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CN-121987756-A - Traditional Chinese medicine composition for treating repeated planting failure and preparation method and application thereof

CN121987756ACN 121987756 ACN121987756 ACN 121987756ACN-121987756-A

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating repeated planting failure, and a preparation method and application thereof. The traditional Chinese medicine composition has the effects of activating blood circulation, removing blood stasis, tonifying kidney and warming channels, further has the effects of warming channels, warming uterus, tonifying kidney and nourishing blood, improving the intimal acceptance by using the traditional Chinese medicine composition for removing blood stasis, tonifying kidney and treating kidney, and further has the effects of strengthening heart, assisting embryo, nourishing blood, preventing miscarriage and supporting early pregnancy by using the traditional Chinese medicine composition for implantation prevention treatment after transplantation, and the three traditional Chinese medicine compositions realize systematic intervention from eliminating evil to strengthening body resistance to preventing miscarriage by progressive three-stage treatment, so that the embryo implantation rate and clinical pregnancy rate of patients with repeated implantation failure are improved.

Inventors

  • WANG CHAOYANG
  • SUN AIJUN

Assignees

  • 杏霖妇科内分泌研究院

Dates

Publication Date
20260508
Application Date
20260310

Claims (10)

  1. 1. The traditional Chinese medicine composition for treating repeated embryo planting failure is characterized by comprising the following raw materials in parts by weight: 14-16 parts of cassia twig, 14-16 parts of white paeony root, 11-13 parts of semen cuscutae, 11-13 parts of raspberry, 14-16 parts of teasel root, 5-7 parts of ginger, 29-31 parts of jujube, 14-16 parts of fried eucommia bark, 11-13 parts of Chinese angelica, 19-21 parts of astragalus root and 5-7 parts of honey-fried licorice root.
  2. 2. The traditional Chinese medicine composition for treating repeated embryo planting failure according to claim 1, further comprising a traditional Chinese medicine composition for warming uterus and tonifying kidney, wherein the traditional Chinese medicine composition for warming uterus and tonifying kidney comprises the following raw materials in parts by weight: 14-16 parts of cassia twig, 14-16 parts of white peony root, 4-6 parts of evodia rutaecarpa, 11-13 parts of angelica, 7-9 parts of ligusticum wallichii, 9-11 parts of peach kernel, 19-21 parts of campsis grandiflora, 29-31 parts of amethyst, 9-11 parts of cortex moutan, 39-41 parts of jujube, 4-6 parts of sun-dried ginseng, 19-21 parts of radix asparagi, 14-16 parts of semen cuscutae, 11-13 parts of raspberry, 19-21 parts of medicinal cyathula root, 19-21 parts of fried eucommia bark, 5-7 parts of cornu cervi degelatinatum, 5-7 parts of honey-fried licorice root, 14-16 parts of fried spina date seed, 3-5 parts of coptis chinensis, 5-7 parts of donkey-hide gelatin bead, 19-21 parts of honey-fried astragalus root, 11-13 parts of epimedium herb, 5-7 parts of semen lepidii and 9-11 parts of cooked aconite root.
  3. 3. The traditional Chinese medicine composition for treating repeated embryo planting failure according to claim 1 or 2 is characterized by further comprising, by weight, 17-19 parts of cassia twig, 17-19 parts of white peony root, 4-6 parts of fructus evodiae, 11-13 parts of Chinese angelica, 7-9 parts of ligusticum wallichii, 7-9 parts of ground beeltle, 4-6 parts of leech, 9-11 parts of peach kernel, 9-11 parts of cortex moutan, 7-9 parts of semen lepidii, 39-41 parts of jujube, 4-6 parts of sun ginseng, 14-16 parts of semen cuscutae, 11-13 parts of raspberry, 19-21 parts of radix cyathulae, 19-21 parts of fried eucommia bark, 5-7 parts of cornu cervi degelatinatum, 5-7 parts of honey-fried licorice root, 14-16 parts of fried semen zizyphi spinosae, 3-5 parts of coptis chinensis, 5-7 parts of donkey-hide gelatin pearl, 7-9 parts of safflower, 19-21 parts of honey-fried radix astragali and 9-11 parts of radix aconiti carmichaeli.
  4. 4. The traditional Chinese medicine composition for treating repeated embryo planting failure according to claim 3, which comprises a stasis-removing and kidney-tonifying traditional Chinese medicine composition, a uterus-warming and kidney-tonifying traditional Chinese medicine composition and a post-implantation miscarriage-preventing traditional Chinese medicine composition; The traditional Chinese medicine composition for removing blood stasis and tonifying kidney comprises the following raw materials, by weight, 18 parts of cassia twig, 18 parts of white paeony root, 5 parts of evodia rutaecarpa, 12 parts of angelica sinensis, 8 parts of ligusticum wallichii, 8 parts of ground beetle, 5 parts of leech, 10 parts of peach kernel, 10 parts of cortex moutan, 8 parts of semen lepidii, 40 parts of jujube, 5 parts of sun-dried ginseng, 15 parts of semen cuscutae, 12 parts of raspberry, 20 parts of radix cyathulae, 20 parts of fried eucommia bark, 