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CN-121987754-A - Traditional Chinese medicine composition for treating phlegm-dampness obstructing lung and wind-disturbance qi reverse type chronic cough as well as preparation method and application thereof

CN121987754ACN 121987754 ACN121987754 ACN 121987754ACN-121987754-A

Abstract

The invention discloses a traditional Chinese medicine composition for treating phlegm-dampness blocking lung and wind-disturbance qi reverse type chronic cough, and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines, wherein the traditional Chinese medicine composition comprises, by weight, 10-18 parts of radix bupleuri, 7-14 parts of radix scutellariae, 10-18 parts of pinellia ternate, 10-14 parts of magnolia officinalis, 8-12 parts of almond, 7-12 parts of earthworm, 10-15 parts of poria cocos, 6-12 parts of perilla fruit, 6-12 parts of platycodon grandiflorum and 8-12 parts of Chinese angelica sinensis. The invention takes bupleurum and pinellia tuber as principal and direct central pathogenesis, assistant drugs assist and synergy, give consideration to both symptoms, adjuvant drugs comprehensively complement the pathogenesis and target conditioning, lead the medicine to guide the meridian to regulate the middle-jiao and strengthen the body resistance to harmonize, and progressive layer by layer, thereby not only rapidly relieving the symptoms such as cough, asthma, excessive phlegm and the like, but also fundamentally reducing phlegm and eliminating dampness, regulating qi movement, reinforcing and protecting lung and spleen, avoiding relapse, meeting the 'urgent rule for treating the symptoms and the slow rule for treating the root cause', and forming a unique treatment scheme.

Inventors

  • ZHENG JIAKUN
  • YANG XU
  • DU JIAJIE
  • LI YUNQIAO

Assignees

  • 西南医科大学

Dates

Publication Date
20260508
Application Date
20260228

Claims (8)

  1. 1. A traditional Chinese medicine composition for treating phlegm-dampness obstructing lung and wind-disturbance qi reverse type chronic cough is characterized by comprising, by weight, 10-18 parts of bupleurum, 7-14 parts of radix scutellariae, 10-18 parts of pinellia ternate, 10-14 parts of magnolia officinalis, 8-12 parts of almond, 7-12 parts of earthworm, 10-15 parts of poria cocos, 6-12 parts of perilla fruit, 6-12 parts of platycodon grandiflorum and 8-12 parts of angelica sinensis, wherein the bupleurum and the pinellia ternate are monarch drugs, the scutellaria baicalensis, the magnolia officinalis, the almond, the platycodon grandiflorum and the earthworm are ministerial drugs, and the balance is adjuvant drugs.
  2. 2. The traditional Chinese medicine composition for treating phlegm-dampness obstructing lung and wind-disturbance qi reversed type chronic cough according to claim 1, which is characterized by further comprising 6-12 parts of stiff silkworm and 10-20 parts of dandelion.
  3. 3. The traditional Chinese medicine composition for treating phlegm-dampness obstructing lung and wind-disturbance qi reversed type chronic cough according to claim 2, further comprising 3-5 parts of dried ginger and 5-8 parts of schisandra chinensis.
  4. 4. The traditional Chinese medicine composition for treating phlegm-dampness obstructing the lung and wind-disturbance qi reverse type chronic cough according to claim 1, wherein the traditional Chinese medicine composition is characterized by comprising 12 parts of radix bupleuri, 10 parts of radix scutellariae, 15 parts of pinellia ternate, 12 parts of magnolia officinalis, 10 parts of almond, 10 parts of earthworm, 12 parts of poria cocos, 10 parts of perilla fruit, 10 parts of platycodon grandiflorum and 10 parts of Chinese angelica.
  5. 5. The traditional Chinese medicine composition for treating phlegm-dampness obstructing lung and wind-disturbance qi reversed type chronic cough according to claim 2, wherein 9 parts of stiff silkworm and 15 parts of dandelion.
  6. 6. The traditional Chinese medicine composition for treating phlegm-dampness obstructing the lung and wind-disturbance qi reversed flow type chronic cough according to claim 3, wherein the traditional Chinese medicine composition comprises 4 parts of dried ginger and 6 parts of shizandra berry.
  7. 7. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 6, which is characterized by comprising the following steps: S1, accurately weighing all raw materials; S2, placing all the raw materials into a decocting container, adding 6-12 times (based on the total weight of the raw materials) of drinking water, soaking for 35-60 minutes at normal temperature, boiling with strong fire, then turning into slow fire to keep slight boiling, decocting for 30-50 minutes, and filtering out the first liquid medicine with a filter screen; S3, adding 4-8 times of drinking water into the residues again, boiling with strong fire, decocting with slow fire for 20-40 minutes, and filtering out secondary liquid medicine; S4, merging the liquid medicine obtained by the two times of decoction to obtain the decoction of the traditional Chinese medicine composition.
  8. 8. The use of a traditional Chinese medicine composition according to any one of claims 1-6, which is characterized in that the traditional Chinese medicine composition is used for treating phlegm-dampness obstructing the lung and wind-disturbance qi reverse type chronic cough.

