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CN-121987750-A - Nose patch for treating allergic rhinitis and preparation method and application thereof

CN121987750ACN 121987750 ACN121987750 ACN 121987750ACN-121987750-A

Abstract

The invention relates to the technical field of allergic rhinitis, in particular to a nose patch for treating allergic rhinitis as well as a preparation method and application thereof. The nasal patch comprises a medical adhesive application, wherein the medical adhesive application comprises an absorption pad, and the absorption pad is loaded with a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials, by weight, 2-8 parts of schizonepeta, 2-8 parts of peppermint, 2-8 parts of asarum, 2-8 parts of dried ginger, 2-8 parts of ginseng, 3-12 parts of schisandra chinensis, 3-12 parts of myrobalan, 3-12 parts of platycodon grandiflorum and 3-12 parts of liquorice. The product creatively combines the traditional Chinese medicine formula with the functions of tonifying qi, strengthening exterior, dispelling wind and inducing resuscitation with the acupoint transdermal technology, and the medicine effect is delivered in a targeted transdermal manner through Yingxiang acupoint, suliao acupoint, shangxiang acupoint and Bitong acupoint, so that local symptoms such as nasal obstruction, watery nasal discharge and the like can be relieved rapidly, the body immune balance is regulated, and repeated allergic attacks are reduced.

Inventors

  • WANG YONGYU
  • ZHU HUAZHEN
  • CHEN CHEN
  • CHEN JI

Assignees

  • 上海市浦东新区肺科医院(上海市浦东新区第二红十字老年护理院)

Dates

Publication Date
20260508
Application Date
20260113

Claims (10)

  1. 1. The traditional Chinese medicine composition for treating allergic rhinitis is characterized by comprising, by weight, 2-8 parts of schizonepeta, 2-8 parts of peppermint, 2-8 parts of asarum, 2-8 parts of dried ginger, 2-8 parts of ginseng, 3-12 parts of schisandra chinensis, 3-12 parts of myrobalan, 3-12 parts of platycodon grandiflorum and 3-12 parts of liquorice.
  2. 2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials, by weight, 2 parts of schizonepeta, 2 parts of peppermint, 2 parts of asarum, 2 parts of dried ginger, 2 parts of ginseng, 3 parts of schisandra chinensis, 3 parts of myrobalan, 3 parts of platycodon grandiflorum and 3 parts of liquorice.
  3. 3. The composition of claim 1, wherein the composition is an external preparation, preferably the external preparation is one of a plaster, a cataplasm, a gel, an ointment or a film coating agent, and/or the composition further comprises a pharmaceutically acceptable carrier.
  4. 4. A method for preparing a traditional Chinese medicine composition for treating allergic rhinitis according to any one of claims 1 to 3, which is characterized by comprising the following steps: (1) Mixing herba Schizonepetae, herba Menthae and herba asari to obtain a first mixture, mixing the first mixture with water, decocting, filtering, concentrating to obtain water decoction A, distilling the water decoction A, and condensing to obtain distillate A; (2) Mixing fructus Chebulae, radix Platycodi, glycyrrhrizae radix, ginseng radix, fructus Schisandrae chinensis and Zingiberis rhizoma to obtain a second mixture, mixing the second mixture with water, decocting, filtering, and concentrating to obtain water decoction B; (3) And (3) mixing the distillate A obtained in the step (1) with the water decoction B obtained in the step (2) to obtain a mixed solution.
  5. 5. The method of claim 4, further comprising one or more of the following features: 11 The decoction temperature in the step (1) is 95-100 ℃ and the decoction time is 30-50min; 12 The mass-to-volume ratio of the first mixture and water in the step (1) is 1-2g:10-20mL; 13 The distillation temperature in the step (1) is 85-105 ℃, the distillation pressure is less than or equal to 0MPa, and the distillation time is 1-8h; 14 The condensation temperature in the step (1) is 4-15 ℃; 15 The relative density of the water decoction A in the step (1) is 1.02-1.1; 21 The decoction temperature in the step (2) is 110-125 ℃, the decoction pressure is 0.1-0.15MPa, and the decoction time is 30-70min; 22 The mass-to-volume ratio of the second mixture and water in the step (2) is 1-2g:10-20mL; 23 The relative density of the water decoction B in the step (2) is 1.02-1.1.
  6. 6. A nasal patch for treating allergic rhinitis, comprising the Chinese medicinal composition according to any one of claims 1 to 3.
  7. 7. The nasal patch of claim 6, wherein the nasal patch comprises a medical adhesive patch comprising an absorbent pad having the Chinese medicinal composition of any one of claims 1-3 supported thereon.
  8. 8. The nasal patch of claim 7, wherein the medical adhesive application is a band-aid.
  9. 9. A method for preparing a nasal patch for treating allergic rhinitis according to any one of claims 6 to 8, comprising the steps of providing a medical adhesive patch having an absorbent pad, applying the Chinese medicinal composition for treating allergic rhinitis according to any one of claims 1 to 3 to the absorbent pad, and directly packaging to obtain the nasal patch for treating allergic rhinitis.
  10. 10. The use of a Chinese medicinal composition for treating allergic rhinitis according to any one of claims 1 to 3, a preparation method of a Chinese medicinal composition for treating allergic rhinitis according to any one of claims 4 to 5 or a nasal patch for treating allergic rhinitis according to any one of claims 6 to 8 in the preparation of a medicament for treating allergic rhinitis, preferably, the nasal patch is applied to Yingxiang acupoint, suliao acupoint, shangxiang acupoint and Bitong acupoint targeted transdermal delivery medicament.