6 parts of cornu cervi degelatinatum, 6 parts of honey-fried licorice root, 15 parts of fried spina date seed, 4 parts of coptis chinensis, 6 parts of donkey-hide gelatin bead, 8 parts of safflower, 20 parts of honey-fried astragalus root and 10 parts of cooked aconite root; The traditional Chinese medicine composition for warming uterus and tonifying kidney comprises the following raw materials, by weight, 15 parts of cassia twig, 15 parts of white peony root, 5 parts of fructus evodiae, 12 parts of Chinese angelica, 8 parts of szechuan lovage rhizome, 10 parts of peach kernel, 20 parts of campsis grandiflora, 30 parts of amethyst, 10 parts of cortex moutan, 40 parts of Chinese date, 5 parts of sun-dried ginseng, 20 parts of radix asparagi, 15 parts of semen cuscutae, 12 parts of raspberry, 20 parts of medicinal cyathula root, 20 parts of stir-fried eucommia bark, 6 parts of cornu cervi degelatinatum, 6 parts of stir-fried liquorice, 15 parts of stir-fried spina date seed, 4 parts of coptis chinensis, 6 parts of donkey-hide gelatin bead, 20 parts of stir-fried astragalus root, 12 parts of epimedium, 6 parts of pepperweed seed and 10 parts of cooked aconite root; The traditional Chinese medicine composition for treating miscarriage by implantation after transplantation comprises the following raw materials of, by weight, 15 parts of cassia twig, 15 parts of white peony root, 12 parts of semen cuscutae, 12 parts of raspberry, 15 parts of radix dipsaci, 6 parts of ginger, 30 parts of Chinese date, 15 parts of fried eucommia ulmoides, 12 parts of Chinese angelica, 20 parts of astragalus and 6 parts of honey-fried licorice root.
  5. 5. The method for preparing the traditional Chinese medicine composition for treating repeated embryo planting failure according to any one of claims 1 to 4, which is characterized by comprising the following steps: weighing the traditional Chinese medicines in the traditional Chinese medicine composition for treating miscarriage prevention after implantation according to parts by weight, and mixing and soaking the traditional Chinese medicines with water to obtain a first soaked traditional Chinese medicine mixture; And (3) performing first decoction on the first soaked traditional Chinese medicine mixture, and taking medicine liquid to obtain the traditional Chinese medicine composition for treating miscarriage prevention after implantation.
  6. 6. The method of manufacturing according to claim 5, comprising the steps of: Weighing the traditional Chinese medicines in the traditional Chinese medicine composition for warming uterus and tonifying kidney according to parts by weight, wrapping semen Lepidii with a traditional Chinese medicine wrapping and decocting material, and mixing and soaking the wrapped semen Lepidii with other traditional Chinese medicines except donkey-hide gelatin beads and water to obtain a second soaked traditional Chinese medicine composition; Mixing the cooked aconite in the second soaked traditional Chinese medicine composition with water, decocting for 0.5-1 h, mixing with other soaked traditional Chinese medicines, performing second decoction, and mixing the liquid medicine with donkey-hide gelatin beads to obtain the traditional Chinese medicine composition for warming uterus and tonifying kidney.
  7. 7. The preparation method of the traditional Chinese medicine composition according to claim 5 or 6, which is characterized by comprising the following steps of weighing all traditional Chinese medicines in the traditional Chinese medicine composition for removing blood stasis and tonifying kidney according to parts by weight, wrapping semen lepidii with a traditional Chinese medicine wrapping and decocting material, and mixing and soaking the wrapped semen lepidii with other traditional Chinese medicines except donkey-hide gelatin beads and water to obtain a third soaked traditional Chinese medicine composition; Mixing the cooked aconite in the third soaked traditional Chinese medicine composition with water, decocting for 0.5-1 h, mixing with other soaked traditional Chinese medicines, performing third decoction, and mixing the liquid medicine with donkey-hide gelatin beads to obtain the traditional Chinese medicine composition for removing blood stasis and tonifying kidney.
  8. 8. The preparation method according to claim 7, wherein the first decoction time is 0.5 to 1h, and the number of times of the first decoction is 1 to 2 times; the second decoction time is 0.5-1 h, and the second decoction times are 1-2 times; The third decoction time is 0.5-1 h, and the third decoction times are 1-2 times.
  9. 9. The use of a traditional Chinese medicine composition for treating repeated embryo planting failure according to any one of claims 1-4 or a traditional Chinese medicine composition for treating repeated embryo planting failure prepared by the preparation method according to any one of claims 5-8 in preparation of auxiliary reproduction medicines.
  10. 10. The use of claim 9, wherein preparing the assisted reproductive medicament comprises preparing a medicament for treating recurrent embryo planting failure.

