ingredients to 100-120 meshes, adding the composite micro-coating matrix in a semi-fluid state at 45-55 ℃, mixing for 10-20min at a rotating speed of 50-80rpm, and naturally cooling to 20-25 ℃ to solidify the composite micro-coating matrix to obtain pretreated medicinal powder A.
  6. 6. A plaster for treating neck, shoulder, waist and leg pain according to claim 5, wherein, in the preparation process of the plaster, the following treatment is carried out in advance on a medicinal material group which provides heat resistance and main analgesic effect but has toxic components and a floating medicinal material group which provides bone penetration and has functions of promoting blood circulation to remove stiffness together: Mixing the two medicinal materials, pulverizing to 80-100 mesh, spraying the physical activator, and stirring at 40-60rpm for 10-15min to obtain pretreated medicinal powder B.
  7. 7. The plaster for treating neck, shoulder, waist and leg pain according to claim 6, wherein in the preparation process of the plaster, the pretreated medicinal powder A and the pretreated medicinal powder B are mixed for 10-15min at the rotating speed of 30-50rpm to obtain the final mixed powder to be fed; Heating sesame oil in a cooking pot at 190-220 deg.C, pouring the powder to be mixed into the cooking pot, and keeping the temperature in the pot at 180-200 deg.C for 3-8min to obtain primary oil-medicine mixed fluid.
  8. 8. The plaster for treating neck, shoulder, waist and leg pain according to claim 1, wherein the primary oil-drug mixed fluid is transferred into a closed mechanical molding cavity, and is molded specifically through the following warm-pressing coupling process parameters: a step of medium temperature and normal pressure, which is to adjust the temperature of the cavity to 85-100 ℃ and maintain the pressure to 0.09-0.11MPa for 5-10min; Pulling the cavity temperature to 130-150 ℃ and synchronously injecting nitrogen to raise the absolute pressure to 0.3-0.5MPa for 10-20min; and the step of medium-temperature negative pressure suddenly dropping, namely suddenly dropping the cavity temperature to 60-75 ℃ and synchronously starting a vacuum pump to pump the vacuum degree to-0.05 to-0.08 MPa for 5-15min.
  9. 9. A plaster for treating neck, shoulder, waist and leg pain according to claim 1, wherein the total residual amount of diester alkaloids in the plaster product is controlled to be in the range of 0.512-0.665mg/kg, wherein the diester alkaloids comprise aconitine, mesaconitine and hypaconitine.
  10. 10. The plaster for treating neck, shoulder, waist and leg pain according to claim 1, wherein the macroscopic physical property parameter range of the plaster finished product is controlled to be that the softening point is maintained to be 64.3-70.1 ℃, and the oil permeability range is 0.75-1.62% after the plaster is placed for 48-50 hours under the constant temperature condition of 60-65 ℃.

Description

Plaster for treating neck, shoulder, waist and leg pain Technical Field The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a plaster for treating neck, shoulder, waist and leg pain. Background The traditional Chinese medicine plaster is commonly used for treating osteoarthropathy such as neck, shoulder, waist and leg pain, and the like, and the traditional preparation process generally relies on high-temperature oil phase medium to perform decoction extraction and matrix fusion on traditional Chinese medicine materials. In the conventional formula of the plaster, the plaster generally comprises toxic medicinal materials with heat resistance and main analgesic effect, which are represented by radix aconiti and radix aconiti kusnezoffii, and medicinal materials with rich volatile and heat-sensitive active ingredients, which are represented by ephedra and angelica sinensis. This causes a clear thermodynamic process conflict in practical production. The main toxic component in the toxic medicinal materials is diester alkaloid, and the diester alkaloid is required to be hydrolyzed and broken in a high-temperature environment of about two hundred ℃ to be converted into monoester alkaloid or alcohol amine alkaloid with low toxicity. The volatile and thermosensitive components are easy to generate irreversible thermal degradation and phase change vaporization dissipation under the high-temperature environment. In order to avoid the contradiction, the conventional preparation process mostly adopts a distribution processing mode of firstly dropping toxic medicinal materials and then dropping the temperature of volatile medicinal materials. However, in a practical high-viscosity high-temperature sesame oil system, the serious wrapping agglomeration phenomenon is easily caused by directly putting dry medicinal powder into the system, and the high-viscosity fluid medium is difficult to infiltrate the powder by overcoming the surface tension. The low heat and mass transfer efficiency of the solid-liquid interface leads to obvious temperature gradient in the powder agglomerate, and the hydrolysis activation energy obtained by the diester type alkaloid is insufficient, so that the pyrolysis detoxification reaction is not completely carried out, and part of low-boiling pyrolysis products are trapped in viscous medium and cannot effectively escape from the reaction system. Meanwhile, the continuous heating and stirring of the open type hot oil system can cause heat accumulation, and even if the feeding temperature is reduced in the later stage of the process, the volatile gas-liquid exchange interface is still continuously exposed, and the heat sensitivity and volatile components are greatly lost under the long-time mass transfer effect. In addition, the existing plaster molding depends on physical cooling and solidification under normal pressure environment. The paste formed in the normal pressure cooling process is highly compact and homogeneous in internal structure, and the internal part is lack of a communicated medium channel, so that the migration resistance of drug molecules to a skin contact interface is increased, and the macroscopic transdermal release efficiency of a final finished product is low. The cohesive force of a solid-liquid physical fusion interface formed by relying on a normal pressure temperature regulating process is limited, and matrix phase separation and oil seepage phenomena are easy to occur to plaster products in a long-term storage or heat environment, so that the mechanical adhesive property of the products is reduced and the forming stability is poor. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a plaster for treating pain in neck, shoulder, waist and leg, which solves the problems that the thermodynamic contradiction exists between the high-temperature detoxification requirement of heat-resistant toxic medicinal materials and the retention requirement of volatile and thermosensitive active ingredients in the high-temperature decoction preparation process of the traditional Chinese medicine plaster, and the heat transfer and mass transfer efficiency is low, the transdermal release rate of products is low and the molding stability is poor due to the fact that the direct feeding of dry powder is easy to generate package agglomeration. In order to achieve the above purpose, the invention is realized by the following technical scheme: a plaster for treating neck, shoulder, waist and leg pain is prepared from the following raw materials, by weight, 30g of ephedra, 20g of angelica, 10g of safflower, 20g of divaricate saposhnikovia root, 30g of frankincense and 30g of myrrh, 30g of radix aconiti, 30g of kusnezoff monkshood root, 30g of arisaema tuber, 20g of pinellia tuber, 30g of ground beetle, 30g of eucommia bark, 20g of rhizoma sparganii, 20g of rhizoma curcumae, 50g of lycopodium clavatum, 100g