Description

Nose patch for treating allergic rhinitis and preparation method and application thereof Technical Field The invention relates to the technical field of allergic rhinitis, in particular to a nose patch for treating allergic rhinitis as well as a preparation method and application thereof. Background Allergic rhinitis (ALLERGIC RHINITIS, AR), i.e. allergic rhinitis, is one of the common chronic inflammatory diseases of the respiratory tract worldwide. Epidemiological investigation shows that the global prevalence is about 10% -30% and the trend is rising year by year, which has become an important public health problem. The disease is characterized by the main clinical manifestations of nasal itching, paroxysmal sneeze, clear watery nasal discharge and nasal obstruction, and recurrent attacks continuously (perennially) or intermittently (seasonally). If the treatment is not timely and standardized, the disease course can cause various complications such as nasosinusitis, bronchitis, secretory otitis media and pharyngitis, and the risk of inducing or aggravating downstream airway diseases such as allergic asthma, cough variant asthma and the like can be obviously increased, so that the maxillofacial development, sleep quality, cognitive function and daily learning work efficiency of patients (especially children) are seriously affected. At present, the modern medicine is used for treating allergic rhinitis according to the principle of 'prevention and treatment combination and four-in-one', and mainly comprises the following steps: the core of the non-drug treatment is to avoid contacting with known allergen, and assist nasal cavity saline washing, using an air purifier and the like. Although the methods can relieve symptoms to a certain extent, radical treatment cannot be realized, and the allergen is often difficult to realize in real life; The medicine treatment is first line therapy, mainly comprising oral or nasal second generation antihistamine, nasal glucocorticoid and leukotriene receptor antagonist, etc. These drugs are effective in controlling symptoms, but are required to be used for a long period or seasonally. The long-term application can bring about certain side effects, such as nasal hormone can cause nasal cavity dryness and bleeding, systemic administration can have the risks of sleepiness, headache and the like, and partial patients have poor compliance; Immunotherapy, i.e. desensitization therapy, is a therapeutic approach to the etiology, but has a course of treatment of up to 3-5 years, high costs, and risk of systemic anaphylaxis, and limited applicable populations and conditions. Given the limitations of modern medical therapies described above, traditional Chinese Medicine (TCM) has demonstrated unique advantages in treating allergic rhinitis. The traditional Chinese medicine considers that the disease is caused by deficiency of lung, spleen and kidney, exogenous wind-cold or pathogenic wind-heat, and the disease is emphasized in treatment and strengthening body resistance to eliminate pathogenic factors and is regulated as a whole. In addition to the oral administration of traditional Chinese medicines, acupoint application (especially 'Sanvo plaster', 'Sanjiu plaster') is used as an external treatment method with long history, and the medicine and the acupoint dual functions are used for stimulating menstrual qi and regulating immunity, so that the medicine can be widely applied to the prevention and treatment of allergic rhinitis in clinic, and has the advantages of simple operation and relatively light pain-free feeling. However, the traditional manual-prepared acupoint pasting paste has the problems of unstable characters, easiness in drying or mildew, short storage period, strong medicine smell, skin irritation and the like, and influences the standardized popularization and long-term use willingness of patients. In recent years, in order to overcome the shortcomings of the conventional dosage forms, studies have been attempted to formulate the acupoint application. For example: The Chinese patent CN109847048A discloses an acupoint plaster for treating allergic rhinitis of children, which can effectively solve the medication problem of allergic rhinitis of children, and the technical scheme is that 30-40 g of white mustard seed, 15-20g of raw kansui root, 15-20g of asarum herb, 10-15g of rhizoma corydalis, 10-15g of dried ginger, 10-15g of clove, 70-100g of ginger juice and 70-100g of honey are mixed with equal amount of honey to obtain a mixed solution, and the mixed solution is mixed with the mixed solution to form the ointment, and the ointment is fixed on an antiallergic adhesive tape. The raw materials of the invention are natural, and the clinical application shows a certain curative effect. However, the paste taking fresh ginger juice and honey as the matrix has high water content, is easy to cause deterioration due to microorganism breeding, has poor stability and short