Description

Traditional Chinese medicine composition for treating repeated planting failure and preparation method and application thereof Technical Field The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating repeated planting failure, and a preparation method and application thereof. Background In recent years, the incidence of infertility has been on the rise year by year. Assisted reproductive technology (assisted reproductive technology, ART) is an effective treatment for infertility and is widely used worldwide. ART refers to a technique for helping infertility couples to achieve pregnancy by medical means, and mainly comprises two major categories of artificial insemination (ARTIFICIAL INSEMINATION, AI) and in vitro fertilization-embryo transfer (In Vitro Fertilization and Embryo Transfer, IVF-ET) and derivatives thereof. To date, ART technology, despite many milestone advances, still suffers from embryo planting failure in 50% -60% of IVF cycles. The occurrence rate of repeated embryo implantation failure (recurrent implantation failure, RIF) is about 10% -20%, no definite and effective treatment measures are available in clinic at present, and a great economic burden and physical and psychological trauma are brought to patients and families, so that the repeated embryo implantation failure is a great challenge for clinicians, and the repeated embryo implantation failure is an important point and difficulty problem to be solved in the assisted reproduction field. RIF has a complex etiology, and Western medicine is mainly divided into embryo factors, endometrial factors and other factors. Western medicine treatment mainly improves embryo quality in a laboratory, uterine cavity operation improves uterine cavity environment and oral medicine improves immune endocrine state, but is easy to cause complications due to high price and operation, partial medicine effect is poor, clinical curative effect is still unsatisfactory, and the existing treatment means can not meet clinical requirements. Related researches show that the combined treatment of traditional Chinese medicine and western medicine has a certain effect on the aspect of promoting pregnancy. However, the traditional Chinese medicine emphasizes individuation diagnosis and treatment according to different individuals, and is difficult to popularize and apply in a large scale in clinical treatment. Therefore, it is highly desirable to propose a systematic and generalized Chinese medicine general treatment method to solve the problem that the therapeutic effect of treating RIF is not ideal and the personalized treatment is difficult to popularize in the clinic at present. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition for treating repeated planting failure, and a preparation method and application thereof, wherein the traditional Chinese medicine composition can effectively improve embryo implantation rate and clinical pregnancy rate of patients with repeated embryo planting failure. The invention provides a traditional Chinese medicine composition for treating repeated embryo planting failure, which comprises the following raw materials in parts by weight: 14-16 parts of cassia twig, 14-16 parts of white paeony root, 11-13 parts of semen cuscutae, 11-13 parts of raspberry, 14-16 parts of teasel root, 5-7 parts of ginger, 29-31 parts of jujube, 14-16 parts of fried eucommia bark, 11-13 parts of Chinese angelica, 19-21 parts of astragalus root and 5-7 parts of honey-fried licorice root. Preferably, the traditional Chinese medicine composition for warming uterus and tonifying kidney also comprises the following raw materials in parts by weight: 14-16 parts of cassia twig, 14-16 parts of white peony root, 4-6 parts of evodia rutaecarpa, 11-13 parts of angelica, 7-9 parts of ligusticum wallichii, 9-11 parts of peach kernel, 19-21 parts of campsis grandiflora, 29-31 parts of amethyst, 9-11 parts of cortex moutan, 39-41 parts of jujube, 4-6 parts of sun-dried ginseng, 19-21 parts of radix asparagi, 14-16 parts of semen cuscutae, 11-13 parts of raspberry, 19-21 parts of medicinal cyathula root, 19-21 parts of fried eucommia bark, 5-7 parts of cornu cervi degelatinatum, 5-7 parts of honey-fried licorice root, 14-16 parts of fried spina date seed, 3-5 parts of coptis chinensis, 5-7 parts of donkey-hide gelatin bead, 19-21 parts of honey-fried astragalus root, 11-13 parts of epimedium herb, 5-7 parts of semen lepidii and 9-11 parts of cooked aconite root. The traditional Chinese medicine composition for removing blood stasis and tonifying kidney comprises, by weight, 17-19 parts of cassia twig, 17-19 parts of white paeony root, 4-6 parts of fructus evodiae, 11-13 parts of Chinese angelica, 7-9 parts of szechuan lovage rhizome, 7-9 parts of ground beeltle, 4-6 parts of leech, 9-11 parts of peach kernel,