Description

Traditional Chinese medicine composition for treating phlegm-dampness obstructing lung and wind-disturbance qi reverse type chronic cough as well as preparation method and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating phlegm-dampness obstructing the lung and wind-disturbance qi reverse type chronic cough, and a preparation method and application thereof. Background Chronic cough is a clinically common respiratory symptom, the incidence rate is up to 10%, the course of disease is prolonged, and the pathogenesis is complex. Western medicine considers that the occurrence of chronic cough is mostly related to chronic airway inflammation, various inflammatory cells are activated such as eosinophils, and the traditional Chinese medicine belongs to the category of chronic cough and chronic cough, and considers that the chronic cough has various pathogenesis, wherein 'phlegm-dampness obstructing lung and wind disturbing qi reverse' is a core and common syndrome type, which is characterized in that spleen is not good for transportation, phlegm-dampness is generated internally, the lung is disturbed upwards, the lung qi is obstructed and the function of dispersing and descending is lost, meanwhile, liver is not smooth, shaoyang pivot is unfavorable, the lung qi is obstructed due to qi stagnation, and phlegm-dampness is formed by heat generation and phlegm-dampness accumulation, internal pivot is unfavorable and phlegm-dampness Yu Fu, external wind or liver wind is easy to move internally, wind-phlegm is paced, lung qi is disturbed downwards, and cough is not restricted. The clinical manifestations are recurrent cough, sticky or foam-like sputum, itching throat, cough, chest distress, short breath, epigastric fullness, greasy tongue coating and wiry and slippery pulse. Modern western medicine treatment of chronic cough is usually given by inhalation of small dose of glucocorticoid in combination with bronchodilator (beta 2-receptor agonist or aminophylline, etc.), or by compound preparation of both, such as budesonide/formoterol, fluticasone/salmeterol, and short-term oral administration of small dose of glucocorticoid if necessary. The treatment time is not less than 8 weeks, and symptoms can be controlled in a short period, but the method has obvious limitations that the symptoms are easy to repeat after stopping the medicine, long-term management is needed, individual medicine response differences are large, part of patients are allergic or poor in curative effect, and side effects such as oral candida infection, hoarseness and the like can be induced by long-term administration of western medicines and hormone treatment. The modern medicine considers that chronic cough is mostly related to allergic factors, traditional Chinese medicines with antiallergic effect such as paniculate swallowwort root, schizonepeta, cicada slough, earthworm, baikal skullcap root, stiff silkworm, radix sileris and the like are added in the traditional Chinese medicine clinic, and the current prescription for treating chronic cough is various, such as modified formulas of Erchen decoction, cough relieving powder, mulberry leaf chrysanthemum drink, xiaoqinglong decoction, wuling powder and the like, so that the diversity and flexibility of diagnosis and treatment of the traditional Chinese medicine are reflected. However, in dealing with chronic cough with complex pathogenesis and long-lasting course of disease, the clinical application of these prescriptions still has the following problems: (1) The corresponding accuracy of the prescription needs to be improved, the prescription is longer than Wen Huahan phlegm and has the effects of strengthening spleen and eliminating dampness (such as Erchen decoction), but has the effects of dispelling wind and relieving spasm and harmonizing liver and lung for the pathogenesis of wind evil disturbance and qi stagnation, so that the symptoms of sudden cough, paroxysmal and emotion association of some patients are not ideal to be controlled, the prescription is mainly used for dispelling wind and dispersing lung and relieving cough (such as cough relieving powder), but has the effects of reducing phlegm and lowering adverse qi and strengthening body resistance for the people with excessive phlegm and dampness or deficiency of healthy qi, has the relatively weak effects of reducing phlegm and strengthening body resistance and is difficult to block the endogenous source of phlegm and dampness or prevent cough from lasting and relapse, and has the effects of relieving exterior syndrome and dispelling cold and warming lung and resolving phlegm (such as Xiaoqinglong decoction), but has the defect of warming and dryness and fluid consumption and heat assistance for the patients with stasis or yin injury. (2) Modern science of efficacy assessment is undersupported by